Lebanon, NH, United States
Lebanon, NH, United States
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Beckwith J.G.,Simbex, Llc | Greenwald R.M.,Simbex, Llc | Greenwald R.M.,Dartmouth College | Chu J.J.,Simbex, Llc
Annals of Biomedical Engineering | Year: 2012

Over the last decade, advances in technology have enabled researchers to evaluate concussion biomechanics through measurement of head impacts sustained during play using two primary methods: (1) laboratory reconstruction of open-field head contact, and (2) instrumented helmets. The purpose of this study was to correlate measures of head kinematics recorded by the Head Impact Telemetry (HIT) System (Simbex, NH) with those obtained from a Hybrid III (HIII) anthropometric headform under conditions that mimicked impacts occurring in the NFL. Linear regression analysis was performed to correlate peak linear acceleration, peak rotational acceleration, Gadd Severity Index (GSI), and Head Injury Criterion (HIC 15) obtained from the instrumented helmet and HIII. The average absolute location error between instrumented helmet impact location and the direction of HIII head linear acceleration were also calculated. The HIT System overestimated Hybrid III peak linear acceleration by 0.9% and underestimated peak rotational acceleration by 6.1% for impact sites and velocities previously identified by the NFL as occurring during play. Acceleration measures for all impacts were correlated; however, linear was higher (r 2 = 0.903) than rotational (r 2 = 0.528) primarily due to lower HIT System rotational acceleration estimates at the frontal facemask test site. Severity measures GSI and HIC were also found to be correlated, albeit less than peak linear acceleration, with the overall difference between the two systems being less than 6.1% for either measure. Mean absolute impact location difference between systems was 31.2 ± 46.3° (approximately 0.038 ± 0.050 m), which was less than the diameter of the impactor surface in the test. In instances of severe helmet deflection (2.54-7.62 cm off the head), the instrumented helmet accurately measured impact location but overpredicted all severity metrics recorded by the HIII. Results from this study indicate that measurements from the two methods of study are correlated and provide a link that can be used to better interpret findings from future study using either technology. © 2011 Biomedical Engineering Society.


McAllister T.W.,Dartmouth College | Ford J.C.,Dartmouth College | Flashman L.A.,Dartmouth College | Maerlender A.,Dartmouth College | And 8 more authors.
Neurology | Year: 2014

Objective: To determine whether exposure to repetitive head impacts over a single season affects white matter diffusion measures in collegiate contact sport athletes. Methods: A prospective cohort study at a Division I NCAA athletic program of 80 nonconcussed varsity football and ice hockey playerswho wore instrumented helmets that recorded the accelerationtime history of the head following impact, and 79 non-contact sport athletes. Assessment occurred preseason and shortly after the season with diffusion tensor imaging and neurocognitive measures. Results: There was a significant (p = 0.011) athlete-group difference for mean diffusivity (MD) in the corpus callosum. Postseason fractional anisotropy (FA) differed (p = 0.001) in the amygdala (0.238 vs 0.233). Measures of head impact exposure correlated with white matter diffusivity measures in several brain regions, including the corpus callosum, amygdala, cerebellar white matter, hippocampus, and thalamus. The magnitude of change in corpus callosum MD postseason was associated with poorer performance on a measure of verbal learning and memory. Conclusion: This study suggests a relationship between head impact exposure, white matter diffusion measures, and cognition over the course of a single season, even in the absence of diagnosed concussion, in a cohort of college athletes. Further work is needed to assess whether such effects are short term or persistent. © 2013 American Academy of Neurology.


A new apparatus, system and method for fall prevention training is provided that delivers, studies and analyzes the biomechanics of a disturbance event, such as a slip or trip incident, so that an appropriate response can be executed by the person to reduce or eliminate the number of falls experienced. The apparatus includes a platform that delivers a disturbance event in less than about 500 ms and preferably in the range of about 100 ms to about 200 ms. The method includes a unique protocol for fall prevention training using the apparatus. The disturbance event can create instability in the joint of the individual. An individuals walking gait can be monitored with the portions thereof detected. A disturbance event can be triggered when a given portion of the walking gait is detected. Also, the disturbance even can be triggered manually, at preset intervals or according to preset script.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 172.42K | Year: 2011

