Shriram Institute for Industrial Research

Delhi, India

Shriram Institute for Industrial Research

Delhi, India
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Sen I.,Shriram Institute for Industrial Research | Shandil A.,Shriram Institute for Industrial Research | Shrivastava V.S.,Neno chemistry Research Laboratory
Der Pharmacia Lettre | Year: 2011

A simple and reliable Gas chromatography-Mass spectrometer method was developed for the determination of Benzyl alcohol in injectable suspension. Methanol was used for extraction solvent and co-extractive was removed by filtrated through anhydrous sodium sulfate. The method was validated by determining parameters such as, specificity, linearity, limit of detection, limit of quantitation, precision, recovery and robustness. The method was found to be specific against matrix interferences. Linearity was evaluated over the concentration ranges of 0.1 μg/ml to 10 μg/ml and correlation coefficient was more than 0.999. Both the inter day and intra day precision of the system and method were determined. Recovery data obtained by fortifying three matrices at 0.5 μg/g, 1.0 μg/g and 2.0 μg/g with ranged between 98 to 105 % and the relative standard deviation (RSD) was obtained below 5%. Limit of detection and quantitation of Benzyl alcohol were 0.05 and 0.1 μg/g.


Singh A.K.,Shriram Institute for Industrial Research | Mehra D.S.,Shriram Institute for Industrial Research | Niyogi U.K.,Shriram Institute for Industrial Research | Sabharwal S.,Bhabha Atomic Research Center | Khandal R.K.,Shriram Institute for Industrial Research
Journal of Polymer Materials | Year: 2011

Pressure-sensitive adhesives (PSAs) present an interesting class of products that offer great potential to produce a novel generation of self-adhesives with excellent properties. The term pressure sensitive describes adhesives that are aggressively and permanently tacky in the dry form at room temperature and firmly adhere to a variety of dissimilar surfaces upon mere contact of finger or hand pressure. In this paper various classes and medical applications of e-beam cured polyurethane pressure sensitive adhesives, their cure characteristics and requirements have been reviewed and presented. The paper also reviews the evolution of biomedical adhesives, their merits and demerits and finally gap areas, challenges and opportunities in this area. © MD Publications Pvt. Ltd.


Karunanithi D.,National Institute of Technology Tiruchirappalli | Karunanithi D.,Shriram Institute for Industrial Research | Radhakrishna A.,Shriram Institute for Industrial Research | Sivaraman K.P.,Shriram Institute for Industrial Research | Biju V.M.N.,National Institute of Technology Tiruchirappalli
Journal of Food Science and Technology | Year: 2014

A rapid, reliable and sensitive LC-MS/MS method for the determination of melatonin in milk was developed and validated. Sample was extracted with dichloromethane and cleaned by passing through Chem Elut solid phase extraction cartridge. The solvent was evaporated to dryness, reconstituted with methanol and analysed by LC-MS/MS on Agilent zorbax Eclipse XDB C-18 rapid resolution analytical column. The analytical procedure was found to be accurate, precise and linear. The method accuracy was 92.2 % (range 90.06-94.58) and the mean precision was 1.55 % and the calibration was linear for 1 to 150 pg mL -1 (R2∈>∈0.99), the lowest limit of quantification (LLOQ) was 1 pg mL-1. 7-D Melatonin (7-DM) was used as an internal standard. This method was proved to be a promising method for the determination of melatonin for market milk and human milk samples. © 2013 Association of Food Scientists & Technologists (India).


Pramanik N.K.,Shriram Institute for Industrial Research | Haldar R.S.,Shriram Institute for Industrial Research | Niyogi U.K.,Shriram Institute for Industrial Research | Alam M.S.,Jamia Hamdard University
Defence Science Journal | Year: 2014

When Nylon 66 was irradiated by an optimum dose of e-beam in presence of polyurethane as impact modifier in combination with triallyl isocyanurate as cross-linker, a superior performance was observed for the irradiated nylon 66. Significant improvement of properties, such as hardness, tensile strength, flexural modulus and impact strength was obtained on radiation processing of nylon 66 by e-beam. More interestingly, percent water absorption of such irradiated nylon 66 was reduced substantially. Improvement of mechanical properties and reduction of water absorption of irradiated nylon 66 were due to the cross-linking of the polymer system. Increase of cross-linking with dose of e-beam was verified by the increased gel content at higher doses. Irradiated nylon 66 showed better dimensional stability than those achieved with pristine nylon 66. The increase in dimensional stability may be attributed to reduction in crystallinity with increasing dose of e-beam as revealed by DSC studies. © 2014, DESIDOC.


