Siena Biotech SpA Strada del Petriccio e Belriguardo 35 53100 Siena Italy

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Siena Biotech SpA Strada del Petriccio e Belriguardo 35 53100 Siena Italy

Italy

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Mellini P.,University of Rome La Sapienza | De Vita D.,University of Rome La Sapienza | Di Rienzo B.,University of Rome La Sapienza | La Rosa S.,Siena Biotech SpA Strada del Petriccio e Belriguardo 35 53100 Siena Italy | And 4 more authors.
Journal of Heterocyclic Chemistry | Year: 2014

3,5-Dicarbamoyl-1,4-dihydropyridines were prepared in high yields using a green protocol by reduction of the corresponding pyridinium salts in aqueous buffered sodium dithionite solutions. The pH value is a fundamental parameter for the reduction step and depends on the nature of substituent groups at positions 1, 3, and 5 of the pyridinium salts. These 3,5-dicarbamoyl dihydropyridines show a lower tendency towards oxidation and a higher stability than N-benzyl-3-carbamoyl-1,4-dihydropyridine at low pH values. " >. © 2014 HeteroCorporation.

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