For the college in Redding, California associated with the Christian and Missionary Alliance, see Simpson University.Simpson College is a four-year, coeducational liberal arts institution situated in Indianola, Iowa, USA, and affiliated with the United Methodist Church. Simpson, which has been fully accredited by North Central Association since 1913, is a small school with approximately 1,400 full-time students and 500 part-time students. In addition to the main campus in Indianola, the college has classroom facilities in West Des Moines and Ankeny.Simpson has been recognized by U.S. News and World Report as one of the top 10 comprehensive colleges in the Midwest. In the 2004 report, Simpson College was named number 1 in the "Best Value" category for midwestern comprehensive colleges. Simpson was also named by College and Character, A national initiative of the John Templeton Foundation as one of 60 colleges that offer students an exemplary first-year program. And Peterson's Competitive Colleges guide features Simpson as one of approximately 440 colleges and universities that the top students in the nation attend.Simpson's campus is located 12 miles south of Des Moines, providing Simpson students with easy access to various attractions, resources, and employment and internship opportunities in the Greater Des Moines area. Wikipedia.
Smith K.M.,Simpson College |
Ziel E.,CORE , Inc.
Strength and Conditioning Journal | Year: 2017
THE BENEFITS OF PRENATAL EXERCISE ARE EXTENSIVE FOR THE MOTHER AND CHILD. AEROBIC AND RESISTANCE TRAINING ARE SAFE WITH PROPER MODIFICATIONS SPECIFIC TO THE CLIENT'S NEEDS AND ADVANCING GESTATION. TRAINING A PRENATAL CLIENT REQUIRES UNDERSTANDING OF THE PHYSIOLOGICAL CHANGES OF PREGNANCY TO OPTIMIZE THE EXERCISE PRESCRIPTION AND RESULTING OUTCOMES. Copyright © 2017 National Strength and Conditioning Association.
Ziel E.,CORE , Inc. |
Smith K.M.,Simpson College
Strength and Conditioning Journal | Year: 2017
PRENATAL AEROBIC AND RESISTANCE TRAINING CAN HAVE TREMENDOUS BENEFITS FOR MOTHER AND CHILD, IMPROVING DELIVERY AND POSTPARTUM RECOVERY. DAILY MOVEMENTS TO ENCOURAGE DEEP CORE STRENGTHENING, EMPHASIZING THE IMPORTANCE OF POSTURE, AND AVOIDING EXERCISES THAT CAUSE DISCOMFORT MAY MINIMIZE COMMON AILMENTS OF PREGNANCY MEANWHILE IMPROVING MOBILITY OF DAILY FUNCTION. A VIDEO ABSTRACT OF THIS ARTICLE CAN BE FOUND IN VIDEO, SUPPLEMENTAL DIGITAL CONTENT 1, HTTP://LINKS.LWW.COM/SCJ/A218. Copyright © 2017 National Strength and Conditioning Association.
Wang Y.-M.,National Taiwan University |
Parmelee J.,Simpson College |
Guo Y.-W.,A-Life Medical |
Tsai I.-H.,National Taiwan University
Toxicon | Year: 2010
To investigate the peculiar absence of phospholipases A2 (PLA2s) in most Crotalus horridus (CH) venom, we cloned and sequenced the venom PLA2s of three CH specimens from different regions. The results revealed that all the venom glands contained mRNAs that encoded an acidic PLA2 (designated as either CH-E6 or CH-E6'). The predicted CH-E6 from the Iowan CH and CH-E6' from the South Carolinian CH differed by only one amino acid residue, while the PLA2 cDNA cloned from the Kentuckian CH contained an early stop codon instead of a Tyr22 codon. Only the individual South Carolinian CH venom was found to contain the CH-E6' protein whose mass was confirmed by MALDI-TOF analysis. Our results suggest that low PLA2 expression levels in most CH venom can be attributed to translation blockage. We also purified two acidic PLA2s and canebrake toxin from the pooled venom of Crotalus horridus atricaudatus (neurotoxic CH subspecies). One of the acidic PLA2s was identical to CH-E6 and showed high lipolytic activity and weak anti-platelet activities. The possibility that C. h. atricaudatus could be a hybrid between CH and Crotalus scutulatus is discussed. © 2010 Elsevier Ltd.
Ung H.,Stanford University |
Ung H.,University of Pennsylvania |
Brown J.E.,Stanford University |
Brown J.E.,Simpson College |
And 4 more authors.
Cerebral Cortex | Year: 2014
Chronic low back pain (cLBP) has a tremendous personal and socioeconomic impact, yet the underlying pathology remains a mystery in the majority of cases. An objective measure of this condition, that augments self-report of pain, could have profound implications for diagnostic characterization and therapeutic development. Contemporary research indicates that cLBP is associated with abnormal brain structure and function. Multivariate analyses have shown potential to detect a number of neurological diseases based on structural neuroimaging. Therefore, we aimed to empirically evaluate such an approach in the detection of cLBP, with a goal to also explore the relevant neuroanatomy. We extracted brain gray matter (GM) density from magnetic resonance imaging scans of 47 patients with cLBP and 47 healthy controls. cLBP was classified with an accuracy of 76% by support vector machine analysis. Primary drivers of the classification included areas of the somatosensory, motor, and prefrontal cortices-all areas implicated in the pain experience. Differences in areas of the temporal lobe, including bordering the amygdala, medial orbital gyrus, cerebellum, and visual cortex, were also useful for the classification. Our findings suggest that cLBP is characterized by a pattern of GM changes that can have discriminative power and reflect relevant pathological brain morphology. © 2012 The Author. Published by Oxford University Press. All rights reserved.
