Shri Gs Institute Of Technology And Science

Indore, India

Shri Gs Institute Of Technology And Science

Indore, India
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Arya L.D.,Shri Gs Institute Of Technology And Science | Choube S.C.,Rajiv Gandhi Technical University
International Journal of Electrical Power and Energy Systems | Year: 2012

This paper describes a technique for selection of buses in a sub transmission system for location of distributed generation (DG) and determination of their optimum capacities by minimizing transmission losses. The buses have been selected based on incremental voltage (dV/dP) sensitivities. Line flow constraints have been accounted. Type-3 DG i.e. wind turbine along with induction generator has been considered for the study. Differential evolution (DE) has been used to evaluate the optimum DG capacity and results have been compared with those obtained using bare bones particle swarm optimization (BBPSO) and multi-membered non-recombinative (μ + λ) evolution strategy (MMNRES). The developed algorithms have been implemented on standard 6-bus and 30-bus test systems. © 2012 Elsevier Ltd. All rights reserved.


Agrawal A.,Shri Gs Institute Of Technology And Science | Maheshwari R.K.,Shri Gs Institute Of Technology And Science
Asian Journal of Pharmaceutics | Year: 2011

The present study was aimed to develop a mucoadhesive in situ nasal gel containing domperidone with enhanced drug loading and transnasal permeation properties, which were achieved by improving drug solubility using the concept of mixed solvency. Poloxamer 407 was used as thermosensitive polymer and carbopol 934P as mucoadhesive polymer. Initially solubility of domperidone was enhanced in aqueous solution by using various solubilizers like sodium citrate (SC), urea (UR), polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG), propylene glycol (PG) etc, individually and as a combination of two, three, and four solvents, respectively. Maximum solubility of domperidone was achieved at 30% w/w solvent concentration, containing mixed blend of PVP K30 (7.5% w/w) + PEG 400 (7.5% w/w) + PEG 600 (7.5% w/w) + Propylene Glycol (7.5% w/w), enhancing solubility of domperidone by 172.20 times as compared to its solubility in water. In situ gel was prepared by cold technique. Evaluation of the prepared gel was carried out, including properties like phase transition temperature, viscosity, in vitro drug release, drug content, transnasal permeation and stability studies. In vitro drug release studies of aqueous solution of mixed blend were performed and permeability coefficient was found to be 1.576 × 10 -02 cm/hr and flux was found to be 8.64 g/cm 2 hr. Similarly in vitro studies for in situ nasal gel were performed and percent cumulative drug release was 73.05±0.57% in 6 h. Transnasal drug permeation studies results in flux value of 7.04 μg/cm 2 hr and percent cumulative drug permeated across the membrane as 86.620.992%. The results from stability studies revealed that the prepared thermogel showed no significant decrease in drug content and no physicochemical change was observed upon storage in different temperature conditions resulting as a stable formulation.


Maheshwari R.K.,Shri Gs Institute Of Technology And Science | Karawande V.U.,Shri Gs Institute Of Technology And Science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2013

Ethyl acetate (class III solvent) has been used to prepare oral floating microspheres replacing methylene chloride (class II). The concept of mixed solvency has been utilized to increase the solubility of drug in the internal phase. One step emulsification solvent evaporation technique (o/w) was used to prepare microspheres. Internal phase consisted of solution of drug in ethyl acetate containing dissolved polymer i.e. Eudragit RSPO. The solubilizer i.e. PEG 200 along with polymer aided to dissolve the drug completely in internal phase. Petroleum ether was used as porosity generator. The microspheres with good floating ability (73% floating after 8 hrs on simulated gastric fluid) and controlled release (85% cumulative release after 12 hrs in-vitro) were successfully prepared. Average particle size of microspheres was in micron range (D0.5 = 67μm) with 1.703 as polydispersity index. Floating microspheres using safer solvents i.e. ethyl acetate (class 3) were prepared replacing generally used solvent methylene chloride (class 2). Buoyancy of microspheres was increased with increasing amount of petroleum ether. Drug release was decreased with increasing polymer: drug ratio. Encapsulation efficiency was also enhanced with increasing polymer: drug ratio.


