Siberian State Medical University
Tomsk, Russia

The Siberian State Medical University is a medical school in Tomsk, Russia. Previously, it was called the Tomsk Medical Institute. Founded in 1878 as the Faculty of Medicine of the Imperial Tomsk University, opened in 1888, this is one of Russia's oldest medical schools. The school is also the oldest medical school east of the Urals. The current Acting Rector is Olga Kobyakova. In a 2003 rating of the 100 best Russian universities by the magazine "Career Formula", the school was rated third out of all medical schools in Russia. A rating of universities by the Russian Ministry of Higher Education rated the school second among all Russian medical schools. Wikipedia.

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News Article | November 22, 2016

The international conference "Social Sciences & Health Innovations: Making Health Public" is the third event organized as a collaborative endeavor between Maastricht University, the Netherlands, and Tomsk State University, the Russian Federation, with participation from Siberian State Medical University (the Russian Federation). The previous conference in the series took place in 2015 and was titled Social Sciences and Medical Innovations: Doing things together. The goals of preventing disease, prolonging life, and promoting health have long been the locus of efforts by states, cities and other actors in the public health field. Over the past decades public health has built a sophisticated disease surveillance apparatus to identify and track population health issues, and has worked to generate knowledge on the (social) causes of poor health. Public health has brought to life policies and large scale programmes to monitor and prevent infectious diseases, to stimulate healthy eating and living, and to build healthy environments and infrastructures. Currently, the links between global ecological problems (air, water, climate) and public health are increasingly recognized. At the same time classic divides between clinical medicine and public health are vanishing, with new genetic technologies being used to detect risk groups and many clinical specialists recognizing the value of healthy environments and life styles. Against this background, this conference aims to explore how health is, and can be, made public. What exactly does the 'public' stand for in public health? Public refers to collectives and solidarities on a local, national and global scale; but how are they made, maintained and legitimized amidst diversity of the globalizing world? Public, also refers to the responsibilities of public institutions for health, and engagement of these institutions with people's concerns. However, during the last decades it has become clear that there are often big gaps between institutional perspectives and the perspectives of communities and citizens on health and ways to improve it. International debates about HIV prevention have been an eye-opener in this respect. Many public health bodies tend to work in a top down manner and do not attune well to local practices, needs and perspectives. One often wonders, where the publics of public health are. Does the development of evidence-based public policies improve the quality of public health programs, or does it increase the gap with everyday practices? What counts as relevant evidence? Which kinds of knowledge shape public health programmes and how is this knowledge developed? The rise of big data poses the question of how to relate statistical risk technologies to narratives and everyday life notions of risk, illness, responsibility, and a good life. Is it necessary to make public health more participatory and more 'public' to make it more effective, and if so, how to do that? Which roles do innovations, whether, conceptual, technical or social, play in this regard and how can they contribute into 'making health public'? How do media construct health as a public issue, and how can media - through encouraging literacy, storytelling, and entertainment - contribute to empowering publics? Social sciences play a central role in analysing public health innovations' dynamics and for understanding the corresponding challenges. This conference examines the complexities of making health public by engaging the perspectives of the social sciences, including science and technology studies (STS), medical anthropology, sociology and history. Furthermore, it is meant to serve as a platform to facilitate dialogue between social and biomedical scientists, public health professionals and policy makers, and for engagement between scholars and practitioners working in the field of health innovations in the post-Soviet region and globally. The conference considers public health-related innovations on different levels (from the community level to national programmes and global efforts) and of different kinds (conceptual, organisational, political). Such innovations can include, but are not limited to, new tools for diagnosing antibiotic resistance in remote areas, food fortification programmes to address nutrient deficiencies, the use of mobile devices to encourage healthier living, the construction of new urban infrastructures to deal with traffic and garbage, and the use of media to improve mental health after traumatic events. We welcome both individual paper proposals and proposals for closed thematic panels. Please submit your applications via the electronic form by 15 January 2017. If you have any questions contact the conference organizers: Individual paper submissions should be limited to 600 words (including a short CV up to 100 words). The title of the paper should be limited to 10 words. To assist the program chairs in grouping the papers into sessions, please add three keywords. Panel proposals should include a title, panel description (up to 300 words), and a list of panel speakers (not more than 6 panelists) with their affiliations and titles of the conference presentations.

