Shri sarvajanik Pharmacy College

Mehsana, India

Shri sarvajanik Pharmacy College

Mehsana, India
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Samixa Rameshbhai P.,RK University | Samixa Rameshbhai P.,Atmiya Institute of Pharmacy | Chhaganbhai Nanjibhai P.,Shri Sarvajanik Pharmacy College
Asian Journal of Pharmaceutical Research and Health Care | Year: 2013

The present paper describes simple, accurate, rapid, precise and sensitive UV spectrophotometric absorption correction method for the simultaneous determination of amlodipine and aliskiren in combined tablet dosage form. methanol was used as solvent. The wavelengths selected for the analysis using absorption correction method were 354.5 nm and 256.0 nm for estimation of amlodipine and aliskiren respectively. Beer's law obeyed in the concentration range of 10-60 μg/mL and 20-120 μg/mL for amlodipine and aliskiren, respectively. The mean percentage drug content for amlodipine and aliskiren were found to be 99.9. ± 1.38 and 99.87 ± 1.25 respectively and the % RSD value was found to be less than 2 which shows the precision of method. The high recovery and low coefficients of variation conforms the suitability for the routine quality control analysis of amlodipine and aliskiren in pure and pharmaceutical dosage forms.

Tiwari P.,Shri Sarvajanik Pharmacy College
Pharmacologyonline | Year: 2012

The present study was designed to evaluate the cardio protective activity of Ashwagandharishta-T, Ashwagandahrishta-M prepared by traditional and modern methods respectively and its marketed preparation on isoproterenol (ISO) induced myocardial infarction (MI) in albino rats. Wistar albino rats of either sex were randomly divided into 06 groups comprising 06 animals in each group as normal control, ISO control, pretreatment with Inderal*10 (10 mg/kg) per os, pretreatment with Ashwagandharishta-T, M and its marketed preparation at the dose of 2 ml/kg per os per day for 30 days. MI was induced in all the groups except normal control, by administering ISO (85 mg/kg) intraperitoneally, on 29th and 30th day. On 31st day, level of serum marker enzymes was determined and serum lipid profile was also measured. Then, animals were subsequently sacrificed, hearts were removed, weighed and immediately processed for biochemical studies. Pretreatment with Inderal*10 and all the test preparations of Ashwagandharishta significantly prevented the ISO-induced adverse changes in the levels of serum marker enzymes as creatine kinase (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and also improved serum lipid profile. All the test formulations pretreated groups showed significant increase in glutathione (GSH) content and significantly reduced malonyldialdehyde (MDA). Thus, experimental finding suggests that the cardio protective activity of Ashwagandharishta-T, M and its marketed preparation may be due to an augmentation of endogenous antioxidants as GSH and inhibition of lipid peroxidation of cardiac membrane.

Jani R.,Gujarat University | Jani R.,Shri Sarvajanik Pharmacy College | Patel D.,Shri Sarvajanik Pharmacy College
Asian Journal of Pharmaceutical Sciences | Year: 2014

Over the recent few decades, many groups of formulation scientists are concentrating on rapid release dosage forms in oral cavity. Among all fast release dosage forms, orodispersible films are successful to attract pharmaceutical industry due to ease of formulation and extension patent life. Films are popular in patients too because of quick onset and user friendliness of dosage form. From the beginning, solvent casting has been selected as method of choice for manufacturing of orodispersible films. Solvent casting has been proved as a benchmark technology because of ease in product development, process optimization, process validation and technology transfer to production scale despite of some drawbacks like more number of unit operations involved and consumption of large quantity of solvents with controlled limits of organic volatile impurities in final formulation. The application of hot-melt extrusion (HME) in the pharmaceutical industry is consecutively increasing due to its proven innumerable advantages like solvent free continuous process with fewer unit operations and better content uniformity. Very few development activities has been initiated in the field of hot melt extruded orodispersible films so far. This extensive review covers detailed discussion of heavy duty industrial extruders, selection of downstream equipments, selection of excipients, common problems found in formulations and their remedies. Successive part of review addresses identification of critical quality attributes, quality target profile of product, criticality in selection of process parameters and material for substantial simulation in laboratory scale and production for successful technology transfer. © 2015 The Authors.

