Sikkim Manipal Institute of Medical science SMIMS

Sikkim, India

Sikkim Manipal Institute of Medical science SMIMS

Sikkim, India
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Barua A.,Melaka Manipal Medical College MMMC | Ghosh M.,Sikkim Manipal Institute of Medical science SMIMS | Kar N.,Corner House Resource Center | Basilio M.,Saint Mary's University
Annals of Saudi Medicine | Year: 2011

Community-based mental health studies have revealed that the point prevalence of depressive disorders in the elderly population of the world varies between 10% and 20%, depending on cultural situations. A retrospective study based on analysis of various study reports was conducted, to determine the median prevalence rates of depressive disorders in the elderly population of India and various other countries in the world. All the studies that constituted the sample were conducted between 1955 and 2005. Included are only community-based, cross-sectional surveys and some prospective studies that had not excluded depression at baseline. These studies were conducted on a homogenous community of the elderly population in the world, who were selected by a simple random sampling technique. After applying the inclusion and exclusion criteria on published and indexed articles, 74 original research studies that surveyed a total of 487275 elderly individuals, in the age group of 60 years and above, residing in various parts of the world, were included for the final analysis. The median prevalence rate and its corresponding interquartile range were calculated. The chi-square test and chi-square for linear trend were applied. A P value of <.05 was considered as statistically significant. The median prevalence rate of depressive disorders in the world for the elderly population was determined to be 10.3% (interquartile range [IQR], 4.7%-16.0%). The median prevalence rate of depression among the elderly Indian population was determined to be 21.9% (IQR, 11.6%-31.1%). Although there was a significant decrease in the trend of world prevalence of geriatric depression, it was significantly higher among Indians, in recent years, than the rest of the world.


Tiwari V.K.,Sikkim Manipal Institute of Medical Science SMIMS | Barua A.,Sikkim Manipal Institute of Medical Science SMIMS | Kesari S.P.,Sikkim Manipal Institute of Medical Science SMIMS
Journal International Medical Sciences Academy | Year: 2010

A noticeable increase in health care burden from the various respiratory sicknesses including tuberculosis in India as well as in several areas of the world had been observed. The change in epidemiology and clinical spectrum of the respiratory sicknessess is a global concern. An analytical study with case control design on socio-demographic correlates of repiratory disorders was conducted on 110 individuals in the age groups of 10 years and above, who were permanent residents of east Sikkim for two months duration. Age and Sex mathching was done to identify each case with its corresponding control and Simple random sampling method was applied to select the case and control for the study. Chi Square Test was applied for univariat analysis and multiple logistic regression analysis was done to study the independent effect of each variable over the outcome. Thirteen (13) risk factors marital status, type of fuel used literacy status, smoking habit passive smoking, overcrowding, H/O of chronic respiratory ilness within last 5 years, pets at home, H/O of chronic exposure to allergens, family H/O of chronic exposure to allergens, parasitic diseases, psychiatric and H/O of chronic respiratory illness within past 5 years.


Barua A.,Kasturba Medical College | Ghosh M.K.,Sikkim Manipal Institute of Medical science SMIMS | Kar N.,Sikkim Manipal Institute of Medical science SMIMS | Basilio M.A.,Sikkim Manipal Institute of Medical science SMIMS
Journal International Medical Sciences Academy | Year: 2011

The pint prevalence of depressive disorders in the elderly population of the world varies between 10% and 20% depending on cultural situations. Objective of the study was to determine the median prevalence rates of depressive disorders in elderly population of India and various other countries in the world. retrospective study based on meta-analysis of various study reports of community based mental health surveys on geriatric depressive disorders conducted between 1955 and 2005in continents of Asia, Europe. Australia, North America and South America conducted . 74 original research studies that surveyed a total of 4,87,275 elderly individuals in the age group of 60 years and above, residing in various parts of the world were included for the final analysis. These studies were conducted on homogenous community of elderly population in the world, who were selected by simple random sampling technique. Median prevalence rate and its corresponding inter-quartile range, Chisquare test and Chi-square for Linear Trend were applied. P value < 0.05 was considered as statistically significant. The Median Prevalence rate of depressive disorders in the world for the elderly population was determined to be 10.3% [Interquartile Range (IQR) = (4.7% - 16.0%)]. The Median Prevalence Rate of depression among elderly Indian population was determined to be 21.9% [IQR = (11.6% -31.1%)]. Though there was a significant decrease trend in world prevalence of geriatric depression, but it was significantly higher among the Indians in recent years than the rest of the world.