Yusubov M.S.,Siberian State Medical University | Nemykin V.N.,University of Minnesota | Zhdankin V.V.,University of Minnesota
Tetrahedron | Year: 2010

Several transition metal-mediated oxidations using hypervalent iodine species are reported. A convenient procedure for preparation of iodylarenes via RuCl3-catalyzed oxidation of iodoarenes has been developed. This procedure allows the generation of highly reactive monomeric iodine(V) species, which are excellent oxidants toward alcohols and hydrocarbons in situ. A broad range of substrates can be oxidized to carbonyl compounds by a tandem catalytic system based on the Ru(III)-catalyzed reoxidation of ArIO to ArIO2 using Oxone® as oxidant. It was shown that electrophilic iodine(III) species, originating from oligomeric iodosylbenzene sulfate (PhIO)3SO3, are efficient oxygenating agents in catalytic oxidation of aromatic hydrocarbons in the presence of metalloporphyrin complexes. © 2010 Elsevier Ltd.

Yusubov M.S.,Siberian State Medical University | Zhdankin V.V.,University of Minnesota
Mendeleev Communications | Year: 2010

Recent advances in the development of polymer-supported iodine(V) oxidants, recyclable monomeric hypervalent iodine(III) reagents and catalytic systems based on hypervalent iodine compounds are discussed. These efficient and environmentally friendly reagents and catalysts are particularly useful for oxidative transformations of alcohols to carbonyl compounds and for oxidations at the benzylic position. © 2010 Mendeleev Communications. All rights reserved.

Zagulyaeva A.A.,University of Minnesota | Yusubov M.S.,Siberian State Medical University | Zhdankin V.V.,University of Minnesota
Journal of Organic Chemistry | Year: 2010

"Chemical Equation Presented" [Bis(trifiuoroacetoxy)iodo] perfiuoroalkanes CnF2n+1I(OC-OCF3)2 (n = 4, 6, 8, 10, 12) can be conveniently prepared by the oxidation of the corresponding perfluoroalkyl iodides with Oxone in trifluoroacetic acid at room temperature and subsequently converted to the stable [hydroxy(tosyloxy)-iodo] perfluoroalkanes, CnF2n+1I(OH)OTs, by treatment with p-toluenesulfonic acid. This general and convenient procedure has been further extended to the synthesis of various [bis(trifluoroacetoxy)iodo]arenes, ArI(OCOCF3)2. © 2010 American Chemical Society.

Yusubov M.S.,Siberian State Medical University | Zhdankin V.V.,University of Minnesota
Current Organic Synthesis | Year: 2012

Recent advances in the development of environmentally friendly recyclable reagents and catalytic systems based on hypervalent iodine are discussed. The review covers the following topics of active current research: polymer-supported iodine(III) and iodine(V) oxidants, recyclable monomeric hypervalent iodine(III) reagents, reactions of hypervalent iodine in solid state, application of water or recyclable organic solvents in these reactions, and catalytic systems based on hypervalent iodine compounds. These efficient and ecofriendly reagents and catalytic systems are now widely used in organic synthesis for various oxidative transformations of organic substrates. © 2012 Bentham Science Publishers.

Zagulyaeva A.A.,University of Minnesota | Banek C.T.,University of Minnesota | Yusubov M.S.,Siberian State Medical University | Zhdankin V.V.,University of Minnesota
Organic Letters | Year: 2010

Alkylcarboxamides can be converted to the respective amines by Hofmann rearrangement using hypervalent iodine species generated in situ from PhI and Oxone in aqueous acetonitrile. On the basis of this reaction, a convenient experimental procedure for the preparation of alkylcarbamates using Oxone as the oxidant in the presence of iodobenzene in methanol has been developed. An efficient method for direct conversion of substituted benzamides to the respective quinone derivatives by treatment with Oxone and iodobenzene in aqueous acetonitrile has also been found. © 2010 American Chemical Society.

Kolosova N.G.,RAS Institute of Cytology and Genetics | Muraleva N.A.,RAS Institute of Cytology and Genetics | Zhdankina A.A.,Siberian State Medical University | Stefanova N.A.,RAS Institute of Cytology and Genetics | And 2 more authors.
American Journal of Pathology | Year: 2012

