Mujawar P.,Shri Bhausaheb Hire Government Medical College |
Suryawanshi K.H.,ACPM Medical College |
Nikumbh D.B.,ACPM Medical College
Journal of Cytology | Year: 2015
Hydatid cyst in the breast is very rare and unusual for its location. Reported incidence of hydatid cyst in the breast is 0.27% in the literature. Herein, we report a case of hydatid cyst of breast in a 65-year-old female who presented with painless, slowly growing lump in the breast mimicking breast neoplasm clinically. Radiological investigations such as ultrasonography and mammography may be helpful but not conclusive. Preoperative fine-needle aspiration cytology (FNAC) diagnosis was consistent with hydatid cyst of breast and was without any complications. Histopathological examination of lumpectomy specimen confirmed the diagnosis of hydatid cyst of breast. High suspicion of this entity should be there in the differential diagnosis in the evaluation of breast lump in endemic as well as in migrant population in nonendemic areas. © 2015 Journal of Cytology | Indian Academy of Cytologists | Published by Wolters Kluwer - Medknow.
PubMed | Shri Bhausaheb Hire Government Medical College and ACPM Medical College
Type: Journal Article | Journal: Journal of cytology | Year: 2016
Hydatid cyst in the breast is very rare and unusual for its location. Reported incidence of hydatid cyst in the breast is 0.27% in the literature. Herein, we report a case of hydatid cyst of breast in a 65-year-old female who presented with painless, slowly growing lump in the breast mimicking breast neoplasm clinically. Radiological investigations such as ultrasonography and mammography may be helpful but not conclusive. Preoperative fine-needle aspiration cytology (FNAC) diagnosis was consistent with hydatid cyst of breast and was without any complications. Histopathological examination of lumpectomy specimen confirmed the diagnosis of hydatid cyst of breast. High suspicion of this entity should be there in the differential diagnosis in the evaluation of breast lump in endemic as well as in migrant population in nonendemic areas.
Khan B.,Shri Bhausaheb hire government medical college |
Shaikh S.,Government medical college
International Journal of Pharma and Bio Sciences | Year: 2014
The present study is conducted to observe the early cellular events and histological maturity of mesodermal component of thymus. After ethical approval from the institutional ethics committee 53 human fetuses were obtained from department of Obstetrics and Gynecology with permission of head of department and written informed consent from respective parents. The gestational age was determined by menstrual history and Crown Rump length (CRL). The specimen were dissected through parasternal incision and processed in paraffin. The sections were taken by rotary microtome. The slides were stained by Haematoxylin & eosin, Massons trichrome and Periodic acid-Schiff(PAS) stains. Differentiation of thymus started at 9th week and all significant structural changes such as lobulation, appearance of blood vessels and corticomedullary differentiation were occured within 17th week and thereafter thymus showed microscopic growth and maturity. The findings of the present study are comparable with the findings of standard text books and previous workers.
Joshi-Khadke S.,Shri Bhausaheb Hire Government Medical College |
Khadke V.V.,Shri Bhausaheb Hire Government Medical College
Journal of the Indian Medical Association | Year: 2013
The aim of present study is to report our experience concerning the effectiveness, quality of analgesia, ease of performance, complications and safety of spinal anaesthesia in children undergoing infra-umbilical surgery. An open, non-comparative study was performed on 40 children aged 5-15 years undergoing elective infra-umbilical surgery. After parents' written consent and premedication, spinal anaesthesia was induced with hyperbaric bupivacaine (5mg/ml), 0.4mg/kg for children up to 15 kg body weight and 0.3mg/kg for >15 kg via L3-L4 or L4-L5 interspace in lateral decubitus position. A 26-gauge disposable hypodermic needle with attached syringe and drug appearing at the tip of needle was used for lumbar puncture. The success rate, spread and duration of analgesia, degree of motor block, additional anaesthetic, haemodynamic parameters and adverse effects were recorded. The descriptive results were presented as mean (SD) or number (%). Value of p<0.05 was considered significant. The success rate of the procedure was 92.5%. The mean onset of analgesia was 4.2(1.8) minutes. The highest sensory level (T8) was achieved within 6.2(3.1) minutes. The duration of block was 69.8(15) minutes. The dose of intrathecal bupivacaine used was 4-9 mg. No evidence of cardiovascular instability, postdural puncture headache, transient neurological symptoms, urinary complication was observed. Spinal anaesthesia with hyperbaric bupivacaine using 26-gauge hypodermic needle provides safe and effective analgesia for paediatric infra-umbilical surgery with high success rate.
