Sinochem Corporation is a Chinese conglomerate primarily engaged in the production and trading of chemicals and fertilizer and exploration and production of oil. Its majority owned fertilizer subsidiary Sinofert is involved throughout the chain from production of the product and procurement on international markets to distribution and retail. Wikipedia.
Sinochem Group | Date: 2013-03-18
Cefodroxil monohydrate is formed by a processing which includes a) bringing an aqueous solution of cefadroxil monohydrate to a pH of between 7 to 9 with a suitable titrant; b) lowering the pH to a value of between 5 and 6.5 to obtain a suspension of cefadroxil monohydrate in crystal form; and c) isolating the cefadroxil monohydrate in crystal form from the suspension obtained in step b). The cefadroxil monohydrate thereby obtained exhibits a CIE b value of below 6, and advantageously a CIE b value of below 12 when stored at a temperature of 25 C. for at least 1 month.
Sinochem Group | Date: 2013-01-28
The present invention relates to the preparation of -lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation.
Sinochem Group | Date: 2013-01-07
The present invention relates to a method for the fermentation of cyclopeptides such as pneumocandins in the presence of increased concentrations of any or all of calcium, copper, iron, magnesium, manganese, molybdenum and zinc ions.
Sinochem Group | Date: 2014-04-28
The present invention relates to a method for isolating caspofungin and to a novel crystalline form of caspofungin diacetate thus obtained.
Guan A.,Sinochem Group |
Liu C.,Sinochem Group |
Yang X.,University of Colorado at Denver |
Dekeyser M.,Chemtura Canada
Chemical Reviews | Year: 2014
The IDM approach to agrochemical discovery may be considered to fit between the conventional methods used in agrochemical discovery and the recent novel methods reported in the pharmaceutical field. The basic idea behind IDM is to apply a wide variety of synthetic methodology on key intermediates resulting in an efficient route to innovative chemical structures, which, in conjunction with biological screening, become patentable leads or target compounds. The key to the success of this method is to apply new chemical reactions or new synthesis routes to obtain novel structures that are totally different from previously known agrochemicals, pharmaceuticals, or natural products. These newly synthesized compounds can be screened and each optimized to obtain new lead compounds, ultimately leading to the discovery of new agrochemicals. In contrast with the conventional methods described previously, CIM is mainly based on suitably functionalized and commercially available chemical intermediates rather than based on random design.