Age-related macular degeneration, a neurodegenerative and vascular retinal disease, is the most common cause of blindness in the Western countries. Evidence accumulates that target of rapamycin is involved in aging and age-related diseases, including neurodegeneration. The target of rapamycin inhibitor, rapamycin, suppresses the senescent cell phenotype and extends life span in diverse species, including mice. Rapamycin decreases senescence-associated phenotypes in retinal pigment epithelial cells in culture. Herein, we investigated the effect of rapamycin on spontaneous retinopathy in senescence-accelerated OXYS rats, an animal model of age-related macular degeneration. Rats were treated with either 0.1 or 0.5 mg/kg rapamycin, which was given orally as a food mixture. In a dose-dependent manner, rapamycin decreased the incidence and severity of retinopathy. Rapamycin improved some (but not all) histological abnormalities associated with retinopathy. Thus, in retinal pigment epithelial cell layers, rapamycin decreased nuclei heterogeneity and normalized intervals between nuclei. In photoreceptor cells, associated neurons, and radial glial cells, rapamycin prevented nuclear and cellular pyknosis. More important, rapamycin prevented destruction of ganglionar neurons in the retina. Rapamycin did not exert any adverse effects on the retina in control disease-free Wistar rats. Taken together, our data suggest the therapeutic potential of rapamycin for treatment and prevention of retinopathy. © 2012 American Society for Investigative Pathology.

Mordvinov V.A.,RAS Institute of Cytology and Genetics | Yurlova N.I.,Russian Academy of Sciences | Ogorodova L.M.,Siberian State Medical University | Katokhin A.V.,RAS Institute of Cytology and Genetics
Parasitology International | Year: 2012

Liver fluke infections are gradually transforming from a local problem of individual geographic regions to a widespread problem. The observed expansion is likely to be connected with the ever-increasing intensity of traffic flow and migration of the infected carriers between cities, regions, and countries. Opisthorchis felineus, the trematode belonging to the family Opisthorchiidae, is a well known causative agent of the infection called opisthorchiasis. Metorchis bilis, also a member of the family Opisthorchiidae, causes metorchiasis, a disease very close to opisthorchiasis in symptomatology. Genetic markers can be used to develop methods for differential diagnostics of these diseases. However, the questions connected with epidemiology of these trematode infections, their clinical characteristics, prognosis and therapy remain open. This review briefs the general biological characteristics of O. felineus and M. bilis persisting in various countries of Eurasia, their geographical range, epidemiology and molecular diagnostics of these liver flukes. © 2011 Elsevier Ireland Ltd.

Stefanova N.A.,RAS Institute of Cytology and Genetics | Muraleva N.A.,RAS Institute of Cytology and Genetics | Korbolina E.E.,RAS Institute of Cytology and Genetics | Kiseleva E.,RAS Institute of Cytology and Genetics | And 2 more authors.
Oncotarget | Year: 2015

The amyloid cascade hypothesis posits that deposition of the amyloid β (Aβ) peptide in the brain is a key event in the initiation of Alzheimer's disease (AD). Nonetheless, it now seems increasingly unlikely that amyloid toxicity is the cause of sporadic AD, which leads to cognitive decline. Here, using accelerated-senescence nontransgenic OXYS rats, we confirmed that aggregation of Aβ is a later event in AD- like pathology. We showed that an age-dependent increase in the levels of Aβ1-42 and extracellular Aβ deposits in the brain of OXYS rats occur later than do synaptic losses, neuronal cell death, mitochondrial structural abnormalities, and hyperphosphorylation of the tau protein. We identified the variants of the genes that are strongly associated with the risk of either late-onset or early-onset AD, including App, Apoe4, Bace1, Psen1, Psen2, and Picalm. We found that in OXYS rats nonsynonymous SNPs were located only in the genes Casp3 and Sorl1. Thus, we present proof that OXYS rats may be a model of sporadic AD. It is possible that multiple age-associated pathological processes may precede the toxic amyloid accumulation, which in turn triggers the final stage of the sporadic form of AD and becomes a hallmark event of the disease.

Potekaev A.I.,Tomsk State University | Kulagina V.V.,Siberian State Medical University
Russian Physics Journal | Year: 2012

The conditions of formation of low-stability condensed state systems, their behavior and structure are investigated. The objects under study are alloys and compounds undergoing structural-phase transitions of the second type or close to it. The low-stability (pre-transitional) state is treated here as the state of a system near its structural-phase transformations, in which its structure and properties exhibit anomalies. An attempt is made to interpret the system from the physical standpoint relying on a new insight into its state, in which the traditionally accepted phase-transition point is represented by a range of values of the parameter controlling the transition. The material state within this range of values is structurally weakly stable in terms of slight variations in the controlling parameter. It is shown that the thermodynamics of structural-phase transformations of the material in this transient state is significantly affected by the interaction of structure defects. © 2011 Springer Science+Business Media, Inc.

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