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Sharma M.,Shri Ram Institute of Technology Pharmacy | Kohli S.,KN Polytechnic College | Pal A.,Siksha ‘O’ Anusandhan University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2017

Objective: To develop and evaluate floating microspheres of repaglinide (RG). Materials and Methods: RG loaded noneffervescent microspheres of different ratios of ethylcellulose (EC) and hydroxypropyl methylcellulose (HPMC K4M) were prepared using polyvinyl alcohol as emulsifier by solvent evaporation technique. Various process variables such as polymer ratio, stirring speed, concentration of drug, and emulsifying agent were studied. Compatibility of drug and polymers was studied by Fourier-transform infrared spectroscopy (FTIR). Characterization, in-vitro evaluation, and kinetic studies were performed. Results: FTIR spectra have revealed no drug-excipient incompatibility. The average particle size of microspheres was in the range of 312-359 µm. The results showed that floating microspheres were successfully prepared with good yield (56.15-64.3%), high entrapment efficiency (58.22-70.14%), and good floating behavior (63.1-76.2%), respectively. In-vitro release data indicates appreciable amount of drug is released (62.28-73.27%) from the microspheres in gastric fluid. The mechanism of drug release founds to follow first order kinetics (r2=0.986). Conclusion: The developed floating microspheres of RG may be used for prolonged drug release for at least 12 hrs, thereby improving bioavailability and patient compliance. © 2017 The Authors.


Shukla S.,Shri Ram Institute of Technology Pharmacy | Jain D.,Shri Ram Institute of Technology Pharmacy | Verma K.,SGSITS | Verma S.,Shri Ram Institute of Technology Pharmacy
Asian Journal of Pharmaceutics | Year: 2010

The aim of the research work was to develop cyst-targeted alginates microspheres of diloxanide furoate (DF) for the effective treatment of amoebiasis. Calcium alginates microspheres of DF were prepared using emulsification method using calcium chloride as a cross-linking agent. Alginate is a natural polysaccharide found in brown algae. Alginates are widely used in the food and pharmaceutical industries and have been employed as a matrix for the entrapment of drugs, macromolecules and biological cells. Alginate microspheres produced by the emulsification method using calcium chloride. Formulations were characterized for particle size and shape, surface morphology, entrapment efficiency, and in vitro drug release in simulated gastrointestinal fluids. XRD and differential scanning calorimetery were used to confirm successful entrapment of DF into the alginates microspheres. All the microsphere formulations showed good % drug entrapment (73.82±1.99). Calcium alginate retarded the release of DF at low pH (1.2 and 4.5) and released microspheres slowly at pH 7.4 in the colon without colonic enzymes.


Bhadoriya S.S.,Shri Ram Institute of Technology Pharmacy | Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Narwaria J.,Shri Ram Institute of Technology Pharmacy | Rai G.,Shri Ram Institute of Technology Pharmacy | Jain A.P.,Shri Ram Institute of Technology Pharmacy
Pharmacognosy Reviews | Year: 2011

Tamarindus is a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the Indian subcontinent. Tamarind fruit was at first thought to be produced by an Indian palm, as the name Tamarind comes from a Persian word "Tamar-I-hind," meaning date of India. Its name "Amlika" in Sanskrit indicates its ancient presence in the country. T.indica is used as traditional medicine in India, Africa, Pakistan, Bangladesh, Nigeria,and most of the tropical countries. It is used traditionally in abdominal pain, diarrhea and dysentery, helminthes infections, wound healing, malaria and fever, constipation, inflammation, cell cytotoxicity, gonorrhea, and eye diseases. It has numerous chemical values and is rich in phytochemicals, and hence the plant is reported to possess antidiabetic activity, antimicrobial activity, antivenomic activity, antioxidant activity, antimalarial activity, hepatoprotective activity, antiasthmatic activity, laxative activity, and anti-hyperlipidemic activity. Every part of the plant from root to leaf tips is useful for human needs. Thus the aim of the present review is to describe its morphology, and explore the phytochemical constituents, commercial utilization of the parts of the plant, and medicinal and pharmacologic activities so that T. indica's potential as multipurpose tree species can be understood.


Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Kohli S.,P.A. College | Rai G.,Guru Ramdas Khalsa Institute of Technology and Science
International Journal of Medicinal Mushrooms | Year: 2014

This study was designed to examine the antihyperglycemic potential of the polysaccharide fraction of Pleurotus florida. Hyperglycemia was induced by streptozotocin (50 mg/kg intraperitoneal). Single- and multiple-dose studies were performed to assess the antihyperglycemic potential of the P. florida polysaccharides (PFPs). Organisation for Economic Co-operation and Development guideline 423 was followed to study the acute toxicity of PFP. PFP was found to be nontoxic up to 4000 mg/kg. In this investigation, 200- and 400-mg/kg doses of PFP were used. Blood glucose, serum cholesterol, triglycerides, urine glucose and ketones, and glycosylated hemoglobin were estimated, and biological markers were determined. Treatment with PFP (200 and 400 mg/kg) significantly lowered glucose concentrations compared to the control group. Serum cholesterol, triglycerides, and urine glucose and ketones in animals treated with PFP also decreased. There was a significant decrease in the concentrations of malondialdehyde and nitric oxide, whereas concentrations of superoxide dismutase, catalase, and reduced glutathione were restored. Therefore, these results suggest that PFPs may ameliorate hyperglycemia and hypercholesteremia associated with diabetes. Thus PFPs could be used as adjunct therapy along with first-line therapy in type 2 diabetes mellitus. © 2014 Begell House, Inc.


Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Rai G.,Shri Ram Institute of Technology Pharmacy | Jain A.,Shri Ram Institute of Technology Pharmacy
Pharmacognosy Reviews | Year: 2010

The arising awareness about functional food has created a boom in this new millennium. Mushrooms are widely consumed by the people due to their nutritive and medicinal properties. Belonging to taxonomic category of basidiomycetes or ascomycetes, these mushrooms possess antioxidant and antimicrobial properties. They are also one of the richest source of anticancer and immunomodulating agents. Thus these novel myochemicals from these mushrooms are the wave of future.


Dubey S.,Shri Ram Institute of Technology Pharmacy | Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Bansal D.,Shri Ram Institute of Technology Pharmacy | Dubey N.,Shri Ram Institute of Technology Pharmacy
Indian Journal of Pharmacology | Year: 2015

Aim: The severity of adverse reactions due to antiepileptics is observed during initiation and early treatment in which impairment of cognitive effects are common. Since long time, herbal medicine is a natural remedy to treat neural symptoms. Phytochemicals have been proven to be potent neuro-protective agents. Rutin, a bioflavonoid is established to be nootropic in many studies. In this study, we aimed to determine the protective effect of rutin in zebrafish against the side effects produced by AEDs. Materials and Methods: Seizures were induced in zebrafish by phenylenetetrazole. Rutin pretreatment (50 mg/kg, single injection, i.p.) was done before commencement of the study. Behavioral studies were performed as: latency to move high in the tank, locomotion effects, color effect, shoal cohesion, light/dark test on Zebrafish. Results: Treatment with rutin reverted the locomotor behavior to normal. Treatment with AEDs caused fishes to move in all regions while, in case of treatment with rutin, the response reverted to normal. Treatment with AEDs altered swimming behavior of zebrafish, however, rutin showed a positive effect over this behavior. Treatment with AEDs resulted in restricted movement of zebrafish to the dark zone. Treatment with rutin caused increased latency of zebrafish to move in the light compartment. Similarly, time spent in the light compartment by zebrafish treated with rutin was significantly (P < 0.01) higher as compared to zebrafish treated with AEDs. Conclusion: The results suggest a protective role of rutin on cognition impaired by AEDs. © 2015, Medknow Publications. All rights reserved.