Barua A.,Sikkim Manipal Institute of Medical science SMIMS | Barua A.,International Medical University | Tiwari V.K.,Sikkim Manipal Institute of Medical science SMIMS | Kesari S.P.,Sikkim Manipal Institute of Medical science SMIMS
BMC Research Notes | Year: 2013

Background: Due to the difficult geographic terrain with lack of roads and transport, the Sikkim State in India finds difficulties in contending the respiratory diseases especially during the rainy seasons. Findings. A case-control study was conducted for two months at the Central Referral Hospital of East Sikkim involving 110 individuals in the age group of 10 years and above. Due to feasibility constraints, 55 cases and 55 controls were selected by applying the non-probability sampling method with age and sex matching. The collected data were tabulated and analyzed by using the SPSS (Statistical Package for Social Sciences) version 10.0 for windows. Findings were expressed in terms of proportion, Chi Square Test and Multiple Logistic Regression Analysis. Here, p-value <0.05 was considered as statistically significant. This study revealed that the presence of overcrowding, chronic exposure to allergens, smoking habits, chronic respiratory illnesses within last 5 years, family history of chronic respiratory illnesses and mental illnesses were independently associated with respiratory diseases. Conclusion: This study should be replicated in other parts of Sikkim to obtain more confirmatory evidence on determinants of respiratory diseases. © 2013 Barua et al.; licensee BioMed Central Ltd.


Renjhen P.,Sikkim Manipal Institute of Medical Science SMIMS | Gupta S.D.,Sikkim Manipal Institute of Medical Science SMIMS | Barua A.,Sikkim Manipal Institute of Medical Science SMIMS | Jaju S.,Sikkim Manipal Institute of Medical Science SMIMS | Khati B.,Sikkim Manipal Institute of Medical Science SMIMS
Journal International Medical Sciences Academy | Year: 2010

The need for studies to understand the factors determining the fertility rates and family planning practices & barriers of contraceptives in particular Communities is essential to gather more specific knowledge about factors determining family planning acceptance for making necessary modifications in Reproductive & Child Health (RCH) programmer to suit their needs. Objective of the study were (1) to assess the Knowledge, Attitude & Practice on family planning among women of reproductive age group in east Sikkim. (2) to determine the barriers of contraceptive use among them. This is a hospital-based cross-sectional study. 443 women of reproductive age group (15-44) years, who gave informed verbal consent to participate in this study. Data collected were tabulated and analyzed using the statistical package of SPSS (Statistical) Majority of women in study population had adequate knowledge regarding family planning (98%) and contraceptives (94.2%). Majority (54.4%) had gained information from media, Majority (98%) believed that contraceptive use was beneficial but only 55.2% had used contraceptives in past and 84% of them were satisfied with the use. 62% were currently using contraceptives. Among the users of contraceptives 37.9% were using oral contraceptive pills and 31% were using condoms.


Barua A.,Kasturba Medical College | Barua A.,Sikkim Manipal Institute of Medical science SMIMS | Ghosh M.K.,Kasturba Medical College | Ghosh M.K.,Sikkim Manipal Institute of Medical science SMIMS | And 4 more authors.
Annals of Tropical Medicine and Public Health | Year: 2012

Background: Depression is a common mental health problem in the elderly population of the world. Objective: To study the chronic co-morbid conditions associated with depression in elderly population. Materials and Methods: A systematic review was conducted on 74 community-based mental health surveys on depression in elderly which were conducted in continents of Asia, Europe, Australia, North America, and South America. All the studies were conducted between 1955 and 2005. The researchers had included only community-based cross-sectional surveys and some prospective studies that had not excluded depression on baseline. These studies were conducted on homogenous community of elderly population in the world, who were selected by simple random sampling technique. A qualitative analysis on 11 of these articles was conducted to study the chronic co-morbidities associated with depression in elderly. Results and Conclusion: The univariate analysis results from 11 studies on various chronic co-morbid conditions associated with depression in elderly revealed that depression in elderly was significantly associated with arthritis, cognitive impairment, visual impairment, functional impairment, and restricted activities of daily living (ADL). The prevalence of depression followed an increasing trend as the number of chronic co-morbidities increased.


Bhatia A.,National Institute of Oceanography of India | Bhatia A.,Sikkim Manipal Institute of Medical science SMIMS | Pal R.,Sikkim Manipal Institute of Medical science
Wilderness and Environmental Medicine | Year: 2012

To evaluate morbidity prototype of 27th Indian Scientific Expedition to Antarctica (ISEA). Twenty-six team members of 27th ISEA wintered over at the Indian Antarctic Station, Maitri, from February 2008 to January 2009. The morbidity pattern was sourced from the medical records. Preexisting illnesses were also considered in this analysis. The team consisted of men between 27 and 59 years of age (mean age, 43 years). Nine team members had preexisting illnesses. A total of 93 illness incidents were recorded during the stay in Antarctica. Most of these (27) were musculoskeletal injuries, bruises, and lacerations. Thirty-two (34%) incidents of illness were noted under the purview of medicine; 26 (28%), surgery; 15 (16%), orthopedics; 9 (10%), otorhinolaryngology; 8 (9%), ophthalmology; 2 (2%), dentistry; and 3 (3%), psychiatry. Oral ulcers were noted in 8 (8%) participants primarily during early wintering. Injuries continue to be the most common cause of morbidity in Antarctica. Nutritional deficiencies and cold-related injuries are relatively less common. © 2012 Wilderness Medical Society.


