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Subongkot T.,Burapha UniversityChonburi | Ngawhirunpat T.,Silpakorn UniversityNakhon Pathom
International Journal of Nanomedicine | Year: 2015

The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin labels for phospholipid bilayer fluidity at the C5 atom of the acyl chain near the polar head group (hydrophilic region) and the C16 atom of the acyl chain (lipophilic region), respectively. The electron spin resonance study revealed that Tween 20 increased the fluidity at the C5 atom of the acyl chain, whereas terpenes increased the fluidity at the C16 atom of the acyl chain of the phospholipid bilayer. The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein. Confocal laser scanning microscopy showed that ultradeformable liposomes with terpenes increase the skin penetration of sodium fluorescein by enhancing hair follicle penetration. © 2015 Subongkot and Ngawhirunpat.

Buasri A.,Silpakorn UniversityNakhon Pathom | Buasri A.,Chulalongkorn University | Loryuenyong V.,Silpakorn UniversityNakhon Pathom | Loryuenyong V.,Chulalongkorn University
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2015

In this research, poly(butylene succinate) (PBS)/titanium dioxide (TiO2) nanocomposites were prepared by internal melt mixer and compression molding machine. The severe aggregation of TiO2 nanoparticles in polymer matrix were reduced by the modification of TiO2 surface with propionic acid and n-hexylamine. Photodegradation and thermal properties of biopolymer nanocomposites were investigated over a range of filler content 0-10 wt%. All samples with a wide range of filler addition exhibit the translucency. The surface morphology showed that a uniform dispersion of filler in the matrix existed when the nanoparticles content was less than 5 wt%. The results indicated that nanocomposites could be efficiently photodegraded by UV-A, UV-C and solar radiation in comparison with neat PBS. The photodegradability of composites can be efficiently promoted, and the photodegradation rate can be controlled by filler content. The materials exhibited elevated degree of crystallinity (Xc) and decreased melting temperature (Tm) as the nanoparticles concentrations were increased. © 2015, National Institute of Optoelectronics. All rights reserved.

Jitman S.,Silpakorn UniversityNakhon Pathom | Ling S.,Nanyang Technological University | Sangwisut E.,Thaksin University
Advances in Mathematics of Communications | Year: 2016

In this paper, cyclic codes over the Galois ring GR(p2, s) are studied. The main result is the characterization and enumeration of Hermitian self-dual cyclic codes of length pa over GR(p2, s). Combining with some known results and the standard Discrete Fourier Transform decomposition, we arrive at the characterization and enumeration of Euclidean self-dual cyclic codes of any length over GR(p2, s). © 2016 AIMS.

Suksomboon N.,Mahidol University | Poolsup N.,Silpakorn UniversityNakhon Pathom | Juanak N.,Mahidol University
Journal of Clinical Pharmacy and Therapeutics | Year: 2015

