Silesian Medical University in Katowice

Katowice, Poland

Silesian Medical University in Katowice

Katowice, Poland

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Kazik A.,Silesian Medical University in Katowice | Wilczek K.,Silesian Medical University in Katowice | Polonski L.,Silesian Medical University in Katowice
Cardiology Journal | Year: 2010

Diastolic heart failure (HF) is also referred to as HF with preserved left ventricular systolic function. The distinction between systolic and diastolic HFs is a pathophysiological one and isolated forms of left ventricular dysfunction are rarely observed. In diastolic HF left ventricular systolic function is normal or only slightly impaired, and the typical manifestations of HF result from increased filling pressure caused by impaired relaxation and compliance of the left ventricle. The predisposing factors for diastolic dysfunction include elderly age, female sex, obesity, coronary artery disease, hypertension and diabetes mellitus. Treatment of diastolic HF is aimed to stop the progression of the disease, relieve its symptoms, eliminate exacerbations and reduce the mortality. The management should include antihypertensive treatment, maintenance of the sinus rhythm, prevention of tachycardia, venous pressure reduction, prevention of myocardial ischemia and prevention of diabetes mellitus. The European Society of Cardiology specifies the type of therapy in diastolic HF based on: angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, non-dihydropyridine calcium channel blockers, diuretics. In order to improve the currently poor prognosis in this group of patients the treatment of diastolic HF must be optimised. © 2010 Via Medica.


Bergler-Czop B.,Silesian Medical University in Katowice
International Journal of Cosmetic Science | Year: 2014

Synopsis Acne vulgaris is the most frequently diagnosed dermatosis in patients between 11 and 30. It is believed that it affects about 80% of persons in this age group or even, taking into account lesions of low intensity, 100% of young people. The aetiopathogenesis of acne is multifactorial. In all patients with acne, the following symptoms occur: excessive sebum production, excessive keratosis of excretory ducts and openings of sebaceous glands, development of bacterial flora and release of inflammatory mediators in the skin. Development of molecular biology, genetics and immunology contributed to a significant progress in studies on the pathogenesis of acne. © 2014 Society of Cosmetic Scientists and the Société Française de Cosmétologie.


Nawarycz L.O.,Medical University of Lódz | Krzyaniak A.,Poznan University of Medical Sciences | Stawinska-Witoszynska B.,Poznan University of Medical Sciences | Krzywinska-Wiewiorowska M.,Poznan University of Medical Sciences | And 4 more authors.
Obesity Reviews | Year: 2010

The aim of the study was to develop waist circumference (WC) percentiles in Polish children and youth and to compare these with the results obtained in other countries. The study comprised a random group of 5663 Polish children aged 7-18 years. Smoothed WC percentile curves were computed using the LMS method. The curves displaying the values of the 50th (WC50) and the 90th (WC90) percentile were then compared with the results of similar studies carried out in children from the UK, Spain, Germany, Turkey, Cyprus, Canada and the USA. WC increased with age in both boys and girls and in all observed age periods the boys were seen to dominate. For 18-year-old Polish boys and girls the values of WC90 were 86.5 and 78.2, respectively, and were lower than the current criteria developed by the International Diabetes Federation. Both WC50 and WC90 were higher in Polish boys and girls compared with their counterparts in the UK, Turkey and Canada and significantly lower than in children from the USA, Cyprus and Spain. The percentile curves for Polish children and youth, which were developed here for the first time, are base curves that can be applied in analysing trends as well as making comparisons with results of similar studies performed in other countries. © 2009 International Association for the Study of Obesity.