Arya L.D.,Shri Gs Institute Of Technology And Science | Choube S.C.,Rajiv Gandhi University | Arya R.,Medi Caps Institute of Science and Technology
International Journal of Electrical Power and Energy Systems | Year: 2011

This paper describes a methodology for reliability enhancement of radial distribution system by determining optimal values of repair times and failure rates of each section. Penalty cost functions have been constructed as function of failure rates and repair times. Constraints on customer and energy based indices, i.e. SAIFI, SAIDI, CAIDI and AENS have been considered. The problem has been decomposed in two stages. One stage determines the optimum failure rates and second stage optimizes repair times satisfying constraints. A population based approach, i.e. differential evolution (DE) has been used as optimization technique. The algorithm has been implemented on a sample test system. Results obtained have been compared with those obtained using particle swarm optimization (PSO) and co-ordinated aggregation based particle swarm optimization techniques (CAPSO). © 2010 Elsevier Inc. All rights reserved.


Arya R.,Medi Caps Institute of Science and Technology | Choube S.C.,Rajiv Gandhi University | Arya L.D.,Shri Gs Institute Of Technology And Science
International Journal of Electrical Power and Energy Systems | Year: 2012

This paper describes an analytical methodology for reliability evaluation and enhancement of distribution system having distributed generation (DG). Standby mode of operation of DG has been considered for this purpose. Reliability of the composite distribution system has been optimized with respect to failure rate and repair time of each section of the distribution system subject to constraints on (i) failure rates/ repair times and (ii) customer and energy based reliability indices i.e. SAFI, SAIDI, CAIDI and AFNS. The objective function includes (i) cost of modification for failure rates/repair times (ii) additional cost of expected energy supplied by DG. Differential evolution (DE), Particle swarm optimization (PSO) and co-ordinated aggregation based PSO (CAPSO) have been used to develop computational algorithms. Developed algorithms have been implemented on a sample distribution system. © 2012 Elsevier Ltd. All rights reserved.


Jain Pancholi N.,Shri Gs Institute Of Technology And Science | Gupta S.,P.A. College | Sapre N.,SGSITS | Sapre N.S.,Shri Gs Institute Of Technology And Science
Molecular BioSystems | Year: 2014

Researchers are on the constant lookout for new antiviral agents for the treatment of AIDS. In the present work, ligand based modeling studies are performed on analogues of substituted phenyl-thio-thymines, which act as non-nucleoside reverse transcriptase inhibitors (NNRTIs) and novel leads are extracted. Using alignment-dependent descriptors, based on group center overlap (SALL, HDALL, HAALL and RALL), an alignment-independent descriptor (S log P), a topological descriptor (Balaban index (J)) and a 3D descriptor dipole moment (μ) and shape based descriptors (Kappa 2 index (2κ)), a correlation is derived with inhibitory activity. Linear and non-linear techniques have been used to achieve the goal. Support Vector Machine (SVM, R = 0.929, R2 = 0.863) and Back Propagation Neural Network (BPNN, R = 0.928, R2 = 0.861) methods yielded near similar results and outperformed Multiple Linear Regression (MLR, R = 0.915, R2 = 0.837). The predictive ability of the models are cross-validated using a test dataset (SVM: R = 0.846, R2 = 0.716, BPNN: R = 0.841, R2 = 0.707 and MLR: R = 0.833, R2 = 0.694). It is concluded that the hydrophobicity (S log P) and the polarity (μ) of a ligand and the presence of hydrogen donor (HDALL) moieties are the deciding factors in improving antiviral activity and pharmaco-therapeutic properties. Based on the above findings, a virtual dataset is created to extract probable leads with reasonable antiviral activity as well as better pharmacophoric properties. © 2014 The Royal Society of Chemistry.