DESCRIPTION (provided by applicant): Anterior cruciate ligament (ACL) injuries are a significant problem for athletes, and women in particular. Both surgical and non-surgical treatment options exist, with the ultimate goal of regaining joint stability, knee kinematics, and quadriceps strength compared to the uninjured contralateral limb to allow full return of function and activity level and to prevent additional injury to the cartilage and the meniscus in the knee which might lead to an increased likelihood of osteoarthritis (OA). Published research has demonstrated clinically relevant effects of perturbation of support surface training for both ACL-deficient and ACL-reconstructed populations for improving dynamic knee stability, particularly in females. The clinically available methods of delivering the desired perturbations are currently limited to static balance boards that are manually pushed or pulled by the physical therapist. These perturbations may not simulate real-life perturbations that would occur during walking or running. The Principal Objective of this Fast Track SBIR project is to develop and validate a cost-effective commercial product, ActiveStep-Sport , for providing task-specific, neuromuscular, dynamic perturbation training to improve outcomes for both conservative and surgical treatment of ACL injury (ACL), particularly in young athletes and women. PUBLIC HEALTH RELEVANCE: The proposed ActiveStep-Sport system provides the enabling technology for large-scale application of clinicallyrelevant perturbation of support surface training for anterior cruciate ligament (ACL) injury rehablitiation. Approximately 100,000-175,000 ACL reconstructions performed annually in the US annually, with females significantly more likely to suffer an ACL rupture than males. Perturbation training in certain ACL injured populations has been shown to reduce episodes of giving way and to reduce abnormal knee kinematics, both of which often lead to an inability to regain functional levels of sports participationand increase the potential for developing knee osteoarthritis. Use of perturbation training is hypothesized to improve knee kinematics compared to strengthening alone, and to improve outcomes for ACL rehabilitation. The technology developed here represents a translation of validated laboratory-based research methodology to a system more suited for widespread clinical use. If technically and economically feasible, ActiveStep-Sport will help reduce the overall health care costs associated with the treatmentand rehabilitation of ACL injuries and the onset of osteoarthritis.


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 620.15K | Year: 2016

DESCRIPTION provided by applicant Anterior cruciate ligament ACL injuries are a significant problem for athletes and the prevalence has increased exponentially due to the fold increase in sports participation by women Despite demonstrated ability to decrease injury rates through the use of neuromuscular training programs the incidence of ACL injuries remains high due to poor adoption and subsequent integration of these programs into traditional strength and performance training routines Ideally a prophylactic training program would incorporate training features that address both intrinsic and extrinsic factors associated with ACL injury risk without increasing athlete training time supervision or specialized training requirements for the coach Perturbation training in particular has been shown to cause adaptation in the sensorimotor system and restoration of normal neuromuscular coordination that results in improved dynamic postural stability postural control and enhanced muscle activation patterns that actively stabilize the knee during unanticipated movements To date adoption of perturbation training has been limited because it requires specialized equipment additional training time and additional resources The Principal Objective of this Phase IIB SBIR project is to complete product development and demonstrate usability in the field of a cost effective and fully automated perturbation platform that improves an athleteandapos s neuromuscular response due to unanticipated perturbations for the prevention of ACL injuries PUBLIC HEALTH RELEVANCE More than Anterior Cruciate Ligament ACL injuries occur annually in the US and approximately of these are non contact related There are a disproportionate number of injuries in female athletes when compared to their male counterparts with females having a times higher incidence rate than males and increased from to per person years from to The largest increases over this time period occurred in female athletes younger than years and likely related to the increase in female participation in high school and college sports For each ACL injury the lifetime costs can range from $ to over $ depending on surgical and non surgical interventions Due to other structural damage to the knee that often accompanies ACL injuries of ACL injured patients will eventually show radiographic evidence of osteoarthritis OA requiring additional costs and potential surgeries Despite demonstrated ability to decrease injury rates through the use of neuromuscular training programs the incidence of ACL injuries remains high The technology developed here represents a translation of validated clinic based training approach for ACL rehabilitation to a system more suited for widespread use for ACL prevention


