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Kohli D.V.,Dr Hari Singh Gour University | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Digest Journal of Nanomaterials and Biostructures | Year: 2010

The aim of present study was to assess the anti-inflammatory activity of polyherbal formulation of leaves of Annona squamosa, Azadiracta indica and rhizome of Curcuma longa. The mature green leaves of Annona squamosa, Azadiracta indica and rhizome of Curcuma longa were collected and authenticated. Extractions of dried leaves and rhizome were carried out with ethanol in soxhlet apparatus. The polyherbal formulation showed the significant anti-inflammatory activity comparable to the standard drug Indomethacin against carrageenan induced rat paw edema method. The polyherbal formulation reduced the inflammation induced by carrageenan by 49.3% and 61.73% on oral administration at 100 mg/ kg and 200 mg/kg respectively as compared to the control treated group an analgesic activity comparable to the standard drug tramadol HCl. Source


Sharma M.C.,Devi Ahilya University | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2010

Validated high performance liquid chromatographic (HPLC) method for estimation of Torsemide (TOR) and Spironolactone (SPI) in tablet dosage form. Isocratic RP-HPLC separation was achieved on Licrosphere C18 column (250 x 4.6mm) using Methanol: Acetonitrile: Phosphate buffer, pH 6.5 (60:20:20 v/v) at flow rate of 1.5 ml/min at 30 oC temperature. Quantitation was achieved by UV detection at 252 nm over the conc. range 0-25 μg/ml for both the drugs with mean recoveries of 100.01% + 0.12 and 100.64% + 0.20 for TOR and SPI respectively. This method is simple, precise and sensitive and applicable for the simultaneous estimation of TOR and SPI in tablet pharmaceutical combined dosage form. Source


Sharma S.,Yadhunath Mahavidyalya | Sharma M.C.,Devi Ahilya University | Kohli D.V.,A And G Pharmaceutical, Inc. | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2010

This paper described validated high performance liquid chromatographic (HPLC) method for estimation of Rosuvastatin Calcium (ROS) and Ezetimibe (EZE) in tablet dosage form. HPLC separation was achieved on Licrosphere C18 column (250 × 4.6mm) using Methanol: Acetonitrile: Phosphate buffer, pH 3.5(60:20:20 v/v) at flow rate of 1.0ml/min at 25°C temperature. Quantitation was achieved by UV detection at 279 nm over the concentration range 5-10 mg/ml for both the drugs with mean recoveries of 99.01% + 0.12 and 100.64% + 0.20 for ROS and EZE respectively. This method is simple, precise and sensitive and it is applicable for the simultaneous estimation of ROS and EZE in tablet dosage form. Source


Smita S.,Yadhunath Mahavidyalya | Sharma M.C.,Devi Ahilya University | Kohli D.V.,A And G Pharmaceutical, Inc. | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2010

Validated high performance liquid chromatographic (HPLC) method for estimation of Torsemide (TOR) and Spironolactone (SPI) in tablet dosage form. Isocratic RP-HPLC separation was achieved on Licrosphere C18 column (250 × 4.6mm) using Methanol: Acetonitrile: Phosphate buffer, pH 6.5 (60:20:20 v/v) at flow rate of 1.5 ml/min at 30 °C temperature. Quantitation was achieved by UV detection at 252 nm over the conc. range 0-25 μg/ml for both the drugs with mean recoveries of 100.01% + 0.12 and 100.64% + 0.20 for TOR and SPI respectively. This method is simple, precise and sensitive and applicable for the simultaneous estimation of TOR and SPI in tablet pharmaceutical combined dosage form. Source


Sharma M.C.,Yadhunath Mahavidyalya | Kohli D.V.,Dr Hari Singh Gour University | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Digest Journal of Nanomaterials and Biostructures | Year: 2010

The aim of present study was to assess the anti-inflammatory activity of polyherbal formulation of leaves of Annona Squamosa and rhizome of Curcuma longa. The mature green leaves of Annona Squamosa and Curcuma longa were collected and authenticated. Extractions of dried leaves and rhizome were carried out with ethanol in soxhlet apparatus. The polyherbal formulation showed the significant anti-inflammatory activity comparable to the standard drug Indomethacin against carrageenan induced rat paw edema method. The polyherbal formulation reduced the inflammation induced by carrageenan by 49.3% and 61.73% on oral administration at 100 mg/ kg and 200 mg/kg respectively as compared to the control treated group an analgesic activity comparable to the standard drug tramadol HCl. Antidepressant activity comparable to the standard drug Fluoxetine HCl. Source

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