Shri Satya Sai Medical College and Research Institute

Nellikuppam, India

Shri Satya Sai Medical College and Research Institute

Nellikuppam, India
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Krishnan R.D.Y.,Shri Satya Sai Medical College and Research Institute | Kumarasekaran P.,Shri Satya Sai Medical College and Research Institute | Raja R.V.,Shri Satya Sai Medical College and Research Institute
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2017

Isolated disease of sphenoid sinus is rare, representing 2-3% of all paranasal sinus lesions. Usually it is inflammatory in origin; very rarely it is due to neoplasm. Isolated sphenoid sinus diseases are difficult to diagnose and to treat because either the symptoms are very vague or they present to us very late as a result of disease complications. Here we are presenting a case of isolated sphenoid fungal sinusitis. A 40 year female came to our ENT outpatient department with complaints of intermittent headache for past 3 months. She was treated for similar complaints by a general practitioner with antibiotics and analgesics before three months. She was referred to an ophthalmologist and neurologist as the headache did not subside. Since there was no abnormality in ophthalmological examination, the neurologist suggested a MRI which showed opacification of the sphenoid sinus. Hence she was referred to an ENT specialist. ENT Clinical examination was normal. Urgent CT scan along with MRI was ordered which revealed complete opacification of the sphenoid sinus. There was no air fluid level, no hyper dense foci suggestive of fungal elements. There was no bony erosion. A provisional diagnosis of Chronic Sphenoid sinusitis was made and planned for endoscopic sphenoidotomy under general anesthesia. Sphenoid sinus was opened and fungal debri was seen inside, which was sent for culture. Sphenoid ostium was widened. Post operatively patient was completely relieved of headache. Patient was started on Tab.Itraconazole 200mg/day for 6 weeks, since the culture was suggestive of aspergillosis. Owing to the non specific presentation and the vague symptomology of the disease there may be considerable delay in diagnosing and treating the patient. Hence imaging studies like CT and MRI is necessary when the disease is suspected for prompt diagnosis. © 2017 Association of Otolaryngologists of India


Vijaya Kumar Nair G.,Shri Satya Sai Medical College and Research Institute | Barman D.D.,Shri Satya Sai Medical College and Research Institute
Journal of Indian Academy of Forensic Medicine | Year: 2016

The crime among the youngsters is the most suspected factor for the increase in rate and intensity of existing risks. The highest probability of extreme crime cases and the emergence of new vulnerabilities in Southern delta regions of India has stood out as the reason for undertaking this study in major prisons of this multi hazardous region. The different criminal activities among the youth are becoming one of the most important economic and political issue in the coming decades of Southern India, especially when it has a negative impact on the economic growth and has displaced lives and livelihoods of the public. This intention of committing crimes has led to decline in 'security' and 'social capital' which are the two main prerequisites for the development and progress in any society, and lacking them may end up in recession and increased crime.


Sukla P.,Shri Satya Sai Medical College and Research Institute | Sharma K.D.,Gsl Medical College And General Hospital | Rana M.,Medical College and Hospital | Zaidi S.H.N.,Shri Satya Sai Medical College and Research Institute
Indian Journal of Community Health | Year: 2013

Polio eradication continues to be a priority in the South-East Asia Region. For developing countries, considering that the practice of open defecation and fecal contamination of drinking water easily precipitates virus transmissions, the eradication of polio called for rounds after rounds of campaign. In the districts of western Uttar Pradesh (UP), in India, which continues to be polio endemic, key challenge is the low levels of sanitation and personal hygiene. The residents of polio endemic areas are now reluctant to frequent pulse polio immunization rounds and are using these rounds to raise their voice against chronic apathy to providing the basic amenities such as adequate sanitation facilities. Newer initiatives such as Urban Sanitation and Hygiene Action (USHA) Project, in western UP and "107 block" campaign launched in UP and Bihar aiming to improve sanitation, water quality and routine immunizations in the high risk polio endemic administrative blocks have the potential to significantly strengthen eradication efforts, especially in high risk areas for wild poliovirus transmission in North India.


