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Begum R.,Chettinad Hospital and Research Institute | Shree R.,Shri Satya Sai Medical College and Research Institute
International Journal of Pharma and Bio Sciences | Year: 2016

This study was undertaken to determine the correlation between brain natriuretic peptide (BNP) and red cell distribution width (RDW) in the acute coronary syndrome. It was done on hundred adult patients who were diagnosed with acute coronary syndrome and hospitalized in the Coronary care unit in Chettinad Hospital Research and Institute (CHRI), Kelambakkam. Patients were selected based on the inclusion criteria. 1) ST-segment elevation and ST-segment depression proven by electrocardiography. 2) Acute failure shows an ejection fraction less than 50% proven by echocardiography 3) Serum BNP levels > 400 pg/mL Complete blood count and biochemical markers which include BNP, Troponin I, CPKMB were used for analyses within less than 24 hours of admission. The correlation between the three outcome variables and the explanatory variables was assessed by calculating correlation coefficients and its P-value and 95% CI. The study observations are as follows: A) The mean age was older and there were more males in the ACS study group. b) RDW showed statistically significant positive correlation with BNP levels (correlation coefficient 0.147, p value < 0.001) c) There was a weak positive correlation between Total leucocytes count and BNP levels (Correlation coefficient 0.013) and it was statistically not significant (P value 0.267). To conclude, Elevated RDW levels is independently associated with a higher BNP level in patients with acute coronary syndrome. RDW has been proven to be as good as BNP.

Lavakumar S.,Shri Satya Sai Medical College and Research Institute | Manimekalai K.,Mahatma Gandhi Institute | Karthikeyan K.,Mahatma Gandhi Institute
International Journal of Pharma and Bio Sciences | Year: 2015

Despite effective antibiotics treatment, mortality due to neonatal sepsis remains high. Immunomodulatory therapy like intravenous immunoglobulin (IV Ig) has been used as an adjunct in an effort to decrease mortality from neonatal sepsis, as newborn infants, particularly those who are preterm and are deficient in IgG. The objective of this study was to assess the outcome of intravenous immunoglobulin therapy as an adjuvant in the treatment of neonatal sepsis. A total of 42 babies who were given IV Ig as an adjuvant along with antibiotics for proven neonatal sepsis formed the potential subjects. Clinical and hematological parameters were assessed following IV Ig administration. The total duration of Neonatal intensive care unit stay was noted. The source, dose, frequency and adverse effects, if any of IV Ig were noted. In our study, both male and female babies were equally affected. More than 90% of the babies were preterm and all the babies had low birth weight. The source of IV Ig was IgG, obtained from pooled human plasma. It was given at the dose of 0.5-0.9 g/kg. No adverse reaction following IV Ig was noted. Following IV Ig administration as an adjuvant in treatment of neonatal sepsis, the improvement in clinical and hematological parameters were better and quicker. The average duration of hospitalization was 6-8 days when IV Ig was given as an adjuvant. Thus duration of NICU stay was less when compared to being treated with antibiotics alone. Hence to conclude, IV Ig as an adjuvant along with antibiotics is a better strategy for both prophylactic as well as treatment of proven neonatal sepsis.

Sukla P.,Shri Satya Sai Medical College and Research Institute | Sharma K.D.,Gsl Medical College And General Hospital | Rana M.,Medical College and Hospital | Zaidi S.H.N.,Shri Satya Sai Medical College and Research Institute
Indian Journal of Community Health | Year: 2013

Polio eradication continues to be a priority in the South-East Asia Region. For developing countries, considering that the practice of open defecation and fecal contamination of drinking water easily precipitates virus transmissions, the eradication of polio called for rounds after rounds of campaign. In the districts of western Uttar Pradesh (UP), in India, which continues to be polio endemic, key challenge is the low levels of sanitation and personal hygiene. The residents of polio endemic areas are now reluctant to frequent pulse polio immunization rounds and are using these rounds to raise their voice against chronic apathy to providing the basic amenities such as adequate sanitation facilities. Newer initiatives such as Urban Sanitation and Hygiene Action (USHA) Project, in western UP and "107 block" campaign launched in UP and Bihar aiming to improve sanitation, water quality and routine immunizations in the high risk polio endemic administrative blocks have the potential to significantly strengthen eradication efforts, especially in high risk areas for wild poliovirus transmission in North India.

Bharathi K.,Shri Satya Sai Medical College and Research Institute | Ajay Chandrasekar V.S.,Shri Satya Sai Medical College and Research Institute | Hemanathan G.,Shri Satya Sai Medical College and Research Institute | Anuradha S.,Shri Satya Sai Medical College and Research Institute
Journal of Clinical and Diagnostic Research | Year: 2014

Myofibroblastoma is a rare benign mesenchymal tumour of the breast commonly reported in males. It is a spindle cell neoplasm exhibiting myofibroblastic differentiation with characteristic immunohistochemical staining. Herein, we present a case of myofibroblastoma in a premenopausal female which was mimicking like malignancy clinically. Lump was growing rapidly in size measuring 8 cm × 6 cm and stony hard in consistency. Mammogram showed a large homogeneous hyperdense lump suggestive of fibroadenoma, Hamartoma and fibromatosis. FNAC and trucut biopsy of mass could not be done due to stony hard consistency. Hence excision biopsy was done. Histopathological examination revealed the tumour as myofibroblastoma. Immunohistochemical staining for markers of myofibroblasts like CD-34 and Vimentin showed strong positivity. A negative expression for cytokeratin was noted. This case is presented for its rarity, unusual clinical presentation and stony hard consistency.

Khan D.M.,Shri Satya Sai Medical College and Research Institute | Manimaran D.,Shri Satya Sai Medical College and Research Institute | Bharathi K.,Shri Satya Sai Medical College and Research Institute | Tulasi Raman R.,Shri Satya Sai Medical College and Research Institute | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Papillary carcinoma of the thyroid was regarded previously as a single group with indolent clinical course and excellent prognosis. This view has changed. Recent histopathological reports emphasize that papillary carcinoma should be further classified into its variants because of the prognostic implications. We report its incidence, clinical behaviour and outcome of variants of papillary thyroid cancers at Narayana Medical College, Nellore. To study the incidence, age and gender of variants of papillary thyroid carcinoma and to analyze the results with published data. These cases were received in the surgical pathology laboratory of Narayana Medical College, Nellore from July 2006-June 2008. We have reviewed clinical case sheets, microscopic slides and histopathological reports of these carcinomas. Accordingly we report our experience of different variants, a series of 37 papillary carcinoma. The following results have been obtained:19 cases were Classical (usual) papillary carcinoma, 8 Follicular variant, 4 Diffuse sclerosing variant, 3 Encapsulated variant, 2 Mixed tall cell columnar cell variant and 1 Tall cell variant. These variants differ from each other not only on a morphologic basis, but also in clinical behavior and prognosis. Rightly subtyped histopathological report will help the clinicians for its management and prognostic implications.

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