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Sichuan Gooddoctor Pharmaceutical GroupCo. Ltd. and Sichuan Gooddoctor; Pharmaceutical Co. | Date: 2009-02-17

Medicines for human purposes, namely, Antiallergic medicines, medicines for the treatment of gastrointestinal diseases, pharmaceutical preparations, namely, a blood clotting aid and delivery system for use in human and veterinary medicine, radioactive substances for use in nuclear medicine, preparations for the treatment of colds, analgesics; pharmaceutical preparations for the treatment of high blood pressure; vitamin tablets; pharmaceutical preparations for the treatment of alimentary canal diseases; pharmaceutical preparations for treating diabetes; medicines for the prevention of diarrhea; pharmaceutical preparations for the treatment of muscle rigidity and to promote blood circulation; Chinese medicinal preparations, namely, oral liquid used to remove toxic substances and dissipate heat in the body for use in the treatment of fevers, throat pain caused by heat toxicity in the body, influenza and upper respiratory tract infection under principles of Chinese medicine; Chinese medicinal preparations, namely, oral liquid used to remove toxic substances and dissipate heat in the body during the summer, for use in the treatment of colds caused by summer heat, headaches, feelings of body heaviness and constriction of the chest, abdominal distention and pain, vomiting and diarrhea under principles of Chinese medicine; pharmaceutical preparations used to stimulate the heart and invigorate the brain, namely, medicine comprised of red sage root, root of pseudo-ginseng and borneol, for the purpose of stimulating blood circulation, dissipating blood stasis, regulating qi, alleviating pain, and for the treatment of such illnesses as coronary heart disease and angina pectoris; Edible plant fibers, namely, plant extracts for medical, veterinary and pharmaceutical purposes; Medicinal tea, namely, herbal teas for medicinal purposes; Lotions for pharmaceutical purposes, namely, antibacterial hand lotions, athletes foot lotions, barrier lotion for protection from toxic oils of poisonous plants, calamine lotion, medicated diaper rash ointments and lotions, medicated lotions for skin, hair, sunburn, face, and body, medicated skin care preparations, namely, creams, lotions, gels, toners, cleaners and peels, medicated sunburn lotions, nutritional supplements in lotion form sold as a component of nutritional skin care products, pharmaceutical skin lotions; Biological preparations for medical purposes, Dietetic substances adapted for medical use, namely, dietary food supplements, dietary fiber as an additive for food products; dietetic foods adapted for medical purposes, nutritional additives for medical purposes for use in foods and dietary supplements for human consumption.


Yang T.,University of Sichuan | Chen J.-X.,University of Sichuan | Fu Y.,University of Sichuan | Chen K.,Sichuan Gooddoctor Pharmaceutical Co. | And 4 more authors.
Organic Process Research and Development | Year: 2014

A concise, environmentally benign, and cost-effective route was developed for the large-scale preparation of 1, a novel oxazolidinone antibacterial candidate. The key intermediate 2-(1-(2-fluoro-4-nitrophenyl)-1H-pyrazol-4-yl) pyridine 7 was prepared with high purity by mild deamination of the regioisomeric mixture 21. The mixture was prepared from a nucleophilic SNAr reaction by selective C-N coupling of the secondary amine functionality of 4-(pyridin-2-yl)-1H-pyrazol-3-amine 14 with 1,2-difluoro-4-nitrobenzene 10 in optimized conditions with the primary amine group remaining intact. The gaseous nitrogen release rate and reaction mixture temperature of the deamination step can be well controlled by altering the feeding manner, thereby providing safety guarantees. The optimized synthetic strategy of 1 with an overall yield of 27.6%, including seven sequential transformations by only five solid-liquid isolations, significantly improved the product separation workup. The strategy bypassed time-consuming and laborious procedures for any intermediate involved as well as for the final API. This study presents a process enabling the rapid delivery of a multikilogram quantity of API with high purity. © 2014 American Chemical Society. Source

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