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Sigma-Aldrich | Date: 2015-01-30
The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.
Sigma-Aldrich and Sangamo BioSciences | Date: 2014-02-24
Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided.
Sigma-Aldrich | Date: 2015-10-22
This disclosure provides methods and devices for quantitating, separating and/or detecting water in a liquid, gas or solid sample comprising one or more chemicals, the method comprising: providing the liquid, gas or solid sample comprising water and the one or more chemicals; and exposing said liquid, gas or solid sample to at least one solid support including at least one dicationic and/or tricationic species of Formula I or II adsorbed, absorbed or immobilized on the solid support.
Sigma-Aldrich | Date: 2015-10-02
Methods and systems for sequestering carbon dioxide and, in particular, methods and systems for sequestering carbon dioxide by reacting carbon dioxide with an organic substrate, a carboxylase and a salt. Processes for producing 3-phosphoglycerate are also provided. In addition, uses for the 3-phosphoglycerate produced by the methods and systems are provided.
Sigma-Aldrich | Date: 2014-05-30
The present invention provides methods for modifying chromosomal sequences. In particular, methods are provided for using RNA-guided endonucleases or modified RNA-guided endonucleases to modify targeted chromosomal sequences.