Arya L.D.,Shri Gs Institute Of Technology And Science | Koshti A.,IPS Academy | Choube S.C.,Rajiv Gandhi University
International Journal of Electrical Power and Energy Systems | Year: 2013

This paper presents a methodology for composite distribution system well being analysis based on non-sequential Monte Carlo simulation technique accounting uncertainties in capacity of distribution substation and distributed generation (DG). The method is based on a system state transition sampling approach which is used to calculate frequency and duration indices along with probabilities in healthy state, marginal state and risky state for a composite distribution system. Capacity of distribution substation and distributed generations are considered as normally distributed i.e. continuous capacity. The effectiveness of the method for evaluation of annual well being indices is demonstrated for a sample test system with DG capacity variation considering a seven step load model based on annual load duration curve. A comparative study is carried out which illustrates the effect of distributed generation capacity on well being indices of a distribution system. © 2012 Elsevier Ltd. All rights reserved.


Sharma S.,Shri Gs Institute Of Technology And Science | Singh B.,Indian Institute of Technology Delhi
IET Power Electronics | Year: 2012

This study deals with an implementation of a constant speed permanent magnet synchronous generator (PMSG)-based three-phase stand-alone wind energy conversion system (SWECS). The voltage and frequency controller is realised using only a single voltage source converter (VSC) and a battery energy storage system (BESS). The BESS is used to provide load levelling under varying wind speeds and to control frequency of SWECS. The voltage of PMSG is regulated under varying wind speeds and loads by supplying the reactive power from VSC. The performance of SWECS is demonstrated as a load leveller, a load balancer, a harmonic compensator and a voltage and frequency controller. © 2012 The Institution of Engineering and Technology.


Gupta N.,Shri Gs Institute Of Technology And Science | Amritphale S.S.,Advanced Materials and Processes | Chandra N.,Advanced Materials and Processes
Bioresource Technology | Year: 2010

Hybrid precursor (HP) of silicon and carbon was synthesized from rice hulls by a novel low temperature method, using sol-gel route. The potential of hybrid precursor to remove Zn (II) ions from aqueous solutions was investigated under different experimental conditions. Hybrid precursor removes Zn (II) ions with efficiency higher than 95% at low concentration. The data revealed that initial uptake was rapid and equilibrium was established in 30 min. Pseudo first order, Pseudo second order and Intraparticle diffusion kinetic models were applied to the kinetic data and it was found that adsorption process followed pseudo second order with activation energy of 1.093 kJ mol -1. Zn (II) removal was quantitatively evaluated using Langmuir and Freundlich isotherm model and monolayer sorption capacity show the value 28.76 mg/g indicating the affinity of HP for Zn (II) ions. The negative value of Gibbs free energy obtained in this study with hybrid precursor confirms the feasibility and spontaneous nature of adsorption process. © 2009 Elsevier Ltd. All rights reserved.


Kumar S.,Shri Gs Institute Of Technology And Science | Tiwari M.,Shri Gs Institute Of Technology And Science
Journal of Chemometrics | Year: 2013

A grid potential analysis employing a novel approach of 3D quantitative structure-activity relationships (QSAR) as AutoGPA module in MOE2009.10 was performed on a dataset of 42 compounds of N-arylsulfonylindoles as anti-HIV-1 agents. The uniqueness of AutoGPA module is that it automatically builds the 3D-QSAR model on the pharmacophore-based molecular alignment. The AutoGPA-based 3D-QSAR model obtained in the present study gave the cross-validated Q2 value of 0.588, r2 pred value of 0.701, r2 m statistics of 0.732 and Fisher value of 94.264. The results of 3D-QSAR analysis indicated that hydrophobic groups at R1 and R2 positions and electron releasing groups at R3 position are favourable for good activity. To find similar analogues, virtual screening on ZINC database was carried out using generated AutoGPA-based 3D-QSAR model and showed good prediction. In addition to those mentioned earlier, in-silico ADME absorption, distribution, metabolism and excretion profiling and toxicity risk assessment test was performed, and results showed that majority of compounds from current dataset and newly virtually screened hits generated were within their standard limit. © 2013 John Wiley & Sons, Ltd.

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