Siddha Central Research Institute

Arumbakkam, India

Siddha Central Research Institute

Arumbakkam, India
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Selvarajan S.,Siddha Regional Research Institute | Gayathri Devi V.,Siddha Regional Research Institute | John A.,Siddha Central Research Institute | Jeyakannan J.,Siddha Central Research Institute | And 2 more authors.
International Journal of Pharmacy and Technology | Year: 2015

Tinospora cordifolia commonly known as Guduchi is used in traditional systems of medicine for general debility, dyspepsia, fevers and urinary diseases. The plant also possesses antiviral as well as antibacterial properties. The present study provides a detailed pharmacognostic study based on its physicochemical, macroscopic, microscopic and chromatographic features. The physicochemical parameters such as loss on drying, solubility in different solvents, ash content, acid insoluble ash, water soluble ash, volatile oil, fibre content etc. were determined by standard methods. Anatomical features of the stems of Tinospora cordifolia were determined. For this the sample was fixed in FAA, cast into paraffin blocks and sectioned with the help of Rotary Microtome. The stomata morphology, venation pattern and trichome distribution were studied. Microscopic descriptions of tissues were supplemented with micrographs wherever necessary. Photographs of different magnifications were taken with Nikon Labphot 2 Microscopic Unit. Powder microscopy was carried out using standard methods. HPTLC profile of the methanolic plant extract was carried out in short UV, long UV and using anisaldehyde - sulphuric acid as detection reagent. The Rf values of the spots developed were noted which is an important parameter for identification of plant materials. The pharmacognostical parameters along with the HPTLC profile may be utilized to identify the drug material and for laying down the pharmacopoeial standards. © 2015 International Journal of Pharmacy and Technology. All rights reserved.


Venkatasubbu G.D.,University of Madras | Ramasamy S.,Anna University | Gaddam P.R.,Siddha Central Research Institute | Kumar J.,Anna University
International Journal of Nanomedicine | Year: 2015

Nanoparticles are widely used for targeted drug delivery applications. Surface modification with appropriate polymer and ligands is carried out to target the drug to the affected area. Toxicity analysis is carried out to evaluate the safety of the surface modified nanoparticles. In this study, paclitaxel attached, folic acid functionalized, polyethylene glycol modified hydroxyapatite and titanium dioxide nanoparticles were used for targeted drug delivery system. The toxicological behavior of the system was studied in vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical, hematological, and histopathological analysis was also done. There were no significant alterations in the biochemical parameters at a low dosage. There was a small change in alkaline phosphatase (ALP) level at a high dosage. The results indicate a safe toxicological profile. © 2015 Venkatasubbu et al.


PubMed | Anna University, University of Madras and Siddha Central Research Institute
Type: | Journal: International journal of nanomedicine | Year: 2015

Nanoparticles are widely used for targeted drug delivery applications. Surface modification with appropriate polymer and ligands is carried out to target the drug to the affected area. Toxicity analysis is carried out to evaluate the safety of the surface modified nanoparticles. In this study, paclitaxel attached, folic acid functionalized, polyethylene glycol modified hydroxyapatite and titanium dioxide nanoparticles were used for targeted drug delivery system. The toxicological behavior of the system was studied in vivo in rats and mice. Acute and subchronic studies were carried out. Biochemical, hematological, and histopathological analysis was also done. There were no significant alterations in the biochemical parameters at a low dosage. There was a small change in alkaline phosphatase (ALP) level at a high dosage. The results indicate a safe toxicological profile.


Parthasarathy K.,Siddha Central Research Institute | Parthasarathy K.,Orchid Chemicals & Pharmaceuticals Ltd. | Praveen C.,CSIR - Central Electrochemical Research Institute | Saranraj K.,CSIR - Central Leather Research Institute | And 2 more authors.
Medicinal Chemistry Research | Year: 2016

Microwave-assisted tandem double condensation between isatins and 4-hydroxycoumarin under zinc triflate catalysis to afford spirooxindoles in excellent yield is reported. The synthesized compounds were screened for their in vitro antibacterial and antifungal activities. The compounds that showed promising antimicrobial activity (3a, 3j and 3m) were studied for their binding affinity towards AmpC-β-lactamase receptor, which revealed that compound 3a is highly stabilized by strong hydrogen bond interactions with in the binding pocket. The synthesized spirooxindoles were also evaluated for their cytotoxic potential against COLO320 adenocarcinoma colorectal cancer cells. Biological assay and in silico studies indicated compound 3n as the most active in terms of low IC50 value (50.7 μM) and least free energy of binding (−8.89 kcal/mol) respectively. © 2016 Springer Science+Business Media New York


Meena R.,Siddha Central Research Institute | Ramaswamy R.S.,Central Council for Research in Siddha
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

Uthiravatha suronitham is one of the 80 types of vatha diseases described by sage Yugi. This can be correlated to Rheumatoid arthritis in modern science. This is a poly arthritis of autoimmune etiology. Varmam treatment is a special external manipulation technique in Siddha system. A 40 year old married female is treated with Amukkara chooranam, Pinda thylam and Varmam technique for 40 days. Clinical and laboratory were analyzed before and after treatment. The treatment package resulted in reduction of pain, swelling and stiffness of affected joints.


