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Cairo, Egypt

Sinai University is a private university in Sinai, Egypt. It was established in 2006. Its president is Professor Hatem Mostafa El-Bolok and the chairman of its board of trustees is the Egyptian businessman Hassan Rateb. It comprises 7 faculties which are: Faculty of Dentistry Faculty of Business Administration Faculty of Engineering science Faculty of Information System and Computer Science Faculty of Media Technology Faculty of Pharmacy and Pharmaceutical Industries Faculty of Humanities↑ ↑ ↑ Wikipedia.

Bogdanovic E.,Sinai University
Biochimica et Biophysica Acta - General Subjects

Background Since the initial discovery of mutations in the isocitrate dehydrogenase 1 (IDH1) gene in a large subset of human low-grade gliomas and acute myelogenous leukemia (AML), much interest focused on the function of IDH1 and on the relationship between mutations in IDH1 and tumor progression. To date, mutations in the IDH1 gene have been found in numerous cancers with the highest frequencies occurring in gliomas, chondrosarcomas/enchondromas and cholangiocarcinomas. Scope of review IDH1 was first described in the scientific literature as early as 1950. Early researchers proposed that the enzyme likely functions in cellular lipid metabolism based on the observation that the enzymatic reaction produces NADPH and partially localizes to peroxisomes. This article highlights the studies implicating IDH1 in cytoplasmic and peroxisomal lipid metabolism from the early researchers to the recent studies examining mutant IDH1R132, the most common IDH1 mutation found in cancer. Major conclusions While a role for IDH1 in lipid biosynthesis in the liver and adipose tissue is now established, a role in lipid metabolism in the brain and tumors is beginning to be examined. The recent discoveries that IDH1R132H interferes with the metabolism of phospholipids in gliomas and that IDH1 activity could participate in the synthesis of acetyl-CoA from glutamine in hypoxic tumors highlight roles for IDH1 in lipid metabolism in a broad spectrum of tissues. General significance Interferences in cytoplasmic and peroxisomal lipid metabolism by IDH1R132 may contribute to the more favorable clinical outcome in patients whose tumors express mutations in the IDH1 gene. © 2015 Elsevier B.V. All rights reserved. Source

Empirical evidences in the last three decades confirmed that designs that connect humans to natural contents and landscape configurations, help to enhance humans' overall sense of wellbeing, with positive and therapeutic consequences on physiology. Findings in the field of environmental psychology showed also that these features have positive effects on human productivity and can reduce stress. Opportunities for contact with these elements are, however, increasingly reduced in modern urban life. Therefore, more attention has been recently paid by architectural theorists to find ways to reconnect the built environment to these elements. Biophilia is one of the most recent and viable reconnection theories in this field. This paper highlights the underpinnings of this design theory and addresses the assumption that one of the reasons behind the great admiration that most of the people have for historical buildings attributes to the biophilic qualities found in these buildings. By drawing inspiration from historical architecture, and by use of a qualitative analytical methodology that typify certain characteristics in then, this paper brings in conclusion specific biophilic strategies and settings that might help 'bringing life to buildings', as seen in these buildings. © 2014 Elsevier Ltd. All rights reserved. Source

Many agents, both pharmacologic and nonpharmacologic, have been studied to alleviate neonatal pain, and the research is extensive. The 2 most commonly studied nonpharmacologic agents studied have been sucrose and nonnutritive sucking (NNS). There is increasing evidence that the synergistic effect of sucrose and NNS is more effective than the effect of sucrose or NNS alone. The purpose of this integrative review of the literature was to determine whether there is a relationship between the synergistic effect of combining sucrose and NNS administered before and during painful procedures, and reducing procedural pain in both preterm and term neonates. This integrative review indicates that the combination of sucrose and NNS is a safe, effective, and clinically significant means of providing procedural pain relief in neonates, both term and preterm. Copyright © 2013 by The National Association of Neonatal Nurses. Source

Gregorieff A.,Sinai University
Cell Research

Wnt morphogens are notoriously elusive proteins. Thanks to a recent study published in Nature, Clevers and colleagues give us a first glimpse of a mammalian Wnt in action in the gut epithelium. © 2016 Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Source

Logan A.G.,Sinai University
Expert Review of Cardiovascular Therapy

Hypertension, especially isolated systolic hypertension, is commonly found in older (60-79 years of age) and elderly (≥80 years of age) people. Antihypertensive drug therapy should be considered in all aging hypertensive patients, as treatment greatly reduces cardiovascular events. Most classes of antihypertensive medications may be used as first-line treatment with the possible exception of α- and -blockers. An initial blood pressure treatment goal is less than 140/90 mmHg in all older patients and less than 150/80 mmHg in the nonfrail elderly. The current paradigm of delaying therapeutic interventions until people are at moderate or high cardiovascular risk, a universal feature of hypertensive patients over 60 years of age, leads to vascular injury or disease that is only partially reversible with treatment. Future management will likely focus on intervening earlier to prevent accelerated vascular aging and irreversible arterial damage. © 2011 Expert Reviews Ltd. Source

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