Chattopadhyay S.K.,Shriram Institute for Industrial Research | Khandal R.K.,Shriram Institute for Industrial Research | Uppaluri R.,Indian Institute of Technology Guwahati | Ghoshal A.K.,Indian Institute of Technology Guwahati
Journal of Applied Polymer Science | Year: 2011

Short bamboo fiber reinforced polypropylene composites were prepared by incorporation of various loadings of chemically modified bamboo fibers. Maleic anhydride grafted polypropylene (MA-g-PP) was used as compatibilizer to improve fiber-matrix adhesion. The effects of bamboo fiber loading and modification of the resin on the physical, mechanical, thermal, and morphological properties of the bamboo reinforced modified PP composites were studied. Scanning electron microscopy studies of the composites were carried out on the interface and fractured surfaces. Thermogravimetric analysis and IR spectroscopy were also carried out. At 50% volume fraction of the extracted bamboo fiber in the composites, considerable increase in mechanical properties like impact, flexural, tensile, and thermal behavior like heat deflection temperature were observed. © 2010 Wiley Periodicals, Inc.


Chattopadhyay S.K.,Shriram Institute for Industrial Research | Singh S.,Shriram Institute for Industrial Research | Pramanik N.,Shriram Institute for Industrial Research | Niyogi U.K.,Shriram Institute for Industrial Research | And 3 more authors.
Journal of Applied Polymer Science | Year: 2011

Various composites of polypropylene (PP) produced using natural fibers such as pineapple leaf fiber, banana fiber, and bamboo fiber were studied for their degree and rate of aerobic biodegradation. Composites used contained 10, 15, and 50% volume fractions of pineapple leaf fiber, banana fiber, and bamboo fiber, respectively, which are the optimum fiber percentages of the respective composites as reported by these authors in their previous works. Cellulose has been used as positive reference material. All the composites exhibited partial biodegradation in the range of 5-15% depending on the fiber content. Degradation had not taken place in the covalent ester linkages between the natural fiber and the MA-g-PP compatibilizer but in those areas of the fibers which have remained only physically embedded in the resin matrix. Thus, although natural fibers reinforced PP composites are not excellent biodegradable material, they can address to the management of waste plastics by reducing the amount of polymer content used that in turn will reduce the generation of nonbiodegradable polymeric wastes. © 2011 Wiley Periodicals, Inc.


Chattopadhyay S.K.,Shriram Institute for Industrial Research | Khandal R.K.,Shriram Institute for Industrial Research | Uppaluri R.,Indian Institute of Technology Guwahati | Ghoshal A.K.,Indian Institute of Technology Guwahati
Journal of Applied Polymer Science | Year: 2010

Composites were prepared with chemically modified banana fibers in polypropylene (PP). The effects of 40-mm fiber loading and resin modification on the physical, mechanical, thermal, and morphological properties of the composites were evaluated with scanning electron microscopy (SEM), thermogravimetric analysis (TGA), Infrared (IR) spectroscopy, and so on. Maleic anhydride grafted polypropylene (MA-g-PP) compatibilizer was used to improve the fiber-matrix adhesion. SEM studies carried out on fractured specimens indicated poor dispersion in the unmodified fiber composites and improved adhesion and uniform dispersion in the treated composites. A fiber loading of 15 vol % in the treated composites was optimum, with maximum mechanical properties and thermal stability evident. The composite with 5% MA-g-PP concentration at a 15% fiber volume showed an 80% increase in impact strength, a 48% increase in flexural strength, a 125% increase in flexural modulus, a 33% increase in tensile strength, and an 82% increase in tensile modulus, whereas the heat deflection temperature increased by 18°C. © 2010 Wiley Periodicals, Inc.


