Singapore Health Services Pte Ltd

Singapore, Singapore

Singapore Health Services Pte Ltd

Singapore, Singapore
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Patent
Nanyang Technological University and Singapore Health Services Pte Ltd | Date: 2017-08-02

A probe for iridocorneal angle imaging of an eye, the probe comprising: a distal end having a corneal contact surface; a camera having an imaging lens at the distal end and an imaging axis orthogonal to the corneal contact surface; and at least two illumination sources, each illumination source having an illumination axis at an angle to the corneal contact surface such that the imaging axis and the illumination axes converge in the eye.


Patent
Singapore Health Services PTE LTD. | Date: 2015-06-08

The present invention relates to methods of diagnosing autoimmune disease, predicting suitable treatments of autoimmune disease or identifying autoantigens of autoimmune disease using a population of immunogenic HLA-DR+ T cells.


Patent
Singapore Health Services Pte. Ltd. | Date: 2017-08-02

A hip prosthesis device including a femoral stem, the femoral stem including an elongate stem sleeve having a blind hole extending in a longitudinal direction and a hole opening at an upper frontal end of the stem sleeve; a stem core having an elongate stem shaft inserted in the blind hole and slidable in the longitudinal direction, a neck having a lower neck portion and an upper neck portion, a lower end of a lower neck portion attached to an upper end of the stem shaft, the upper neck portion attachable to a femoral head; a shock absorber mechanism operatively provided between the stem shaft and the stem sleeve to act against a downwardly directed longitudinal sliding motion of the stem shaft relative to the stem sleeve; and a closure cap positioned to close the hole opening with a through hole which the neck extends with its lower neck portion.


Patent
Singapore Health Services Pte Ltd | Date: 2016-06-06

Natural-KilleifT-Cell Lymphoma (NKTCL) susceptibility prediction, diagnosis and therapy. The invention relates to a method for predicting Natural Killer T-cell Lymphoma (NKTCL) susceptibility and/or diagnosing NKTCL in a subject comprising testing for JAK mutations. The invention also relates to a method of screening for candidate agents capable of treating NKTCL using a cell line comprising at least one JAK mutation. The invention includes an NKTCL animal model comprising at least one JAK mutation. The invention also includes JAK inhibitors for treating NKTCL.


Patent
National University of Singapore and Singapore Health Services Pte Ltd | Date: 2017-01-18

The present invention provides methods and agents for modulating WARS2 expression, WARS2 activity, or a combination thereof, thereby modulating angiogenesis. Also provided herein are methods for identifying individuals who could benefit from agents that modulate WARS2 expression, WARS2 activity, or a combination thereof.


Patent
Singapore Health Services Pte Ltd and Nanyang Technological University | Date: 2016-08-03

A method of producing an artificial neural network capable of predicting the survivability of a patient, including: storing in an electronic database patient health data comprising a plurality of sets of data, each set having at least one of a first parameter relating to heart rate variability data and a second parameter relating to vital sign data, each set further having a third parameter relating to patient survivability; providing a network of nodes interconnected to form an artificial neural network, the nodes comprising a plurality of artificial neurons, each artificial neuron having at least one input with an associated weight; and training the artificial neural network using the patient health data such that the associated weight of the at least one input of each artificial neuron is adjusted in response to respective first, second and third parameters of different sets of data from the patient health data.


Patent
Singapore Health Services PTE LTD. and National University of Singapore | Date: 2016-12-16

Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.


Patent
Agency For Science and Singapore Health Services PTE LTD | Date: 2015-02-27

A method is proposed for identifying an anatomical structure within a spatial-temporal image (i.e. a series of frames captured as respective times). A current frame of spatial-temporal medical image is processed using information from one or more previous and/or subsequent temporal frames, to aid in the segmentation of an object or a region of interest (ROI) in a current frame. The invention is applicable to both two- and three-dimensional spatial-temporal images (i.e., 2D+time or 3D+time), and in particular to cardiac magnetic resonance (CMR images). An initialisation process for this method segments the left ventricle (LV) in a CMR image by a fuzzy c-means (FCM) clustering algorithm which employs a circular shape function as part of the definition of the dissimilarity measure.


Patent
Singapore Health Services Pte Ltd | Date: 2017-04-12

The present invention relates to methods of diagnosing autoimmune disease, predicting suitable treatments of autoimmune disease or identifying autoantigens of autoimmune disease using a population of immunogenic HLA-DR+ T cells.


Patent
Agency For Science and Singapore Health Services Pte Ltd. | Date: 2016-07-26

We describe a method of monitoring the state of a cell, tissue, organ or organism. The method comprises establishing, for a sample of micro-particles from the cell, tissue, organ or organism, a ratio. The ratio is of a selected polypeptide in microparticles which comprise GM1 gangliosides, preferably which bind to Cholera Toxin B (CTB) (GM1 ganglioside microparticle polypeptide) to the selected polypeptide in microparticles which comprise exposed phosphotidylserine, preferably which bind to Annexin V (Annexin V microparticle polypeptide). The GM1 ganglioside microparticle polypeptide to Annexin V microparticle polypeptide ratio so established may be indicative of the state of the cell, tissue, organ or organism.

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