Simcyp Ltd a Certara company Sheffield UK
Bonner J.J.,Cancer Research UK Research Institute |
Vajjah P.,UCB Celltech Slough UK |
Abduljalil K.,Simcyp Ltd a Certara company Sheffield UK |
Jamei M.,Simcyp Ltd a Certara company Sheffield UK |
And 3 more authors.
Biopharmaceutics and Drug Disposition | Year: 2015
Purpose. Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than in older children and adults. The aim of this study was to investigate the impact of age and other covariates on the rate of GE. Methods. The effect of age on the mean gastric residence times (MGRT) of liquid and solid food was assessed by analysing 49 published studies of 1457 individuals, aged from 28weeks gestation to adults. The data were modelled using the nonlinear mixed-effects approach within NONMEM version 7.2 (ICON, Dublin, Ireland), with evaluation of postnatal age, gestational age and meal type as covariates. A double Weibull function was selected as a suitable model since it could account for the typical biphasic nature of GE. Results. Age was not a significant covariate for GE but meal type was. Aqueous solutions were associated with the fastest emptying time (mean simulated gastric residence time of 45min) and solid food was associated with the slowest (98min). Conclusions. These findings challenge the assertion that GE is different in neonates, as compared with older children and adults due to age, and they reinforce the significance of food type in modulating GE. © 2015 John Wiley & Sons, Ltd.