A new apparatus, system and method for fall prevention training is provided that delivers, studies and analyzes the biomechanics of a disturbance event, such as a slip or trip incident, so that an appropriate response can be executed by the person to reduce or eliminate the number of falls experienced. The apparatus includes a platform that delivers a disturbance event in less than about 500 ms and preferably in the range of about 100 ms to about 200 ms. The method includes a unique protocol for fall prevention training using the apparatus. The disturbance event can create instability in the joint of the individual. An individuals walking gait can be monitored with the portions thereof detected. A disturbance event can be triggered when a given portion of the walking gait is detected. Also, the disturbance even can be triggered manually, at preset intervals or according to preset script.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 969.03K | Year: 2010

DESCRIPTION (provided by applicant): The Center for Disease Control (CDC) estimates the yearly incidence of mild Traumatic Brain Injury (mTBI) at approximately 1.2 million cases in the United States alone. Approximately 1/3 of these injuries occur in football. The Principal Objective of this NIH Phase II SBIR project is to develop and validate HitAlert , a low cost head impact alert system for monitoring mTBI for widespread use. Brain injury is difficult to see , particularly on the field. What is lacking from the current state-of-the-art clinical techniques is the identification of the impact or series of impacts that triggers the clinical symptoms and changes in brain physiology that are indicative of concussion in the athlete. HitAlert provides the enabling technology that allows users at all playing levels to receive the highest level of care.


Grant
Agency: Department of Health and Human Services | Branch: | Program: SBIR | Phase: Phase II | Award Amount: 1.06M | Year: 2014

DESCRIPTION (provided by applicant): The Center for Disease Control (CDC) estimates the yearly incidence of mild Traumatic Brain Injury (mTBI) at approximately 1.2 million cases in the United States alone. Approximately 1/3 of these injuries occur in football. The Principal Objective of this NIH Phase IIb SBIR project is to expand the utility of the current, and now commercially available, InSite impact alert monitoring system developed in Phase I/Phase II to integrate long-term player specific head impactexposure tracking for identifying both at- risk impacts (i.e. on-field alerting) and high-risk behavior (i.e. poor tackling technique). Brain injur is difficult to see , particularly on the field. We have successfully developed a sideline tool that can identify atypical impacts or series of impacts in the field that can be used to trigger management of concussion on the sideline. What is currently lacking is the ability to identify high-risk behavior that may eventually lead to concussion. The propose


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase I | Award Amount: 99.96K | Year: 2014

Vicitms of blast exposure can experience considerable polytrauma resulting from various modes of mechanical input. Although tolerance curves and new injury metrics have been developed to understand the response of the thorax to blunt impact, this research has been limited by focusing on either overpressurization or blunt impact effects. To further our understanding of human survivability to these complex conditions and to develop improved protective equipment, there is a need to collect real field data that quantifies both overpressure and blunt impact. Based on previous in blast dosimetry and impact monitoring, we have demonstrated a unique approach that utilizes a comformable thin film sensing material as multimodal sensor for simultaneous measurement of blunt impact force and blast overpressurization. The purpose of this effort is to leverage this existing work into high resolution universal blast exposure recorder (UBER) tape for use on complex and conformable surfaces.


Grant
Agency: Department of Defense | Branch: Army | Program: SBIR | Phase: Phase II | Award Amount: 729.74K | Year: 2010

Traumatic brain injury (TBI) or mild TBI (mTBI) resulting from direct impact or indirectly from blast waves represents a significant threat to personnel in combat or blast intensive training environments. Due to the complexity of brain injuries, onset of symptoms may not occur immediately or be initially identifiable, posing a potential threat to both the injured soldier and surrounding personnel. Direct measurement of key biomechanical head impact variables from these blasts or impacts in real combat situations has been significantly limited by the measurement, storage and power technologies available in the correct form factor. Furthermore, traditional approaches of data collection and post-processing are too limited (i.e. not enough memory, too large and expensive) and time consuming to provide clinically relevant information that can be used by medics for treatment decisions. The purpose of this SBIR proposal is to develop the Head Injury Dosimeter (HID) - a low-cost, retrofittable, unobstrusive, and fieldable solution for continuous monitoring and alerting of potentially injurious threats to the head from blasts or direct impacts.

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