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Silchar, India

Patgiri S.J.,Multidisciplinary Research Laboratory ICMR | Borthakur A.K.,Silchar Medical College | Borkakoty B.,Regional Medical Research Center | Saikia L.,Assam Medical College and Hospital | And 2 more authors.
Indian Journal of Pathology and Microbiology | Year: 2014

Context: Japanese encephalitis (JE), an acute mosquito-borne viral disease, is one of the leading causes of viral encephalitis in the South-East Asian region. JE is endemic in Assam. The morbidity and mortality due to JE is significant with outbreaks every year during the monsoons. Aims: The aim was to study the clinicopathological profile of JE; to examine their role in predicting disease outcome; and to document the increase in the incidence of JE among the adult population in this region. Materials and Methods: Clinically suspected acute encephalitis syndrome (AES) cases admitted in Assam Medical College and Hospital during the period of May 2011 to April 2012 were tested by JE virus specific Immunoglobulin M capture ELISA. Statistical Analysis Used: Data analysis was performed using SPSS version 16.0. Results: Out of 424 AES cases, 194 were JE positive. The occurrence of JE in adults was higher (P < 0.001) than the pediatric age group. The study recorded a high rate of renal dysfunction in JE cases. A single case of JE induced abortion and two cases of JE-neurocysticercosis co-infections were documented. Regression analysis revealed that adult population, unconsciousness, paresis and elevated cerebrospinal fluid protein level were associated with a worse prognosis in JE cases. Mortality in JE positive cases was higher than the JE negative cases (P = 0.001). Conclusion: The study attempts to highlight the role played by a combination of clinical and laboratory parameters in assessing the severity and outcome in JE and may help in directing the limited medical resources toward those that need it the most. Source

Hedau S.,Institute of Cytology and Preventive Oncology ICMR | Kumar U.,Institute of Cytology and Preventive Oncology ICMR | Hussain S.,Institute of Cytology and Preventive Oncology ICMR | Shukla S.,Institute of Cytology and Preventive Oncology ICMR | And 13 more authors.
BMC Cancer | Year: 2011

Background: Two clinically relevant high-risk HPV (HR-HPV) types 16 and 18 are etiologically associated with the development of cervical carcinoma and are also reported to be present in many other carcinomas in extra-genital organ sites. Presence of HPV has been reported in breast carcinoma which is the second most common cancer in India and is showing a fast rising trend in urban population. The two early genes E6 and E7 of HPV type 16 have been shown to immortalize breast epithelial cells in vitro, but the role of HPV infection in breast carcinogenesis is highly controversial. Present study has therefore been undertaken to analyze the prevalence of HPV infection in both breast cancer tissues and blood samples from a large number of Indian women with breast cancer from different geographic regions.Methods: The presence of all mucosal HPVs and the most common high-risk HPV types 16 and 18 DNA was detected by two different PCR methods - (i) conventional PCR assays using consensus primers (MY09/11, or GP5+/GP6+) or HPV16 E6/E7 primers and (ii) highly sensitive Real-Time PCR. A total of 228 biopsies and corresponding 142 blood samples collected prospectively from 252 patients from four different regions of India with significant socio-cultural, ethnic and demographic variations were tested.Results: All biopsies and blood samples of breast cancer patients tested by PCR methods did not show positivity for HPV DNA sequences in conventional PCRs either by MY09/11 or by GP5+/GP6+/HPV16 E6/E7 primers. Further testing of these samples by real time PCR also failed to detect HPV DNA sequences.Conclusions: Lack of detection of HPV DNA either in the tumor or in the blood DNA of breast cancer patients by both conventional and real time PCR does not support a role of genital HPV in the pathogenesis of breast cancer in Indian women. © 2011 Hedau et al; licensee BioMed Central Ltd. Source

Bhattacharjee A.,Assam University | Bahar I.,Cachar Cancer Institute | Saikia A.,Silchar Medical College
Indian Journal of Palliative Care | Year: 2015

Introduction: Head and neck cancer (HNCA) patients have poor nutritional status which clearly bears a negative prognosis in cancer. There is no study and consensus on nutritional assessment tools and diet structure for such patients. This study intends to determine the prevalence of malnutrition and formulate a diet chart keeping in view the general food habit and economic condition of HNCA patients of North East (NE) region. Aim: To find out an affordable dietary intervention for HNCA patients based on dietary principles. To assess the role of nutritional assessment tools in these group of patients. Materials and Methods: This is a 1-year prospective interventional study on HNCA patients attending the Dept of ENT of a teaching hospital. The outcome of the nutritional intervention using a specific diet were assessed using clinical, laboratory and anthropomorphic assessment tools and indices like Prognostic Nutritional Index (PNI) and Nutritional Assessment Index (NAI). Results: The study diet provided appropriate amounts of nutrients to HNCA patients as evident from improvements in anthropomorphic parameters and nutritional indices. Clinically, Hemoglobin percentage (Hb%), Body Mass Index (BMI), Mid Arm Circumference (MAC) and triceps skin fold thickness (TST) were found to be reliable malnutrition markers. Conclusion: Nutritional Assessment Index has been found to be the best index to evaluate malnutrition. The daily requirement of nutrients for HNCA patients can be satisfactorily met by adopting specific diet chart presented in our study. As no structured diet plan are available in literature, our diet chart can act as a template diet appropriate for HNCA patients of this region. Source

Devi D.,Silchar Medical College
Indian Journal of Practical Pediatrics | Year: 2010

Vesicoureteric reflux is one of the most common anomalies of the urinary tract. Despite considerable experience of pediatric surgeons and nephrologists worldwide, there is lack of unamity in its approach till now. There is lack of evidence based data because of paucity of well conducted studies. It was regarded as an important and preventable cause of renal parenchymal damage. Therapeutic approaches changed over time from surgical to conservative approach concentrating on aggressive investigation after UTI for early diagnosis. During the past decade, there is considerable debate on the clinical significance and current approach of VUR. The previous accepted dogma of ascent of bacteria from the bladder to the kidney in presence of VUR is now changing. It is now regarded as a marker of congenital hypodysplasia, voiding dysfunction and predisposition to UTI. It may be the time to retreat from the aggressive diagnostic approach after UTI. Prompt treatment of UTI and individualized approach with less invasive investigation in the high risk group may be most appropriate in this preconsensus era. DMSA has been suggested as the preferred imaging to evaluate children with UTI rather than USG and VUCG. Source

Choudhury N.,Silchar Medical College | Talukdar R.,Asian Institute of Gastroenterology | Hagjer S.,Silchar Medical College
Indian Journal of Surgery | Year: 2012

Right upper quadrant abdominal pain may be due to many causes, and at times may give rise to diagnostic dilemma. We present here a young lady with biliary type of pain who was eventually found to have gall bladder agenesis with aerobilia, in the absence of prior biliary intervention. © 2012 Association of Surgeons of India. Source

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