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Burbank, CA, United States

Sigmagraft | Date: 2015-01-20

Bone grafting medical device.

Sigmagraft | Date: 2015-01-20

Collagen implant medical device.

Lee D.S.H.,Missouri University of Science and Technology | Pai Y.,SigmaGraft | Chang S.,SigmaGraft | Kim D.H.,Korea Animal Medical Science Institute
Materials Science and Engineering C | Year: 2016

The nano-sized β-tricalcium phosphate granules for the practical application of bone graft substitutes could be prepared from the wet chemically precipitated β-TCP powders by the liquid-solid mixture route and by controlling the pH of mixture solution to 7.5 within a shorter processing time. The phase purity of prepared β-TCP granules was higher above 99% and their particle sizes ranged from 200 to 650 nm. Also, their average compressive strength was higher at 2.22 MPa. It is considered that the phase purity, particle refinement, and mechanical compressive strength of β-TCP granules could be significantly improved through the β-TCP powders synthesized through the liquid-solid mixture precipitation at pH of 7.5. Meanwhile both the porosity and the specific surface area positively associated with the osteoconductivity for bone regeneration were higher at 75% and 2.50 m2/g respectively due to the nano-sized particles of porous β-TCP granules. Furthermore, the histological analysis in beagle mandibular defect showed that β-TCP granules demonstrated remarkable bone regeneration effectcompared with that of the non-treatment group, indicating the increased new formation of bone (except for callus) (48.42 ± 6.57%) and rapid resorption (69.49 ± 2.40%) without toxicologically significant changes at 12 weeks after implantation. © 2015 Elsevier B.V.

The β-tricalcium phosphate (β-TCP; Ca3(PO 4)2) powders with high purity could be attained through mixing and precipitating (NH4)2HPO4 with solution state and Ca(NO3)2 · 4H2O with solid state and controlling the pH of mixture solution in a range from 7.0 to 8.5 within a short time. The FT-IR results showed that the peak of calcium pyrophosphate (Ca2P2O7) excluding the peaks associated with β-TCP appeared at a pH ranging from 5.0 to 7.0 but did not appear at a pH ranging from 7.0 to 8.5. It is considered that the phase purity of β-TCP powders could be significantly improved through liquid-solid mixture precipitation and pH control of mixture solution. The XRD and SEM results showed that the phase purity and the particle size of precipitated β-TCP powders were above 99% and ranged from 200 nm to 600 nm, respectively. © 2013 Elsevier B.V. All rights reserved.

Lee D.S.H.,SigmaGraft | Pai Y.,SigmaGraft | Chang S.,SigmaGraft
Materials Chemistry and Physics | Year: 2014

The anorganic bovine bone grafting materials have been widely used to fill bone defects in periodontal and maxillofacial surgery. The purpose of present study was to fully characterize our anorganic bone, InterOss®, by physical and chemical methods and to compare it with another anorganic bone, Bio-Oss® that has been commercially distributed in dental bone graft substitute market since 1995. InterOss® anorganic bone had been successfully prepared by chemical treatment (NaOH and H2O 2) and low temperature (350°C) annealing process with an extremely low heating rate (<0.3°C min-1). Commercially available Bio-Oss® anorganic bone was chosen for comparison. The physical and chemical analysis indicated that the pore structure, microstructure, phase structure, and chemical composition of InterOss ® is substantially equivalent to that of Bio-Oss®. The BET analysis also showed that the inner surface area of InterOss ® is comparatively higher than that of Bio-Oss®. Specially, the protein analysis showed that the content of residual protein of InterOss® is relatively lower than that of Bio-Oss ®. Based on an equivalency to Bio-Oss® in terms of physical and chemical characterization with both higher inner surface area and lower residual protein content, the InterOss® can be a promising candidate as dental bone grafting material in periodontal and maxillofacial surgery. © 2014 Elsevier B.V. All rights reserved.

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