Wlodarczyk P.,Silesian University | Kaminski K.,Silesian University | Haracz S.,Silesian University | Dulski M.,Silesian University | And 3 more authors.
Journal of Chemical Physics | Year: 2010

Dielectric spectroscopy has been recently used to monitor mutarotation in undercooled D-fructose. This method can be viewed as a universal method to study mutarotation phenomenon in the whole family of monosaccharides. In this paper, we studied kinetics of mutaration of anhydrous D-ribose at ambient pressure as well as pressure effect on the rate constant of this process. Ribose mutarotation behavior is compared to the one obtained for D-fructose. In addition, we attempted to determine the "direction" of mutarotation in undercooled monosaccharides after quenching the melted sample. To this end, analysis of dipole moments of different tautomers of D-fructose and D-ribose have been performed. Conformational analysis of studied carbohydrates was done with use of density functional theory. Geometry optimizations as well as calculations of dipole moments were done on the 6-311++G (d,p) /B3LYP level. Finally, it turned out that data obtained from the mutarotation experiment might be helpful in understanding the origin of γ -process occurring in the whole family of carbohydrates. © 2010 American Institute of Physics.


Muc A.,Cracow University of Technology | Muc-Wierzgon M.,Silesian Medical University in Katowice
Composite Structures | Year: 2015

An optimization design methodology of composite materials and structures subjected to fatigue life constraints is presented and discussed in the paper. It is assumed that laminates are made of plies having three different fiber orientations: 0°, ±45°, 90°. A special type of new, discrete design variables is introduced in order to find optimal stacking sequences for laminated structures. The results of the optimization of buckling loads for compressed plates are demonstrated herein. The accuracy of the prediction procedure depends directly on the selected stiffness degradation model based on the experimental data. The existence of fatigue constraints may change both optimal stacking sequences and buckling modes. © 2015 .


Mrowka-Kata K.,Silesian Medical University in Katowice | Kata D.,Silesian Medical University in Katowice | Lange D.,Center of Oncology of Poland | Namyslowski G.,Silesian Medical University in Katowice | And 2 more authors.
European Archives of Oto-Rhino-Laryngology | Year: 2010

Sarcoidosis and its aetiopathogenesis, epidemiology and diagnostic procedures (including the Kveim reaction) are presented in this paper. The clinical manifestations of this disease, especially in otolaryngological organs, including the larynx, salivary glands, nose and paranasal sinuses, are described. Treatment procedures, including surgical interventions and prognosis, are also discussed. © 2010 Springer-Verlag.


Kohut M.,Silesian Medical University in Katowice | Hartleb M.,Silesian Medical University in Katowice | Hartleb T.,Silesian Medical University in Katowice
Polski Merkuriusz Lekarski | Year: 2010

A simple, non-invasive examination separating patients with irritable bowel syndrome from those affected by Crohn's disease (CD) has not been found, so far. Immune disturbances associated with release of various cytokines play an important role in CD pathogenesis. The aim of the study: was to investigate the diagnostic efficacy of serum levels of broad panel of pro- and anti-inflammatory cytokines in differentiation between patients with CD and intact bowel. Material and methods: To the study were included 57 patients with established diagnosis of ileo-coecal CD (according to endoscopic, radiologic and histopathologic criteria) and 21 subjects with no organic bowel pathology. Serum concentrations of CRP and proinflammatory (IL-1β, IL-6, TNF-α) and anti-inflammatory (IL-10, IL-1, IL-1RA, IL-6sR, TNF-α R2) cytokines were measured by immunoenzymatic method in both groups. Results: Serum levels of IL-1ß, IL-6, IL-10, TNF-a and TNF-α R2 were significantly different in CD patients than in control group. Among these cytokines TNF-a serum level showed the highest discriminative diagnostic efficacy between both groups. The diagnostic efficacies of CRP (cut-off value was 4.25 mg/dl) and TNF-α (cut-off value2. 5 pg/ml) were similar, showing respectively an accuracy of 81% and 74%, sensitivity of 79% and 65% and specificity of 89% and 100%. Conclusion: TNF-α showed the highest diagnostic efficacy in differentiating patients with CD from healthy subjects, however, the TNF-a does not exceed diagnostic value of CRP.


