Shri Ram Institute of Technology

Jabalpur, India

Shri Ram Institute of Technology

Jabalpur, India
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Bhadoriya S.S.,Adina Institute of Pharmaceutical science | Mishra V.,Dr Hari Singh Gour University | Raut S.,Adina Institute of Pharmaceutical science | Ganeshpurkar A.,Shri Ram Institute of Technology | Jain S.K.,Adina Institute of Pharmaceutical science
Scientia Pharmaceutica | Year: 2012

The present study aimed to investigate the anti-inflammatory and anti- nociceptive potential of a hydroethanolic extract of Tamarindus indica L. leaves (HTI) along with its possible mode of action. The anti-inflammatory activity of HTI was estimated by carrageenan-induced hind paw oedema in male Wistar albino rats. Furthermore, HTI was assessed to determine its effects on membrane stabilization. The antinociceptive action was determined by acetic acid-induced writhing, tail-flick, and the hot plate model. Oral administration of HTI at the dose of 500, 750, and 1000 mg/kg body weight produced significant (P< 0.01) anti-inflammatory as well as antinociceptive actions in a dose- dependent manner. Among all tested doses, 1000 mg/kg, p. o. reduced carrageenan-induced rat paw oedema at 1, 2, 3, and 4 h. Moreover, the 1000 mg/kg dose exhibited maximum percentage inhibition of acetic acid-induced writhing (48.9%), whereas standard drug diclofenac (25 mg/kg, p. o.) showed maximum inhibition (50.9%) of writhing. In the hot plate model, HTI (1000 mg/kg, orally) increased mean basal reaction time after 120 min (7.12±0.05 sec). In the tail flick model, HTI increased the maximum percentage of latency (36.06%), whereas the standard drug pethidine (4 mg/kg, intraperitoneally) showed maximum percentage of latency (43.85%) after 60 min. The findings of the present study supported anti-inflammatory and antinociceptive claims of T. indica as were mentioned in Indian traditional and folklore practices. © Bhadoriya et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria.


Dubey N.,Rajiv Gandhi University | Varshney R.,Institute of Nuclear Medicine and Allied Sciences | Shukla J.,All India Institute of Medical Sciences | Ganeshpurkar A.,Shri Ram Institute of Technology | And 4 more authors.
Drug Delivery | Year: 2012

Purpose: Neuroendocrine tumors often present a diagnostic and therapeutic challenge. We have aimed to synthesize and develop biodegradable nanoparticles of somatostatin analogue, octreotide for targeted therapy of human neuroendocrine pancreatic tumor. Methods: Direct solid phase peptide synthesis of octreotide was done. Octreotide loaded PCL/PEG nanoparticles were prepared by solvent evaporation method and characterized for transmission electron microscopy, differential scanning calorimetery (DSC), Zeta potential measurement studies. The nanoparticles were evaluated in vitro for release studies and peptide content. For biological evaluations, receptor binding & cytotoxicity studies were done on BON-1 neuroendocrine tumor cell line. Biodistribution of radiolabeled peptide and nanoparticles, tumor regression studies were performed on tumor-bearing mouse models. Results: We have synthesized and purified octreotide with the purity of 99.96% in our laboratory. PEG/PCL nanoparticles with an average diameter of 130-195 nm having peptide loading efficiency of 66-84% with a negative surface charge were obtained with the formulation procedure. Octreotide nanoparticles have a negative action on the proliferation of BON-1 cells. In vivo biodistribution studies exhibited major accumulation of octreotide nanoparticles in tumor as compared to plain octreotide. Octreotide nanoparticles inhibited tumor growth more efficiently than free octreotide. Conclusions: Thus, it was concluded that the PCL/PEG nanoformulation of octreotide showed high tumor uptake due to the enhanced permeation and retention (EPR) effect and then peptide ligand imparts targetability to the sst2 receptor and there by showing increase tumor growth inhibition. Selective entry of nanoparticles to the tumor also give the reduce side effects both in vivo and in vitro. © 2012 Informa Healthcare USA, Inc.