Ganeshpurkar A.,Shri Ram Institute of Technology Pharmacy | Vaishya P.,Shri Ram Institute of Technology Pharmacy | Jain S.,Shri Ram Institute of Technology Pharmacy | Pandey V.,Shri Ram Institute of Technology Pharmacy | And 2 more authors.
Indian Journal of Dermatology | Year: 2014

Background: Amphotericin B (AmB) is among the gold standard antifungal agents used for the treatment of the wide range of fungal infections. However, the drug has various side-effects. Transdermal approach for the delivery of drug is one of the accepted and convenient modes of drug delivery. Aim: The current work was designed to formulate and to evaluate the AmB emulgel system. Materials and Methods: In the preparation of AmB emulgel, Carbopol 930 was used as a gel in this study. The formulation was evaluated for viscosity, spreadability, drug content, drug release and in vitro and in vivo antifungal testing. Results: AmB emulgel was found to penetrate skin effectively and without any irritation. Further, in vivo studies revealed effective therapeutic potential against Candida albicans induced dermal mycosis. Conclusions: The current work, for the first time, revealed effective delivery of AmB across the skin.


PubMed | Shri Ram Institute of Technology Pharmacy
Type: Journal Article | Journal: Journal of dietary supplements | Year: 2016

Amaranthus cruentus (Amaranthaceae) is one of the popularly grown leafy vegetables in the Indian subcontinent. Leaves of the plant are rich in polyphenols, tannins, flavonoids, steroids, terpenoids, saponins, and betalains. The plant also contains rich amounts of protein, calcium, iron, vitamins A, E, and C, and folic acid. The present work was undertaken to evaluate the antianemic effect of Amaranthus cruentus. Ethanol extract of Amaranthus cruentus was prepared. Acute oral toxicity of the extract was determined by Organization for Economic Cooperation and Development (OECD) Guideline 423. Doses of 200 and 400mg/kg were used in the present study. Phenylhydrazine (60mg/kg, intraperitoneal injection for three consecutive days) was used to induce anemia in rats. After anemia induction, animals were treated with standard preparation and extract. Amaranthus cruentus extract significantly aided in restoring the levels of red blood cells, white blood cells (WBCs), and hemoglobin. There was also an increase in hematocrit. Thus, it can be concluded that Amaranthus cruentus is a rich source of phytochemicals that are responsible for demonstrating hematopoietic effects. Isolation and structure elucidation of constituents, responsible for antianemic activity, is necessary to affirm the aforementioned effect.


PubMed | Shri Ram Institute of Technology Pharmacy and A & P Technology
Type: Journal Article | Journal: International journal of medicinal mushrooms | Year: 2016

This work was undertaken to evaluate in vitro antimicrobial and cytotoxic potential of Pleurotus ostreatus cv. Florida. Mushroom basidiocarps were extracted in water:ethanol (1:1, v/v), and the resulting extract was subjected to antimicrobial studies against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella oxytoca, Bacillus subtilis, and Candida albicans. Cytotoxic potential on viable human leukocytes was studied. In vitro results showed excellent antimicrobial and cytotoxic potentials of the mushroom extract. Thus, functional properties of P. ostreatus cv. Florida could be used in the search for novel therapeutics.


PubMed | Shri Ram Institute of Technology Pharmacy
Type: Comparative Study | Journal: Indian journal of pharmacology | Year: 2016

To study the effect of the co-administration of phenytoin (PHT) and rutin in comparison with PHT and piracetam (PIM) on seizure control, cognitive, and motor functions in mice.Increasing current electroshock seizure (ICES) test was used to evaluate the effect of the co-administration of PHT and PIM on convulsions. Cognitive functions in mice were assessed by a spontaneous alternation in behavior on a plus maze while motor functions were screened using rolling roller apparatus and by counting the number of arms entries on a plus maze. Brain acetyl-cholinesterase (AChE) activity was also estimated.The expression of data was done as mean standard error of the mean. The normally distributed data were subjected to one-way ANOVA followed by Dunnetts test. P < 0.05 was considered significant.The study showed that rutin when co-administered with PHT, significantly reversed PHT-induced reduction in spontaneous alternation without altering the efficacy of PHT against ICES, in both acute and chronic studies. Further, it also reversed PHT-induced increase in AChE activity.Rutin alleviated the PHT-induced cognitive impairment without compromising its antiepileptic efficacy.

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