Meyer C.K.,Southern Illinois University Carbondale |
Meyer C.K.,Simpson College |
Whiles M.R.,Southern Illinois University Carbondale |
Baer S.G.,Southern Illinois University Carbondale
Restoration Ecology | Year: 2010
Wetlands historically provided many ecosystem services but most have been lost or degraded through land conversion. Recent appreciation for wetland values and increasing ecotourism in the Central Platte River Valley (U.S.A.) has promoted restoration of wet meadow systems, although recovery patterns are not well known. We quantified plant community structure in sloughs (deeper habitats) and adjacent margins (slightly higher elevation) of six wetland sites, restored for 1-7 years at the onset of a 3-year study, and three natural wetlands to assess recovery dynamics. Plant community metrics recovered differentially between habitats. Within restored margins, richness and diversity showed a weak quadratic response with time since restoration, indicating that both indexes overshoot natural levels shortly following restoration. Within sloughs, richness and diversity showed no change with time, suggesting that recovery occurs more quickly in these deeper, moister habitats. Percent similarity of plant communities in restorations and natural wetlands increased linearly over time. However, ordinations of plant community composition showed that recovery was strongly influenced by site-specific hydrology and that recovery may not be a linear trajectory toward natural systems. The analysis and interpretation of plant community dynamics revealed several challenges to restoration assessment, including the role of interannual variability in precipitation, limitations to hydrologic recovery, and temporal variability in plant community structure in natural systems that resulted in " moving targets" for recovery comparisons. Temporal variability in climate must be considered when assessing restoration success in systems where plant community structure is responsive to variable moisture regimes. © 2008 Society for Ecological Restoration International.
Brown J.E.,Stanford University |
Brown J.E.,Simpson College |
Chatterjee N.,Stanford University |
Chatterjee N.,Northwestern University |
And 2 more authors.
PLoS ONE | Year: 2011
Pain often exists in the absence of observable injury; therefore, the gold standard for pain assessment has long been self-report. Because the inability to verbally communicate can prevent effective pain management, research efforts have focused on the development of a tool that accurately assesses pain without depending on self-report. Those previous efforts have not proven successful at substituting self-report with a clinically valid, physiology-based measure of pain. Recent neuroimaging data suggest that functional magnetic resonance imaging (fMRI) and support vector machine (SVM) learning can be jointly used to accurately assess cognitive states. Therefore, we hypothesized that an SVM trained on fMRI data can assess pain in the absence of self-report. In fMRI experiments, 24 individuals were presented painful and nonpainful thermal stimuli. Using eight individuals, we trained a linear SVM to distinguish these stimuli using whole-brain patterns of activity. We assessed the performance of this trained SVM model by testing it on 16 individuals whose data were not used for training. The whole-brain SVM was 81% accurate at distinguishing painful from non-painful stimuli (p<0.0000001). Using distance from the SVM hyperplane as a confidence measure, accuracy was further increased to 84%, albeit at the expense of excluding 15% of the stimuli that were the most difficult to classify. Overall performance of the SVM was primarily affected by activity in pain-processing regions of the brain including the primary somatosensory cortex, secondary somatosensory cortex, insular cortex, primary motor cortex, and cingulate cortex. Region of interest (ROI) analyses revealed that whole-brain patterns of activity led to more accurate classification than localized activity from individual brain regions. Our findings demonstrate that fMRI with SVM learning can assess pain without requiring any communication from the person being tested. We outline tasks that should be completed to advance this approach toward use in clinical settings. © 2011 Brown et al.
Mezulis A.,Seattle Pacific University |
Salk R.H.,University of Wisconsin - Madison |
Hyde J.S.,University of Wisconsin - Madison |
Priess-Groben H.A.,Simpson College |
Simonson J.L.,U.S. Air force
Journal of Abnormal Child Psychology | Year: 2014
Heterogeneity in the longitudinal course of depressive symptoms was examined using latent growth mixture modeling among a community sample of 382 U.S. youth from ages 11 to 18 (52.1 % female). Three latent trajectory classes were identified: Stable Low (51 %; displayed low depressive symptoms at all assessments), Increasing (37 %; reported low depressive symptoms at age 11, but then significantly higher depressive symptoms than the Stable Low class at ages 13, 15, and 18), and Early High (12 %; reported high early depressive symptoms at age 11, followed by symptoms that declined over time yet remained significantly higher than those of the Stable Low class at ages 13, 15, and 18). By age 15, rates of Major Depressive Disorder diagnoses among the Early High (25.0 %) and Increasing (20.4 %) classes were more than twice that observed among the Stable Low class (8.8 %). Affective (negative affectivity), biological (pubertal timing, sex) and cognitive (cognitive style, rumination) factors were examined as predictors of class membership. Results indicated general risk factors for both high-risk trajectories as well as specific risk factors unique to each trajectory. Being female and high infant negative affectivity predicted membership in the Increasing class. Early puberty, high infant negative affectivity for boys, and high rumination for girls predicted membership in the Early High class. Results highlight the importance of examining heterogeneity in depression trajectories in adolescence as well as simultaneously considering risk factors across multiple domains. © 2013 Springer Science+Business Media New York.
