Silesian University of Medicine

Zabrze, Poland

Silesian University of Medicine

Zabrze, Poland
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Weng J.,Guangdong Provincial Key Laboratory of Diabetology | Weng J.,Sun Yat Sen University | Soegondo S.,University of Indonesia | Schnell O.,Helmholtz Center Munich | And 5 more authors.
Diabetes/Metabolism Research and Reviews | Year: 2015

Background: Alpha-glucosidase inhibitors are recommended in some international guidelines as first-line, second-line and third-line treatment options but are not used worldwide due to perceived greater effectiveness in Asians than Caucasians. Methods: Data from ten post-marketing non-interventional studies using acarbose, the most widely used alpha-glucosidase inhibitor, from 21 countries, provinces and country groups were pooled. Effects on glycated hemoglobin (HbA1c) were analysed for four major ethnicity/region groups (European Caucasians and Asians from East, Southeast and South Asia) to identify differences in the response to acarbose. Results: The safety and efficacy populations included 67 682 and 62 905 patients, respectively. Mean HbA1c in the total population decreased by 1.12±1.31% at the 3-month visit from 8.4% at baseline (p<0.0001). Reductions in HbA1c, fasting plasma glucose and post-prandial plasma glucose were greater in patients with higher baseline values. Acarbose was well tolerated, with few episodes of hypoglycemia (0.03%) and gastrointestinal adverse events (2.76%). Data from 30 730 Caucasians from Europe and Asians from three major regions of Asia with non-missing gender/age information and baseline/3-month HbA1c data were analysed by multivariable analyses of covariance. After adjustment for relevant baseline confounding factors, Southeast and East Asians had slightly better responses to acarbose than South Asians and European Caucasians; however, the differences were small. Conclusions: Acarbose was effective in both European Caucasians and Asians; however, after adjustment for baseline confounding factors, significant small differences in response favoured Southeast and East Asians. © 2014 The Authors.


Dolowy M.,Silesian University of Medicine | Niestroj A.,University of Silesia
Journal of Liquid Chromatography and Related Technologies | Year: 2010

In this work a very simple and rapid TLC densitometric method used to quantitative analysis of ursodeoxycholic acid in commercial drugs was presented. Ursodeoxycholic acid (UDCA) was effective extracted from pharmaceutical formulations in form of tablets and capsules by means of methanol. Chromatography was performed on glass plates precoated with silica gel 60F 254 (E. Merck, Art. 1.05715) with the use of mixture: n-hexane-ethyl acetate-acetic acid in volume composition 22:22:5 as a mobile phase. Under these optimum conditions the RF value for ursodeoxycholic acid is equal to 0.48. After visualization of spots with the use of 10% H2SO4 and next heating them in temp. 120°C, the chromatograms were quantitative scanned by densitometer at maximum wavelength λ=360nm. On the basis of obtained results it was stated, that elaborated method can be used in routine quantity control of ursodeoxycholic acid in selected pharmaceutical formulations.


Alio J.L.,Vissum Corporation | Alio J.L.,University Miguel Hernández | Grzybowski A.,Poznan City Hospital | Grzybowski A.,University of Warmia and Mazury | And 5 more authors.
Survey of Ophthalmology | Year: 2014

Advances in small incision surgery have enabled cataract surgery to evolve from being concerned primarily with the safe removal of the opaque crystalline lens to a procedure refined to yield the best possible postoperative refractive result. As the outcomes of cataract surgery have improved, the use of lens surgery as a refractive modality in patients without cataracts (clear lens extraction) has increased in popularity. The removal of the crystalline lens for refractive purposes, or so-called refractive lens exchange (RLE), offers distinct advantages over corneal refractive surgery in selected cases. Nevertheless, in some middle-aged patients with high refractive errors, corneal refractive surgery can be a safe and effective treatment. In addition, the use of multifocal lenses offers an alternative for the correction of presbyopia. A further advantage of RLE is that it simultaneously eliminates the need for cataract surgery in the future. The keys for success in RLE are effectiveness and consistency in the refractive outcome, providing at the same time surgical and postoperative safety. To achieve these goals, adequate indications following strict risk/benefit criteria and refractive precision based on accurate preoperative protocols for IOL calculation and selection are mandatory, together with an appropriate choice of surgical procedure based on the surgeon's skills, minimizing complications. © 2014 Elsevier Inc.