Ismail T.S.E.S.,Shri Bhausaheb Hire Government Medical College |
Deshmukh S.A.,Shri Bhausaheb Hire Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2012
Diabetes mellitus has emerged as a major healthcare problem in India. Management of postprandial plasma glucose (PPG) level is important to prevent the complications associated with type-2 diabetes. Considering paucity of studies motivated us to compare the effect of Acarbose, Miglitol and Voglibose on postprandial hyperglycemia and HbA1C. It was single blind, randomized, parallel group, comparative, prospective clinical trial on 90 diabetes type 2 patients defined as post prandial plasma glucose (PPG) levels more than 200 mg % and glycosylated haemoglobin more than 7 % at visit 1. Glycosylated hemoglobin (p=0.78) and post prandial blood glucose (p=0.61) was reduced more by Voglibose than Miglitol and Acarbose. Though this finding is not statistically significant, adverse effect profile was better with Voglibose (6.66%) than Miglitol (16.66%) and Acarbose(33.33%). Present study recommends use of Voglibose looking at its efficacy and safety profile as preferential choice in the management of postprandial hyperglycaemia in treatment of type-2 diabetes mellitus.
Deshmukh S.A.,Shri Bhausaheb Hire Government Medical College |
Ismail T.S.E.S.,Shri Bhausaheb Hire Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2012
Psychotropic drugs are costly, imparting pill burden on patients and monitorial burden on health care system due to irrational prescribing. Our aim was to find drug utilization pattern amongst out-patients attending the psychiatry out-patient department of Government Medical College, Nagpur. This was the prospective, cross sectional and observational study over 22 weeks on 515 newly diagnosed psychiatric patients. Results are expressed in percentage (%). Average drugs per prescription were 2.05±0.006 in men and 1.90±0.05 in women. 100% drugs were prescribed by brand names. The cost of drugs per prescription in Indian rupees was 68.33±7.30. Most common drug group prescribed was antidepressant (60.4%). Olanzapine use was highest (26.6%). Irrational co-prescription, antidepressant + BZD (15.5%) was commonest. Women were prescribed more antidepressants (Tricyclics > SSRI) (17.7%, χ2=4.26, p<0.039). Less than 45 years accounted for most prescription. The common psychiatric illness was ". schizophrenia and other psychiatric illnesses". None of drug was prescribed by generics. So we are at conclusion that prescription pattern is irrational and this should be intervened by educating prescribers about rational prescribing in psychiatry.
Joshi S.A.,Shri Bhausaheb Hire Government Medical College |
Khadke V.V.,Shri Bhausaheb Hire Government Medical College |
Subhedar R.D.,Shri Bhausaheb Hire Government Medical College |
Patil A.W.,Shri Bhausaheb Hire Government Medical College |
Motghare V.M.,Shri Bhausaheb Hire Government Medical College
Indian Journal of Pharmacology | Year: 2012
Background: The study was planned to assess the comparative efficacy, safety and duration of analgesia produced by low-dose clonidine and midazolam when used as adjuvant for spinal anesthesia. Materials and Methods: This is a randomized, participant and observer blind, prospective, parallel group clinical trial. Fifty ASA grade I and II patients posted for lower abdominal surgery were randomly allocated into two groups. BC group received spinal clonidine 30 μg and BM group received preservative-free midazolam 2 mg with 15 mg hyperbaric bupivacaine. Postoperative analgesia, analgesic requirement in 24 hours, onset and duration of block, hemodynamic stability and adverse effects were observed (P<0.05 - considered significant, P<0.01 considered highly significant). Results: The duration of postoperative analgesia was prolonged in BM group (391.64 132.98 min) than BC group (296.60 ± 52.77 min) (P<0.01). The mean verbal rating pain score was significantly less in BM group than BC group (P<0.01). The number of analgesic doses in 24 hours were significantly less in BM group (P<0.05). Nine patients (36%) in BC group required additional analgesia as against none in BM group (P<0.01). The onset of sensory block and peak sensory level was significantly earlier in BM group as compared to BC group. Duration of sensory block was longer in BM group (P<0.05). Subjects in BC group(36%) had bradycardia as compared to none in BM group (P<0.01). Hypotension was observed in 44% patients in BC group as against 16% in BM group (P<0.05). Conclusion: Postoperative analgesia with clonidine is short lived with some bradycardia. Intrathecal midazolam provides superior analgesia without clinically relevant adverse effects.
