Sichuan Cancer Hospital & Sichuan Cancer Center

Chengdu, China

Sichuan Cancer Hospital & Sichuan Cancer Center

Chengdu, China
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Wang X.,Sichuan Cancer Hospital & Sichuan Cancer Center | Li B.,Sichuan Cancer Hospital & Sichuan Cancer Center | Bao Y.,Sichuan Cancer Hospital & Sichuan Cancer Ccenter | Wang Y.,Sichuan Cancer Hospita & Sichuan Cancer Center | And 2 more authors.
Zhonghua zhong liu za zhi [Chinese journal of oncology] | Year: 2017

目的: 分析食管癌高发区高危人群的内镜筛查结果,以期为食管癌早诊早治效果评价提供科学依据。 方法: 选择四川省10个食管癌高发市县,以40~69岁界定为高危人群,对其进行上消化道内镜检查,并行组织病理学诊断确诊。 结果: 2006—2014年四川省10个市县共完成105 561人筛查,癌前病变检出率为5.53%(5 841/105 561),阳性病例检出率1.13%(1 193/105 561),其中轻、中度异型增生检出率分别为3.87%(4 089/105 561)和1.66%(1 752/105 561),重度异型增生及原位癌、早期癌和浸润性癌的检出率分别为0.77%(816/105 561)、0.08%(84/105 561)和0.28%(293/105 561)。男性食管各级病变检出率均明显高于女性(P<0.05),食管各级病变检出率随着年龄增长而增加(P<0.05)。 结论: 四川省农村食管癌高发区食管癌内镜筛查及早诊早治工作的效果明显,食管癌高发区40~69岁农村居民存在相当数量的癌前病变患者,重视癌前病变人群的随访工作可提高早诊早治效果。.Objective: To analyze the efficacy of endoscopic screening for esophageal cancer in high risk population from high risk areas in order to provide scientific basis for evaluation of the results of early diagnosis and treatment of esophageal cancer. Methods: Ten high incidence cities and counties of esophageal cancer in Sichuan province were included in this study. Subjects aged 40-69 years were selected to participate in the endoscopic screening based on the cluster sampling, and the screening-positive subjects were further confirmed by pathological examination. Results: A total of 105 561 subjects were screened during 2006-2014 in 10 cities and counties in Sichuan Province. The detection rate of precancerous lesions was 5.53% (5 841/105 561), and the positive detection rate was 1.13% (1 193/105 561). The overall detection rates of low-grade hyperplasia, moderate hyperplasia, high-grade hyperplasia/carcinoma in situ, early esophageal cancer and invasive carcinoma were 3.87% (4 089/105 561), 1.66% (1 752/105 561), 0.77% (816/105 561), 0.08% (84/105 561) and 0.28% (293/105 561), respectively. The detection rates of all lesions in males were significantly higher than those in females (P<0.05), and were gradually increased with age (P<0.05). Conclusions: At these ten cities and counties in Sichuan Province with high incidence of esophageal cancer, the endoscopic screening has good effect. There are considerable numbers of patients aged 40-69 with precancerous lesions from the high risk areas. Improving the follow-up work of the population with precancerous lesions will achieve better results of early diagnosis and early treatment.

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