PubMed | Silesian University of Medicine and St Lukes Roosevelt Hospitals
Type: Review | Journal: Journal of anesthesia history | Year: 2016

Dr. Ryszard Rodzinski was a Polish surgeon who, in spite of his short life, had a productive career. His most important discovery was a safer method of performing regional anesthesia for abdominal surgery. The first description of combined spinal epidural anesthesia is generally attributed to Soresi in 1937. In the early 20th century, Rodzinski invented a novel technique, combined lumbosacral anesthesia, which combined lumbar spinal anesthesia and sacral epidural anesthesia. During the 19th Meeting of Polish Surgeons in July 1922 in Warsaw, Rodzinski presented an article entitled On Combined Lumbosacral Anaesthesia, in which he described this technique used in surgical clinic in Lww since October 1921. Given this presentation, Rodzinski could be considered to have made the first known presentation of the combined spinal and epidural anesthesia.


Zalejska-Fiolka J.,Silesian University of Medicine | Wielkoszynski T.,Silesian University of Medicine | Kasperczyk S.,Silesian University of Medicine | Kasperczyk A.,Silesian University of Medicine | Birkner E.,Silesian University of Medicine
Biological Trace Element Research | Year: 2010

The effects of administration of oxidized rapeseed oil and α-lipoic acid on activities of hepatic antioxidant enzymes and lipid peroxidation were studied in laboratory rats. There was an increase of the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase in rats fed a high fat diet to which 10% oxidized oil was added. Administration of α-lipoic acid resulted in a decrease of the activities of these enzymes. Addition of oxidized oil also resulted in increased production of oxygen radicals, evidenced by elevated malondialdehyde production. Such effect was counteracted by administration of α-lipoic acid. © 2010 Springer Science+Business Media, LLC.


Dolowy M.,Silesian University of Medicine
Current Issues in Pharmacy and Medical Sciences | Year: 2012

In this work, the researchers determined the chromatographic parameter of the lipophilicity (RMW) of ursodeoxycholic acid under various chromatographic conditions, and using the RP-TLC and RP-HPTLC methods. This chromatographic analysis was performed on different glass and aluminum plates (RP-I8F254, RP-I8WF254 and on RP-2F254), with the use of a mixture of various organic modifiers (methanol, acetone or dioxane) and water, in respective volume compositions. The results of these chromatographic investigations (RMW values) were compared with the partition coefficient (logP) obtained by way of the use of several theoretical methods (expressed as: AlogPs, logPKowwiN, xlogP2, xlogP3, milogP, AlogP, and MlogP) and with the experimental logP (logPeXp), respectively. The similarity between the chromatographically determined and computational calculated parameters of lipophilicity shows the possibility of applying both the chromatographic and theoretical methods to predict the lipophilicity value of ursodeoxycholic acid. The further direction of this study will be towards the application of the obtained lipophilicity parameters of examined bile acid in SAR studies (structure activity relationships).


Dolowy M.,Silesian University of Medicine
Current Issues in Pharmacy and Medical Sciences | Year: 2012

A simple and sensitive TLC-densitometric method for qualitative and quantitative analysis of diosgenin in pure sample was elaborated. Satisfactory results of the densitometric analysis of examined compound was obtained using chloroform-acetone in volume composition 40:10 (v/v) as a mobile phase and by means of the chromatographic plates precoated with silica gel 6OF254 and silica gel 60. Visualization of the diosgenin spots was achieved by dipping the plates into 10% ethanol solution of phosphomolybdic acid and 10% ethanol solution of sulfuric acid respectively. The limit of detection (LOD) and the limit of quantification (LOQ) of diosgenin investigated under different chromatographic conditions was determined. The results obtained in this work indicate that, the elaborated method is suitable for densitometric analysis of diosgenin but only in pure sample. © 2012 Curr. Issues Pharm. Med. Sci.