Priya P.,Shri Ram Institute of Technology | Pal J.A.,Shri Ram Institute of Technology | Aditya G.,Shri Ram Institute of Technology | Gopal R.,Shri Ram Institute of Technology
Pharmacognosy Journal | Year: 2010

The aim of the present study was to evaluate the antimicrobial, anti-oxidant and anthelmintic potential of extracts of the herb Solanum xanthocarpum. The antimicrobial activity was tested against selected bacterial and fungal species by agar well diffusion method and the antioxidant activity was assessed using FRAP and reducing power scavenging assays. While that of anthelmintic activity was performed against the erthworms. The FRAP assay evaluates the ability of a substance to reduce Fe3+ to Fe 2+. Preliminary phytochemical screening revealed the presence of saponins; phytosterols and carbohydrates in the plant. © 2010 Phcog.net.


Dubey V.,Shri Ram Institute of Technology | Sairam R.,Shri Ram Institute of Technology
International Conference on Advanced Computing and Communication Technologies, ACCT | Year: 2014

This paper presents a design of a 4-bit arithmetic logic unit (ALU) by taking vantage of the concept of gate diffusion input (GDI) technique. ALU is the most crucial and core component of central processing unit as well as of numbers of embedded system and microprocessors. In this, ALU consists of 4x1 multiplexer, 2x1 multiplexer and full adder designed to implements logic operations, such as AND, OR, etc. and arithmetic operations, as ADD and SUBTRACT. GDI cells are used in the design of multiplexers and full adder which are then associated to realize ALU. The simulation is carried out Tanner EDA 13.0 simulator using TSMC BSIM 250nm technologies and compared with previous designs realized with Pass transistor logic and CMOS logic. The simulation shows that the design is more efficient with less power consumption, less surface area and is faster as compared to pass transistor and CMOS techniques. © 2014 IEEE.


Ganeshpurkar A.,Shri Ram Institute of Technology | Rai G.,Guru Ramdas Khalsa Institute of Science and Technology
Indian Journal of Pharmacology | Year: 2013

Background: Edible mushrooms have been used as flavorful foods and as health nutritional supplements for several centuries. A number of bioactive molecules have been identified in numerous mushroom species Objective: To evaluate the analgesic and anti-inflammatory potential of Oyster Mushroom Pleurotus florida using various experimental models in Wistar rats. Materials and Methods: Acute toxicity studies were performed whereby dose of 250 mg/kg and 500 mg/kg was selected for present study, Analgesic activity was determined using hot plate method, tail flick method, acetic acid induced writhing and formalin induced pain in rats, while carrageenan was used to induce inflammation and anti-inflammatory studies were performed. Results: HEE showed significant (P < 0.01) analgesic and anti-inflammatory response against all experimental models. Conclusion: These studies conclude that Pleurotus florida possesses analgesic and anti-inflammatory potential which might be due to presence of myochemicals like flavonoids, phenolics and polysaccharides.


Choubey S.D.,Shri Ram Institute of Technology | Namdeo M.K.,Shri Ram Institute of Technology
Proceedings of the 2015 International Conference on Green Computing and Internet of Things, ICGCIoT 2015 | Year: 2015

Cloud computing is a rapidly growing model of computation. It is the delivery of computing services by shared resources, software and information over the network (Internet or Intranet). It allows user to store large amount of data in cloud storage and use as when required from any part of the world by networks. Cloud computing is network based technology since security issues like privacy, data security, confidentiality etc. are encountered. It has a number of users, who are using cloud services like social network, email, file-sharing and other which are increasing the data load in cloud storage regularly. It is also increasing the risk of data vulnerability. Therefore, the data security must be provided in cloud computing models. There are some solutions proposed, to resolve these issues, based on encryption techniques. The main contribution of this paper is to perform a study of different solutions to provide data security and privacy in existing cloud computing scenario. © 2015 IEEE.


Gore A.,Shri Ram Institute of Technology | Choubey S.D.,Shri Ram Institute of Technology | Gangrade K.,Shri Ram Institute of Technology
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2016

The need of bug localization tools and increased popularity of text based IR models to locate the source code files containing bugs is growing continuously. Time and cost required for fixing bugs can be considerably minimized by improving the techniques of reducing the search space from few thou‐ sand source code files to a few files. The main contribution of this paper is to propose a Hybrid model based on two existing IR models (VSM and N-gram) for bug localization. In the proposed hybrid model performance is further improved by using word based bigrams. We have also introduced a weighing factor beta β to calculate the weighted sum of unigram and bigram and analyzed its accuracy for values ranging from (0-1). Using TopN, MRR and MAP measures, we have conducted experiments which show that the proposed hybrid model outperforms some existing state-of-art bug localization techniques. © Springer International Publishing Switzerland 2016.


