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Sikkim, India

Sikkim Manipal University is a co-educational public-private funded university located in Gangtok, Sikkim, India. It was established in 1995 and is the first government-private initiative in the region. Wikipedia.

Bhutia K.L.,Sikkim Manipal University
German medical science : GMS e-journal | Year: 2011

Ascaris lumbricoides or round worm infestation is quite common in the developing world. It affects all age groups but is more common in children. Most of the cases remain asymptomatic. The usual presentation is an intestinal obstruction. The physicians should be aware of this condition and consider it in the differential diagnosis when faced with such a case. The rare fatal complications include bleeding, perforation and gangrene. Source

Imtaiyaz Hassan M.,Jamia Millia Islamia University | Shajee B.,Sikkim Manipal University | Ahmad F.,Jamia Millia Islamia University
Bioorganic and Medicinal Chemistry | Year: 2013

The carbonic anhydrases enzymes (CAs, EC are zinc containing metalloproteins, which efficiently catalyse the reversible conversion of carbon dioxide to bicarbonate and release proton. These enzymes are essentially important for biological system and play several important physiological and patho-physiological functions. There are 16 different alpha-carbonic anhydrase isoforms studied, differing widely in their cellular localization and biophysical properties. The catalytic domains of all CAs possess a conserved tertiary structure fold, with predominately β-strands. We performed an extensive analysis of all 16 mammalian CAs for its structure and function in order to establish a structure-function relationship. CAs have been a potential therapeutic target for many diseases. Sulfonamides are considered as a strong and specific inhibitor of CA, and are being used as diuretics, anti-glaucoma, anti-epileptic, anti-ulcer agents. Currently CA inhibitors are widely used as a drug for the treatment of neurological disorders, anti-glaucoma drugs, anti-cancer, or anti-obesity agents. Here we tried to emphasize how CAs can be used for drug discovery, design and screening. Furthermore, we discussed the role of CA in carbon capture, carbon sensor and metabolon. We hope this review provide many useful information on structure, function, mechanism, and applications of CAs in various discipline. © 2012 Elsevier Ltd. All rights reserved. Source

Dasgupta H.,Sikkim Manipal University
Sensing and Imaging | Year: 2016

The objective of this work is to make a neural network function approximation model to detect human age from the electrocardiogram (ECG) signal. The input vectors of the neural network are the Katz fractal dimension of the ECG signal, frequencies in the QRS complex, male or female (represented by numeric constant) and the average of successive R–R peak distance of a particular ECG signal. The QRS complex has been detected by short time Fourier transform algorithm. The successive R peak has been detected by, first cutting the signal into periods by auto-correlation method and then finding the absolute of the highest point in each period. The neural network used in this problem consists of two layers, with Sigmoid neuron in the input and linear neuron in the output layer. The result shows the mean of errors as (Formula presented.) , 1.03, 0.79 years and the standard deviation of errors as 1.81, 1.77, 2.70 years during training, cross validation and testing with unknown data sets, respectively. © 2016, Springer Science+Business Media New York. Source

Sharma M.,Sikkim Manipal University | Sharma K.,Sikkim Manipal University
Proceedings - International Conference on Communication Systems and Network Technologies, CSNT 2012 | Year: 2012

This paper studies LEACH protocol, some of its modified versions and finally puts forward a new version of LEACH called Energy Efficient Extended LEACH (EEE LEACH) protocol. This new version of LEACH protocol establishes multilevel clustering approach to minimize communication distance between nodes and introduces Master Cluster Heads along with Cluster Heads. Simulation has been done in MATLAB and simulation results show that EEE LEACH is more energy-efficient than LEACH protocol. © 2012 IEEE. Source

Raja J.,Sungkyunkwan University | Jang K.,Sungkyunkwan University | Nguyen C.P.T.,Sungkyunkwan University | Balaji N.,Sungkyunkwan University | And 2 more authors.
IEEE Electron Device Letters | Year: 2014

Effect of short-channel induced instabilities in InSnZnO-based thin-film transistors (TFTs) caused by combination of the drain induced barrier lowering (DIBL) and parasitic resistance is reported. As the active channel length decreased below a critical value of around 8 μm, the draincurrent (2.81 μA) are abruptly increased and N-shaped behavior of the transconductance are observed due to the formation of additional current path in the channel. The magnitude of subgap density of states is also depended on the channel size. The higher value of parasitic resistance RSD (∼42 kω) and DIBL coefficient (76.8 mV/V) in short-channel ITZO TFT devices are also discussed. © 2014 IEEE. Source

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