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Nath K.,Silchar Medical College and Hospital | Bhattacharya A.,Tata Motors | Praharaj S.K.,Kasturba Medical College
Clinical Neuropharmacology

Eslicarbazepine acetate is a novel third-generation antiepileptic related to carbamazepine and oxcarbazepine with a benign adverse effect profile. We report a patient with bipolar mania with intolerance to multiple antimanic drugs, responding to eslicarbazepine without any serious adverse effect. Copyright © 2012 by Lippincott Williams & Wilkins. Source

Siddique M.A.,Silchar Medical College and Hospital | Siddique M.A.,Regional Institute of Ophthalmology | Tiwary B.K.,Assam University | Paul S.B.,Assam University

Purpose This experimental study was conducted with the aim of evaluating the quantitative change, if any, in the phospholipids and protein contents of lens proteolipids during cataract formation, and to establish whether the phospholipid/protein content of the blood is related to cataractogenesis.Methods A total of 120 human lenses were collected. Phospholipids and protein content in proteolipids of these lenses were estimated biochemically. Blood was examined from total 60 persons. Data obtained were analyzed with the help of the ANOVA program of SPSS software (version 7.5).Results A significant (P<0.01) reduction of proteolipid-bound phospholipids was observed in cataracts as compared with the control lenses. An alteration was also noticed in the protein content of proteolipids in the cataractous lenses. Changes were also observed in serum total phospholipids (P<0.01) and total protein (P<0.01) in cataractous atients.Conclusion sAs proteolipids are the main constituents of the membranes of lens fibres, the alterations in its phospholipid and protein moieties may be suggestive of the disintegration of lens membranes, which ultimately leads to cataract formation. Gradual and constant variation in serum parameters may be one of the predisposing factors in cataractogenesis. © 2010 Macmillan Publishers Limited All rights reserved. Source

Choudhury J.H.,Assam University | Choudhury B.,Silchar Medical College and Hospital | Kundu S.,Assam University | Ghosh S.K.,Assam University
Medical Oncology

Tobacco consumption in various forms is one of the major risk factor for the development of head and neck squamous cell carcinoma. Polymorphisms in XRCC1 and XRCC2 genes may alter an individual's susceptibility to tobacco-related cancers. Here, we have investigated the interaction of XRCC1 (Arg399Gln) and XRCC2 (Arg188His) polymorphism and tobacco exposure in the progression of HNSCC in northeast Indian population. The population-based case-control study includes 110 HNSCC patients and 140 controls. The polymorphisms of XRCC1 and XRCC2 were studied by means of PCR-RFLP, and the results were confirmed by DNA sequencing. Smokers and tobacco-betel quid chewers were significantly higher in cases (P = 0.045 and 0.033). The variant homozygote AA genotype of XRCC1 Arg399Gln and heterozygote GA genotype of XRCC2 Arg188His has an increased risk toward HNSCC (OR 2.43; P = 0.031 and OR 3.29; P < 0.01, respectively). The interaction between tobacco-betel quid chewing and variant genotypes of XRCC1 and XRCC2 resulted in several fold increase the risk of HNSCC, when compared to non-chewers. Heavy smokers carrying XRCC1 AA and XRCC2 GA genotypes had a significantly higher risk of HNSCC compared to never smokers (P = 0.017 and 0.003, respectively). Upon gene-gene interaction analysis, individuals carrying both XRCC1 GA (Arg/Gln) and XRCC2 GA (Arg/His) genotypes had the highest risk of HNSCC (P = 0.001).Our finding suggests that interaction of tobacco and polymorphisms of XRCC1 and XRCC2 increases the risk of HNSCC. Furthermore, cross talk between these two DNA repair genes might modulate susceptibility toward HNSCC. © Springer Science+Business Media 2014. Source

Katshu M.Z.U.H.,Bangor University | Bhattacharya A.,Silchar Medical College and Hospital | Nizamie S.H.,Central Institute of Psychiatry

Primary palmoplantar hyperhidrosis (PPH) is believed to be a dysfunction of emotional sweating, with an estimated prevalence of around 3%. Several treatment options including topical antiperspirants, tap water iontophoresis, botulinum toxin injections, oral anticholinergics, and tricyclic antidepressants are available, each with a significant adverse event profile. For the first time, we report a PPH patient with comorbid juvenile myoclonic epilepsy (JME) treated successfully with a combination of paroxetine and divalproex sodium. Paroxetine resulted in improvement in PPH, possibly through its anticholinergic and/or noradrenergic actions. Though the occurrence of PPH and JME together seems to be a chance association, some common frontal lobe mechanisms may be involved that need to be explored further. Copyright © 2011 S. Karger AG, Basel. Source

Dey S.,St Anthonys College | Goswami S.,Shillong College | Goswami M.,Silchar Medical College and Hospital
Turkish Journal of Medical Sciences

Aim: To examine the prevalence of anaemia in Meghalaya, India, by exploring the 2005-2006 National Family Health Survey (NFHS -3) data. Materials and methods: The study population consisted of 3934 ever-married women of reproductive age (15-49 years) from the state Meghalaya, India, which were taken from the NFHS-3 survey, to explore the predictors responsible for the prevalence of anaemia by using different background characteristics such as age, place of residence, nutritional status, number of children ever born, pregnancy status, educational achievement, and economic status. As a response ariable, anaemia levels were categorised as a dichotomous variable, and the predicted probabilities were worked out through a binary logistic regression model, to assess the contribution of the predictors on anaemia. Results: A logistic regression analysis was performed for some selected predictors related to anaemia levels. All the predictors, except total children ever born, were found to be statistically significant. The mean aemoglobin concentration was evaluated as 117.43 g/L, and 49.6% of the women were found to be anaemic. Women of the age group 20-24 years, are at high risk of anaemia [P = 0.320, O.R. (95% C.I.) = 1.509 (0.671, 3.390)]. Conclusion: Pregnant, under nutritious, and poorest women are at high risk of anaemia. Urban women are also at high risk; however, higher educated women are at low risk of anaemia. The habit of cigarette smoking/pan/bidi/gutka etc. also increases the risk of anaemia. © TÜBİTAK. Source

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