Shree Swaminarayan Sanskar Pharmacy College

Gujarat, India

Shree Swaminarayan Sanskar Pharmacy College

Gujarat, India
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Mehta T.A.,Nirma University | Kunal P.,Shree Swaminarayan Sanskar Pharmacy College
International Journal of Drug Development and Research | Year: 2013

Elementary Osmotic Pumps (EOP) consists of osmotic core (coated with a semipermeable membrane (SPM) and a small orifice is created in the membrane. The objective of the present study was to develop an optimized EOP tablets containing inclusion complex of Nicardipine Hydrochloride (NH) using central composite design. Amount of osmotic agent (X1) and size of delivery orifice (X2) were selected as independent variables. Formulations were prepared by direct compression method and evaluated for % Cumulative Drug Release (% CDR) at 540min. as dependent variables. Amount of osmotic agent and size of delivery orifice had a significant effect on % CDR. The results of multiple linear regression analysis revealed that EOP tablets should be prepared using an optimum concentration of osmotic agent and size of delivery orifice to achieve a zero order drug release. Contour plots as well as response surface plots were constructed to show the effects of X1 and X2 on % CDR. A model was validated for accurate prediction of % CDR by performing checkpoint analysis. The computer optimization process, contour plots and response surface plots predicted at the concentration of independent variables X1 and X2 (50mg and 0.8mm respectively), for maximized response. The drug release from the developed formulation was found independent of pH and agitational intensity. The above optimized batch was also evaluated by different pharmacokinetic models. Stability study of optimized batch was conducted at accelerated conditions for six month and it was found to be stable. © 2013 Dr. Tejal A. Mehta et al, publisher and licensee IYPF.

Prajapati P.,Gujarat Forensic Sciences University | Patel H.K.,Shree Swaminarayan Sanskar Pharmacy College
Journal of Chinese Pharmaceutical Sciences | Year: 2014

A rapid and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of moxifloxacin (MOXI) in human plasma. After a simple protein precipitation using acetonitrile, the post treatment samples were analysed on a C18 column interfaced with a Triple Quadropole Tandem Mass Spectrometer. Positive electrosprayionization was employed as the ionization source. The mobile phase consisted of 0.1% formic acid-acetonitrile (60:40, v/v). Ciprofloxacin (CIPRO) was used as an internal standard. The analyte and internal standard (CIPRO) were monitored in the multiple reaction monitoring mode (MRM). The mass transition ion-pair has been followed as m/z 402→358.2 for MOXI and 332→288.1 for CIPRO. The method was linear in the concentration range of 25-5000 ng/mL. The lower limit of quantification was 25 ng/mL. The intra-and inter-day precision (relative standard deviation) and accuracy (relative error) values were within 12.4%. Each plasma sample was analyzed within 3 min.

Patel K.N.,Shree Swaminarayan Sanskar Pharmacy College | Patel H.K.,Shree Swaminarayan Sanskar Pharmacy College
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Diclofenac acid, Pressure Sensitive Adhesive (PSA) like acrylic adhesive by the solvent evaporation technique. Different concentrations of Labrasol, oleic acid and triacetin were used to enhance the transdermal permeation of diclofenac acid. Polyethylene monolayer film as a backing membrane and Silicone coated polyester film as a release liner preferred in preparation of transdermal patches. Formulated transdermal patches were physically evaluated with regard to percentage moisture absorption, thickness, weight variation, drug content, tensile strength, % elongation, folding endurance. All prepared formulations indicated good physical stability. In vitro skin permeation studies of formulations were performed by using Franz diffusion cells. Formulation containing 5% drug, 85% adhesive solution and 10% triacetin as permeation enhancer showed best in vitro skin permeation through human cadaver skin as compared to all other formulations. The results rate was found to follow zero order kinetics. These results indicate that the formulation F3 has shown optimum release in concentration independent manner. Stability study indicates that drug remains stable for six months and primary irritation study indicated that the transdermal patches are non-irritant.

Modi K.P.,Shree Swaminarayan Sanskar Pharmacy College | Rai P.A.,Shree Swaminarayan Sanskar Pharmacy College | Trivedi H.J.,Shree Swaminarayan Sanskar Pharmacy College | Sharma M.,Shree Swaminarayan Sanskar Pharmacy College | Patel K.N.,Shree Swaminarayan Sanskar Pharmacy College
Journal of Applied Pharmaceutical Science | Year: 2016

Palonosetron HCl is a 5HT3 antagonist licensed for the prevention of acute chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy agents (HEC) and the prevention of CINV associated with moderately emetogenic cancer chemotherapy (MEC). It has a substantially longer half-life (Approximately 40 h). So, it was plan to prepare melt in mouth tablet which could rapidly dissolved and absorbed which may produce rapid onset of action. Melt in mouth tablets were prepared by direct compression method using various superdisintegrants like Kyron T314 and Vivasol, and evaluated for pre compression and post compression parameters. A 32 full factorial design was applied systematically to optimize responses. The concentration of Kyron T314 (X1) and concentration of Vivasol (X2) were selected as independent variables and disintegration time (Y1) and wetting time (Y2) as dependent variables. The prepared tablets were evaluated for hardness, friability, disintegration time, wetting time, drug content and in vitro drug release. The results indicated that concentration of X1 and X2 significantly affected Y1 and Y2. Regression analysis and numerical optimization were performed to identify the best formulation. Similarity (f2) and dissimilarity (f1) study for optimized batch was also carried out. Batch P9 was found to be best batch with 10.43 s. disintegration time, 19.53 s. wetting time and 99.02% drug release in 30 min. There was no drastic change in the result of tablets of optimized batch at end of six month accelerated stability study. © 2016 Kinjal P Modi et al.

Patel J.B.,Shree Swaminarayan Sanskar Pharmacy College | Dangar R.D.,Shree Swaminarayan Sanskar Pharmacy College | Dangar R.R.,Shree Swaminarayan Sanskar Pharmacy College | Patel B.H.,Shree Swaminarayan Sanskar Pharmacy College | And 2 more authors.
International Journal of Advances in Pharmaceutical Sciences | Year: 2010

Crinum asiaticum (Amaryllidaceae) commonly known as Nagdovan in Gujarati is distributed throughout India. The plant is used traditionally in warm infestation. Medicinally, it has been proven to possess various pharmacological activities like antitumour, anti inflammatory, antimicrobial, antiemetic, antiuretic, haemogogue, and anthelmintic activities. Further, studies reveal the presence of various phytochemical constituents mainly phenolics, alkaloids and fatty acids. These studies reveals that Crinum asiaticum is a source of medicinally active compounds and having a various important pharmacological effects so this drug encourage finding its new therapeutic uses. ©

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