SigmaGraft

Burbank, CA, United States

SigmaGraft

Burbank, CA, United States

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Lee D.S.H.,Missouri University of Science and Technology | Pai Y.,SigmaGraft | Chang S.,SigmaGraft | Kim D.H.,Korea Animal Medical Science Institute
Materials Science and Engineering C | Year: 2016

The nano-sized β-tricalcium phosphate granules for the practical application of bone graft substitutes could be prepared from the wet chemically precipitated β-TCP powders by the liquid-solid mixture route and by controlling the pH of mixture solution to 7.5 within a shorter processing time. The phase purity of prepared β-TCP granules was higher above 99% and their particle sizes ranged from 200 to 650 nm. Also, their average compressive strength was higher at 2.22 MPa. It is considered that the phase purity, particle refinement, and mechanical compressive strength of β-TCP granules could be significantly improved through the β-TCP powders synthesized through the liquid-solid mixture precipitation at pH of 7.5. Meanwhile both the porosity and the specific surface area positively associated with the osteoconductivity for bone regeneration were higher at 75% and 2.50 m2/g respectively due to the nano-sized particles of porous β-TCP granules. Furthermore, the histological analysis in beagle mandibular defect showed that β-TCP granules demonstrated remarkable bone regeneration effectcompared with that of the non-treatment group, indicating the increased new formation of bone (except for callus) (48.42 ± 6.57%) and rapid resorption (69.49 ± 2.40%) without toxicologically significant changes at 12 weeks after implantation. © 2015 Elsevier B.V.


PubMed | Korea Animal Medical Science Institute, SigmaGraft and Missouri University of Science and Technology
Type: | Journal: Materials science & engineering. C, Materials for biological applications | Year: 2015

The nano-sized -tricalcium phosphate granules for the practical application of bone graft substitutes could be prepared from the wet chemically precipitated -TCP powders by the liquid-solid mixture route and by controlling the pH of mixture solution to 7.5 within a shorter processing time. The phase purity of prepared -TCP granules was higher above 99% and their particle sizes ranged from 200 to 650 nm. Also, their average compressive strength was higher at 2.22 MPa. It is considered that the phase purity, particle refinement, and mechanical compressive strength of -TCP granules could be significantly improved through the -TCP powders synthesized through the liquid-solid mixture precipitation at pH of 7.5. Meanwhile both the porosity and the specific surface area positively associated with the osteoconductivity for bone regeneration were higher at 75% and 2.50 m(2)/g respectively due to the nano-sized particles of porous -TCP granules. Furthermore, the histological analysis in beagle mandibular defect showed that -TCP granules demonstrated remarkable bone regeneration effect compared with that of the non-treatment group, indicating the increased new formation of bone (except for callus) (48.42 6.57%) and rapid resorption (69.49 2.40%) without toxicologically significant changes at 12 weeks after implantation.


The β-tricalcium phosphate (β-TCP; Ca3(PO 4)2) powders with high purity could be attained through mixing and precipitating (NH4)2HPO4 with solution state and Ca(NO3)2 · 4H2O with solid state and controlling the pH of mixture solution in a range from 7.0 to 8.5 within a short time. The FT-IR results showed that the peak of calcium pyrophosphate (Ca2P2O7) excluding the peaks associated with β-TCP appeared at a pH ranging from 5.0 to 7.0 but did not appear at a pH ranging from 7.0 to 8.5. It is considered that the phase purity of β-TCP powders could be significantly improved through liquid-solid mixture precipitation and pH control of mixture solution. The XRD and SEM results showed that the phase purity and the particle size of precipitated β-TCP powders were above 99% and ranged from 200 nm to 600 nm, respectively. © 2013 Elsevier B.V. All rights reserved.


Lee D.S.H.,SigmaGraft | Pai Y.,SigmaGraft | Chang S.,SigmaGraft
Materials Chemistry and Physics | Year: 2014

The anorganic bovine bone grafting materials have been widely used to fill bone defects in periodontal and maxillofacial surgery. The purpose of present study was to fully characterize our anorganic bone, InterOss®, by physical and chemical methods and to compare it with another anorganic bone, Bio-Oss® that has been commercially distributed in dental bone graft substitute market since 1995. InterOss® anorganic bone had been successfully prepared by chemical treatment (NaOH and H2O 2) and low temperature (350°C) annealing process with an extremely low heating rate (<0.3°C min-1). Commercially available Bio-Oss® anorganic bone was chosen for comparison. The physical and chemical analysis indicated that the pore structure, microstructure, phase structure, and chemical composition of InterOss ® is substantially equivalent to that of Bio-Oss®. The BET analysis also showed that the inner surface area of InterOss ® is comparatively higher than that of Bio-Oss®. Specially, the protein analysis showed that the content of residual protein of InterOss® is relatively lower than that of Bio-Oss ®. Based on an equivalency to Bio-Oss® in terms of physical and chemical characterization with both higher inner surface area and lower residual protein content, the InterOss® can be a promising candidate as dental bone grafting material in periodontal and maxillofacial surgery. © 2014 Elsevier B.V. All rights reserved.


Trademark
Sigmagraft | Date: 2015-01-20

Collagen implant medical device.


Trademark
Sigmagraft | Date: 2015-01-20

Bone grafting medical device.