Sharma S.,Gyan Ganga Institute of Technology and Sciences | Mishra N.K.,Shri Ram Institute of Technology
Communications in Computer and Information Science | Year: 2011

The invention of public-key cryptography was of central importance to the field of cryptography and provided answers to many key management problems for large scale networks. For all its benefits, however, public-key cryptography did not provide a comprehensive solution to the key management problem. Indeed, the possibilities brought forth by public-key cryptography heightened the need for sophisticated key management systems to answer questions such as the following: "How can I easily encrypt a file once for a number of different people using public-key cryptography?" "If I lose my keys, how can I decrypt all of my files that were encrypted with those keys?" "How do I know that I really have Alice's public key and not the public key of someone pretending to be Alice?" "How can I know that a public key is still trustworthy?" The paper discusses public key cryptography and its use in applications such as Key Agreement, Data Encryption and Digital Signature. The paper discusses some public key algorithms such as DH, RSA, and DSA and also gives working explanations of these algorithms. © 2011 Springer-Verlag.


Kurmi R.,Shri Ram Institute of Technology | Ganeshpurkar A.,Shri Ram Institute of Technology | Bansal D.,Shri Ram Institute of Technology | Agnihotri A.,Shri Ram Institute of Technology | Dubey N.,Shri Ram Institute of Technology
Indian Journal of Ophthalmology | Year: 2014

Aim of Study: The aim of current work was to evaluate in vitro anticataract potential of Moringa oliefera extract. Materials and Methods: Goat eye lenses were divided into 4 groups; Group served as control, Group II as toxic control, Group III and Group IV were incubated in extract (250 μg/ml and 500 μg/ml of extract of M. oliefera) Group II, III and IV were incubated in 55 mM glucose in artificial aqueous humor to induce lens opacification. Estimation of total, water soluble protein, catalase, glutathione and malondialdehyde along with photographic evaluation of lens was done. Results: Group II (toxic control) lenses showed high amount of MDA (Malondialdehyde), soluble, insoluble protein, decreased catalase and glutathione levels, while lenses treated with Moringa oliefera extract (Group III and Group IV) showed significant (FNx01 P < 0.05) reduction in MDA and increased level of catalase, glutathione, total and soluble protein. Conclusion: Results of present findings suggest protective effect of Moringa oliefera in prevention of in vitro glucose induced cataract.


Bansal D.,Shri Ram Institute of Technology | Gulbake A.,Pharmaceutics Research Projects Laboratory | Tiwari J.,Bundelkhand Medical College | Jain S.K.,Pharmaceutics Research Projects Laboratory
International Journal of Biological Macromolecules | Year: 2016

Background: Folic Acid conjugated liposomes encapsulating Oxaliplatin (L-OHP) were entrapped in alginate beads and further coated with Eudragit-S-100 for effective delivery to colon tumors. Methods: Liposomes were prepared by cast film method and folic acid was coupled on the surface of liposomes. They were further entrapped in alginate beads which were Eudragit coated for degradation in the colonic region. The prepared beads were characterized for shape and surface morphology, percentage entrapment efficiency and drug release studies. The in vitro drug release was investigated using a USP dissolution paddle type apparatus in different simulated gastrointestinal fluids. In vivo studies of the beads containing free drug, folic acid coupled and uncoupled liposomes bearing L-OHP was administered orally at the dose of 10. mg L-OHP/kg body weight to tumor bearing NUDE/SCID mice. Results: γ-Scintigraphic study showed that Eudragit coated alginate beads entered into the colon of Balb/c mice between 4.20 and 4.50. h after oral administration. In vivo data showed that folic acid coupled liposomes entrapped in alginate beads delivered 2.82 ± 0.58 and 21.52 ± 2.76. μg L-OHP/g tissues in the colon and tumor after 12. h, reflecting its targeting potential to colon and tumor. Conclusion: The results clearly demonstrate that Eudragit coated calcium alginate beads bearing folic acid coupled liposome can be used as a prospective carrier for drug delivery to colon specific tumor. © 2015 Elsevier B.V..

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