Lavakumar S.,Shri Satya Sai Medical College and Research Institute | Manimekalai K.,Mahatma Gandhi Institute | Karthikeyan K.,Mahatma Gandhi Institute
International Journal of Pharma and Bio Sciences | Year: 2015

Despite effective antibiotics treatment, mortality due to neonatal sepsis remains high. Immunomodulatory therapy like intravenous immunoglobulin (IV Ig) has been used as an adjunct in an effort to decrease mortality from neonatal sepsis, as newborn infants, particularly those who are preterm and are deficient in IgG. The objective of this study was to assess the outcome of intravenous immunoglobulin therapy as an adjuvant in the treatment of neonatal sepsis. A total of 42 babies who were given IV Ig as an adjuvant along with antibiotics for proven neonatal sepsis formed the potential subjects. Clinical and hematological parameters were assessed following IV Ig administration. The total duration of Neonatal intensive care unit stay was noted. The source, dose, frequency and adverse effects, if any of IV Ig were noted. In our study, both male and female babies were equally affected. More than 90% of the babies were preterm and all the babies had low birth weight. The source of IV Ig was IgG, obtained from pooled human plasma. It was given at the dose of 0.5-0.9 g/kg. No adverse reaction following IV Ig was noted. Following IV Ig administration as an adjuvant in treatment of neonatal sepsis, the improvement in clinical and hematological parameters were better and quicker. The average duration of hospitalization was 6-8 days when IV Ig was given as an adjuvant. Thus duration of NICU stay was less when compared to being treated with antibiotics alone. Hence to conclude, IV Ig as an adjuvant along with antibiotics is a better strategy for both prophylactic as well as treatment of proven neonatal sepsis.


Khan D.M.,Shri Satya Sai Medical College and Research Institute | Manimaran D.,Shri Satya Sai Medical College and Research Institute | Bharathi K.,Shri Satya Sai Medical College and Research Institute | Tulasi Raman R.,Shri Satya Sai Medical College and Research Institute | And 4 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Papillary carcinoma of the thyroid was regarded previously as a single group with indolent clinical course and excellent prognosis. This view has changed. Recent histopathological reports emphasize that papillary carcinoma should be further classified into its variants because of the prognostic implications. We report its incidence, clinical behaviour and outcome of variants of papillary thyroid cancers at Narayana Medical College, Nellore. To study the incidence, age and gender of variants of papillary thyroid carcinoma and to analyze the results with published data. These cases were received in the surgical pathology laboratory of Narayana Medical College, Nellore from July 2006-June 2008. We have reviewed clinical case sheets, microscopic slides and histopathological reports of these carcinomas. Accordingly we report our experience of different variants, a series of 37 papillary carcinoma. The following results have been obtained:19 cases were Classical (usual) papillary carcinoma, 8 Follicular variant, 4 Diffuse sclerosing variant, 3 Encapsulated variant, 2 Mixed tall cell columnar cell variant and 1 Tall cell variant. These variants differ from each other not only on a morphologic basis, but also in clinical behavior and prognosis. Rightly subtyped histopathological report will help the clinicians for its management and prognostic implications.


Bharathi K.,Shri Satya Sai Medical College and Research Institute | Ajay Chandrasekar V.S.,Shri Satya Sai Medical College and Research Institute | Hemanathan G.,Shri Satya Sai Medical College and Research Institute | Anuradha S.,Shri Satya Sai Medical College and Research Institute
Journal of Clinical and Diagnostic Research | Year: 2014

Myofibroblastoma is a rare benign mesenchymal tumour of the breast commonly reported in males. It is a spindle cell neoplasm exhibiting myofibroblastic differentiation with characteristic immunohistochemical staining. Herein, we present a case of myofibroblastoma in a premenopausal female which was mimicking like malignancy clinically. Lump was growing rapidly in size measuring 8 cm × 6 cm and stony hard in consistency. Mammogram showed a large homogeneous hyperdense lump suggestive of fibroadenoma, Hamartoma and fibromatosis. FNAC and trucut biopsy of mass could not be done due to stony hard consistency. Hence excision biopsy was done. Histopathological examination revealed the tumour as myofibroblastoma. Immunohistochemical staining for markers of myofibroblasts like CD-34 and Vimentin showed strong positivity. A negative expression for cytokeratin was noted. This case is presented for its rarity, unusual clinical presentation and stony hard consistency.