Aggarwal M.L.,Shriram Institute for Industrial Research | Chacko K.M.,Shriram Institute for Industrial Research | Kuruvilla B.T.,Arjuna Natural Extracts Ltd.
Molecular Medicine Reports | Year: 2016

Curcumin, the active component present in Curcuma longa of the family Zingiberaceae, has a number of pharmacological effects, including potential anti-inflammatory activity. One of the major limitations of curcumin/turmeric extract is its poor absorption through the gastrointestinal tract. Several approaches have been adopted to increase the bioavailability of curcumin, including loading curcumin into liposomes or nanoparticles, complexation with phospholipids, addition of essential oils and synthesizing structural analogues of curcumin. In the present study, the toxicity and safety of one such bioavailable turmeric formulation, curcuminoid-essential oil complex (CEC), the toxicity profile of which has not been reported, were examined using in vivo and in vitro models, as per the guidelines of the Organisation for Economic Co-operation and Development. Investigations of acute toxicity study were performed in rats and mice, and the results revealed no signs and symptoms or toxicity or mortality in any of the animals at the maximum recommended dose level of 5,000 mg/kg body weight. The repeated administration of CEC for 90 days in Wistar rats at a dose of 1,000 mg/kg body weight did not induce any observable toxic effects, compared with corresponding control animals. Mutagenicity/genotoxicity investigations were also performed using a bacterial reverse mutation assay (Ames test), a mammalian bone marrow chromosome aberration test and a mammalian erythrocyte micronucleus test in mice. CEC was found to be non-mutagenic in all three mutagenic investigations. Consequently, the present study indicated that CEC elicited no toxic effects in animals or in vitro. Therefore, following investigations of acute toxicity, repeated dose toxicity and mutagenicity, CEC was deemed a safe, non-toxic pharmacological formulation.


Haldar R.S.,Shriram Institute for Industrial Research | Chauhan R.,Shriram Institute for Industrial Research | Kapoor K.,Shriram Institute for Industrial Research | Niyogi U.K.,Shriram Institute for Industrial Research
Optical Materials | Year: 2014

A hydrophobic composition for foldable intraocular lenses was developed by copolymerizing phenyl ethyl acrylate, phenyl ethyl methacrylate and butanediol diacrylate by gamma irradiation. Aqueous solution of heparin, a biocompatibilizer absorbed in hydroxyethyl methacrylate was added to the monomer mixture before irradiation to impart desired level of hydrophilicity and improved biocompatibility to the hydrophobic composition. Ketorolac tromethamine, an anti-inflammatory agent and L-glutathione, an antioxidant were added to the composition as functional additive for exhibiting improved performance while in use. Concentrations of monomers, biocompatibilizer and functional additives were optimized to develop an advanced material for foldable intraocular lenses. Transmittance, refractive index, Abbe number, hardness, tensile strength, flexibility and foldability were studied on the final composition. Scanning electron microscopic study, differential scanning calorimetric analysis, leachability and viscometry confirmed the permanent incorporation of additives into the polymer. Results of haemocompatibility, tissue implantation and cytotoxicity confirm that the biocompatibility of the base polymer was improved by incorporation of heparin. © 2014 Elsevier B.V. All rights reserved.


PubMed | Arjuna Natural Extracts Ltd. and Shriram Institute for Industrial Research
Type: Journal Article | Journal: Molecular medicine reports | Year: 2015

Curcumin, the active component present in Curcuma longa of the family Zingiberaceae, has a number of pharmacological effects, including potential antiinflammatory activity. One of the major limitations of curcumin/turmeric extract is its poor absorption through the gastrointestinal tract. Several approaches have been adopted to increase the bioavailability of curcumin, including loading curcumin into liposomes or nanoparticles, complexation with phospholipids, addition of essential oils and synthesizing structural analogues of curcumin. In the present study, the toxicity and safety of one such bioavailable turmeric formulation, curcuminoidessential oil complex (CEC), the toxicity profile of which has not been reported, were examined using in vivo and in vitro models, as per the guidelines of the Organisation for Economic Co-operation and Development. Investigations of acute toxicity study were performed in rats and mice, and the results revealed no signs and symptoms or toxicity or mortality in any of the animals at the maximum recommended dose level of 5,000 mg/kg body weight. The repeated administration of CEC for 90 days in Wistar rats at a dose of 1,000 mg/kg body weight did not induce any observable toxic effects, compared with corresponding control animals. Mutagenicity/genotoxicity investigations were also performed using a bacterial reverse mutation assay (Ames test), a mammalian bone marrow chromosome aberration test and a mammalian erythrocyte micronucleus test in mice. CEC was found to be nonmutagenic in all three mutagenic investigations. Consequently, the present study indicated that CEC elicited no toxic effects in animals or in vitro. Therefore, following investigations of acute toxicity, repeated dose toxicity and mutagenicity, CEC was deemed a safe, nontoxic pharmacological formulation.

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