Silchar Medical College and Hospital

Silchar, India

Silchar Medical College and Hospital

Silchar, India
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Devi S.S.,National Institute of Technology Silchar | Laskar R.H.,National Institute of Technology Silchar | Sheikh S.A.,Silchar Medical College and Hospital
Neural Computing and Applications | Year: 2017

Malaria, being a life-threatening disease caused by parasites, demands its rapid and accurate diagnosis. In this paper, we develop a computer-assisted malaria-infected life-cycle stages classification based on a hybrid classifier using thin blood smear images. The major issues are: feature extraction, feature selection and classification of erythrocytes infected with different life-cycle stages of malaria. Feature set (134 dimensional features) has been defined by the combination of the proposed features along with the existing features. Features such as prediction error, co-occurrence of linear binary pattern, chrominance channel histogram, R–G color channel difference histogram and Gabor features are the newly proposed features in our system. In the feature selection, a two-stage algorithm utilizing the filter method to rank the feature, along with the incremental feature selection technique, has been analyzed. Moreover, the performance of all the individual classifiers (Naive Bayes, support vector machine, k-nearest neighbors and artificial neural network) is evaluated. Finally, the three individual classifiers are combined to develop a hybrid classifier using different classifier combining techniques. From the experimental results, it may be concluded that hybrid classifier formed by the combination of SVM, k-NN and ANN with majority voting technique provides satisfactory results compared to other individual classifiers as well as other hybrid model. An accuracy of 96.54 ± 0.73% has been achieved on the collected clinical database. The results show an improvement in accuracy (11.62, 6.7, 3.39 and 2.39%) as compared to the state-of-the-art individual classifiers, i.e., Naive Bayes, SVM, k-NN and ANN, respectively. © 2017 The Natural Computing Applications Forum

Pandey P.K.,Silchar Medical College and Hospital | Swami A.,Silchar Medical College and Hospital | Biswas T.K.,Silchar Medical College and Hospital | Thakuria R.,Silchar Medical College and Hospital
Archives of Rheumatology | Year: 2017

Objectives: This study aims to assess the prevalence of metabolic syndrome (MetS) in treatment naïve rheumatoid arthritis (RA) in an Indian population and correlate RA disease characteristics with presence of MetS. Patients and methods: The study included 84 RA patients (18 males, 66 females; mean age 44.8±12.5 years; range 18 to 72 years) diagnosed according to 2010 American College of Rheumatology-European League Against Rheumatism classification criteria who were treatment naïve or did not receive disease modifying antirheumatic drugs for more than six weeks and 120 age and sex-matched apparently healthy controls (35 males, 85 females; mean age 44.1±12.7 years; range 18 to 75 years). The frequency of MetS was assessed using National Cholesterol Education Program-Adult Treatment Panel III 2004 revised criteria. Patients were also assessed in terms of disease activity, using disease activity score 28 erythrocyte sedimentation rate. Logistic regression was used to identify predictors of MetS in RA. Results: Metabolic syndrome was found in 39.28% of RA group and 20% of control group according to National Cholesterol Education Program-Adult Treatment Panel III 2004 (p<0.005). MetS was most commonly detected in the 51 to 60 age group (65%). RA group was significantly more likely to have low high-density lipoprotein (63.09%), high triglyceride (53.57%), elevated blood pressure (41.66%) levels, and elevated waist circumference (38.09%). In RA group, disease activity score 28 (odds ratio: 6.51, confidence interval: 1.19-35.46 p=0.03), C-reactive protein (odds ratio: 1.13, confidence interval: 1.05-1.21 p<0.001), and duration of disease (odds ratio: 1.82, confidence interval: 1.04-3.18 p=0.03) remained independent predictors for presence of MetS in RA. Conclusion: The frequency of MetS was higher in RA group compared to control group. Higher systemic inflammatory marker, disease duration, and disease activity score 28 remained independent predictors associated with presence of MetS. These findings suggest that RA patients should be screened early for presence of MetS to check for and reduce risk of atherosclerotic vascular diseases. © 2017 Turkish League Against Rheumatism. All rights reserved.