News Article | November 23, 2016
Site: www.newsmaker.com.au

This report studies Dental Biomaterial in Global market, especially in North America, Europe, China, Japan, Southeast Asia and India, focuses on top manufacturers in global market, with Production, price, revenue and market share for each manufacturer, covering  Osstem  Straumann  Dentsply  NobelBiocare  SpofaDental  Kerr Corporation  Ceramisys  Datum Dental  DMG  NORAKER  Keystone Dental  AT&M Biomaterials  Hangzhou Xihu Biomaterials  SigmaGraft  PROMEDICA Market Segment by Regions, this report splits Global into several key Regions, with production, consumption, revenue, market share and growth rate of Dental Biomaterial in these regions, from 2011 to 2021 (forecast), like  North America  Europe  China  Japan  Southeast Asia  India Split by product type, with production, revenue, price, market share and growth rate of each type, can be divided into  Type I  Type II  Type III Split by application, this report focuses on consumption, market share and growth rate of Dental Biomaterial in each application, can be divided into  Application 1  Application 2  Application 3 Global Dental Biomaterial Market Research Report 2016  1 Dental Biomaterial Market Overview  1.1 Product Overview and Scope of Dental Biomaterial  1.2 Dental Biomaterial Segment by Type  1.2.1 Global Production Market Share of Dental Biomaterial by Type in 2015  1.2.2 Type I  1.2.3 Type II  1.2.4 Type III  1.3 Dental Biomaterial Segment by Application  1.3.1 Dental Biomaterial Consumption Market Share by Application in 2015  1.3.2 Application 1  1.3.3 Application 2  1.3.4 Application 3  1.4 Dental Biomaterial Market by Region  1.4.1 North America Status and Prospect (2011-2021)  1.4.2 Europe Status and Prospect (2011-2021)  1.4.3 China Status and Prospect (2011-2021)  1.4.4 Japan Status and Prospect (2011-2021)  1.4.5 Southeast Asia Status and Prospect (2011-2021)  1.4.6 India Status and Prospect (2011-2021)  1.5 Global Market Size (Value) of Dental Biomaterial (2011-2021) 7 Global Dental Biomaterial Manufacturers Profiles/Analysis  7.1 Osstem  7.1.1 Company Basic Information, Manufacturing Base and Its Competitors  7.1.2 Dental Biomaterial Product Type, Application and Specification  7.1.2.1 Type I  7.1.2.2 Type II  7.1.3 Osstem Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.1.4 Main Business/Business Overview  7.2 Straumann  7.2.1 Company Basic Information, Manufacturing Base and Its Competitors  7.2.2 Dental Biomaterial Product Type, Application and Specification  7.2.2.1 Type I  7.2.2.2 Type II  7.2.3 Straumann Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.2.4 Main Business/Business Overview  7.3 Dentsply  7.3.1 Company Basic Information, Manufacturing Base and Its Competitors  7.3.2 Dental Biomaterial Product Type, Application and Specification  7.3.2.1 Type I  7.3.2.2 Type II  7.3.3 Dentsply Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.3.4 Main Business/Business Overview  7.4 NobelBiocare  7.4.1 Company Basic Information, Manufacturing Base and Its Competitors  7.4.2 Dental Biomaterial Product Type, Application and Specification  7.4.2.1 Type I  7.4.2.2 Type II  7.4.3 NobelBiocare Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.4.4 Main Business/Business Overview  7.5 SpofaDental  7.5.1 Company Basic Information, Manufacturing Base and Its Competitors  7.5.2 Dental Biomaterial Product Type, Application and Specification  7.5.2.1 Type I  7.5.2.2 Type II  7.5.3 SpofaDental Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.5.4 Main Business/Business Overview  7.6 Kerr Corporation  7.6.1 Company Basic Information, Manufacturing Base and Its Competitors  7.6.2 Dental Biomaterial Product Type, Application and Specification  7.6.2.1 Type I  7.6.2.2 Type II  7.6.3 Kerr Corporation Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.6.4 Main Business/Business Overview  7.7 Ceramisys  7.7.1 Company Basic Information, Manufacturing Base and Its Competitors  7.7.2 Dental Biomaterial Product Type, Application and Specification  7.7.2.1 Type I  7.7.2.2 Type II  7.7.3 Ceramisys Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.7.4 Main Business/Business Overview  7.8 Datum Dental  7.8.1 Company Basic Information, Manufacturing Base and Its Competitors  7.8.2 Dental Biomaterial Product Type, Application and Specification  7.8.2.1 Type I  7.8.2.2 Type II  7.8.3 Datum Dental Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.8.4 Main Business/Business Overview  7.9 DMG  7.9.1 Company Basic Information, Manufacturing Base and Its Competitors  7.9.2 Dental Biomaterial Product Type, Application and Specification  7.9.2.1 Type I  7.9.2.2 Type II  7.9.3 DMG Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.9.4 Main Business/Business Overview  7.10 NORAKER  7.10.1 Company Basic Information, Manufacturing Base and Its Competitors  7.10.2 Dental Biomaterial Product Type, Application and Specification  7.10.2.1 Type I  7.10.2.2 Type II  7.10.3 NORAKER Dental Biomaterial Production, Revenue, Price and Gross Margin (2015 and 2016)  7.10.4 Main Business/Business Overview  7.11 Keystone Dental  7.12 AT&M Biomaterials  7.13 Hangzhou Xihu Biomaterials  7.14 SigmaGraft  7.15 PROMEDICA

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