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Gupta A.,Pandit Ravishankar Shukla University | Kaur C.D.,Pandit Ravishankar Shukla University | Kaur C.D.,Shri Rawatpura Sarkar Institute of Pharmacy | Saraf S.,Pandit Ravishankar Shukla University
Artificial Cells, Nanomedicine and Biotechnology | Year: 2016

The aim of this study was to design a targeted drug delivery system carrying a natural anticancer drug Quercetin (Qu), specifically for skin cancer. A central composite design was applied separately for each ligand, and the quadratic model was used for the process. The surface morphology was confirmed by transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR), and in vitro release studies were also performed. The MTT assay was performed against two different cell lines, to measure their anticancer potentials and their targeting ability. The study thus reveals that MA-Qu-PLGA and FA-Qu-PLGA nanoparticles (NPs) can be used as effective drug delivery systems for skin cancer treatment encompassing natural drugs. © 2015 Informa Healthcare USA, Inc. Source


Saraf S.,Pandit Ravishankar Shukla University | Gupta A.,Pandit Ravishankar Shukla University | Kaur C.D.,Shri Rawatpura Sarkar Institute of Pharmacy | Jangde M.,Pandit Ravishankar Shukla University
Pakistan Journal of Biological Sciences | Year: 2014

Photosensitization is a process in which the skin reacts to exposure to ultraviolet radiations. There are various associated dennatological consequences like photoxicity and photoallergic reactions which make the disease more complicated. There are various drugs which together with solar radiations worsen the situation of photosensitivity and hence termed as photosensitizers. The developments on the use of phytoconstituents from the herbal extract is the ardent need for fighting against the deleterious photosensitization reactions. This review attempts to highlight the problems of photosensitivity its pathological manifestation with the approach to treat them naturally with the help of skin rejuvenating herbs. © 2014 Asian Network for Scientific Information. Source


Dhongade H.,Shri Rawatpura Sarkar Institute of Pharmacy
International Journal of Biological Macromolecules | Year: 2016

In the present work, an unreported graft copolymer of carboxymethyl xanthan gum and acrylamide has been synthesised by free radical polymerisation in a nitrogen atmosphere using ammonium persulphate as an initiator. The optimum reaction conditions adopted for affording maximum percentage of grafting including its grafting efficiency were obtained by varying the concentration of carboxymethyl xanthan gum from 4 to 24 g dm-3; ammonium persulphate from 5 × 10-4 to 30 × 10-4mol dm-3; acrylamide from 0.4 to 1.2 mol dm-3; reaction temperature from 55 to 75°C and reaction time from 30 to 90 min. The synthesised graft copolymer has been characterised by 1H NMR, FTIR spectroscopy, X-ray diffraction measurement, thermal analysis, viscosity measurement and scanning electron microscopy. However, grafting of acrylamide onto carboxymethyl xanthan gum backbone enhanced its thermal stability. This graft copolymer might be well exploited globally as a potential carrier for drug delivery system. © 2016 Elsevier B.V. Source


Singh M.K.,Shri Rawatpura Sarkar Institute of Pharmacy | Gidwani B.,Shri Rawatpura Sarkar Institute of Pharmacy | Gupta A.,Shri Rawatpura Sarkar Institute of Pharmacy | Dhongade H.,Shri Rawatpura Sarkar Institute of Pharmacy | And 2 more authors.
International Journal of Biological Chemistry | Year: 2015

In the genus Orthosiphon (Lamiaceae), Orthosiphon aristatus, Orthosiphon pallidus, Orthosiphon thymiflorus, Orthosiphon stamineus are widely used in traditional medicine to prevent different diseases such as diabetes, kidney stone, edema, rheumatism, hepatitis, hypertensive and jaundice. A different variety of phytoconstituents has been isolated from the Orthosiphon species which include monoterpenes, diterpenes, triterpenes, saponins, organic acid and flavonoids compound. Antidiabetic, anti-inflammatory, antioxidant, hepatoprotective, analgesic and nephroprotective activities have been reported in the plant extract and phytoconstituents. Hence, the purpose of this review is to provide a comprehensive report about the Orthosiphon genus based on its toxicity in order to identify its therapeutic potential and future prospects for betterment of research. © 2015 Academic Journals Inc. Source


Sahu S.,Shri Rawatpura Sarkar Institute of Pharmacy | Sahu S.,Pandit Ravishankar Shukla University | Saraf S.,Pandit Ravishankar Shukla University | Kaur C.D.,Shri Rawatpura Sarkar Institute of Pharmacy | Kaur C.D.,Pandit Ravishankar Shukla University
Pakistan Journal of Biological Sciences | Year: 2013

This study describes the release and retention of a herbal lipophilic drug in sustained and controlled manner in skin layers, given topically, intended for skin cancer. Quercetin -loaded nanoparticles were prepared by nanoprecipitation technique using ethylcellulose as polymer. Ethylcellulose was selected as it is biocompatible, but non-biodegradable and hence can act as a reservoir in skin furrows and ducts. It was observed that the Quercetin: Ethylcellulose: Tween 80 at different ratios affects particle sizes along with yield and entrapment efficiency. It was found that the size of nanoparticles could be varied by changing the speed of agitation and sonication. The nanoparticles were prepared in particle size range 228.77±2.0 nm and the zeta potential of the selected formulation were found to be -16.7 mV, which shows the stability of the preparation. The percent entrapment efficiency was found to be in the range from 51.96 to 53.93% and percent loading capacity in the range 34.19 to 5.12%. The amount of drug release from nanoparticles and of drug retained in skin was compared using ex vivo study which shows that the drug being lipophilic could be retained in the skin for longer duration thus reducing the dose and frequency of drug administration. Further the amount of drug reaching to other organs is also reduced since the systemic absorption of drug was low. Thus, Quercetin loaded nanoparticles were prepared for topical use. © 2013 Asian Network for Scientific Information. Source

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