Sharma M.,National University of Singapore |
Sharma M.,Singapore Institute of Clinical science SICS |
McFarlane C.,Singapore Institute of Clinical science SICS |
Kambadur R.,Singapore Institute of Clinical science SICS |
And 4 more authors.
IUBMB Life | Year: 2015
Myostatin is a secreted growth and differentiation factor that belongs to the TGF-β superfamily. Myostatin is predominantly synthesized and expressed in skeletal muscle and thus exerts a huge impact on muscle growth and function. In keeping with its negative role in myogenesis, myostatin expression is tightly regulated at several levels including epigenetic, transcriptional, post-transcriptional, and post-translational. New revelations regarding myostatin regulation also offer mechanisms that could be exploited for developing myostatin antagonists. Increasingly, it is becoming clearer that besides its conventional role in muscle, myostatin plays a critical role in metabolism. Hence, molecular mechanisms by which myostatin regulates several key metabolic processes need to be further explored. © 2015 IUBMB Life, 67(8):589-600, 2015.