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St Louis, MO, United States

Sigma-Aldrich Corporation is an American life science and high technology company with over 9,600 employees and operations in 40 countries. Its chemical and biochemical products and kits are used in scientific research, biotechnology, pharmaceutical development, the diagnosis of disease, and as key components in high technology manufacturing. Wikipedia.

The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.

Sigma-Aldrich and Sangamo BioSciences | Date: 2014-02-24

Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided.

Sigma-Aldrich | Date: 2015-10-22

This disclosure provides methods and devices for quantitating, separating and/or detecting water in a liquid, gas or solid sample comprising one or more chemicals, the method comprising: providing the liquid, gas or solid sample comprising water and the one or more chemicals; and exposing said liquid, gas or solid sample to at least one solid support including at least one dicationic and/or tricationic species of Formula I or II adsorbed, absorbed or immobilized on the solid support.

Sigma-Aldrich | Date: 2015-10-02

Methods and systems for sequestering carbon dioxide and, in particular, methods and systems for sequestering carbon dioxide by reacting carbon dioxide with an organic substrate, a carboxylase and a salt. Processes for producing 3-phosphoglycerate are also provided. In addition, uses for the 3-phosphoglycerate produced by the methods and systems are provided.

Sigma-Aldrich | Date: 2014-05-30

The present invention provides methods for modifying chromosomal sequences. In particular, methods are provided for using RNA-guided endonucleases or modified RNA-guided endonucleases to modify targeted chromosomal sequences.

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