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Zhao J.,Sichuan Academy of Medical science and Sichuan Provincial | Li J.,Sichuan Academy of Medical science and Sichuan Provincial
Journal of Sichuan University (Medical Science Edition) | Year: 2013

Objective To analysis the clinical characteristics of children with cough variation asthma (CVA) who received treatments with Carboxymethl starch sodium solution and inhaled Glucocorticoid budesonide. Methods A total of 96 children with CVA were divided into two group randomly. The control group (n = 49) received inhaled budesonide treatment (500 μg/times in 1-5 years old children, 1 mg/times and 2 times/day in 6-14 years old children over a 12 week period). The children in treatment group (n = 47) were given carboxymethl starch sodium solution (3 mL/times in 1-3 years old children, 5 mL/times in 4-7 years old children, 7 mL/times in 8-14 years old children, 3 times/day) in addition to the inhaled budesonide treatment. Observations were made on clinical therapeutic effects, cough score and the level of IgE 4 weeks, 8 weeks and 12 weeks after the treatments, respectively. Recurrence rate and adverse reactions were investigated. Results Compared with the control group, the treatment group had significantly improved clinical characteristics after 8 weeks and 12 weeks of treatments P< 0.05), and reduced cough scores after 4 weeks, 8 weeks and 12 weeks of treatments P<0.05). The IgE level of the children in the treatment group was significantly lower than the controls after 12 weeks of treatments (P<0.05). The treatment group also had significantly lower recurrence rate and adverse reactions than the controls P<0.05). Conclusion Carboxymethl starch sodium solution can boost the clinical efficiency of inhaled budesonide in the treatment of children with cough variant asthma. It is safe and effectual. Source


Li L.,Xihua University | Tong R.-S.,Sichuan Academy of Medical science and Sichuan Provincial | Li J.-Q.,Sichuan Academy of Medical science and Sichuan Provincial | Shi J.-Y.,Sichuan Academy of Medical science and Sichuan Provincial
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title compound, C16H11N3O, the dihedral angles between the 3-cyanobenzene and benzene planes and the 1H-pyrazol-5(4H)-one plane are 4.97 (9) and 9.91 (9)°, respectively. © 2012 International Union of Crystallography. Source


Shi J.-Y.,Sichuan Academy of Medical science and Sichuan Provincial | Li J.-Q.,Sichuan Academy of Medical science and Sichuan Provincial | Tong R.-S.,Sichuan Academy of Medical science and Sichuan Provincial | Lin H.,Sichuan Academy of Medical science and Sichuan Provincial | Lu C.,Sichuan Academy of Medical science and Sichuan Provincial
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

In the title compound, C12H12N2O 4, the dihedral angle between the pyridine and enamine planes is 3.5 (3)°, while the angle between the dioxanedione (seven atoms) and enamine planes is 4.6 (3)°. The dioxane ring approximates an envelope conformation. Source

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