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Mujawar P.,Shri Bhausaheb Hire Government Medical College | Suryawanshi K.H.,ACPM Medical College | Nikumbh D.B.,ACPM Medical College
Journal of Cytology | Year: 2015

Hydatid cyst in the breast is very rare and unusual for its location. Reported incidence of hydatid cyst in the breast is 0.27% in the literature. Herein, we report a case of hydatid cyst of breast in a 65-year-old female who presented with painless, slowly growing lump in the breast mimicking breast neoplasm clinically. Radiological investigations such as ultrasonography and mammography may be helpful but not conclusive. Preoperative fine-needle aspiration cytology (FNAC) diagnosis was consistent with hydatid cyst of breast and was without any complications. Histopathological examination of lumpectomy specimen confirmed the diagnosis of hydatid cyst of breast. High suspicion of this entity should be there in the differential diagnosis in the evaluation of breast lump in endemic as well as in migrant population in nonendemic areas. © 2015 Journal of Cytology | Indian Academy of Cytologists | Published by Wolters Kluwer - Medknow.

Ismail T.S.E.S.,Shri Bhausaheb Hire Government Medical College | Deshmukh S.A.,Shri Bhausaheb Hire Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2012

Diabetes mellitus has emerged as a major healthcare problem in India. Management of postprandial plasma glucose (PPG) level is important to prevent the complications associated with type-2 diabetes. Considering paucity of studies motivated us to compare the effect of Acarbose, Miglitol and Voglibose on postprandial hyperglycemia and HbA1C. It was single blind, randomized, parallel group, comparative, prospective clinical trial on 90 diabetes type 2 patients defined as post prandial plasma glucose (PPG) levels more than 200 mg % and glycosylated haemoglobin more than 7 % at visit 1. Glycosylated hemoglobin (p=0.78) and post prandial blood glucose (p=0.61) was reduced more by Voglibose than Miglitol and Acarbose. Though this finding is not statistically significant, adverse effect profile was better with Voglibose (6.66%) than Miglitol (16.66%) and Acarbose(33.33%). Present study recommends use of Voglibose looking at its efficacy and safety profile as preferential choice in the management of postprandial hyperglycaemia in treatment of type-2 diabetes mellitus.

Deshmukh S.A.,Shri Bhausaheb Hire Government Medical College | Ismail T.S.E.S.,Shri Bhausaheb Hire Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2012

Psychotropic drugs are costly, imparting pill burden on patients and monitorial burden on health care system due to irrational prescribing. Our aim was to find drug utilization pattern amongst out-patients attending the psychiatry out-patient department of Government Medical College, Nagpur. This was the prospective, cross sectional and observational study over 22 weeks on 515 newly diagnosed psychiatric patients. Results are expressed in percentage (%). Average drugs per prescription were 2.05±0.006 in men and 1.90±0.05 in women. 100% drugs were prescribed by brand names. The cost of drugs per prescription in Indian rupees was 68.33±7.30. Most common drug group prescribed was antidepressant (60.4%). Olanzapine use was highest (26.6%). Irrational co-prescription, antidepressant + BZD (15.5%) was commonest. Women were prescribed more antidepressants (Tricyclics > SSRI) (17.7%, χ2=4.26, p<0.039). Less than 45 years accounted for most prescription. The common psychiatric illness was ". schizophrenia and other psychiatric illnesses". None of drug was prescribed by generics. So we are at conclusion that prescription pattern is irrational and this should be intervened by educating prescribers about rational prescribing in psychiatry.

Joshi-Khadke S.,Shri Bhausaheb Hire Government Medical College | Khadke V.V.,Shri Bhausaheb Hire Government Medical College
Journal of the Indian Medical Association | Year: 2013

The aim of present study is to report our experience concerning the effectiveness, quality of analgesia, ease of performance, complications and safety of spinal anaesthesia in children undergoing infra-umbilical surgery. An open, non-comparative study was performed on 40 children aged 5-15 years undergoing elective infra-umbilical surgery. After parents' written consent and premedication, spinal anaesthesia was induced with hyperbaric bupivacaine (5mg/ml), 0.4mg/kg for children up to 15 kg body weight and 0.3mg/kg for >15 kg via L3-L4 or L4-L5 interspace in lateral decubitus position. A 26-gauge disposable hypodermic needle with attached syringe and drug appearing at the tip of needle was used for lumbar puncture. The success rate, spread and duration of analgesia, degree of motor block, additional anaesthetic, haemodynamic parameters and adverse effects were recorded. The descriptive results were presented as mean (SD) or number (%). Value of p<0.05 was considered significant. The success rate of the procedure was 92.5%. The mean onset of analgesia was 4.2(1.8) minutes. The highest sensory level (T8) was achieved within 6.2(3.1) minutes. The duration of block was 69.8(15) minutes. The dose of intrathecal bupivacaine used was 4-9 mg. No evidence of cardiovascular instability, postdural puncture headache, transient neurological symptoms, urinary complication was observed. Spinal anaesthesia with hyperbaric bupivacaine using 26-gauge hypodermic needle provides safe and effective analgesia for paediatric infra-umbilical surgery with high success rate.

Khan B.,Shri Bhausaheb Hire Government Medical College | Shaikh S.,Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2014

The present study is conducted to observe the early cellular events and histological maturity of mesodermal component of thymus. After ethical approval from the institutional ethics committee 53 human fetuses were obtained from department of Obstetrics and Gynecology with permission of head of department and written informed consent from respective parents. The gestational age was determined by menstrual history and Crown Rump length (CRL). The specimen were dissected through parasternal incision and processed in paraffin. The sections were taken by rotary microtome. The slides were stained by Haematoxylin & eosin, Massons trichrome and Periodic acid-Schiff(PAS) stains. Differentiation of thymus started at 9th week and all significant structural changes such as lobulation, appearance of blood vessels and corticomedullary differentiation were occured within 17th week and thereafter thymus showed microscopic growth and maturity. The findings of the present study are comparable with the findings of standard text books and previous workers.

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