Shrimati Indira Gandhi College

Tiruchirappalli, India

Shrimati Indira Gandhi College

Tiruchirappalli, India
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Suriyamoorthy P.,Karpagam University | Fathima Mary M.R.,Shrimati Indira Gandhi College | Subrhamanian H.,Karpagam University | Kanagasapabathy D.,Karpagam University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Objective: Hyperlipidemia is a serious health problem and greatest cause of death all over the world, and if not treated, it is responsible for many complications affecting various organs in the body. The present research was carried out to find the inhibitory activity of HMGCoA reductase, ACAT (Acyl coenzymeA cholesterol acyl transferase) and antihyperlipidemic effect of Aegle marmelos and Camellia sinensis in oil fed rats. Methods: The aqueous leaf extract of Aegle marmelos and Camellia sinensis was administered to the control and experimental rats for 21 days. After the experimental period the animals were sacrificed and the serum, tissue samples were used for its enzyme inhibitory activity and lipid metabolism analysis by using standard protocol. Results: HMGCoA reductase is a key enzyme which continued the rate limiting step of cholesterol biosynthesis. Treatment with herbal drugs like Aegle marmelos and Camellia sinensis showed a significant decrease in the ACAT, HMGCoA reductase levels and significant increase in high density lipoprotein level. After treatment with Aegle marmelos and Camellia sinensis the histopathology results of liver proves the promising effect againt hyperlipidemia. Conclusion: It is concluded that the aqueous leaf extract of Aegle marmelos and Camellia sinensis can be applied clinically for the management of hyperlipidemia and cardiovascular complications.


Varalakshmi B.,Shrimati Indira Gandhi College | Anand A.V.,MIET College | Karpagam T.,Shrimati Indira Gandhi College | Bai J.S.,Seethalakshmi Ramaswami College | Manikandan R.,SSK polytechnic college
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

One of the most common threats is the spread of multidrug resistant pathogens. Cancer is another major problem leads to death. Hence a search for new, plant based, risk-free, superior compounds with novel antimicrobial and anticancer activities is the need of the day. The aim of this study was to evaluate the antimicrobial and anticancer effects of bark of Cinnamomum zeylanicum. The antimicrobial activity of extracts of Cinnamomum zeylanicum bark (aqueous, methanol and chloroform) against bacterial and fungal clinical isolates like Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Aspergillus niger and Candida albicans was determined. The anticancer activity was studied by MTT and AO/EB staining on hepato carcinoma cell lines ((Hep G2 cell line). The result of antimicrobial study showed that methanolic extract had better antibacterial and antifungal activity. The most susceptible bacterial and fungal strains were Bacillus subtilis and Aspergillus niger, respectively. The methanolic extract showed MIC value of 2.5mg/ml for Bacillus subtilis and 5mg/ml for Aspergillus niger. The results of in vitro anticancer studies by MTT assay on Hep G2 cell line in the presence of methanolic extract of Cinnamomum zeylanicum bark showed an IC50 value of 150μg/ ml. The AO/EB staining also showed that the methanolic extract was able to induce apoptotic activity in HepG2 cells after 24 hours of incubation at a concentration 150μg/ ml. This study proved that Cinnamomum zeylanicum bark is a reliable and safer herbal drug that can be used in pharmaceutical preparations for infectious and malignant diseases.


Sugunabai J.,Seethalakshmi Ramaswamy College | Karpagam T.,Shrimati Indira Gandhi College | Varalakshmi B.,Shrimati Indira Gandhi College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2014

Diabetes mellitus (DM) is a metabolic disorder throughout the world. This disorder could be treated with herbal plants. Medicinal plants are exploited for many drugs to treat various ailments. The drugs derived from the plants promote health, augmented the resistance of the body against disease. Plants such as Moringa oleifera, Solanum nigrum have hypoglycemic properties and other beneficial properties. The objective of the study was to analyze and compare anti diabetic and hypolipidemic effect of Moringa oleifera and Solanum nigrum on known diabetic and hyperlipidemic patients. The aqueous extract of these plants were assessed for their hypoglycemic and hypolipidemic effects. Presence of primary and secondary metabolites was also screened. Patients in the age group of 35 - 60 years were selected for the study. Only male patients were selected and the study was carried out for 90 days. The level of glucose, glycosylated haemoglobin, total cholesterol, triglyceride, LDL- cholesterol was reduced to 23, 12.5, 40, 18% and HDL- cholesterol was increased to 20% on treatment with Moringa oleifera and while on treatment with Solanum nigrum the level was reduced to 19,10,17,8% and increased to 2% respectively. Among these two extract treatment Moringa oleifera was found to be more effective than Solanum nigrum. Presence of primary and secondary metabolites played a significant role in hypoglycemic activity. The preliminary screening results indicated that the plants possessed various constituents like tannins, phenols, alkaloids, flavonoids and carotenoids.


