Simon Fraser University is a public research university in Burnaby, British Columbia, Canada, with its main campus on Burnaby Mountain and satellite campuses in Downtown Vancouver and Surrey. The 1.7 km2 main campus on Burnaby Mountain, located 20 km from downtown Vancouver, was established in 1965 and comprises more than 30,000 students and approximately 950 faculty members. The university is adjacent to an urban village, UniverCity. The university was named after Simon Fraser, a North West Company fur trader and explorer. Undergraduate and graduate programs operate on a year-round tri-semester schedule. It is the only Canadian university competing in the National Collegiate Athletic Association . In 2007, Simon Fraser University was the first and remains the only university to be awarded the Prix du XXe siècle from the Royal Architectural Institute of Canada recognizing the "enduring excellence of nationally significant architecture", although the campus is in declining physical condition. The university's 2011 capital plan reports 53% of buildings in "poor" condition and 27% ranked "fair," due to provincial and federal austerity in the education sector.SFU is ranked 24th from the 100 Under 50 universities 2014 in the world by the Times Higher Education. SFU was ranked first among Canada's comprehensive universities in 1993, 1996-1998, 2000, 2008-2013 and in 2015 by Maclean's. Based on solely Canadian Universities for 2014, SFU is ranked 17th in CWUR, 8th in ARWU, 11th in Times, and 2nd in Maclean's Comprehensive. SFU faculty and alumni have won 43 fellowships to the Royal Society of Canada, three Rhodes Scholarships and one Pulitzer Prize. Wikipedia.
University of British Columbia and Simon Fraser University | Date: 2015-04-09
This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.
Simon Fraser University | Date: 2015-04-15
Described herein are stable hydroxide ion-exchange polymers. The polymers include ionenes, which are polymers that contain ionic amines in the backbone. The polymers are alcohol-soluble and water-insoluble. The polymers have a water uptake and an ionic conductivity that are correlated to a degree of N-substitution. Methods of forming the polymers and membranes including the polymers are also provided. The polymers are suitable, for example, for use as ionomers in catalyst layers for fuel cells and electrolyzers.
Simon Fraser University | Date: 2015-09-01
A process for increasing the energy conversion and electrochemical efficiency of a scaffold material using a deposition material comprises flowing by at least one surface of the scaffold material a solution which comprises the deposition material, forming agglomerations of the deposition material with at least one surface of the scaffold material, wherein the deposition material fills pores on the at least one surface of the scaffold material (scaffold pores) thereby increasing the surface area of the scaffold material, electrically connecting deposition material to the scaffold material via the formation of agglomerations, wherein said scaffold material is conductive and flow-through and wherein deposition material has a pore size (deposition material pore size) which is no larger than the scaffold pore size.
Ballard Power Systems and Simon Fraser University | Date: 2016-08-18
Methods for detecting a hydrogen leak and quantifying a rate of the same in a polymer electrolyte membrane fuel cell stack are provided, as well as a fuel cell diagnostic apparatus that diagnoses a hydrogen leak in a fuel cell stack.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 6.75M | Year: 2017
The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4\ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planned novel strategy is to successfully combine immune-based therapies, including therapeutic vaccines and broadly neutralizing antibodies with latency reversing agents, in a proof-of-concept phase IIa clinical trial. HIVACAR project will lead to a reduction of the actual costs related to HIV treatment and management and of the social public health as well as an improvement in the patients quality of life. HIVACAR project has been conceived under the framework of responsible research and innovation, so patients and other stakeholders will have a key role from the inception of the project until obtaining the results. Patients will be perfectly aware of how this therapy has been conceived and the real impact and change in their actual quality of life, as well as how the clinical trial has been designed and the consequences of participating in it. In addition, patients (and the general population) will tailor the project and its results dissemination and communication. This patient engagement will not be limited to the clinical trial but also to the rest of the activities of the project, so patients and the general society will be aware of how the research is developed and can include the patients point of view in the research activities. In addition, the socio-economic and psycho-social impact of the new treatment will be also analysed so overwhelming data on the benefits and impact of the new treatment will be obtained and shown to all the stakeholders.
