Shri Ram Institute of Technology Pharmacy

Jabalpur, India

Shri Ram Institute of Technology Pharmacy

Jabalpur, India
SEARCH FILTERS
Time filter
Source Type

Sharma M.,Shri Ram Institute of Technology Pharmacy | Kohli S.,KN Polytechnic College | Pal A.,Siksha ‘O’ Anusandhan University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: To develop and evaluate floating microspheres of repaglinide (RG). Materials and Methods: RG loaded noneffervescent microspheres of different ratios of ethylcellulose (EC) and hydroxypropyl methylcellulose (HPMC K4M) were prepared using polyvinyl alcohol as emulsifier by solvent evaporation technique. Various process variables such as polymer ratio, stirring speed, concentration of drug, and emulsifying agent were studied. Compatibility of drug and polymers was studied by Fourier-transform infrared spectroscopy (FTIR). Characterization, in-vitro evaluation, and kinetic studies were performed. Results: FTIR spectra have revealed no drug-excipient incompatibility. The average particle size of microspheres was in the range of 312-359 µm. The results showed that floating microspheres were successfully prepared with good yield (56.15-64.3%), high entrapment efficiency (58.22-70.14%), and good floating behavior (63.1-76.2%), respectively. In-vitro release data indicates appreciable amount of drug is released (62.28-73.27%) from the microspheres in gastric fluid. The mechanism of drug release founds to follow first order kinetics (r2=0.986). Conclusion: The developed floating microspheres of RG may be used for prolonged drug release for at least 12 hrs, thereby improving bioavailability and patient compliance. © 2017 The Authors.


Ganeshpurkar A.,Gujarat Technological University | Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy
Chemico-Biological Interactions | Year: 2017

Diet and dietary intake can persuade the development, safeguard and proper functioning of immune system. Ruin, an important bioflavonoid, is abundantly found in various foodstuffs. Rutin has been acknowledged for its protective and beneficial effects on various aspects of the biological system. The present study was aimed to examine the effect of rutin on the regulation of the immune response in experimental animal models. Effect of rutin of cellular immunity was determined by delayed-type hypersensitivity (DTH) response, carbon clearance assay, leucocyte mobilization test, and cyclophosphamide-induced myelosuppression, whereas humoral immunity was analyzed by the haemagglutinating antibody (HA) titre assay. Rutin (25, 50 and 100 mg/kg, p.o.) evoked a significant increase in antibody titre in the haemagglutination test, increased immunoglobulin levels, and enhanced the delayed type hypersensitivity reaction induced by sheep red blood cells. It also significantly restored the functioning of leucocytes in cyclophosphamide treated rats and augmented phagocytic index in the carbon clearance assay. The outcomes from the present study indicate that rutin possesses sufficient potential for increasing immune activity by cellular and humoral mediated mechanisms. © 2017


Ganeshpurkar A.,Gujarat Technological University | Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Saluja A.K.,Gujarat Technological University
Saudi Pharmaceutical Journal | Year: 2017

The contemporary scientific community has presently recognized flavonoids to be a unique class of therapeutic molecules due to their diverse therapeutic properties. Of these, rutin, also known as vitamin P or rutoside, has been explored for a number of pharmacological effects. Tea leaves, apples, and many more possess rutin as one of the active constituents. Today, rutin has been observed for its nutraceutical effect. The present review highlights current information and health-promoting effects of rutin. Along with this, safety pharmacology issues and SAR of the same have also been discussed. © 2016 The Authors


Yadav P.,Shri Ram Institute of Technology Pharmacy | Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Rai G.,Guru Ramdas Khalsa Institute of Science and Technology
Pharmacognosy Research | Year: 2012

Objective: This study was undertaken to study in vitro H +-K + ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Materials and Methods: Total phenolic and flavonoid contents from extract was quantified and H +-K + ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. Results: Extract showed significant (FNx01P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. Conclusions: These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.