Boruah A.K.,Silchar Medical College and Hospital | Nath L.K.,Dibrugarh University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2016

Objective: The objective of the present investigation is to extract, purify and characterize the physicochemical properties of the mucilage obtained from the fruits of Chrysophyllum lanceolatum (Blume) DC and also to evaluate the bioadhesiveness of Chrysophyllum lanceolatum Mucilage (CLM) to be used as the biodegradable mucoadhesive agent. Methods: The mucilage was extracted, purified and identified by the methods as described in the official books. Purified CLM was characterized for physicochemical properties, swelling capacity, loss on drying and flow properties. The CLM was further characterized by Fourier Transform Infrared (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC) and High-Performance Liquid Chromatography (HPLC). The mucoadhesivity of the mucilage was assessed by shear stress method and falling sphere method using goat intestine as mucosal substrate and the results were compared with Hydroxy Propyl Methyl Cellulose (HPMC) and Carbopol 934P (CP). The acute oral toxicity study was also conducted in Swiss Albino mice. Results: The nature of the CLM is confirmed as polysaccharide from the experimental data. The physicochemical property and toxicity study also shows its acceptability as bioadhesive excipient. The bioadhesive test of CLM showed a good adhesive strength to the biological membrane. Conclusion:The present investigation showed better bioadhesive property of the isolated mucilage and hence may provide an alternative to conventional synthetic/semi-synthetic mucoadhesive agents. © 2016 The Authors. Published by Innovare Academic Sciences Pvt Ltd.

Roy S.,Silchar Medical College and Hospital | Chanda D.D.,Silchar Medical College and Hospital
Journal of Pure and Applied Microbiology | Year: 2017

This study was undertaken to determine the frequently isolated organism from pus culture and to determine the antibiotic sensitivity patterns so that it helps to manage the drug resistant organism well in time which poses challenge to clinician to treat the patients. Total 2050 samples were collected from April 2016 to March 2017 to study antibiograms of various organisms. Organisms were identified as per standerd operative procedure and drug sensitivity was done as per CLSI guidelines. Most commonly encountered organism was Staph.aureus followed by Klebsiella, Pseudomonas, Proteus, Citrobacter, E.coli and Acinetobacter. Staph.aureus was showing sensitivity towards Vancomycin, whereas gram negative organisms were showing sensitivity towards Imipenem, Gentamycin, Ciprofloxacin and Ceftriaxone. Antimicrobial resistence is a predictable outcome of antimicrobial use. Lengthy or inappropriate antimicrobial therapy allow microbes to mutate into new forms that help them to survive antibiotic treatment and quickly become resistance strain. Knowledge of local common pathogens and their resistance status can guide clinician to choose appropriate antibiotic for empirical treatment of patients.

Laskar J.I.,Silchar Medical College and Hospital | Chakravarty P.,Silchar Medical College and Hospital | Dewan B.,Silchar Medical College and Hospital
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objectives: The objective of this case study is to evaluate the importance of detection, assessment, and reporting of an adverse drug reaction and to improve the medication perseverance. Methods: This is an observational type of case report which was observed and analyzed in Silchar Medical College and Hospital on regular ward rounds. Results: A case report of toxic epidermal necrolysis due to carbamazepine (CBZ) administration by a 47-year-old male patient who presented as a follow-up case of ischemic stroke. Causality assessment of the event done with Naranjo’ causality assessment scale suggests to be “Probable.” Conclusion: Daily, CBZ is being increasingly prescribed for control of pain in neuralgias and diabetic neuropathy, apart from control of seizures. Awareness about the drugs implicated in life-threatening drug reactions will help physicians in preventing them by cautious use of the drugs. Moreover, proper counseling to the patient regarding the use of medications is of utmost importance, in such life-threatening conditions where treatment guidelines remain indistinct. © 2017 The Authors. Published by Innovare Academic Sciences Pvt Ltd.

Nath K.,Silchar Medical College and Hospital | Bhattacharya A.,Tata Motors | Praharaj S.K.,Kasturba Medical College
Clinical Neuropharmacology | Year: 2012

Eslicarbazepine acetate is a novel third-generation antiepileptic related to carbamazepine and oxcarbazepine with a benign adverse effect profile. We report a patient with bipolar mania with intolerance to multiple antimanic drugs, responding to eslicarbazepine without any serious adverse effect. Copyright © 2012 by Lippincott Williams & Wilkins.