Ranade A.R.,Shri Bhausaheb Hire Government Medical College |
Kulkarni G.V.,Shri Bhausaheb Hire Government Medical College
International Journal of Pharma and Bio Sciences | Year: 2015
Today few literatures are available regarding normative data of the basal physiological parameters for Indian population. So the present study is undertaken to study the basal physiological parameters of standard X students. We performed an observational study in 70 students of standard X. Various parameters were measured in these students namely: body mass index (BMI), % Body fat, basal blood pressure, heart rate, sympathetic activity test like cold pressure test & parasympathetic activity tests like lying to standing test and various pulmonary function test parameters. Values of all anthropometric, cardiovascular and respiratory parameters were within normal ranges for particular age groups when compared to standard western references. As basal physiological parameters are subjected to variation by age, sex, race, genetic factor etc, values obtained from our study can be considered as normal reference values for the Indian population.
Patil P.,Shri Bhausaheb Hire Government Medical College |
Thakare G.,Shri Bhausaheb Hire Government Medical College |
Patil S.,Shri Bhausaheb Hire Government Medical College
National Journal of Physiology, Pharmacy and Pharmacology | Year: 2013
Background: Traffic policemen are in outdoor environment exposed to dust and other pollutants without any preventive measures making them susceptible for compromised lung functions with time being. Aims & Objective: Examination and comparative analysis of effects of exposure to environmental pollution on PEFR, MVV, FEV1, FVC between policemen in traffic and General duty in Dhule, Maharashtra. Materials and Methods: The Study was carried out from 1st to 30th November 2011. Study group included 50 traffic policemen and 60 policemen in general duty. Subjects were selected randomly with age, height and weight matched from nonsmoker policemen's fulfilling inclusion criteria's. Results: Group A policemen had statistically significant (p<0.01) lower levels of FVC, FEV1, PEFR, MMV values compared to their predictive values. Policemen in Group A had lower FVC by 0.32L, FEV1 by 0.21L/min and FEV1/FVC ratio was higher by 6.8% than the Group B (p<0.01).Percent to the predicted of value of FVC & FEV1 was lower by 11.8% and 10.2% respectively while FEV1/FVC ratio was 7.3% greater than Group B policemen (p<0.01). Forced vital capacity (FVC) of 30.8% was mildly reduced and in 17.3% it was moderately affected in Group A. Conclusion: There is significant decrement in lung function parameters in the traffic policemen in both the groups with more reduction in those regularly exposed to vehicle exhaust as compared to others.
PubMed | Shri Bhausaheb Hire Government Medical College
Type: Journal Article | Journal: Anesthesia, essays and researches | Year: 2015
Intrathecal neostigmine and magnesium sulfate (MgSO4) produce substantial antinociception, potentiate analgesia of bupivacaine without neurotoxicity.The aim was to investigate the effect of neostigmine and MgSO4 on characteristics of spinal anesthesia (SA), hemodynamic stability and postoperative analgesia when added to 0.5% hyperbaric bupivacaine for SA.In this prospective, randomized, double-blind study 75 American Society of Anesthesiologist status I and II adult females posted for major gynecological surgery were assigned to one of the three groups (n = 25). Group N received Neostigmine 25 g, Group M received MgSO4 50 mg, Group C received 0.5 ml saline as an adjuvant to 17.5 mg hyperbaric bupivacaine. Onset, duration of block, heart rate, mean arterial pressure, postoperative analgesia, analgesic requirement, and adverse effects were recorded. Data expressed as mean (standard deviation) or number (%). P <0.05 were statistically significant.The three groups were comparable in characteristics of SA. The mean duration of analgesia was significantly longer in Group N (5.1 h) followed by Group M (4.2 h) and Group C (3.8 h) (P = 0.0134). Analgesic requirement was significantly less in Group N followed by Group M and Group C (P = 0.00232). The pain score was significantly less in Group M (P < 0.05). The incidence of hypotension and vasopressor requirement was lowest (48%) in Group N than in Group M (64%) and Group C 84% (P = 0.0276). The incidence of bradycardia and atropine requirement was the lowest in Group M (P = 0.0354). Sedation was observed in 56% patients in Group M compared to 20% in Group N and 8% in Group C (P = 0.0004).Intrathecal Neostigmine and MgSo4 does not affect characteristics of SA. Postoperative analgesia of neostigmine was better than MgSO4. Neostigmine provides some protection against hypotension of SA whereas MgSO4 protects against bradycardia.