Sinhgad Institute of Pharmaceutical science SIPS

Lonāvale, India

Sinhgad Institute of Pharmaceutical science SIPS

Lonāvale, India

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Jadhav V.B.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Thakare V.N.,Sinhgad Institute of Pharmaceutical science SIPS | Suralkar A.A.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Naik S.R.,Sinhgad Institute of Pharmaceutical science SIPS
Indian Journal of Experimental Biology | Year: 2013

The present study reports protective effect of hydro-alcoholic extract of Luffa acutangula (HAELA) on doxorubicin (DXR) induced cardio and nephro toxicity in mice by studying various serum biomarkers, antioxidants in target organs and histoarchitecture alterations. Pretreatment with HAELA reversed significantly the elevated serum biomarkers, alanine amino transferase, lactate dehydrogenase and creatinine phosphokinase in heart and kidney in DXR treated mice. In addition, HAELA treatment inhibited elevated malondialdehyde formation and restored the depleted glutathione, catalase, superoxide dismutase in heart and kidney tissue. The altered histoarchitecture of heart and kidney tissue due to DXR treatment were also improved with HAELA. The protective activity observed with HAELA on DXR induced cardio and nephrotoxicity in mice was found to be related to its antioxidant property which finally results in membrane stabilization.


Thakare V.N.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Suralkar A.A.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Deshpande A.D.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Naik S.R.,Sinhgad Institute of Pharmaceutical science SIPS
Indian Journal of Experimental Biology | Year: 2010

In the present study, anti-inflammatory and analgesic effect of aqueous extract of Ficus bengalensis (AEFB) and methanolic extract of F. bengalensis (MEFB) was evaluated in animal models. Preliminary results indicated that MEFB treatment possesses significant anti-inflammatory potential as compared to AEFB. The anti-inflammatory activity of MEFB exhibited in both acute (carrageenan induced hind paw edema and acetic acid induced vascular permeability) and sub-chronic (cotton pellet-induced granuloma) models of inflammation was found to be significant. In addition, the extract also showed significant analgesic activity in acetic acid induced writhing. Pretreatment with MEFB during inflammatory condition (both acute and sub-chronic) prevented increase in malondialdehyde (MDA) formation and myeloperoxidase activity in edematous as well as granulomatous tissue. Further, serum marker enzymes (AST, ALT and ALP) increased in inflammatory conditions were also inhibited with MEFB treatment. Hence, the anti-inflammatory activity observed in the present study with MEFB could be attributed largely to its antioxidant and lysosomal membrane stabilizing effects.


Jadhav V.B.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Thakare V.N.,Sinhgad Institute of Pharmaceutical science SIPS | Suralkar A.A.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Deshpande A.D.,Padm Dr D Y Patil Institute of Pharmaceutical science and Research | Naik S.R.,Sinhgad Institute of Pharmaceutical science SIPS
Indian Journal of Experimental Biology | Year: 2010

Hepatoprotective activity of hydroalcoholic extract of Luffa acutangula (HAELA) against carbon tetrachloride (CCl4) and rifampicin-induced hepatotoxicity in rats was evaluated and probable mechanism(s) of action has been suggested. Administration of standard drug- silymarin and HAELA showed significant hepatoprotection against CCl4 and rifampicin induced hepatotoxicity in rats. Hepatoprotective activity of HAELA was due to the decreased levels of serum marker enzymes viz., (AST, ALT, ALP and LDH) and increased total protein including the improvement in histoarchitecture of liver cells of the treated groups as compared to the control group. HAELA also showed significant decrease in malondialdehyde (MDA) formation, increased activity of non-enzymatic intracellular antioxidant, glutathione and enzymatic antioxidants, catalase and superoxide dismutase. Results of this study demonstrated that endogenous antioxidants and inhibition of lipid peroxidation of membrane contribute to hepatoprotective activity of HAELA.


Lende A.B.,Pad Dr D Y Patil Institute Of Pharmaceutical Science And Research | Kshirsagar A.D.,Pad Dr D Y Patil Institute Of Pharmaceutical Science And Research | Deshpande A.D.,Pad Dr D Y Patil Institute Of Pharmaceutical Science And Research | Muley M.M.,Pad Dr D Y Patil Institute Of Pharmaceutical Science And Research | And 3 more authors.
Inflammopharmacology | Year: 2011

Anti-inflammatory and analgesic activity of protocatechuic acid (PCA), a natural product, was evaluated in different rat models (viz., carrageenan-induced paw oedema, cotton pellet-induced granuloma and Freund's adjuvant arthritis) of inflammation and chemical and heat induced mouse models of pain. Treatment with PCA inhibited significantly different biological parameters like hind paw oedema, granuloma exudates formation and arthritis index in carrageenan oedema, cotton pellet granuloma and Freund's adjuvant arthritis, respectively. The biochemical changes viz., glutathione, superoxide dismutase, catalase, lipid peroxidation and NO in oedematous or in liver tissues and serum alanine aminotransferase and lactic dehydrogenase occurred during different types of inflammation were either significantly restored or inhibited with PCA pretreatment. Present experimental findings demonstrate promising anti-inflammatory and analgesic activity of PCA which is comparable with that of standard drugs used. © 2011 Springer Basel AG.

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