Begum R.,Chettinad hospital and Research institute | Shree R.,Shri Satya Sai Medical College and Research institute
International Journal of Pharma and Bio Sciences | Year: 2016

This study was undertaken to determine the correlation between brain natriuretic peptide (BNP) and red cell distribution width (RDW) in the acute coronary syndrome. It was done on hundred adult patients who were diagnosed with acute coronary syndrome and hospitalized in the Coronary care unit in Chettinad Hospital Research and Institute (CHRI), Kelambakkam. Patients were selected based on the inclusion criteria. 1) ST-segment elevation and ST-segment depression proven by electrocardiography. 2) Acute failure shows an ejection fraction less than 50% proven by echocardiography 3) Serum BNP levels > 400 pg/mL Complete blood count and biochemical markers which include BNP, Troponin I, CPKMB were used for analyses within less than 24 hours of admission. The correlation between the three outcome variables and the explanatory variables was assessed by calculating correlation coefficients and its P-value and 95% CI. The study observations are as follows: A) The mean age was older and there were more males in the ACS study group. b) RDW showed statistically significant positive correlation with BNP levels (correlation coefficient 0.147, p value < 0.001) c) There was a weak positive correlation between Total leucocytes count and BNP levels (Correlation coefficient 0.013) and it was statistically not significant (P value 0.267). To conclude, Elevated RDW levels is independently associated with a higher BNP level in patients with acute coronary syndrome. RDW has been proven to be as good as BNP.


PubMed | Shri Satya Sai Medical College and Research Institute
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2014

Myofibroblastoma is a rare benign mesenchymal tumour of the breast commonly reported in males. It is a spindle cell neoplasm exhibiting myofibroblastic differentiation with characteristic immunohistochemical staining. Herein, we present a case of myofibroblastoma in a premenopausal female which was mimicking like malignancy clinically. Lump was growing rapidly in size measuring 8 cm x 6 cm and stony hard in consistency. Mammogram showed a large homogeneous hyperdense lump suggestive of fibroadenoma, Hamartoma and fibromatosis. FNAC and trucut biopsy of mass could not be done due to stony hard consistency. Hence excision biopsy was done. Histopathological examination revealed the tumour as myofibroblastoma. Immunohistochemical staining for markers of myofibroblasts like CD-34 and Vimentin showed strong positivity. A negative expression for cytokeratin was noted. This case is presented for its rarity, unusual clinical presentation and stony hard consistency.


PubMed | Shri Satya Sai Medical College and Research Institute
Type: Journal Article | Journal: Tropical parasitology | Year: 2013

Enterobius vermicularis is one of the most common intestinal nematode worldwide. Enterobius rarely causes a symptomatic disease. We report here an unusual case of a 60-year old man who came with a polypoidal growth in the anal canal increasing in size for past 20 years. He had pain and intense itching over the mass. The differential diagnosis of squamous papilloma, fibroma and foreign body granuloma were considered. The mass lesion was excised surgically and sent to the pathology laboratory. The mass turned out to be an E. vermicularis worm granuloma by histopathologic examination. Thus, timely reporting and surgical resection of such lesion is necessary to prevent further complications. This case is reported here for the unusual presentation of pinworm as a pseudoneoplasm in the anal canal. Incidence of these cases reflected the poor personal hygiene and improper disposal of human excreta in the rural areas. We insist that health education is the only way to control the spread of helminthic infections that causes a heavy disease burden to our country.


PubMed | Shri Satya Sai Medical College and Research Institute
Type: | Journal: Advanced biomedical research | Year: 2014

Oculosporidiosis caused by Rhinosporidium seeberi is a common infectious disease of south India. Here we are reporting a rare case of oculosporidial polyp containing another parasite Enterobius vermicularis as a co infection. This is the first report of its kind in literature. A nine year old school going girl from a rural area presented with a reddish polypoidal lesion from conjunctiva along with complaints of severe itching over it. On examination, the polyp measured 5 mm 5 mm in size, reddish, granular with a tendency to bleed on touch. Her vision was normal. All the basic investigations were within normal limits. A differential diagnosis of conjunctival papilloma, foreign body granuloma and oculosporidiosis were considered clinically. The polyp was removed completely using electro cautery with healthy margins around the lesion. To our surprise histopathological examination of the swelling revealed the presence of two different parasites in the conjunctival polyp. Sections showed sporangia of Rhinosporidium seeberi, fragments of Enterobius vermicularis and its eggs. She was then treated with anti helminthic drugs. Two months of follow up till now showed no recurrence of the lesion.

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