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Nakhon Pathom, Thailand

Jitman S.,Silpakorn UniversityNakhon Pathom | Ling S.,Nanyang Technological University | Sangwisut E.,Thaksin University
Advances in Mathematics of Communications | Year: 2016

In this paper, cyclic codes over the Galois ring GR(p2, s) are studied. The main result is the characterization and enumeration of Hermitian self-dual cyclic codes of length pa over GR(p2, s). Combining with some known results and the standard Discrete Fourier Transform decomposition, we arrive at the characterization and enumeration of Euclidean self-dual cyclic codes of any length over GR(p2, s). © 2016 AIMS.

Subongkot T.,Burapha UniversityChonburi | Ngawhirunpat T.,Silpakorn UniversityNakhon Pathom
International Journal of Nanomedicine | Year: 2015

The purpose of this study was to investigate the effect of ultradeformable liposome components, Tween 20 and terpenes, on vesicle fluidity. The fluidity was evaluated by electron spin resonance spectroscopy using 5-doxyl stearic acid and 16-doxyl stearic acid as spin labels for phospholipid bilayer fluidity at the C5 atom of the acyl chain near the polar head group (hydrophilic region) and the C16 atom of the acyl chain (lipophilic region), respectively. The electron spin resonance study revealed that Tween 20 increased the fluidity at the C5 atom of the acyl chain, whereas terpenes increased the fluidity at the C16 atom of the acyl chain of the phospholipid bilayer. The increase in liposomal fluidity resulted in the increased skin penetration of sodium fluorescein. Confocal laser scanning microscopy showed that ultradeformable liposomes with terpenes increase the skin penetration of sodium fluorescein by enhancing hair follicle penetration. © 2015 Subongkot and Ngawhirunpat.

Suksomboon N.,Mahidol University | Poolsup N.,Silpakorn UniversityNakhon Pathom | Juanak N.,Mahidol University
Journal of Clinical Pharmacy and Therapeutics | Year: 2015

Summary What is known and objective CoenzymeQ10 (CoQ10), or ubiquinone, is an endogenous enzyme cofactor produced by most human cells. It is a potent antioxidant and is necessary for energy production in mitochondria. Diabetes mellitus is a chronic disease with multiple metabolic abnormalities, principally resulting from the inflammation and oxidative stress associated with mitochondrial dysfunctions. Clinical trials of the effects of supplementary CoQ10 on metabolic control in diabetes have reported inconsistent results. We undertook a systematic review and meta-analysis of randomized controlled trials to assess the effects of CoQ10 supplementation on glycaemic control, lipid profile and blood pressure in patients with diabetes. Methods A systematic search was conducted on MEDLINE, The Cochrane Library, CINAHL, NCCAM, Web of Science, Scopus, ClinicalTrials.gov and historical search of reference lists of relevant articles. The bibliographic databases were searched from inception to February 2015. We included randomized, placebo-controlled trials of CoQ10 in diabetes lasting at least 12 weeks. HbA1c or fasting plasma glucose had to be reported. Primary outcome was glycemic control, and secondary outcomes were lipid profile and blood pressure. Treatment effect was estimated with mean difference. Results and discussion Seven trials were included in the meta-analysis, involving 356 patients. Neither CoQ10 alone nor CoQ10 plus fenofibrate improved glycemic control. In addition, CoQ10, alone or in combination with fenofibrate, did not alter LDL-C, HDL-C and blood pressure. Triglycerides levels were significantly reduced with CoQ10 (mean difference -0·26 mmol/L, 95% CI -0·05 mmol/L to -0·47 mmol/L, P = 0·02) and CoQ10 plus fenofibrate (mean difference -0·72 mmol/L, 95% CI -0·32 mmol/L to -1·12 mmol/L, P = 0·0004). CoQ10 plus fenofibrate also effectively reduced total cholesterol (mean difference: -0·45 mmol/L, 95% CI -0·06 mmol/L to -0·84 mmol/L, P = 0·02). What is new and conclusions CoQ10 supplementation has no beneficial effects on glycemic control, lipid profile or blood pressure in patients with diabetes. However, it may reduce triglycerides levels. Due to limited data availability, well-powered and well-designed randomized controlled trials are needed to clearly determine the effect of CoQ10 on metabolic profile in diabetes. Dosage effects should also be explored. CoQ10 supplementation has no beneficial effects on glycemic control in diabetes patients. © 2015 John Wiley & Sons Ltd.

Lertnattee V.,Silpakorn UniversityNakhon Pathom | Chomya S.,Silpakorn UniversityNakhon Pathom
Advanced Materials Research | Year: 2014

Traditional Thai medicine has been influenced by several cultures, especially from China and India. It is hard to search herbal information we need using a simple keyword, e.g., a common name of a language. In this paper, the KUIHerbRx2014, a multi-lingual and multi-cultural learning tool for herbal information, is introduced. Herb identification, herbal vocabulary, medicinal usages and reliable references, can be collected from this system. Mechanisms of utilizing this tool for improving results from a multi-lingual and multi-cultural herbal search engine are also proposed: (1) providing a set of technical terms in multiple languages, especially herb names, with can be added into local dictionaries. These terms are utilized by word segmentation tools for improving the indexing and searching processes (2) a set of synonyms of these technical terms is built for helping users from a lot of keywords of the same term (3) a list of references from the learning tool can be used as sources of information. From the results, information collected from KUIHerbRx2014 is useful for searching multi-lingual and multi-cultural herbal information by a search engine. © (2014) Trans Tech Publications, Switzerland.

Phaechamud T.,Silpakorn UniversityNakhon Pathom | Tuntarawongsa S.,Silpakorn UniversityNakhon Pathom
International Journal of Nanomedicine | Year: 2016

Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal phase, and the external phase is composed of Tween 80 as emulsifier. Ibuprofen nanosuspension was prepared by eutectic emulsion solvent evaporating method followed with ultrasonication. During evaporation process, the ibuprofen concentration in emulsion droplets was increased leading to a drug supersaturation but did not immediately recrystallize because of low glass transition temperature (Tg) of ibuprofen. The contact angle of the internal phase on ibuprofen was apparently lower than that of the external phase at all times of evaporation, indicating that the ibuprofen crystals were preferentially wetted by the internal phase than the external phase. From calculated dewetting value ibuprofen crystallization occurred in the droplet. Crystallization of the drug was initiated with external mechanical force, and the particle size of the drug was larger due to Ostwald ripening. Cavitation force from ultrasonication minimized the ibuprofen crystals to the nanoscale. Particle size and zeta potential of formulated ibuprofen nanosuspension were 330.87±51.49 nm and -31.1±1.6 mV, respectively, and exhibited a fast dissolution. Therefore, the combination of eutectic emulsion solvent evaporation method with ultrasonication was favorable for fabricating an ibuprofen nanosuspension, and the transformation mechanism was attained successfully. © 2016 Phaechamud and Tuntarawongsa.

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