Shri Sureshdada Jain Institute of Pharmaceutical Education and Research

Jālgaon, India

Shri Sureshdada Jain Institute of Pharmaceutical Education and Research

Jālgaon, India
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Tapas A.,Maharashtra Institute of Pharmacy | Kawtikwar P.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | Sakarkar D.,Maharashtra Institute of Pharmacy
Acta Poloniae Pharmaceutica - Drug Research | Year: 2012

Spherically agglomerated solid dispersions of carvedilol (CAR) were prepared with polyvinyl-pyrrolidone (PVP) using acetone, water and dichloromethane as solvent, non-solvent and bridging liquid, respectively. The prepared agglomerates were evaluated for its percentage yield, drug content, morphology, thermal behavior, micromeritic properties, aqueous solubility and in vitro drug release. Differential scanning calorimetric and powder X-ray diffraction studies confirm that formulation process altered the crystalline nature of carvedilol. The recrystallized agglomerates exhibited significant increase (p < 0.05) in micromeritic properties than untreated carvedilol. Solubility and in vitro drug release studies indicated that the spherical agglomerates showed significant increase (p < 0.05) in solubility and dissolution rate than pure carvedilol alone.


Tapas A.R.,Maharashtra Institute of Pharmacy | Kawtikwar P.S.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | Sakarkar D.M.,Maharashtra Institute of Pharmacy
Latin American Journal of Pharmacy | Year: 2011

SUMMARY. Spherical crystallization (SC) is a promising alternative for improiving micromeritic properties and dissolution rate of active pharmaceutical ingredients. In the present work spherical agglomerates of carvedilol (CAR) were prepared by emulsion solvent diffusion (ESD) method using acetone, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. Agglomerates were prepared by using β-cyclodextrin and hydroxy propyl-β-cyclodextrin as a hydrophilic polymers. The agglomerates were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM) and were evaluated for flowability, solubility and drug release. CAR agglomerates exhibited significantly improved micromeritic properties, solubility as well as dissolution behaviors in comparison with pure CAR crystals. Differential scanning calorimetric and powder X-ray diffraction studies confirm that formulation process altered the crystalline nature of carvedilol.


Tapas A.R.,Maharashtra Institute of Pharmacy | Kawtikwar P.S.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | Sakarkar D.M.,Maharashtra Institute of Pharmacy
American Journal of Drug Discovery and Development | Year: 2011

The objective of the present work was to enhance the solubility, dissolution rate and micromeritic properties of Felodipine (FL) a poorly water soluble antihypertensive, using spherical agglomeration by Quasi Emulsion Solvent Diffusion (QESD) method. In this study methanol, water and dichloromethane were used as good solvent, poor solvent and bridging liquid, respectively. The hydrophilic polymers like Hydroxypropyl β-cyclodextrin, β-cyclodextrin, Lutrol F68, Lutrol F127 were used in agglomeration process. The pure drug (FL) and its agglomerates with different polymers were characterize for their drug loading as well as by Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), FTIR spectroscopic studies and Scanning Electron Microscopy (SEM). The DSC results indicated decrease in melting enthalpy related to disorder in the crystalline content. XRD studies also showed changes in crystallanity, IR spectroscopy revealed that there were no chemical changes in the re crystallized agglomerates. The spherically agglomerated solid dispersions with different polymers exhibited marked increase in solubility (53.69±0.53 jig mL-1), dissolution rate (100.09±2.27% in 60 min) and micromeritic properties (bulk density, flow property, comparability) compared with FL. The SEM studies showed that the agglomerate possesses a good spherical shape. © 2011 Academic Journals Inc.


Pagar H.B.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | Shinde U.P.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | Agrawal Y.S.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | Barhate S.D.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | And 2 more authors.
Research Journal of Pharmacy and Technology | Year: 2012

Taste masking of bitter drugs has been challenge to scientists. Several oral pharmaceuticals and bulking agents have unpleasant bitter taste. In order to ensure patient compliance bitterness masking becomes essential. The desire of improving the palatability has prompted the development of numerous formulations with improved performance and acceptability. Several approaches namely sensory, barrier, chemical and complication have been tried to mask the unpleasant taste of formulation. Palatability is recognized as being a critical factor in patient compliance, particularly for children in whom the acceptability of medicament and hence its ease of administration can be greatly affected by taste. In the present review approaches used for the taste masking of the pharmaceuticals are discussed in detail. Taste is an important parameter-governing acceptance of products for administration through mouth. Several of the oral pharmaceuticals, numerous food and beverage products and bulking agents have unpleasant bitter tasting components. Administration of bitter drugs orally with acceptable level of palatability is a key issue for health care providers, especially for pediatric patients. Masking of the unpleasant taste of a drug improves the compliance of patients and thereby the commercial success of the product. Undesirable taste of these drugs have been eliminated or minimized by various known processes, but no universally applicable technology for bitterness reduction has ever been recognized. © RJPT All right reserved.


Tapas A.,Maharashtra Institute of Pharmacy | Kawtikwar P.,Shri Sureshdada Jain Institute of Pharmaceutical Education and Research | Sakarkar D.,Maharashtra Institute of Pharmacy
Turkish Journal of Pharmaceutical Sciences | Year: 2012

The objective of the present work was to improve micromeritic properties and dissolution rate of a poorly water soluble drug, carvedilol, by spherical agglomeration in presence of Inutec SP1. In the present work acetone, water and dichloromethane were used as good solvent, poor solvent and bridging liquid respectively for the agglomeration process. The prepared spherical agglomerates were evaluated for its percentage yield, drug content, morphology, thermal behavior, micromeritic properties and in vitro drug release. The percent drug content of spherical agglomerates was found to be in the range of 93.21±2.01 to 100.0±0.0. Differential scanning calorimetric and powder X-ray diffraction studies confirm that formulation process altered the crystalline nature of carvedilol. The recrystallized agglomerates exhibited significant increase (P<0.05) in micromeritic properties than untreated carvedilol. In vitro drug release studies indicated that the spherical agglomerates CI-1 showed significant increase (P<0.05) in dissolution rate than pure carvedilol alone.


Umarkar A.R.,Shri Sureshdada Jain Institute Of Pharmaceutical Education And Research | Chaudhari S.B.,Manoharbhai Patel Institute of Pharmacy | Bhurat M.R.,Shri Sureshdada Jain Institute Of Pharmaceutical Education And Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

A rapid, simple and precise stability indicating RP-HPLC method for the determination of Thiocolchicoside on C18 column (250mm × 4mm, 5μm) has been developed. A mobile phase consisting of acetonitrile: water (70:30) was used. The flow rate was 1.0 mL min-1 with UV detection at 286 nm. The specificity of the method was ascertained by forced degradation studies by acid and alkali degradation, oxidation and photolysis. Beer Law is obeyed over a concentration range of 0-10 μg/ml and correlation coefficient as 0.9996. This method was also successfully applied for routine analysis of Thiocolchicoside in capsule dosage forms.

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