Blamek S.,Oncology and Radiotherapy Institute | Larysz D.,Oncology and Radiotherapy Institute | Larysz D.,Silesian University of Medicine | Miszczyk L.,Oncology and Radiotherapy Institute
Child's Nervous System | Year: 2013

Purpose: The aim of our study was to evaluate treatment results and toxicity of stereotactic irradiation for arteriovenous malformations (AVMs) in children. Methods: A group of ten consecutive children (four boys and six girls) irradiated between 2002 and 2010 at our institution was included into the study. The mean age at the time of treatment was 15.4 and ranged between 8 and 18 years. There were two Spetzler-Martin grade IV, four grade III, and four grade II lesions. Mean AVM volume was 13.2 cm3 and varied from 0.6 to 36.8 cm3. In five patients, the planned dose of 16-20 Gy was delivered in single fraction, in five the total dose of 16-24 Gy was delivered in two to three fractions. One patient was reirradiated with a dose of 15 Gy, 7 years after the initial treatment. Results: The median follow-up was 38.5 months. The treatment resulted in total obliteration in eight patients and partial in one. The median time to obliteration was 22 months; actuarial total obliteration rates were 20, 54, 54, and 83 % after 1, 2, 3, and 4 years of follow-up, respectively. No patient bled after the treatment. In one patient, new epileptic seizures developed after the treatment; in magnetic resonance imaging, focal necrosis was revealed. In five patients, asymptomatic imaging abnormalities were seen during follow-up. Conclusions: Stereotactic radiotherapy appears to be an effective method of treatment for pediatric AVMs, the patients however require meticulous follow-up because of relative high incidence of radiation-induced imaging abnormalities. © 2012 The Author(s).


PubMed | Freelance Cardiovascular Investigator, University of Bristol and Silesian University of Medicine
Type: Journal Article | Journal: Postepy w kardiologii interwencyjnej = Advances in interventional cardiology | Year: 2016

The main limitation of coronary artery bypass grafting (CABG) is rapid neointimal hyperplasia leading to graft failure.To assess plaque formation in saphenous vein grafts (SVG) covered by an external Dacron stent in comparison with the classical technique.In the study group vein grafts covered by external stent mesh made of Dacron were implanted. An intravascular ultrasonography (IVUS) study was performed in 35 aorto-coronary SVG covered by an external Dacron stent and in 64 normal SVG during the first year after CABG. In each SVG 25 mm of good quality IVUS image, volumes of lumen, plaque (neointima), outer border of the vein graft (external SVG) and adventitia were calculated in three time periods: 0-130 days, 130-260 days and 260-390 days.Between the first and second time period, lumen volume (mmThe experimental technique of implanting SVG covered with an external elastic Dacron stent seems to be inferior to traditional ones. This is probably due to the more complicated process of vein implantation and higher micro-injury occurrence during the surgery.


PubMed | University of Warmia and Mazury, Silesian University of Medicine and University Miguel Hernández
Type: | Journal: Eye and vision (London, England) | Year: 2015

Cataract surgery due to advances in small incision surgery evolved from a procedure concerned with the primary focus on the safe removal of cataractous lens to a procedure focused on the best possible postoperative refractive result. As the outcomes of cataract surgery became better, the use of lens surgery as a refractive modality in patients without cataracts has increased in interest and in popularity. Removal of the crystalline lens for refractive purposes or refractive lens exchange (RLE) presents several advantages over corneal refractive surgery. Patients with high degrees of myopia, hyperopia and astigmatism are still not good candidates for laser surgery. Moreover, presbyopia can currently only be corrected with monovision or reading spectacles. RLE supplemented with multifocal or accommodating intraocular lenses (IOLs) in combination with corneal astigmatic procedures might address all refractive errors including presbyopia, and eliminate the future need for cataract surgery.

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