Sichuan Cancer Hospital and Cancer Institute

Chengdu, China

Sichuan Cancer Hospital and Cancer Institute

Chengdu, China

Time filter

Source Type

Liu H.,Guangxi Medical University | Li C.,Sichuan Cancer Hospital and Cancer Institute | Wang S.,Sichuan Cancer Hospital and Cancer Institute | Wang W.,Sichuan Cancer Hospital and Cancer Institute | Fan J.,Sichuan Cancer Hospital and Cancer Institute
Chinese Journal of Clinical Oncology | Year: 2014

Pleomorphic adenoma ranks first among parotid gland tumors. Surgical procedure, which includes enucleation, extra-capsular resection, partial superficial parotidectomy (PSP), superficial parotidectomy (SP), and total parotidectomy (TP), remains to be the treatment of choice for pleomorphic adenoma. In the last century, physicians lacked understanding on the pathological characteristics of pleomorphic adenoma and facial neurotomia. Thus, simple enucleation of tumors has always been the major therapy for patients to reduce the rate of facial nerve injury. However, postoperative recurrence was frequently observed in patients that have undergone simple enucleation. In this study, the surgeons attempted to control the relapse rate by enlarging the scope of excision when removing a pleomorphic adenoma, and by performing an extra-capsular resection procedure that was developed in the clinic. Although the tumor peplos was excised, the surgeons failed to control the relapse rate. SP and TP apparently decreased the relapse rate of the pleomorphic adenomas. However, these therapies seem to be overcorrected by the aggravation of facial nerve injuries. PSP is a relatively advanced technique that is currently used in parotid surgery. PSP reduces the rate of relapse and facial nerve injury, as verified by basic pathology research. Nevertheless, the controversy between advanced PSP and classic SP still exists. Plastic surgery, pathology research, and gene testing were used to evaluate the advantages of advanced PSP and classic SP. However, the research failed to derive a confirmed result that can determine which treatment method is fit and unfit to treat pleomorphic adenoma. Our study reviews the trend of parotid surgery from a historic point of view.


Li C.,Sichuan Cancer Hospital and Cancer Institute
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2011

To explore the curative effects on surgical methods for the prevention of Frey syndrome and a concave facial deformity after parotidectomy. A literature search was performed using the Wianfang Database, Chinese Biomedical Literature Disk Database, Chinese Digital Hospital Library and Chinese Scientific Journals Database of VIP from January 1989 to December 2008. Twenty-six Chinese language controlled studies involving surgical techniques for prevention of Frey syndrome and the concave facial deformity after parotidectomy were identified. Review manager 4.2 software was applied for Meta analysis. Meta-analysis for surgical techniques to prevent symptomatic Frey syndrome, a positive starch-iodine test, and contour deformity, favored intervention with a cumulative odds ratio (OR) of 0.14 [95% confidence interval (CI), 0.07-0.25]; OR, 0.21 (95% CI, 0.17-0.26); and OR, 0.09 (95% CI, 0.04-0.19), respectively. There was a significant difference in the incidence of these complications between surgical treatment groups and control groups (Z = 6.42, Z = 13.70, Z = 6.43, all P < 0.05). The application of a sternocleidomastoid muscle flap decreased the incidence of symptomatic Frey syndrome (Z = 2.33, P < 0.05), positive starch-iodine test (Z = 7.48, P < 0.05) and contour deformity (Z = 7.78, P < 0.05). The application of acellular dermal matrix decreased the incidence of symptomatic Frey syndrome (Z = 6.02, P < 0.05) and positive starch-iodine test (Z = 5.72, P < 0.05) but did not decrease the incidence of contour deformity (Z = 1.27, P > 0.05). Meta-analysis of operative techniques to prevent symptomatic Frey syndrome, a positive starch-iodine test, and facial asymmetry suggests that such methods are likely to reduce the incidence of these complications and improve the quality of life after parotidectomy.