Choudhury J.H.,Assam University | Choudhury B.,Silchar Medical College and Hospital | Kundu S.,Assam University | Ghosh S.K.,Assam University
Medical Oncology | Year: 2014

Tobacco consumption in various forms is one of the major risk factor for the development of head and neck squamous cell carcinoma. Polymorphisms in XRCC1 and XRCC2 genes may alter an individual's susceptibility to tobacco-related cancers. Here, we have investigated the interaction of XRCC1 (Arg399Gln) and XRCC2 (Arg188His) polymorphism and tobacco exposure in the progression of HNSCC in northeast Indian population. The population-based case-control study includes 110 HNSCC patients and 140 controls. The polymorphisms of XRCC1 and XRCC2 were studied by means of PCR-RFLP, and the results were confirmed by DNA sequencing. Smokers and tobacco-betel quid chewers were significantly higher in cases (P = 0.045 and 0.033). The variant homozygote AA genotype of XRCC1 Arg399Gln and heterozygote GA genotype of XRCC2 Arg188His has an increased risk toward HNSCC (OR 2.43; P = 0.031 and OR 3.29; P < 0.01, respectively). The interaction between tobacco-betel quid chewing and variant genotypes of XRCC1 and XRCC2 resulted in several fold increase the risk of HNSCC, when compared to non-chewers. Heavy smokers carrying XRCC1 AA and XRCC2 GA genotypes had a significantly higher risk of HNSCC compared to never smokers (P = 0.017 and 0.003, respectively). Upon gene-gene interaction analysis, individuals carrying both XRCC1 GA (Arg/Gln) and XRCC2 GA (Arg/His) genotypes had the highest risk of HNSCC (P = 0.001).Our finding suggests that interaction of tobacco and polymorphisms of XRCC1 and XRCC2 increases the risk of HNSCC. Furthermore, cross talk between these two DNA repair genes might modulate susceptibility toward HNSCC. © Springer Science+Business Media 2014.

Katshu M.Z.U.H.,Bangor University | Bhattacharya A.,Silchar Medical College and Hospital | Nizamie S.H.,Central Institute of Psychiatry
Dermatology | Year: 2011

Primary palmoplantar hyperhidrosis (PPH) is believed to be a dysfunction of emotional sweating, with an estimated prevalence of around 3%. Several treatment options including topical antiperspirants, tap water iontophoresis, botulinum toxin injections, oral anticholinergics, and tricyclic antidepressants are available, each with a significant adverse event profile. For the first time, we report a PPH patient with comorbid juvenile myoclonic epilepsy (JME) treated successfully with a combination of paroxetine and divalproex sodium. Paroxetine resulted in improvement in PPH, possibly through its anticholinergic and/or noradrenergic actions. Though the occurrence of PPH and JME together seems to be a chance association, some common frontal lobe mechanisms may be involved that need to be explored further. Copyright © 2011 S. Karger AG, Basel.

Hazarika P.,Silchar Medical College and Hospital
Indian Journal of Pathology and Microbiology | Year: 2015

I have reported a case of endometrioid like yolk sac tumor of the testis in a 20-year-old boy. Endometrioid like yolk sac tumor is a rare tumor. A few cases have been reported in ovary. In case of male, a case of pure glandular endometrioid like yolk sac tumor is reported in a 43 years male in right undescended testis and another case of abdominal metastasis showing endometrioid pattern from mixed testicular germ cell tumor comprising of teratoma and embryonal carcinoma. My patient was a 20-year-old male presented with painless enlargement of right testis. Grossly the tumor was glistening creamish white with a multicystic appearance. Histopathological examination showed the tumor to be composed of glandular elements resembling early secretory endometrium, foci of keratinized thin squamous epithelium and a single focus of benign cartilage. The glandular elements show immunohistochemical positivity for AFP, cytokeratin 7 (CK7) and epithelial membrane antigen (EMA). © 2015 Indian Journal of Pathology and Microbiology | Published by Wolters Kluwer - Medknow.

Maurya A.P.,Assam University | Talukdar A.D.,Assam University | Chanda D.D.,Silchar Medical College and Hospital | Chakravarty A.,Silchar Medical College and Hospital | Bhattacharjee A.,Assam University
Antimicrobial Agents and Chemotherapy | Year: 2014

A total 14 clinical isolates of Pseudomonas aeruginosa that produced VEB-1 and were susceptible only to polymyxin B were recovered from hospitalized patients. VEB-1 was located within variable regions of the class 1 integron, flanked by resistant genes, and was horizontally transferable as well as carried within the IncP-type plasmid. We conclude that the IncP-type plasmid is responsible for the horizontal transmission of VEB-1-mediated expanded-spectrum cephalosporin resistance in this medical center. © 2014, American Society for Microbiology. All Rights Reserved.

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