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İzmir, Turkey

Solak A.,Sifa Hospital | Solak I.,Ege University
Turkish Journal of Gastroenterology | Year: 2012

Sclerosing encapsulating peritonitis, or abdominal cocoon syndrome, was described firstly in young adolescent girls. It is characterized by a thick fibrotic peritoneum that wraps the bowel in a concertina-like fashion with some adhesions. We report a man with intermittent intestinal obstruction and an abdominal cocoon encasing the small bowel. Our patient had no history of peritonitis or tuberculosis. We think he had primary abdominal cocoon syndrome. To the best of our knowledge, very few male patients have been reported in the medical literature as developing this condition. We treated the patient with drug therapy, including steroid and mycophenolate mofetil, and a liquid diet program, without surgical operation. He was symptom-free on follow-up over a period of 11 months. Source


Arslan C.,Izmir Tepecik Research and Training Hospital | Isler M.,Sifa Hospital | Alanoglu G.,Suleyman Demirel University of Turkey
Turkish Journal of Gastroenterology | Year: 2014

Thromboembolic events are rare in the course of ulcerative colitis and related with the activity of the disease. These complications are especially seen in young patients and cause high mortality and morbidity. Arterial thrombotic complications are less frequent and are usually seen after a surgical procedure. Here, we present a 36-year-old man with active ulcerative colitis presenting via digital arterial thrombosis and digital necrosis that was not associated with a surgical procedure. © Copyright 2014 by The Turkish Society of Gastroenterology. Source


Bakirci E.M.,Bayburt State Hospital | Topcu S.,Ataturk University | Kalkan K.,Ataturk University | Tanboga I.H.,Ataturk University | And 3 more authors.
Clinical and Applied Thrombosis/Hemostasis | Year: 2015

We aimed to investigate the relationship between the extent of venous thromboembolism (VTE) and nonspecific inflammatory markers such as neutrophil to lymphocyte ratio (NLR) and high-sensitivity C-reactive protein (hs-CRP). We retrospectively enrolled 77 patients with VTE (distal deep vein thrombosis [DVT], n = 19; proximal DVT, n = 32; and pulmonary thromboembolism [PTE], n = 26) and 34 healthy controls. In the performed analysis of variance, the levels of white blood cell, NLR, and hs-CRP were clearly different among the groups (control, distal and proximal DVT, and PTE) (P < .001). Especially, a significant increase from the control group to the DVT and PTE was observed in the analysis made for NLR. In the performed receiver-operating characteristic curve analysis, area under curve (AUC) = 0.849 and P < .001 were detected for NLR > 1.84. For this value, the sensitivity and specificity were determined as 88.2% and 67.6%, respectively. The NLR is an inexpensive and a readily available marker that may be effective in determining the extent of VTE, and it is useful for risk stratification in patients with VTE. © The Author(s) 2013 Source


Senol A.,Suleyman Demirel University of Turkey | Akn M.,Akdeniz University | Songur Y.,Memorial Sisli Hospital | Isler M.,Sifa Hospital | Kockar M.C.,Suleyman Demirel University of Turkey
Journal of Clinical and Analytical Medicine | Year: 2016

Aim: Alpha-fetoprotein (AFP) has been widely used as a diagnostic marker for hepatocellular carcinoma. Some patients with hepatitis C show high AFP values, but no evidence of hepatocellular carcinoma. The aim of this study is to assess the influence of antiviral treatment on the serum AFP in pa-tients with chronic hepatitis C without hepatocellular carcinoma. Material and Method: Thirty seven chronic hepatitis C patients (20 females and 17 males) were included in the study. All patients were given a combined treat-ment of pegylated or conventional interferon (IFN) and ribavirin. Serum AFP was measured at baseline and on months 3-6-12 of the therapy. Results: Compared to the pretreatment levels of ALT (88,59 ± 57,22 IU), those at 3, 6 and 12 months were statistically lower (p< 0,001). Mean serum AFP levels gradually decreased from pretreatment level of 6,6 ± 6,05 ng/ml to 5,1 ± 3,7 (p>0,05), to 4,34 ± 4,64 (p>0,05) and to 2,63 ± 2,17 (p<0,001) at month 3, 6 and 12 of the therapy, respectively. Although AFP decrease at month 3 was non significant, a significant decrease of mean serum AFP levels after 6 and 12 months of therapy was demonstrated in the patients with high AFP (>10 ng/ml). In these patients, mean serum AFP levels were decreased from pre-treatment level of 15,09 ± 5,92 ng/ml to 11,39±3,30, to 6,97±2,53 (p<0,001) and to 5,67±3,89 (p=0,009) at month 3, 6 and 12, respectively. Discussion: Serum AFP level significantly decreases during therapy in hepatitis C patients receiving IFN-α plus ribavirin for 48 weeks. © 2016, Journal of Clinical and Analytical Medicine. All rights reserved. Source


Erdem F.H.,Sifa Hospital | Karatay S.,Ataturk University | Yildirim K.,Ataturk University | Kiziltunc A.,Ataturk University
Clinics | Year: 2010

OBJECTIVES: The aim of this study was to investigate the activities of serum paraoxonase and arylesterase in patients with ankylosing spondylitis with respect to those of healthy controls, to assess whether these enzyme levels are related to disease activity and functional capacity. METHODS: The study included 32 patients with ankylosing spondylitis whose diagnoses were made according to the modified New York criteria as well as 25 healthy controls matched for age and sex. The Bath Ankylosing Spondylitis Disease Activity Index and the Bath Ankylosing Spondylitis Functional Index were applied to the ankylosing spondylitis patients. As laboratory parameters, the erythrocyte sedimentation rate and serum C-reactive protein level were measured in patients and control subjects. Paraoxonase and arylesterase enzyme activities were measured using appropriate methods. RESULTS: No statistically significant differences (p>0.05) were found between the ankylosing spondylitis patients and controls in terms of serum paraoxonase or arylesterase levels. Furthermore, there was no correlation between clinical and laboratory parameters in patients with ankylosing spondylitis. CONCLUSION: Serum paraoxonase and arylesterase levels in ankylosing spondylitis patients may not differ from those of healthy controls, and there is no significant correlation between antioxidant parameters and the Bath Ankylosing Spondylitis Disease Activity Index or Bath Ankylosing Spondylitis Functional Index scores in ankylosing spondylitis patients. Further research is needed to provide deeper understanding of this disease. Source

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