LaFauci L.E.,Simpson College
Anthropology and Medicine | Year: 2011
'Taking the (southern) waters' argues that, in the pre-Civil War period, the space of Virginia's mineral water resorts and the philosophy of southern hydropathic medicine enabled - indeed, fostered - white southerners' constructions of a 'nationalist,' proslavery ideology. In the first half of the paper, the author explains how white southern health-seekers came to view the springs region as a medicinal resource peculiarly designed for the healing of southern diseases and for the restoration of white southern constitutions; in the second half, she shows how physical and social aspects of the resorts, such as architectural choices and political events, supported and encouraged proslavery ideologies. Taken together, these medical-social analyses reveal how elite white southerners in the antebellum period came to associate the health of their peculiarly 'southern' bodies with the future health of an independent southern nation, one that elided black bodily presence at the same time that its social structures and scientific apparatuses relied upon enslaved black labor. © 2011 Taylor & Francis.
Agency: NSF | Branch: Standard Grant | Program: | Phase: S-STEM:SCHLR SCI TECH ENG&MATH | Award Amount: 586.78K | Year: 2015
This NSF Scholarships in Science, Technology, Engineering, and Mathematics (S-STEM) project at Simpson College located in Indianola, Iowa will contribute to the national effort to produce more STEM graduates by establishing a cohort of 15 academically talented and Pell-eligible students. Scholars will receive academic support while they pursue degrees in actuarial science, computer science, mathematics, or physics. They will participate in a variety of enrichment activities such as (a) a one-week bridge program prior to their freshman year, (b) a mentored relationship with leaders from local industry, (c) a first semester computational modeling colloquium, (d) and a one-credit course on solving industry-generated problems provided by their mentors. Scholarships for academically strong STEM students, who may not otherwise be able to afford college, have an impact on the number of graduates prepared to help national, regional, and local companies.
The project goals are well-defined and the methods outlined for achieving them are scaffolded to maximize student learning. Activities like Campus connect (a first year orientation for skill building, including early exposure to computational modelling and writing), the Simpson Colloquium (a course that builds on modelling skills with real-world problems), and the Bridge to Success course are grounded in the literature and should lead to high academic achievement and retention of the participants. The project will be evaluated on four criteria, Scholar GPA, participation in internships, first to second year retention, and placement in STEM graduate programs or careers upon graduation. The evaluator will gauge the evolution of the scholars perception of STEM careers through the Views About Science Survey at the beginning and end of the project. Thus, project performance will be compared to national standards. Students will also be surveyed about all aspects of the project. Summative evaluation will rely on an analysis of the data in aggregate. Results will be disseminated internally via faculty development workshops. They will also be presented at appropriate regional venues including the Joint Mathematics Meeting and MathFest and at American Association of Physics Teachers, American Physical Society, Council on Undergraduate Research national meetings. This effort is expected to add to the knowledge base on development of recruitment and retention strategies for science and mathematics majors.
Agency: NSF | Branch: Standard Grant | Program: | Phase: SOFTWARE & HARDWARE FOUNDATION | Award Amount: 9.72K | Year: 2011
Pioneering work of Seeman, Winfree, and Rothemund has raised the prospect of engineering useful structures and devices that autonomously assemble themselves from molecular components. Developing this capability will have transformative benefits for medicine, information technology, manufacturing, energy production, and other enterprises of twenty-first century society. In this project a team of scientists with expertise in self-assembly, software engineering, formal verification, programming languages, theory of computing, biochemistry, and molecular biology will explore the power and limitations of this programming of matter at the nanoscale.
The central thesis of this project is that methods that software engineers and theoretical computer scientists have developed for creating, controlling, and reasoning about software, hardware, networks, and environments of immense complexity will be an essential starting point for dealing with the greater challenges that nanotechnology will confront. The project will investigate applications of computational modeling, algorithmic randomness, requirements engineering, product lines, software verification, and software safety to DNA tile assembly, DNA origami, and DNA strand-displacement reactions. The project will conclude with a clear assessment--hopefully a compelling proof of concept--of the applicability and adaptability of software engineering methods in molecular programming and nanoscale self-assembly.
The project will contribute to a rigorously reasoned, verification- and safety-oriented approach to the social benefits of nanoscale self-assembly. It will strengthen software engineering methods as it adapts them to challenging new domains. It will enhance interdisciplinary science education at Iowa State University and nearby Simpson College, and it will provide web-accessible educational materials for such activities elsewhere.