John A.,Siddha Central Research Institute | Gayathri Devi V.,Siddha Regional Research Institute | Selvarajan S.,Siddha Regional Research Institute | Gopakumar K.,Siddha Central Research Institute
International Journal of Pharmacy and Technology | Year: 2015

Gossypiumherbaceum Linn. belongs to the family Malvaceae, is commonly known as Karpas or Cotton. The plantoccurs in Middle East countries,Central Asia and Western India. The area of its greatest variability is found in Baluchistan, Iran, Afghanistan and Russian Turkestan. The cultivated types are found in India, China and Middle East countries. Gossypiumherbaceum has been widely used in theproduction of food and medicine as well. The parts of the plant used in medicine are seeds, leaves, flowers, root and root bark. The plant possesses antifertility, antispermatogenic, antitumor, abortifacient, contraceptive, antidiabetic, antiulcer, antiviral and antibacterial activities. In the present paper, a detailed study on Gossypiumherbaceum(flower) based on its physico-chemical analysis and High Performance Thin Layer Chromatographic (HPTLC) studies were carried out to lay down the pharmacopoeial standards. The physico-chemical parameters such as loss on drying at 105oC, solubility in water and alcohol, ash content and acid insoluble ash were determined by standard methods. A preliminary phytochemical study was carried out using different extractives of the plant material. HPTLC profile of the ethanol extract of the plant material was carried out in UV 254nm, UV 366nm and using vanillin- sulphuric acid as derivatisation reagent and the Rf values were noted. All these parameters are helpful in identification and standardization of the flower of Gossypiumherbaceum. © 2015, International Journal of Pharmacy and Technology. All rights reserved.


Sanath Kumar T.S.S.P.N.S.,Osmania University | Sanath Kumar T.S.S.P.N.S.,Siddha Central Research Institute | Prasant A.,Osmania University | David Krupadanam G.L.,Osmania University | Akshaya Kumar K.,Osmania University
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2012

2-Benzoyl-3-phenacyl-2.3-dihydrobenzofurans are synthesized by the reaction between 2-hydroxychalcones and 2-broinoaceto-phenones with potassium carbonate in boiling acetone in good yield.


Parthasarathy K.,Siddha Central Research Institute | Praveen C.,CSIR - Central Electrochemical Research Institute | Jeyaveeran J.C.,Ramakrishna Mission Vivekananda College | Prince A.A.M.,Ramakrishna Mission Vivekananda College
Bioorganic and Medicinal Chemistry Letters | Year: 2016

Microwave assisted synthesis of spirooxindoles via tandem double condensation between isatins and 4-hydroxycoumarin under gold catalysis is reported. The reaction is practical to perform, since the products can be isolated by simple filtration without requiring tedious column chromatography. The scope of this chemistry is exemplified by preparing structurally diverse spirooxindoles (22 examples) in excellent yields. Antimicrobial evaluation of the synthesized compounds revealed that three compounds (3a, 3f and 3s) exhibited significant MIC values in comparison to the standard drugs. Molecular docking studies of these compounds with AmpC-β-lactamase receptor revealed that 3a exhibited minimum binding energy (−117.819 kcal/mol) indicating its strong affinity towards amino acid residues via strong hydrogen bond interaction. All compounds were also evaluated for their in vitro cytotoxicity against COLO320 cancer cells. Biological assay and molecular docking studies demonstrated that 3g is the most active compound in terms of its low IC50 value (50.0 μM) and least free energy of binding (−8.99 kcal/mol) towards CHK1 receptor, respectively. © 2016 Elsevier Ltd


Shree Devi M.S.,Siddha Central Research Institute | Kannan M.,Siddha Central Research Institute | Sathiya Rajeswaran P.,Siddha Central Research Institute | Natarajan S.,Siddha Central Research Institute | And 2 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Abraga Parpam (AP-S) is a herbo-mineral formulation which is prepared as per the Siddha classical text by the process of calcination. Apraga Bhasma (AP-A) is also available in the market. It has been decided to compare the standardization of the both the drugs available in the market. The present study focussed on standardization and quality control which are essential for the identification of drugs. So, that we can prevent adulteration and misidentification of herbo-mineral drugs. In this paper modern techniques such as SEM with EDAX were used to generate fingerprint for Abraga bhasma (AP-A). The SEM analysis showed the presence of nano and micro particles. Parallel standardization works are being carried out in AP-S. A comparative paper will be published in the near future.


Venkatasubbu G.D.,Anna University | Ramasamy S.,Anna University | Reddy G.P.,Siddha Central Research Institute | Kumar J.,Anna University
Biomedical Microdevices | Year: 2013

Targeted drug delivery using nanocrystalline materials delivers the drug at the deseased site. This increases the efficacy of the drug in killing the cancer cells. Surface modifications were done to target the drug to a particular receptor on the cell surface. This paper reports synthesis of hydroxyapatite and titanium dioxide nanoparticles and modification of their surface with polyethylene glycol (PEG) followed by folic acid (FA). Paclitaxel, an anticancer drug, is attached to functionalized hydroxyapatite and titanium dioxide nanoparticles. The pure and functionalised nanoparticles are characterised with XRD, TEM and UV spectroscopy. Anticancer analysis was carried out in DEN induced hepatocarcinoma animals. Biochemical, hematological and histopathological analysis show that the surface modified paclitaxel attached nanoparticles have an higher anticancer activity than the pure paclitaxel and surface modified nanoparticles without paclitaxel. This is due to the targeting of the drug to the folate receptor in the cancer cells. © 2013 Springer Science+Business Media New York.

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