Holdcroft S.,Simon Fraser University
Chemistry of Materials | Year: 2014
The polymeric ionomer plays a vital role in PEM fuel cell device technology, not simply as the membrane that transports protons and water from one electrode to another but as the binder and transport medium responsible for electrochemical activity within the catalyst layer. This perspective examines critical features of the catalyst layer ionomer. It highlights the current understanding of interactions of ionomer in catalyst inks, where the microstructure of the catalyst layer is largely formed, and in the catalyst layer itself. Properties important to the design and function of next generation ionomers and the challenges faced in replacing PFSA ionomers with hydrocarbon-based analogues are closely examined. © 2013 American Chemical Society.
Herbut I.F.,Simon Fraser University
Physical Review Letters | Year: 2010
The core of the vortex in a general superconducting order parameter in graphene is argued to be ordered, with the possible local order parameters forming the algebra U(1)×Cl(3). A sufficiently strong Zeeman coupling of the magnetic field of the vortex to the electron spin breaks the degeneracy in the core in favor of the anomalous quantum Hall state. I consider a variety of superconducting condensates on the honeycomb lattice and demonstrate the surprising universality of this result. A way to experimentally determine the outcome of the possible competition between different types of orders in the core is proposed. © 2010 The American Physical Society.
Moore M.M.,Simon Fraser University
Current Opinion in Microbiology | Year: 2013
Aspergillus fumigatus is an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised individuals. Siderophore-mediated iron acquisition has been shown to be essential for virulence. New studies have revealed that enzymes involved in siderophore biosynthesis and uptake are compartmentalized in peroxisomes and endosome-like vesicles, respectively. Gene and protein expression studies have revealed coordinated regulation of siderophore and sterol metabolism linked to the common precursor mevalonate. Several A. fumigatus transcription factors have been identified that are unexpectedly involved in the regulation of iron homeostasis. New diagnostic and drug treatments are being developed that exploit the requirement of A. fumigatus for extracellular siderophores. © 2013 Elsevier Ltd.
Vocadlo D.J.,Simon Fraser University
Current Opinion in Chemical Biology | Year: 2012
The addition of N-acetylglucosamine (GlcNAc) O-linked to serine and threonine residues of proteins is known as O-GlcNAc. This post-translational modification is found within multicellular eukaryotes on hundreds of nuclear and cytoplasmic proteins. O-GlcNAc transferase (OGT) installs O-GlcNAc onto target proteins and O-GlcNAcase (OGA) removes O-GlcNAc. Their combined action makes O-GlcNAc reversible and serves to regulate cellular O-GlcNAc levels. Here I review select recent literature on the catalytic mechanism of these enzymes and studies on the molecular basis by which these enzymes identify and process their substrates. Molecular level understanding of how these enzymes work, and the basis for their specificity, should aid understanding how O-GlcNAc contributes to diverse cellular processes ranging from cellular signaling through to transcriptional regulation. © 2012 Elsevier Ltd.
Dhillon B.K.,Simon Fraser University
Nucleic acids research | Year: 2013
IslandViewer (http://pathogenomics.sfu.ca/islandviewer) is a web-accessible application for the computational prediction and analysis of genomic islands (GIs) in bacterial and archaeal genomes. GIs are clusters of genes of probable horizontal origin and are of high interest because they disproportionately encode virulence factors and other adaptations of medical, environmental and industrial interest. Many computational tools exist for the prediction of GIs, but three of the most accurate methods are available in integrated form via IslandViewer: IslandPath-DIMOB, SIGI-HMM and IslandPick. IslandViewer GI predictions are precomputed for all complete microbial genomes from National Center for Biotechnology Information, with an option to upload other genomes and/or perform customized analyses using different settings. Here, we report recent changes to the IslandViewer framework that have vastly improved its efficiency in handling an increasing number of users, plus better facilitate custom genome analyses. Users may also now overlay additional annotations such as virulence factors, antibiotic resistance genes and pathogen-associated genes on top of current GI predictions. Comparisons of GIs between user-selected genomes are now facilitated through a highly requested side-by-side viewer. IslandViewer improvements aim to provide a more flexible interface, coupled with additional highly relevant annotation information, to aid analysis of GIs in diverse microbial species.