Barua A.,Sikkim Manipal Institute of Medical science SMIMS | Barua A.,International Medical University
Arquivos Brasileiros de Cardiologia | Year: 2013

Introduction: Unipolar Major Depression is predicted to become the second-most important cause of morbidity throughout the world by the year 2020 by the World Health Organization (WHO). This systematic review on the prevalence rates of geriatric depression was conducted to draw the attention of all health care personnel for focussing their intense endeavours in addressing this burning issue. Objectives: (1) To determine the Median Prevalence Rates of geriatric depression of the world and in India. (2) To conduct a Time-Trend Analysis on prevalence of geriatric depression in the world. Materials & Methods: This Retrospective study based on Systematic review on prevalence of geriatric depression was conducted on the community based mental health surveys on geriatric depression conducted in continents of Asia, Europe, Australia, North America, and South America. All the studies that constituted the sample were conducted between 1956 and 2005. After applying the inclusion and exclusion criteria, 65 original research studies that surveyed a total of 99,297 elderly individuals in the age group of 60 years and above, residing in various parts of the world were included for the final analysis. Statistical procedures applied were the median prevalence rate and its corresponding inter-quartile range as well as the Chi-square for Linear Trend. P value <0.05 was considered as statistically significant. Results: The Median Prevalence Rate of geriatric depression in the world was determined to be 10.3% with Interquartile Range varying between 4.6% and 16.0%. The Median Prevalence Rate of geriatric depression in Indian population was determined to be 21.9% with Interquartile Range varying between 11.6% and 31.1%. Conclusion: The high prevalence rate of geriatric depression could be attributed to the fact that better diagnostic instruments with optimum validity and reliability had been developed during the recent years to diagnose geriatric depression at an early stage in the community.


PubMed | Sikkim Manipal Institute of Medical science SMIMS, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Darbhanga Medical College and Hospital Near Karpuri Chowk Benta Laheriasarai Darbhanga and University of Lucknow
Type: | Journal: American journal of human biology : the official journal of the Human Biology Council | Year: 2016

The aim of the study was to investigate the association of 55 SNPs in 28 genes with obesity risk in a North Indian population using a multianalytical approach.Overall, 480 subjects from the North Indian population were studied using strict inclusion/exclusion criteria. SNP Genotyping was carried out by Sequenom Mass ARRAY platform (Sequenom, San Diego, CA) and validated TaqmanLogistic regression analysis of 55 SNPs revealed significant associations (P<.05) of 49 SNPs with BMI linked obesity risk whereas the remaining 6 SNPs revealed no association (P>.05). The pathway-wise G-score revealed the significant role (P=.0001) of food intake-energy expenditure pathway genes. In CART analysis, the combined genotypes of FTO rs9939609 and TCF7L2 rs7903146 revealed the highest risk for BMI linked obesity. The analysis of the FTO-IRX3 locus revealed high LD and high order gene-gene interactions for BMI linked obesity. The interaction network of all of the associated genes in the present study generated by GENEMANIA revealed direct and indirect connections. In addition, the analysis with centralized obesity revealed that none of the SNPs except for FTO rs17818902 were significantly associated (P<.05).In this multi-analytical approach, FTO rs9939609 and IRX3 rs3751723, along with TCF7L2 rs7903146 and TMEM18 rs6548238, emerged as the major SNPs contributing to BMI linked obesity risk in the North Indian population.


PubMed | Sikkim Manipal Institute of Medical science SMIMS
Type: | Journal: BMC research notes | Year: 2013

Due to the difficult geographic terrain with lack of roads and transport, the Sikkim State in India finds difficulties in contending the respiratory diseases especially during the rainy seasons.A case-control study was conducted for two months at the Central Referral Hospital of East Sikkim involving 110 individuals in the age group of 10years and above. Due to feasibility constraints, 55 cases and 55 controls were selected by applying the non-probability sampling method with age and sex matching. The collected data were tabulated and analyzed by using the SPSS (Statistical Package for Social Sciences) version 10.0 for windows. Findings were expressed in terms of proportion, Chi Square Test and Multiple Logistic Regression Analysis. Here, p-value <0.05 was considered as statistically significant. This study revealed that the presence of overcrowding, chronic exposure to allergens, smoking habits, chronic respiratory illnesses within last 5years, family history of chronic respiratory illnesses and mental illnesses were independently associated with respiratory diseases.This study should be replicated in other parts of Sikkim to obtain more confirmatory evidence on determinants of respiratory diseases.

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