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Guo Y.,University of Sichuan | Wei C.,University of Sichuan | Liu C.,University of Sichuan | Li D.,University of Sichuan | And 4 more authors.
Archives of Oral Biology | Year: 2015

Objective The pathogenesis of Candida-associated stomatitis involves the dysfunction of flora antagonistic to Candida. Oral Actinomyces species play an important role in regulating the oral microecological balance. The objective of this study was to investigate the antagonism of three oral Actinomyces against Candida albicans. Design Suspensions, culture supernatants and bacterial lysates of Actinomyces viscosus, Actinomyces naeslundii and Actinomyces odontolyticus were investigated for their actions upon C. albicans. In addition to a commercial strain, six clinical strains of C. albicans were also tested. The proliferation of C. albicans was assessed using a liquid co-cultivation assay. The adhesion, acid protease and extracellular phospholipase activity, hyphae growth, and biofilm formation of C. albicans were measured. Results The results showed that the suspensions, culture supernatants and cell lysates of 108 colony forming units/ml oral Actinomyces significantly inhibited the proliferation of C. albicans (all P < 0.001). The culture supernatants exhibited significant antagonistic interactions in terms of adhesion (A. viscosus P < 0.001, A. naeslundii P = 0.016 and A. odontolyticus P = 0.009), acid protease (A. viscosus P = 0.035, A. naeslundii P = 0.022, A. odontolyticus P < 0.001) and phospholipase activities (A. viscosus P = 0.011, A. naeslundii P = 0.042, A. odontolyticus P = 0.021) of Candida, as well as its hyphae growth (A. viscosus P = 0.002, A. naeslundii P = 0.008, A. odontolyticus P = 0.006). Inhibition of C. albicans biofilm formation was also observed. Conclusions This study provides preliminary evidence that oral Actinomyces have inhibitory effects on the proliferation, adhesion, metabolic enzyme activity, hyphae formation and biofilm development of C. albicans. © 2015 Elsevier Ltd. All rights reserved. Source

Lin X.-D.,University of Sichuan | Yang H.-W.,University of Sichuan | Ma S.,University of Sichuan | Li W.-W.,University of Sichuan | And 5 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

In this investigation, a series of 6-phenylimidazo[2,1-b]thiazole derivatives were synthesized. Structure-activity relationship (SAR) analysis of these compounds based on cellular assays led to the discovery of a number of compounds that showed potent activity against FLT3-dependent human acute myeloid leukemia (AML) cell line MV4-11, but very weak or no activity against FLT3-independent human cervical cancer cell line Hela. FLT3 kinase inhibition assays were then performed on the three most active compounds. Among these compounds, 6-(4-(3-(5-(tert-butyl)isoxazol- 3-yl)ureido)phenyl)-N-(3-(dimethylamino)propyl)imidazo[2,1-b]thiazole-3-carboxamide (19) exhibited the highest potency in both cellular (MV4-11, IC50: 0.002 μM) and enzymatic (FLT3, IC50: 0.022 μM) assays. Further in-depth in vitro anti-AML activity and mechanism of action studies were carried out on compound 19. © 2015 Elsevier Ltd. Source

Deng S.,University of Birmingham | Penchev P.,University of Birmingham | Liu J.,Sichuan UniversitySichuan | Wang Y.,University of Birmingham | And 6 more authors.
Nanoscale | Year: 2015

Laser directed patterning of carbon nanotubes-based buckypaper for producing a diffractive optical device is presented here. Using a laser ablation method the buckypaper was patterned into a binary Fresnel zone plate lens. Computational modelling was performed which revealed excellent focusing performance of the lens for both visible and THz radiations. SEM and Raman measurements of the lens were studied to analyse the laser-material interaction. The focusing properties of the lens were characterized and a good agreement with the simulations was achieved. Hence, we exploited a new way to fabricate thin flat lens. The one-step fabrication process is economical, convenient and has great potential for industrial scale up. This journal is © The Royal Society of Chemistry. Source

Chen J.,Sichuan Orthopedic HospitalSichuan | Chen J.,Sichuan UniversitySichuan | Xiao J.,Sichuan UniversitySichuan
International Journal of Clinical and Experimental Medicine | Year: 2015

The purpose of our study was to accurately visualize and measure the normal anatomy and size of the pterygoid canal with thin-section (0.5 mm), high-resolution computed tomography (HRCT) as well as multiplanar reconstruction (MPR) and curved planar reconstruction (CPR) technologies to obtain credible and comprehensive information for clinical management. Both axial HRCT and MPR images of the pterygopalatine fossa were obtained in 167 normal adult subjects, who exhibited variable positions of pterygoid canal relative to the sphenoid sinus floor and cavity. The morphology and size of the pterygoid canal was observed and measured, respectively. All pterygoid canals (100%, 334/334) were well delineated on HRCT images. Statistical analyses showed no significant difference between the mean length of the left (12.6 ± 2.3 mm) and right pterygoid canals (12.5 ± 2.9 mm) (P = 0.405). The mean diameter of anterior, median and posterior opening of the left and right pterygoid canals exhibited no significant differences (all P > 0.05); the bilateral median opening possessed the smallest diameter (P < 0.001). Submillimeter, thin-section HRCT scan and appropriate postprocessing reconstruction technologies could clearly visualize the morphologic features of the pterygoid canal and adjacent structures, which may be helpful for making diagnostic and therapeutic decisions. © 2015, E-Century Publishing Corporation. All rights reserved. Source

Jiang X.,Sichuan UniversitySichuan | Wang Q.,Sichuan UniversitySichuan | Huang R.,Sichuan UniversitySichuan
Clinical Nuclear Medicine | Year: 2015

Nasal iodine activity can be observed on 123Iodine (123I) or 131I wholebody scintigraphy (WBS) commonly as a normal variant caused by nasal or salivary secretion of the tracer. We encountered 2 patients whose increased accumulation of 131I activity was associated with underlying abnormalities. One patient had a nasal polyp, whereas the other had an abscess. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. Source

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