Summary What is known and objective CoenzymeQ10 (CoQ10), or ubiquinone, is an endogenous enzyme cofactor produced by most human cells. It is a potent antioxidant and is necessary for energy production in mitochondria. Diabetes mellitus is a chronic disease with multiple metabolic abnormalities, principally resulting from the inflammation and oxidative stress associated with mitochondrial dysfunctions. Clinical trials of the effects of supplementary CoQ10 on metabolic control in diabetes have reported inconsistent results. We undertook a systematic review and meta-analysis of randomized controlled trials to assess the effects of CoQ10 supplementation on glycaemic control, lipid profile and blood pressure in patients with diabetes. Methods A systematic search was conducted on MEDLINE, The Cochrane Library, CINAHL, NCCAM, Web of Science, Scopus, ClinicalTrials.gov and historical search of reference lists of relevant articles. The bibliographic databases were searched from inception to February 2015. We included randomized, placebo-controlled trials of CoQ10 in diabetes lasting at least 12 weeks. HbA1c or fasting plasma glucose had to be reported. Primary outcome was glycemic control, and secondary outcomes were lipid profile and blood pressure. Treatment effect was estimated with mean difference. Results and discussion Seven trials were included in the meta-analysis, involving 356 patients. Neither CoQ10 alone nor CoQ10 plus fenofibrate improved glycemic control. In addition, CoQ10, alone or in combination with fenofibrate, did not alter LDL-C, HDL-C and blood pressure. Triglycerides levels were significantly reduced with CoQ10 (mean difference -0·26 mmol/L, 95% CI -0·05 mmol/L to -0·47 mmol/L, P = 0·02) and CoQ10 plus fenofibrate (mean difference -0·72 mmol/L, 95% CI -0·32 mmol/L to -1·12 mmol/L, P = 0·0004). CoQ10 plus fenofibrate also effectively reduced total cholesterol (mean difference: -0·45 mmol/L, 95% CI -0·06 mmol/L to -0·84 mmol/L, P = 0·02). What is new and conclusions CoQ10 supplementation has no beneficial effects on glycemic control, lipid profile or blood pressure in patients with diabetes. However, it may reduce triglycerides levels. Due to limited data availability, well-powered and well-designed randomized controlled trials are needed to clearly determine the effect of CoQ10 on metabolic profile in diabetes. Dosage effects should also be explored. CoQ10 supplementation has no beneficial effects on glycemic control in diabetes patients. © 2015 John Wiley & Sons Ltd.

Rangsimawong W.,Silpakorn UniversityNakhon Pathom | Opanasopit P.,Silpakorn UniversityNakhon Pathom | Rojanarata T.,Silpakorn UniversityNakhon Pathom | Ngawhirunpat T.,Silpakorn UniversityNakhon Pathom
International Journal of Nanomedicine | Year: 2015

The effect of low frequency sonophoresis (SN, 20 kHz) on the skin transport of sodium fluorescein (NaFI)-loaded liposomes was investigated. An in vitro skin penetration study in open and blocked hair follicles was performed, and confocal laser scanning microscopy and scanning electron microscopy were used to visualize the penetration pathways. The results showed that SN significantly increased the flux of NaFI solution, whereas it significantly decreased the flux of NaFI-loaded polyethylene glycol-coated (PEGylated) liposomes with d-limonene (PL-LI). SN did not significantly affect the flux of NaFI-loaded conventional liposomes and PEGylated liposomes. In the blocked follicles, the flux of NaFI-loaded PL-LI both with and without SN decreased, indicating that NaFI-loaded PL-LI penetrated the skin via the transfollicular pathway. A confocal laser scanning microscopy image showed that in the skin without SN, the fluorescence intensity of NaFI-loaded PL-LI was observed in the skin and along the length of hair inside the skin, whereas in the skin with applied SN, the fluorescence intensity was detected only on the top of hair outside the skin. From scanning electron microscopy images, SN dislocated the corneocytes and reduced the deposition of PL-LI around hair follicles. These results revealed that SN may partially plug hair follicle orifices and reduce percutaneous absorption through the follicular pathway. © 2015 Rangsimawong et al.

Phaechamud T.,Silpakorn UniversityNakhon Pathom | Tuntarawongsa S.,Silpakorn UniversityNakhon Pathom
International Journal of Nanomedicine | Year: 2016

Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature (Tg) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and -31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully. © 2016 Phaechamud and Tuntarawongsa.

Sumalroj S.,Silpakorn UniversityNakhon Pathom | Worawannotai C.,Silpakorn UniversityNakhon Pathom
Electronic Journal of Combinatorics | Year: 2016

We prove that a distance-regular graph with intersection array {22; 16; 5; 1; 2; 20} does not exist. To prove this, we assume that such a graph exists and derive some combinatorial properties of its local graph. Then we construct a partial linear space from the local graph to display the contradiction. © 2016, Australian National University. All rights reserved.

