Silver Child Development Center

Anderson, United States

Silver Child Development Center

Anderson, United States

Time filter

Source Type

Shytle R.D.,Center for Excellence in Aging and Brain Repair | Shytle R.D.,University of South Florida | Shytle R.D.,Natura Therapeutics Inc | Tan J.,Center for Excellence in Aging and Brain Repair | And 15 more authors.
Current Alzheimer Research | Year: 2012

In a previous in vitro study, the standardized turmeric extract, HSS-888, showed strong inhibition of Aβ aggregation and secretion in vitro, indicating that HSS-888 might be therapeutically important. Therefore, in the present study, HSS-888 was evaluated in vivo using transgenic 'Alzheimer' mice (Tg2576) over-expressing Aβ protein. Following a six-month prevention period where mice received extract HSS-888 (5mg/mouse/day), tetrahydrocurcumin (THC) or a control through ingestion of customized animal feed pellets (0.1% w/w treatment), HSS-888 significantly reduced brain levels of soluble (~40%) and insoluble (~20%) Aβ as well as phosphorylated Tau protein (~80%). In addition, primary cultures of microglia from these mice showed increased expression of the cytokines IL-4 and IL-2. In contrast, THC treatment only weakly reduced phosphorylated Tau protein and failed to significantly alter plaque burden and cytokine expression. The findings reveal that the optimized turmeric extract HSS-888 represents an important step in botanical based therapies for Alzheimer's disease by inhibiting or improving plaque burden, Tau phosphorylation, and microglial inflammation leading to neuronal toxicity. © 2012 Bentham Science Publishers.

Loading Silver Child Development Center collaborators
Loading Silver Child Development Center collaborators