Kohli S.,K N Polytechnic College | Sharma M.,Shri Ram Institute of Technology Pharmacy | Pal A.,Siksha ‘O’ Anusandhan University
International Journal of Applied Pharmaceutics | Year: 2017

Objective: To develop and evaluate floating type gastro-retentive dosage form, appropriate for controlled release of repaglinide (RG) having a narrow therapeutic window. Methods: Repaglinide loaded microspheres (MS) using biological macromolecule ethylcellulose (EC) was prepared by a solvent diffusion-evaporation technique using polyvinyl alcohol (PVA) emulsifier. Compatibility of drug and polymer was studied by Fourier-transform infrared spectroscopy (FTIR). During formulation, various process optimisation parameters studied were stirring speed, the concentration of drug, polymer and emulsifier. Characterization and in vitro evaluation was performed. In vivo antidiabetic activity was performed on alloxan induced diabetic rats followed by histopathological screening. Results: The average particle size was in the range of 174-243 μm. Yield, entrapment and buoyancy of microspheres were 68.4-79.8, 58.6-73.1 and 71.8-84.1% respectively. 65.1% release of drug from optimised formulation was obtained which follows first-order kinetics (r2 = 0.989). Optimised formulation treated group shows significant (p<0.01) decrease in glucose level of blood as compared to pure drug treated group during the later hours of study with satisfactory results of histology. Conclusion: The investigation revealed the promising potential of gastro retentive microspheres for delivering RG for the treatment of non-insulin dependent diabetes mellitus (NIDDM). © 2016 The Authors.


Sharma M.,Shri Ram Institute of Technology Pharmacy | Sharma M.,Shiksha usandhan University | Kohli S.,P.A. College | Dinda A.,Shiksha usandhan University
Saudi Pharmaceutical Journal | Year: 2015

During the study repaglinide encapsulated floating microspheres were formulated and characterized for enhancing residence time of drug in git and thereby increasing its bioavailability. Floating microspheres of ethylcellulose (EC) and hydroxypropyl methyl cellulose (HPMC) (5 and 100. cps) were prepared by emulsion solvent diffusion technique. During process optimization various parameters were studied such as: drug: polymer ratio, polymer ratio, concentration of emulsifier and stirring speed. Selected optimized formulations were studied for SEM, entrapment, floating behavior, drug release and kinetics. In-vivo floating ability (X-ray) study and in-vivo antidiabetic activity were performed on alloxan induced diabetic rats. Microspheres prepared with different viscosity grade HPMC were spherical shaped with smooth surface. Size of microspheres was in the range of 181.1-248. μm. Good entrapment and buoyancy were observed for 12. h. X-ray image showed that optimized formulation remained buoyant for more than 6. h. Optimized formulation treated group shows significant (. p<. 0.01) reduction in blood glucose level as compared to pure drug treated group. Repaglinide loaded floating microspheres expected to give new choice for safe, economical and increased bioavailable formulation for effective management of NIDDM. © 2015 The Authors.


Bhadoriya S.S.,Shri Ram Institute of Technology Pharmacy | Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Narwaria J.,Shri Ram Institute of Technology Pharmacy | Rai G.,Shri Ram Institute of Technology Pharmacy | Jain A.P.,Shri Ram Institute of Technology Pharmacy
Pharmacognosy Reviews | Year: 2011

Tamarindus is a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the Indian subcontinent. Tamarind fruit was at first thought to be produced by an Indian palm, as the name Tamarind comes from a Persian word "Tamar-I-hind," meaning date of India. Its name "Amlika" in Sanskrit indicates its ancient presence in the country. T.indica is used as traditional medicine in India, Africa, Pakistan, Bangladesh, Nigeria,and most of the tropical countries. It is used traditionally in abdominal pain, diarrhea and dysentery, helminthes infections, wound healing, malaria and fever, constipation, inflammation, cell cytotoxicity, gonorrhea, and eye diseases. It has numerous chemical values and is rich in phytochemicals, and hence the plant is reported to possess antidiabetic activity, antimicrobial activity, antivenomic activity, antioxidant activity, antimalarial activity, hepatoprotective activity, antiasthmatic activity, laxative activity, and anti-hyperlipidemic activity. Every part of the plant from root to leaf tips is useful for human needs. Thus the aim of the present review is to describe its morphology, and explore the phytochemical constituents, commercial utilization of the parts of the plant, and medicinal and pharmacologic activities so that T. indica's potential as multipurpose tree species can be understood.


Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Kohli S.,P.A. College | Rai G.,Guru Ramdas Khalsa Institute of Technology and Science
International Journal of Medicinal Mushrooms | Year: 2014

This study was designed to examine the antihyperglycemic potential of the polysaccharide fraction of Pleurotus florida. Hyperglycemia was induced by streptozotocin (50 mg/kg intraperitoneal). Single- and multiple-dose studies were performed to assess the antihyperglycemic potential of the P. florida polysaccharides (PFPs). Organisation for Economic Co-operation and Development guideline 423 was followed to study the acute toxicity of PFP. PFP was found to be nontoxic up to 4000 mg/kg. In this investigation, 200- and 400-mg/kg doses of PFP were used. Blood glucose, serum cholesterol, triglycerides, urine glucose and ketones, and glycosylated hemoglobin were estimated, and biological markers were determined. Treatment with PFP (200 and 400 mg/kg) significantly lowered glucose concentrations compared to the control group. Serum cholesterol, triglycerides, and urine glucose and ketones in animals treated with PFP also decreased. There was a significant decrease in the concentrations of malondialdehyde and nitric oxide, whereas concentrations of superoxide dismutase, catalase, and reduced glutathione were restored. Therefore, these results suggest that PFPs may ameliorate hyperglycemia and hypercholesteremia associated with diabetes. Thus PFPs could be used as adjunct therapy along with first-line therapy in type 2 diabetes mellitus. © 2014 Begell House, Inc.


Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Rai G.,Shri Ram Institute of Technology Pharmacy | Jain A.,Shri Ram Institute of Technology Pharmacy
Pharmacognosy Reviews | Year: 2010

The arising awareness about functional food has created a boom in this new millennium. Mushrooms are widely consumed by the people due to their nutritive and medicinal properties. Belonging to taxonomic category of basidiomycetes or ascomycetes, these mushrooms possess antioxidant and antimicrobial properties. They are also one of the richest source of anticancer and immunomodulating agents. Thus these novel myochemicals from these mushrooms are the wave of future.


Dubey S.,Shri Ram Institute of Technology Pharmacy | Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Bansal D.,Shri Ram Institute of Technology Pharmacy | Dubey N.,Shri Ram Institute of Technology Pharmacy
Indian Journal of Pharmacology | Year: 2015

Aim: The severity of adverse reactions due to antiepileptics is observed during initiation and early treatment in which impairment of cognitive effects are common. Since long time, herbal medicine is a natural remedy to treat neural symptoms. Phytochemicals have been proven to be potent neuro-protective agents. Rutin, a bioflavonoid is established to be nootropic in many studies. In this study, we aimed to determine the protective effect of rutin in zebrafish against the side effects produced by AEDs. Materials and Methods: Seizures were induced in zebrafish by phenylenetetrazole. Rutin pretreatment (50 mg/kg, single injection, i.p.) was done before commencement of the study. Behavioral studies were performed as: latency to move high in the tank, locomotion effects, color effect, shoal cohesion, light/dark test on Zebrafish. Results: Treatment with rutin reverted the locomotor behavior to normal. Treatment with AEDs caused fishes to move in all regions while, in case of treatment with rutin, the response reverted to normal. Treatment with AEDs altered swimming behavior of zebrafish, however, rutin showed a positive effect over this behavior. Treatment with AEDs resulted in restricted movement of zebrafish to the dark zone. Treatment with rutin caused increased latency of zebrafish to move in the light compartment. Similarly, time spent in the light compartment by zebrafish treated with rutin was significantly (P < 0.01) higher as compared to zebrafish treated with AEDs. Conclusion: The results suggest a protective role of rutin on cognition impaired by AEDs. © 2015, Medknow Publications. All rights reserved.

Loading Shri Ram Institute of Technology Pharmacy collaborators
Loading Shri Ram Institute of Technology Pharmacy collaborators