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Kokil G.R.,Sinhgad Institute of Pharmaceutical science | Naik S.R.,Off Mumbai
Current Medicinal Chemistry | Year: 2010

Diabetes mellitus, an epidemic metabolic disorders characterized by high blood glucose level associated with various macrovascular and microvascular complications, is one of the main causes of human suffering across the globe. Researchers around the world mainly focused on insulin, insulin analogues, oral hypoglycemic agents and various other complementary and alternate medicines to control the blood glucose levels in diabetes. The present review summarizes the disorders associated with elevation of blood glucose level, biochemical & endocrinological aspects and the current strategies to control. The emphasis has been laid in particular on the new potential biological targets and the possible treatment as well as the current ongoing research status on new generation hypoglycemic agents. © 2010 Bentham Science Publishers Ltd.

Naik S.R.,Sinhgad Institute of Pharmaceutical science
Indian Journal of Experimental Biology | Year: 2014

Administration of rutin (50 and 100 mg/kg) and pioglitazone (10 mg/kg) orally for 3 weeks treatment significantly improved body weight, reduced plasma glucose and glycosylated hemoglobin, pro-inflammatory cytokines (IL-6 and TNF-α), restored the depleted liver antioxidant status and serum lipid profile in high fat diet + streptozotocin induced type 2 diabetic rats. Rutin treatment also improved histo-architecture of ß islets and reversed hypertrophy of hepatocytes. Rutin exhibited significant antidiabetic activity, presumably by inhibiting inflammatory cytokines, improving antioxidant and plasma lipid profiles in High fat diet + streptozotocin induced type 2 diabetic model and may be useful as a diabetic modulator along with standard antidiabetic drugs. However, such effects need to be confirmed on human subjects in clinical condition.

Thakare V.N.,Sinhgad Institute of Pharmaceutical science
Experimental and Toxicologic Pathology | Year: 2011

The present study investigates the protective effects of curcumin on experimentally induced inflammation, hepatotoxicity, and cardiotoxicity using various animal models with biochemical parameters like serum marker enzymes and antioxidants in target tissues. In addition, liver and cardiac histoarchitecture changes were also studied. Curcumin treatment inhibited carrageenin and albumin induced edema, cotton pellet granuloma formation. The increased relative weight of liver and heart in CCl4 induced liver injury and isoproterenol induced cardiac necrosis were also reduced by curcumin treatment. Elevated serum marker enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) increased lipid peroxidation, decreased gluthione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in edematous, granulomatus, liver and heart tissues during inflammation, liver injury and cardiac necrosis, respectively. Curcumin treatment reversed all these above mentioned biochemical changes significantly in all animal models studied. Even histoarchitecture alterations observed in liver injury and cardiac necrosis observed were partially reversed (improved) by curcumin treatments. In in vitro experiments too curcumin inhibited iron catalyzed lipid peroxidation in liver homogenates, scavenged nitric oxide spontaneously generated from nitroprusside and inhibited heat induced hemolysis of rat erythrocytes. The present in vitro and in vivo experimental findings suggest the protective effect of curcumin on experimentally induced inflammation, hepatotoxicity, and cardiotoxicity in rats. © 2010 Elsevier GmbH.

Bumrela S.B.,Sinhgad Institute of Pharmaceutical science | Naik S.R.,Sinhgad Institute of Pharmaceutical science
International Journal of Phytomedicine | Year: 2011

The Dipteracanthus patulus (Jacq) nees is undershrub belonging to the family acantheaceae. Antimicrobial activity (disc diffusion method) and antioxidant activity by different in-vitro methods (DPPH, hydrogen peroxide, nitric oxide radical scavenging and reducing power) of methanolic extract of Dipteracanthus patulus (MEDP) was evaluated. The qualitative and quantitative estimation of β-carotene and β- sitosterol in MEDP was carried out by high performance thin layer chromatography (HPTLC). The total phenolic content of was determined by Folin-Ciocalteu method. Experimental findings indicate promising antimicrobial activity (antibacterial and antifungal) and potent antioxidant activity of MEDP. In addition, phytochemical analysis and spectral studies of MEDP were also performed. It is presumed that antimicrobial and antioxidant activity observed with MEDP may largely be attributed to the presence of major phytoconstituents (β-carotene, β-sitosterol and iridoid glycosides) and other minor components may participate as promoters.

Naik S.R.,Sinhgad Institute of Pharmaceutical science | Wala S.M.,Sinhgad Institute of Pharmaceutical science
Recent Patents on Inflammation and Allergy Drug Discovery | Year: 2013

Inflammation, allergy and asthma are the manifestation of multitude reactions of biological, cellular and immunological events. The various associated biological, cellular, and molecular events with inflammation, allergy and asthma participate to induce increased vascular permeability, vasodilatation, cellular migration, increased mucus secretion, broncho- constriction, structural changes of airway architecture, decline in pulmonary functions, release of intracellular mediators, increased formation of reactive oxygen species, cartilage degradation and loss of function. The participation of variety of effector cells viz. leukocytes, neutrophils, eosinophils, basophils, monocytes, macrophages, mast cells, dendritic cells, T-cells, B-cells, NK-cells, lead to cascade of events trigger of intracellular mediators (cytokines, chemokines etc.) activating diverse biological effects and immune responses. Eicosanoids are major precursors in cyclooxygenase and lipooxygenase pathways and play an important role in inflammation, allergy and asthma. Such biological and cellular events are further enhanced by stress related effects. The wide varieties of synthetic and natural compounds have been showed to act on different molecular targets (receptor, enzymes, mediators, and cells) involved in inflammation, allergy and asthma and to alter produce specific/definite therapeutic activity. The present review describes pathogenesis and etiological aspects of inflammation, allergy and asthma with few relevant patents which would be immensely useful for researchers in the field of immunology and molecular pharmacology to explore new avenues/strategies for development of new generation of therapeutically active agents for treatment of inflammation and allergic disorders. © 2012 Bentham Science Publishers.

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