Pasierbek M.,Silesian Medical University in Katowice
Lymphatic Research and Biology | Year: 2014

Background: The lymphatic system remains poorly recognized, yet for oncological reasons, it appears to be of great interest to both scientists and physicians. Methods and Results: Protocols were performed on 55 adult male Wistar rats. All procedures were conducted after intraperitoneal administration of 4% chloral hydrate and artificial ventilation. The observations of the rats' anatomy of lymphatic structures and observations of lymphatic drainage were conducted after injection of the tracer (ink suspension and/or 1% solution of fluorescein isothiocyanate dextran) into the thoracic wall, intraperitoneally, and into bile ducts, as well as after experimental cutting of the outflow of the lymph from the liver to the mediastinal lymph nodes. The author's own terminology was suggested: medial mediastinal lymph node and lateral mediastinal lymph node. The presence of the tracer was found in the mediastinal nodes after its injection into the posterior wall of the thoracic wall, intraperitoneally, and into bile ducts. After injection into bile ducts, the tracer was observed only in the left mediastinal nodes. After experimental cutting of the basic outflow of the lymph from the liver to the mediastinal nodes, the whole outflow took place through the thoracic duct to the left venous angle. Conclusions: 1. The locations of the lymph nodes in the thorax as well as the drainage area of those nodes are asymmetrical. 2. Left-sided nodes show larger range of drainage. 3. Cutting the basic lymph outflow from the liver to the mediastinal nodes stops immunological information being transferred to regional nodes of the liver situated in the mediastinum. © Mary Ann Liebert, Inc. 2014.


Stawiarska-Pieta B.,Silesian Medical University in Katowice | Bielec B.,Silesian Medical University in Katowice | Birkner K.,Silesian Center for Heart Diseases in Zabrze | Birkner E.,Silesian Medical University in Katowice
Food and Chemical Toxicology | Year: 2012

The aim of this study was to investigate the effects of vitamin E and methionine on the activity of enzymes regulating carbohydrate metabolism and enzymes associated with glutathione as well as to examine the morphology of the liver in rats exposed to sodium fluoride.The study was conducted in 18 male rats of Wistar strain. The rats were divided into three groups: a control group, which received distilled water and two experimental groups, which received sodium fluoride (10. mg/kg of body mass/24. h) in water solution. Animals in the second experimental group received 3. mg of vitamin E/rat/24. h and 2. mg methionine/rat/24. h. The experiment lasted 35. days. In supernatants obtained after homogenization of rat liver slices, the activity of the following enzymes was assayed: fructose-1,6-biphosphate aldolase (ALD) malate dehydrogenase (MDH), lactate dehydrogenase (LDH), sorbitol dehydrogenase (SDH) the activity of glutathione peroxidase (GPx), glutathione transferase (GST) and glutathione reductase (GR). Pathomorphological evaluation was conducted on preparations made by standard paraffin method, followed by staining with hematoxylin and eosin. The administration of antioxidants counteracted changes in the activity of the enzymes and the morphological abnormalities of the liver induced by NaF. Antioxidants may be important in preventing toxicity of fluoride compounds. © 2012 Elsevier Ltd.


Sowa P.,Silesian Medical University in Katowice
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society | Year: 2013

The bleeding and haemorrhage is strictly related with accidents and many medical procedures. In some conditions it leads to hypovolaemia and further to hypovolaemic shock. Under conditions of haemorrhagic shock, heart rate and blood pressure critically collapse. Reversing the sympathoinhibitory phase of hypovolaemia could be crucial for clinical management of injured patients after haemorrhage. Systemic administration of 5-HT1A agonists seams to produce resuscitating effects. The aim of this study was to investigate the participation of central serotonin and, in particular, 5-HT1A receptors in cardiovascular regulation in haemorrhagic shock in rats. Intracerebroventricular (i.c.v.) administration of serotonin (5-HT) increased the heart rate (HR), mean arterial pressure (MAP) and implicated that all haemorrhaged animals survived for the whole observation time (2 hours). Similar, although significantly more minor, effects were achieved after selective 5-HT1A activation. Moreover, the i.c.v. administration of selective 5-HT1A antagonist before i.c.v. 5-HT injection partially inhibited 5-HT induced changes. The results of the present work indicate that 5-HT plays an important role in the reversal of the haemorrhagic shock in rats. These effects are at least partially dependent on activation of 5-HT1A receptors.

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