Varalakshmi B.,Shrimati Indira Gandhi College | Anand V.,Bharathiar University | Kumar S.,SASTRA University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2016

Objective: Free radicals play an important role in the pathogenesis of many disorders by damaging important biomolecules such as lipids, proteins and DNA. Natural antioxidants are safer, cheaper and potential therapeutics to scavenge free radicals. Hence, this study was aimed to assess the biomolecular protective effect of Cinnamomum zeylanicum bark, a culinary spice, on the oxidant-treated membrane lipids and DNA in cell-free systems. Methods: The total phenolics and flavonoid content of the bark were estimated. The extent of inhibition of lipid peroxidation (LPO) by aqueous, methanolic and chloroform extracts of bark was studied in vitro in three different membrane models such as goat RBC ghosts, goat liver homogenate, and goat liver slices which differ in architecture and lipid composition. The extent of inhibition of oxidant-induced DNA damage by the bark extracts was assessed in commercial DNA preparations such as pBR322, herring sperm, and calf thymus DNA. Results: The total phenolic content was 153.33±23.09 mg of pyrocatechol equivalents/g, and flavonoid was 33.66±1.15 mg of catechin equivalents/g of powdered bark. All the three extracts exhibited a considerable inhibition of LPO in all the membrane systems, and most significant inhibition was exerted by methanolic extract on the RBC ghosts. All the three extracts were able to revert the oxidant-induced DNA damage, and more significant DNA protection was rendered by methanolic extract on calf thymus DNA. Conclusion: The present study showed that C. zeylanicum bark is a nutraceutical rich in phenolic antioxidants that can protect biomolecules against oxidative stress. © 2016 The Authors.


Prabha P.,PRIST University | Karpagam T.,Shrimati Indira Gandhi College | Varalakshmi B.,Shrimati Indira Gandhi College | Sohna Chandra Packiavathy A.,PRIST University
Pharmacognosy Research | Year: 2011

Background: Peptic ulcer disease (PUD), encompassing gastric and duodenal ulcers is the most prevalent gastrointestinal disorder. The pathophysiology of PUD involves an imbalance between offensive factors like acid, pepsin and defensive factors like nitric oxide and growth factors. The clinical evaluation of antiulcer drugs showed tolerance, incidence of relapses and side-effects that make their efficacy arguable. An indigenous drug like Musa sapientum possessing fewer side-effects is the major thrust area of present day research, aiming at a better and safer approach for the management of PUD. Material and Methods: The unripe plantain bananas (Musa sapientum) were shade-dried, powdered and used for phytochemical analysis and as antiulcer drug. In our present study Group I rats served as control and were treated with saline, Group II was indomethacin-induced ulcerated rats, Group III received aqueous extract of Musa sapientum along with indomethacin and Group IV received esomeprazole along with indomethacin for 21 days. The anti-ulcerogenic activity was investigated by performing hematological, mucosal, antioxidant profile in comparison with the standard drug esomeprazole. Results: Our findings from High - Performance Thin Layer Chromatography (HPTLC) analysis showed that Musa sapientum has an active compound a monomeric flavonoid (leucocyanidin) with anti-ulcerogenic activity. Results were expressed as mean SD. All our results are in congruous with the results of standard drug esomeprazole. Conclusion: It could be clearly concluded that administration of the aqueous extract of Musa sapientum at the dose used in this study tends to ameliorate ulcers. Its use in indigenous medicine should be scientifically scrutinized with further research.