Thavornpradit S.,Silpakorn UniversityNakhon Pathom | Sirirak J.,Silpakorn UniversityNakhon Pathom | Wanichacheva N.,Silpakorn UniversityNakhon Pathom
Journal of Photochemistry and Photobiology A: Chemistry | Year: 2016

A novel turn-on naphthalimide-based fluorescent probe (NM3) containing a disulfide ligand, which served as the selective Cu(II) receptor, was designed and successfully synthesized. Upon the substitution of a diethylamino group to the C-4 position of naphthalimide NMBr, the absorption band exhibited red shift in the visible wavelength with a large Stokes shift of 105 nm. Sensor NM3 provided strong fluorescence enhancement with a high quantum yield of 0.92 toward Cu(II) ions, and exhibited an excellent selectivity in the presence of competitive ions, such as Ag(I), Pb(II), Hg(II), Cd(II), Na(I), K(I), Li(I), Mg(II), Ba(II), Ca(II), Co(II), Fe(II), Mn(II), Ni(II), Zn(II), Pd(II), Al(III) and Au(III) in aqueous acetonitrile solutions. The stoichiometry binding between NM3 and Cu(II) was 1:2, supported by Job's plot analysis. The Cu(II)-NM3 complex structure was also investigated by molecular modeling. Moreover, the detection limit of NM3 for Cu(II) determination was found to be 13.05 μM or 0.83 ppm, which was sufficient for the detection of the maximum allowed copper levels in dietary and environmental sources. © 2016

Lertnattee V.,Silpakorn UniversityNakhon Pathom | Chomya S.,Silpakorn UniversityNakhon Pathom
Advanced Materials Research | Year: 2014

Traditional Thai medicine has been influenced by several cultures, especially from China and India. It is hard to search herbal information we need using a simple keyword, e.g., a common name of a language. In this paper, the KUIHerbRx2014, a multi-lingual and multi-cultural learning tool for herbal information, is introduced. Herb identification, herbal vocabulary, medicinal usages and reliable references, can be collected from this system. Mechanisms of utilizing this tool for improving results from a multi-lingual and multi-cultural herbal search engine are also proposed: (1) providing a set of technical terms in multiple languages, especially herb names, with can be added into local dictionaries. These terms are utilized by word segmentation tools for improving the indexing and searching processes (2) a set of synonyms of these technical terms is built for helping users from a lot of keywords of the same term (3) a list of references from the learning tool can be used as sources of information. From the results, information collected from KUIHerbRx2014 is useful for searching multi-lingual and multi-cultural herbal information by a search engine. © (2014) Trans Tech Publications, Switzerland.

Sukontavaree C.,Silpakorn UniversityNakhon Pathom | Lertnattee V.,Silpakorn UniversityNakhon Pathom
Jurnal Teknologi | Year: 2016

Depression is a mental disorder which is characterized by feeling of guilt, suicidal tendencies and disturbed bodily functions. In 2002, depression is ranked as the fourth of disease burden in worldwide and it will be changed to the second rank in 2030. Furthermore, more than 350 million people worldwide suffer from depression. Clinician staffs must take care of patients closely because these patients have medication adherence problem. To alleviate this problem, an adherence training program is introduced. Due to the limitation of budget and clinical stuffs, it is hard to educate all depressed patients. To deal with this problem, a method for finding rules of medicine use is proposed in three steps, The first step is finding the commonly used medicines with their adherences. In the second step, two groups of patients are classified, i.e., adherence and non-adherence groups for each commonly used medicines. For the last step, association rules are applied on each group of patients. From results, fluoxetine is a popular medicine for treatment depression. The numbers of medicines for a non-adherent group are more than those of an adherent group. Several patterns of drug interactions are found. These patterns should be reported to clinical staffs. In conclusion, results from the proposed method are applied for selecting a set of patients and drugs, which are filled in the adherence training program. © 2016 Penerbit UTM Press. All rights reserved.

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