Shri Rk Parikh Arts And Science College

Petlād, India

Shri Rk Parikh Arts And Science College

Petlād, India

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Shah H.J.,Kk Shah Jarodwala Maninagar Science College | Chaudhari J.A.,Shri Rk Parikh Arts And Science College
Der Pharma Chemica | Year: 2014

Novel heterocyclic compound namely, 4-((1-((4-((dialkylamino)methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2- yl)methyl)-1H-benzo[d]imidazol-2-yl)methylamino)-N-(pyrimidin-2-yl)benzenesulfonamide(4a-e) have been prepared by mannich reaction, a N-(pyrimidin-2-yl)-4-((1-((5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl)-1Hbenzo[ d]imidazol-2-yl)methylamino) benzenesulfonamide(3) react with formaldehyde and different secondary amines. The compound (3) prepared from 4-((1-(2-hydrazinyl-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)methylamino)- N-(pyrimidin-2-yl)benzenesulfonamide(2) with CS2/KOH. 4-((1H-benzo[d]imidazol-2-yl)methylamino)-N- (pyrimidin-2-yl)benzene sulfonamide(1) react with chloro acetic acid and hydrazine hydrate gives compound (2).All the structures of novel synthesized compounds were established on basis of analytical and spectral data. The newly synthesized compounds were studied for their antibacterial and antifungal activities.


Joshi V.S.,Shri Rk Parikh Arts And Science College | Vasant S.R.,Saurashtra University | Vasant S.R.,Government Engineering College | Bhatt J.G.,P.A. College | Joshi M.J.,Saurashtra University
Indian Journal of Geo-Marine Sciences | Year: 2014

Urinary calculi constitute one of the oldest afflictions of humans as well as animals, which are occurring globally. The calculi vary in shape, size and composition, which influence their clinical course. They are usually of the mixed-type with varying percentages of the ingredients. In medical management of urinary calculi, either the nature of calculi is to be known or the exact composition of calculi is required. In the present study, two selected calculi were recovered after surgery from two different patients for detailed examination and investigated by using Fourier-Transform infrared spectroscopy (FT-IR), thermo-gravimetric analysis (TGA), powder X-ray diffraction (XRD), scanning electron microscopy and energy dispersive analysis of X-rays (EDAX) techniques. The study demonstrated that the nature of urinary calculi and presence of major phase in mixed calculi could be identified by FT-IR, TGA and powder XRD, however, the exact content of various elements could be found by EDAX only. © 2014, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.

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