Patel S.,Shri Sarvajanik Pharmacy College | Patel C.,Shri Sarvajanik Pharmacy College | Patel V.,Shri Sarvajanik Pharmacy College
Indian Journal of Pharmaceutical Sciences | Year: 2013

A simple, sensitive, specific, accurate, and stability-indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of aspirin and prasugrel, using a Kromasil 100 C 18 (150×4.6 mm, 5 μ) column and a mobile phase composed of acetonitrile:methanol:water (30:10:60, v/v), pH 3.0 adjusted with o-phosphoric acid. The retention times of aspirin and prasugrel were found to be 3.28 min and 6.61 min, respectively. Linearity was established for aspirin and prasugrel in the range of 15-150 and 2-20 μg/ml, respectively. The percentage recoveries of aspirin and prasugrel were found to be in the range of 99.34-100.32% and 98.92-102.09%, respectively. Both the drugs were subjected to acid, alkali and neutral hydrolysis, oxidation, dry heat, and UV degradation. The degradation studies indicated aspirin to be more susceptible to alkaline hydrolysis, while prasugrel to be more susceptible to neutral hydrolysis. The degradation products were well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for simultaneous quantitative analysis of aspirin and prasugrel in bulk drugs and formulations.

Shah J.S.,Shri Sarvajanik Pharmacy College | Goyal R.K.,M. S. University of Baroda
Journal of Young Pharmacists | Year: 2011

Objective: To investigate the neuropsychopharmacological effect of a polyherbal formulation (PHF) on the learning and memory processes in rats. Materials and Methods: PHF contains Withania somnifera (Ashwagandha), Nardostachys jatamansi (Jatamansi), Rauwolfia serpentina (Sarpagandha), Evolvulus alsinoides (Shankhpushpi), Asparagus racemosus (Shatavari), Emblica officinalis (Amalki), Mucuna pruriens (Kauch bij extract), Hyoscyamus niger (Khurasani Ajmo), Mineral resin (Shilajit), Pearl (Mukta Shukhti Pishti), and coral calcium (Praval pishti). Its effect (500 mg / kg, p.o.) on the learning and memory processes was tested. The activity of PHF on memory acquisition and retention was studied using passive avoidance learning and elevated plus maze model (EPM) in rats. Results: The animals treated with PHF showed a significant decrease in transfer latency as compared to the control group in EPM. PHF also produced significant improvement in passive avoidance acquisition and memory retrieval, as compared to the controls and reduced the latency to reach the shock free zone (SFZ) after 24 hours. Conclusion: The PHF produces significant improvement in passive avoidance acquisition and memory retrieval in rats, which needs further investigation.

Shastri D.,K B Institute Of Pharmaceutical Education And Research | Prajapati S.,Shri Sarvajanik Pharmacy College
Acta Pharmaceutica | Year: 2010

The purpose of the study was to develop an optimized thermoreversible in situ gelling ophthalmic drug delivery system based on Pluronic F 127, containing moxifloxacin hydrochloride as a model drug. A 32 full factorial design was employed with two polymers: Pluronic F 68 and Gelrite as independent variables used in combination with Pluronic F 127. Gelation temperature, gel strength, bioadhesion force, viscosity and in vitro drug release after 1 and 10 h were selected as dependent variables. Pluronic F 68 loading with Pluronic F 127 was found to have a significant effect on gelation temperature of the formulation and to be of importance for gel formation at temperatures 33-36 °C. Gelrite loading showed a positive effect on bioadhesion force and gel strength and was also found helpful in controling the release rate of the drug. The quadratic mathematical model developed is applicable to predicting formulations with desired gelation temperature, gel strength, bioadhesion force and drug release properties.

