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Laboratory, China

Shen Y.,University of Sichuan | Sun Y.,Sichuan Key Laboratory | Sang Z.,University of Sichuan | Sun C.,University of Sichuan | And 2 more authors.

A novel series of 3-(2-furyl)acrylate monosaccharide esters Ia-f and menthyloxycarbonyl monosaccharide esters IIa-f were designed and synthesized. The chemical structures of the target compounds were confirmed by IR, 1H- and 13C-NMR and ESI-MS, and the target compounds were investigated for their in vitro antibacterial and antifungal activities. The antibacterial screening results showed that the 3-(2-furyl)acrylate monosaccharide ester derivatives Ia-f were either inactive or only weakly active against the three Gram-positive bacterial strains tested, whereas the menthyloxycarbonyl monosaccharide ester derivatives IIa-f exhibited higher levels of activity, with compound IIe being especially potent. The results of the antifungal screening revealed that compounds Ib, Ie, IIb and IIc displayed potent in vitro activities, whereas If and IIf showed promising activities against all of the microorganisms tested, with If exhibiting levels of activity deserving of further investigation. © 2012 by the authors. Source

Yu H.,Sichuan University | Yu H.,Sichuan Key Laboratory | Ye J.,Sichuan University | Dai Y.,Sichuan Key Laboratory | And 2 more authors.
International Journal of Refractory Metals and Hard Materials

(Ti, W, Mo, V)(C, N) powders were synthesized by carbothermal reduction-nitridation in an open system. Effect of NH4HCO3 addition on the phase composition and microstructure of the synthesized powders were investigated using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results show that NH4HCO3 addition plays a facilitating role in preparation of high-purity (Ti, W, Mo, V)(C, N) powders. With the temperature increasing, the residual carbon content decreases in the products but the nitrogen content is more stable. It is found that the morphologies of the synthesized powders exhibit high-porosity structure when NH4HCO3 additive is added. © 2014 Elsevier Ltd. Source

Pu Q.,University of Sichuan | Huang Y.,University of Sichuan | Huang Y.,Sichuan Key Laboratory | Lu Y.,University of Sichuan | And 9 more authors.
Thoracic Cancer

In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking-related lung fibrosis. Herein, we determine whether tissue-specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non-small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue-specific and plasma miR-211-3p, miR-3679-3p, and miR-4787-5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR-3613-3p, miR-3675-3p, and miR-5571-5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue-specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC. © 2016 China Lung Oncology Group and John Wiley & Sons Australia, Ltd. Source

Yuchuan H.,University of Sichuan | Yuchuan H.,Sichuan Key Laboratory | Ya D.,Sichuan Key Laboratory | Jie Z.,University of Sichuan | And 9 more authors.
Toxicology and Industrial Health

Cigarette smoking is the major risk factor for smoking-related interstitial fibrosis (SRIF). Despite recent advances, the molecular mechanisms involved in the initiation and progression of this disease remain elusive. We found 6 months of chronic mainstream smoking exposure induced SRIF in C57 mice, which was associated with pronounced enhanced oxidative stress, bronchoalveolar inflammation and fibrosis but not apoptosis of alveolar septal cell. We used Affymetrix microRNA (miRNA) arrays to determine the temporal alteration in global gene expression of peripheral blood during the progression of diffuse pulmonary interstitial fibrosis in C57 mice. Microarray analysis revealed the upregulation of 3 miRNAs (miR-92b, miR-700 and miR-668) and the downregulation of 5 miRNAs (let-7e, miR-142-5p, miR-350, miR-19a and miR191*) in the peripheral blood of mice exposed to mainstream smoking for 1, 2, 3 and 6 months. We proposed that circulating miRNAs might be promising biomarkers to reflect the dynamic pathological changes of SRIF related interstitial fibrosis. © The Author(s) 2012. Source

Huang Y.,Key Laboratory of Transplant Engineering and Immunology | Huang Y.,Sichuan Key Laboratory | Dai Y.,Sichuan Key Laboratory | Zhang J.,Key Laboratory of Transplant Engineering and Immunology | And 8 more authors.

Numerous efforts have been made to indentify reliable and predictive biomarkers to detect the early signs of smoking-induced lung disease. Using 6-month cigarette smoking in mice, we have established smoking-related interstitial fibrosis (SRIF). Microarray analyses and cytokine/chemokine biomarker measurements were made to select circulating microRNAs (miRNAs) biomarkers. We have demonstrated that specific miRNAs species (miR-125b-5p, miR-128, miR-30e, and miR-20b) were significantly changed, both in the lung tissue and in plasma, and exhibited mainstream (MS) exposure duration-dependent pathological changes in the lung. These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease. © 2012 Informa UK, Ltd. Source

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