Meena K.,Bharathidasan University | Vijayalakshmi N.,Shrimati Indira Gandhi College
Indian Journal of Public Health Research and Development | Year: 2015

Statistical Hypothesis Testing methods and Association Rule Mining through Frequent Item-set Mining have been used to analyze and mine knowledge on significant factors causing infertility in women. Even though there are a number of factors causing infertility in women, only three significant factors namely Age, Body Mass Index and Thyroid Stimulating Hormone Levels during prenatal periods have been taken for analysis. Sample data was collected from the case sheets of outpatients visiting a Fertility centre and Maternity Hospital at Trichy. Out of several independent attributes collected about outpatients, only three attributes considered to be significant have been taken up for preliminary study. The aim of the study is to assess the significance of the said factors in the light of fertility in women. Common attributes have been considered among an equal sample size of fertile and infertile outpatients. The results of the study show that the attributes considered are significant in determining fertility of women both individually and together. It is found that age significantly influences Body Mass Index and Thyroid Stimulating Hormone Levels. It is also found that obesity triggers changes in hormonal levels. © 2015, Indian Journal of Public Health Research and Development. All Rights Reserved.


Meena K.,Bharathidasan University | Gomathy M.,Shrimati Indira Gandhi College
ARPN Journal of Engineering and Applied Sciences | Year: 2016

Cloud computing provides computing resource in an on-demand manner. It is provisioned resources from huge data centers situated in different geographical locations in the world. It mainly supports small and medium scale enterprises to startup their business in globally. It has many advantages in resource provisioning and other services but it also has some security related problems. Cloud enables outsourced computing. The nature of outsourced computing brings up many security issues in cloud environment. Due to the security issues in cloud, users are not willing adopt the cloud. This paper presents an elaborated study on different security framework and data protection techniques in cloud environment. Each framework works on their functionality and address security issues in public cloud environment. Finally, paper discusses results of each framework and data protection techniques. © 2006-2016 Asian Research Publishing Network (ARPN). All rights reserved.


Karthikeyan B.,Bishop Heber College | Kanimozhi N.,Shrimati Indira Gandhi College | Hari Ganesh S.,Bishop Heber College
ARPN Journal of Engineering and Applied Sciences | Year: 2016

Resent days Mobile Ad Hoc Network (MANET) mostly uses reactive on-demand routing protocols where routes are launch only when the node needed. Most of the protocols which one is belongs to this category are not including proper security facilities. A MANET is a collection of autonomous mobile nodes with self-configuring, self-administrating features. The Mobile ad hoc environment is accessible by both genuine network users and malicious network attackers. Packets that are routed during route discovery itself it has to be protected in such a way that it has minimum chance of having a malicious node in path formed. In this paper the proposed En-SIm AODV (Encrypt-Security Improved Ad Hoc on Demand Distance Vector Routing Protocol) is the upgraded version of the SIm AODV (Security Improved Ad Hoc on Demand Distance Vector Routing Protocol) which one comes from the previous work. The proposed work uses the private key encryption and decryption to avoid intrusions. © 2006-2016 Asian Research Publishing Network (ARPN).


Gomathy M.,Shrimati Indira Gandhi College | Devi V.K.,Shrimati Indira Gandhi College | Meenakshi D.,Shrimati Indira Gandhi College
Proceedings - 2014 World Congress on Computing and Communication Technologies, WCCCT 2014 | Year: 2014

A framework for detecting and recording the flaws that happen during the usage of web applications is designed and a library functionality to perform this is discussed in this paper. The recorded information can be stored at different levels of detail, commonly called the logging levels. For some modules more than others, it may be required to store more detailed information about any error that arises during its usage according to its importance. A Web Application also needs to print the stack trace containing the error information on the web page when an error occurs for the user to understand the nature of the error. When dealing with legacy web applications, it is difficult to insert code. The proposed and designed framework is tested with a web application called Kic Kart. © 2014 IEEE.


Menaka K.,Shrimati Indira Gandhi College
Proceedings - 2014 World Congress on Computing and Communication Technologies, WCCCT 2014 | Year: 2014

Data hiding is the skill of hiding messages in such a way that only the sender and the receiver of the message know that the message has been hidden. In the contexts of secured information transmission and reception, efficient techniques for data encryption and decryption are very much essential. Though many algorithms have been developed for hiding the data, DNA sequences based data encryption seems to be a promising strategy for fulfilling the current information security needs. In this paper, an algorithm using DNA sequences for data hiding is proposed and discussed for secure data transmission and reception. © 2014 IEEE.

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