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Lahiri A.,Yong In University | Delgado I.M.,Singapore Institute for Neurotechnology Singapore | Sheshadri S.,Singapore Institute for Neurotechnology Singapore | Ng K.-A.,Singapore Institute for Neurotechnology Singapore | And 3 more authors.
Muscle and Nerve

Introduction: A long-term peripheral neural interface is an area of intense research. The use of electrode interfaces is limited by the biological response to the electrode material. Methods: We created an electrode construct to harbor the rat sciatic nerve with interposition of autogenous adipose tissue between the nerve and the electrode. The construct was implanted for 10 weeks. Results: Immunohistochemistry showed a unique laminar pattern of axonal growth layered between fibro-collagenous tissue, forming a physical interface with the tungsten micro-electrode. Action potentials transmitted across the intrerface showed mean conduction velocities varying between 6.99±2.46 and 20.14±4 m/s. Conclusions: We have demonstrated the feasibility of a novel peripheral nerve interface through modulation of normal biologic phenomena. It has potential applications as a chronic implantable neural interface. © 2015 Wiley Periodicals, Inc. Source

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