Patel D.B.,Shri Sarvajanik Pharmacy College
Journal of Global Pharma Technology | Year: 2010

Atrigel® system is a proven sustained-release drug delivery platform that delivers therapeutic levels of a wide spectrum of drugs over a few days to several months with a single injection. Atrigel system is use for both parenteral and site-specific drug delivery. The ease of manufacture of the Atrigel system and its relatively pain-free subcutaneous injection into the body provide significant advantages over both solid implants and microparticles. Most of the standard biodegradable polymers can be used in the Atrigel technology. The hydrophilic solvents employed in the Atrigel system to dissolve the polymers. The low-molecular-weight polymers at low polymer concentrations can be easily injected into the body using standard needles. The high molecular-weight polymers at high polymer concentrations may be used as gels or putties that can be placed into sites in the body where they solidify and provide support. Atrigel technology provides a more stable, ready-to-use formulation. © 2009, JGPT.

Patel B.N.,Shri Sarvajanik Pharmacy College | Suhagia B.N.,JKK Nataraja Dental College and Hospital
International Journal of PharmTech Research | Year: 2012

A simple and accurate method to determine Darunavie ethanolate (DRV) and ritonavir (RTV), in binary mixture, was developed and validated using liquid chromatography (LC). The LC separation was achieved on a Phenomenex Luna C18 column (250 mm, 4.6mm i.d., 5μm), in the isocratic mode using acetonitrile: water (60: 40, v/v), pH adjusted to 3.2 ± 0.02 with formic acid at a flow rate of 1 mL/min. The retention times were about 5.02 and 7.60 min for DRV and RTV, respectively. Quantification was achieved with UV-visible detector at 245 nm over the concentration range of 6-60 and 2-20 μg/mL for DRV and RTV respectively, with mean recoveries of 99.54-100.18 % and 99.16-100.20 % for DRV and RTV, respectively. The method was validated, and was found to be simple, specific, accurate, precise and robust. The method was successfully applied for the determination of DRV and RTV in binary mixture without any interference from common excipients.

Kapadia K.B.,Shri Sarvajanik Pharmacy College | Bhatt P.A.,JKK Nataraja Dental College and Hospital | Shah J.S.,Shri Sarvajanik Pharmacy College
Journal of Pharmacology and Pharmacotherapeutics | Year: 2012

Objective: To determine the association between altered thyroid hormones and insulin resistance (IR). Materials and Methods: Eight euthyroid (EU), eight hypothyroid (HO), and eight hyperthyroid (HR) patients with no past medical history were studied in this cross-sectional study at the Care Institute of Medical Sciences, Ahmedabad, India, The fasting blood sample were analyzed for thyroid stimulating hormone (TSH), lipid profile, insulin, and glucose. Homeostatic model assessment (HOMA) was calculated for assessing IR. Results: HOMA values were significantly higher in HR and HO groups as compared to the EU group (P < 0.05). Insulin levels were also found to be significantly increased in HR and HO groups as compared to the EU group (P < 0.05). Cholesterol, triglycerides (TG), and low density lipoprotein (LDL) were significantly raised in HO as compared to EU and HR groups (P < 0.05) whereas high density lipoprotein levels (HDL) were lower. HOMA and insulin were found to be positively correlated with TSH in HO and negatively in HR. Conclusion: Thyroid disorder, including both hypo- and hyper have been associated with IR due to various mechanisms such as altered insulin secretion and lipid levels. IR was comparable in patients with both HO and HR. Although HO and HR constitute an IR state, more studies need to be done in order to clarify the underlying pathogenic mechanism. Thus, an altered thyroid state can lead to IR leading to glucose-related disorder such as diabetes dyslipidemia.

Chavda H.V.,Shri Sarvajanik Pharmacy College | Patel C.N.,Shri Sarvajanik Pharmacy College
Trends in Biomaterials and Artificial Organs | Year: 2010

The synthesis of superporous hydrogel composites (SPHCs) with carboxylmethylcellulose sodium (NaCMC) as a composite material was carried out by solution polymerization. The characterization studies were performed by measurement of apparent density, swelling studies, mechanical strength studies, and scanning electron microscopy (SEM). In double distilled water SPHCs showed tremendous increase in equilibrium swelling capacity. But, when SPHCs were placed in simulated gastric fluid showed less equilibrium swelling capacity. SPHCs showed improved penetration pressure as the NaCMC concentration increased. SEM images clearly indicate the formation of interconnected pore, capillary channels, and the adherence of NaCMC molecules around the periphery of pores. © Society for Biomaterials and Artificial Organs (India), 2010.

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