Li C.H.,Sichuan Cancer Hospital and Cancer Institute
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2012

To investigate the treatment outcomes of modified sternocleidomastoid myocutaneous flap with a pedicle containing superior thyroid artery in repairing postoperative hypopharyngeal defect. From Dec. 2003 to Sep. 2010, the modified sternocleidomastoid myocutaneous flap was used to restore defect postoperation of hypopharynx defect for twelve patients with pyriform sinus carcinoma, age range from 47 to 72 years old. No patients had treated by radiotherapy before operation. Of 12 patients, 5 cases in T2N0M0, 5 cases in T3N1M0 and 2 cases in T4N1M0. Two cases in T4 with thyroid invasion and 2 cases in T3 with vocal cord fixation had total laryngectomy, and the other 8 cases were non reserved with laryngeal functions. To shape flap with middle and lower segment of sternocleidomastoid muscle and with superior artery as pedicle. All flaps survived after operation. The following-up time was 7-88 months (median 30 months). Four patients died of recurrence or metastasis of tumor during following-up. Modified sternocleidomastoid myocutaneous flap with pedicle is easy to harvest, with smaller damage and a higher survival rate, which is a good flap for the repair of the hypopharyngeal defect after resecting tumour.


PubMed | Sichuan Cancer Hospital and Cancer Institute
Type: Evaluation Studies | Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2012

To investigate the treatment outcomes of modified sternocleidomastoid myocutaneous flap with a pedicle containing superior thyroid artery in repairing postoperative hypopharyngeal defect.From Dec. 2003 to Sep. 2010, the modified sternocleidomastoid myocutaneous flap was used to restore defect postoperation of hypopharynx defect for twelve patients with pyriform sinus carcinoma, age range from 47 to 72 years old. No patients had treated by radiotherapy before operation. Of 12 patients, 5 cases in T2N0M0, 5 cases in T3N1M0 and 2 cases in T4N1M0.Two cases in T4 with thyroid invasion and 2 cases in T3 with vocal cord fixation had total laryngectomy, and the other 8 cases were non reserved with laryngeal functions. To shape flap with middle and lower segment of sternocleidomastoid muscle and with superior artery as pedicle. All flaps survived after operation. The following-up time was 7-88 months (median 30 months). Four patients died of recurrence or metastasis of tumor during following-up.Modified sternocleidomastoid myocutaneous flap with pedicle is easy to harvest, with smaller damage and a higher survival rate, which is a good flap for the repair of the hypopharyngeal defect after resecting tumour.


PubMed | Sichuan Cancer Hospital and Cancer Institute
Type: Journal Article | Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2011

To explore the curative effects on surgical methods for the prevention of Frey syndrome and a concave facial deformity after parotidectomy.A literature search was performed using the Wianfang Database, Chinese Biomedical Literature Disk Database, Chinese Digital Hospital Library and Chinese Scientific Journals Database of VIP from January 1989 to December 2008. Twenty-six Chinese language controlled studies involving surgical techniques for prevention of Frey syndrome and the concave facial deformity after parotidectomy were identified. Review manager 4.2 software was applied for Meta analysis.Meta-analysis for surgical techniques to prevent symptomatic Frey syndrome, a positive starch-iodine test, and contour deformity, favored intervention with a cumulative odds ratio (OR) of 0.14 [95% confidence interval (CI), 0.07-0.25]; OR, 0.21 (95% CI, 0.17-0.26); and OR, 0.09 (95% CI, 0.04-0.19), respectively. There was a significant difference in the incidence of these complications between surgical treatment groups and control groups (Z = 6.42, Z = 13.70, Z = 6.43, all P < 0.05). The application of a sternocleidomastoid muscle flap decreased the incidence of symptomatic Frey syndrome (Z = 2.33, P < 0.05), positive starch-iodine test (Z = 7.48, P < 0.05) and contour deformity (Z = 7.78, P < 0.05). The application of acellular dermal matrix decreased the incidence of symptomatic Frey syndrome (Z = 6.02, P < 0.05) and positive starch-iodine test (Z = 5.72, P < 0.05) but did not decrease the incidence of contour deformity (Z = 1.27, P > 0.05).Meta-analysis of operative techniques to prevent symptomatic Frey syndrome, a positive starch-iodine test, and facial asymmetry suggests that such methods are likely to reduce the incidence of these complications and improve the quality of life after parotidectomy.

Loading Sichuan Cancer Hospital and Cancer Institute collaborators
Loading Sichuan Cancer Hospital and Cancer Institute collaborators