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Sharma S.,Banasthali University | Pareek A.,Banasthali University | Joshi R.,Banasthali University | Bhardwaj Y.R.,Banasthali University | And 2 more authors.
Oriental Journal of Chemistry | Year: 2013

The method has been developed and validated for the assay of Paracetamol using mixed solution of methanol and phosphate buffer 6.8 as a solvent in ratio of (1:3) (further diluted in phosphate buffer 6.8 only). The λ max (absorption maxima) of the drug was found to be 246 nm. Linear response was observed in the range of 2-24ìg/ml with a regression coefficient of 0.999. Furthermore various validation parameters as per ICH Q2B guideline were tested and found accordingly. The method and solution was significantly (P<0.05) stable for 15 days. The percent purity (99.09 %) and % Recovery at 80, 100 and 120 % were found to be 102.00±2.027, 102.10±4.913 and 100.00±4.819 respectively for marketed paracetamol tablets. Developed method was a less toxic, cheap, eco-friendly but equally sensitive spectroscopic method for quantitative determination of paracetamol for regular quality control purpose in laboratories. Source

Pal P.,Mahakal Institute of Pharmaceutical Studies | Choudhary A.,Mahakal Institute of Pharmaceutical Studies | Bhargava S.,Shrinathji Institute of Pharmacy | Ghosh A.K.,IFTM University
Research Journal of Pharmacy and Technology | Year: 2014

The plant Artemisia nilagirica (Clarke) was found to be used by different traditional systems and folklore for the treatment of various disorders. The aim of the present study is to investigate the effect on central nervous system (CNS) of the ethanol extract of Artemisia nilagirica (Clarke) plant in Swiss albino mice and Wistar rats. The CNS effects were evaluated by general behaviour, exploratory behaviour, Muscle relaxant activity and Phenobarbitone sodium-induced sleeping time using standard procedures in experimental animal models the results revealed that the ethanol extract at 100 and 200mg/kg caused a significant reduction in the spontaneous activity (general behavioural profile). Exploratory behaviour pattern (Y-maze and head dip test). Muscle relaxant activity (rotarod and traction test), and significantly potentiated phenobarbitone sodium-induced sleeping time. The results conclude that the extract exhibit CNS depressant activity in tested animal models. © RJPT All right reserved. Source

Bhargava S.,Shrinathji Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2016

In the present work, Preliminary Phytochemical screening of Ethyl acetate, n-Butanol and Hydro-alcoholic (30:70) extracts of leaves was carried out. Acute toxicity study (ALD50) determined by Fixed dose (OCED Guideline No. 420) method of CPCSEA was adopted for toxicity studies. Hypoglycemic activity of these extract has been investigated on Normoglycemic Rats model and Oral Glucose Tolerance Test model. Result reveled that all three extract contain Flavonoids where as Alkaloids are absent. No Mortality observed during acute toxicity study at higher dose 2000 mg/kg bw so that 1/5th of higher dose i.e. 400mg/kg was used for biological evaluation. All the extracts showed significant hypoglycemic activity in Normoglycemic rats and OGTT model compare to Standard (Glibenclamide). Hydroalcoholic extract are superior to other in dose dependent manner. These findings suggest that the leaves of Bombax ceiba L have potential to lower the blood glucose level in experimental animals. Present research directs the importance of further research and development for its mechanism of action and molecular level study. © RJPT All right reserved. Source

Singh M.P.,Shrinathji Institute of Pharmacy | Sharma C.S.,JKK Nataraja Dental College and Hospital
International Journal of ChemTech Research | Year: 2010

The different market samples of Terminalia chebula fruits evaluated by Pharmacognostic parameters compare with standard data. All three samples carried out microscopic characters, ash values, extractive values, T.L.C., & chemical tests. All the data of three samples were compared with standard data, the sample no-1 was more authentic than among all the three samples. Source

Gopinath E.,Shrinathji Institute of Pharmacy | Bhadauria R.S.,Shrinathji Institute of Pharmacy | Jain A.,Shrinathji Institute of Pharmacy
Research Journal of Pharmacy and Technology | Year: 2011

A drug product recall is a request to return to the maker a batch or an entire production run of a product, usually due to the discovery of consumer safety issues. Recalls are costly to a company because they often loss their company name form the consumer. The reason for drug product recall is may be due to wrong drug, unapproved drug, Undeclared drug ingredient, microbial contamination in the formulation, Incorrect usage information on package, May contain particulates prior to expiration date, May contain visible particulates etc,. So Products on the market that are suspected or known to be seriously defective and/or pose a potential risk to patient health must be recalled. This must be done promptly, comprehensively and in accordance. This article provide information regarding to Handling and Decision making of Recall Products in Pharmaceutical Companies and guidelines to heath care systems, hospital to handle the recalled drug products. © RJPT All right reserved. Source

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