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Chang C.,Sichuan Province Hospital of CAPF | Gao B.,Peking University | Liu Z.,Sichuan Province Hospital of CAPF | Mao J.,Sichuan Province Hospital of CAPF | Jiang G.,Sichuan Province Hospital of CAPF
Clinical Biochemistry | Year: 2013

Objectives: Genetic polymorphism of human myeloperoxidase (MPO) -463G/A has been implicated to alter the risk of coronary artery disease (CAD), but the results are controversial. To improve the reliability of the conflicting results, we conducted a meta-analysis of studies relating the MPO -463G/A polymorphism with the risk of CAD. Design and methods: Two investigators independently searched the MEDLINE, EMBASE and Cochrane Library up to June, 2012. Summary odds ratios (OR) and 95% confidence interval (CI) for the MPO -463G/A polymorphism and CAD risk were calculated, and potential sources of heterogeneity and publication bias were explored. Statistical analysis was performed with the software program of Stata 9.0. Results: 5 case-control studies were finally identified for analyses, involving 1938 cases with CAD and 1990 controls. We found that the MPO -463G/A polymorphism has no significant association with overall CAD risk (G/G vs A/A: OR. = 0.595, 95%CI. = 0.298-1.188, P= 0.141; G/G vs G/A. +. A/A: OR. = 0.886, 95%CI. = 0.779-1.008, P= 0.066; G/G. +. G/A vs A/A: OR. = 0.611, 95%CI. = 0.334-1.119, P= 0.111; OR. = 0.886, 95%CI. = 0.779-1.008, P= 0.066; G vs A: OR. = 0.843, 95%CI. = 0.675-1.053, P= 0.133). The heterogeneity test showed that there were significant differences between individual studies in additive, recessive and allelic genetic models (P= 0.008, P= 0.021, P= 0.019, respectively); further analyses revealed that age and sex possibly account for the heterogeneity. Conclusions: Our meta-analysis demonstrated the evidence that there was no significant association between the MPO -463G/A polymorphism and the risk of CAD; larger and well-designed multicenter studies are needed to confirm our results. © 2013 The Canadian Society of Clinical Chemists. Source

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