Shree Sureshdada Jain Institute of Pharmaceutical Education and Research

Jamner, India

Shree Sureshdada Jain Institute of Pharmaceutical Education and Research

Jamner, India
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Bagad Y.M.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Bhurat M.R.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Barhate S.D.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research
Research Journal of Pharmacy and Technology | Year: 2013

In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. The wound healing parameters were evaluated by using incision, and dead space wounds in extract-treated rats and controls. free radical are generated in side every human body these free radicals are beneficial if they are generated in small amount but if they are generated in huge amount they are harmful to our body. At low concentration free radicals can stimulate the proliferation of cells as well as the formation of connective tissue and new blood vessels. Skin wounds are rich in free radicals. There was a longer-lasting free radical effect in the wounds that had been treated with acetone and aqueous extract of LBR. The wound healing activity of acetone and aqueous extracts of Bridelia airyshawii Spreng. (Euphorbiaceae) was evaluated on incision and dead space wound models on albino rats. The healing activity was more significant in acetone extract treated animals. In incision wound models the wound healing process was evidenced by increase in the tensile strength. While in dead space wound model, the weight of the granuloma and tensile strength were increased indicating the increase in collagenation. The results were also compared with control and standard drug. © RJPT.


Devtalu S.V.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Patil A.E.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Bari M.M.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Barhate S.D.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

In modern era bi-layer tablet is for successful development of immediate and modified drug delivery system for various diseases and disorders. Bi-layer tablets have been developed to achieve modified release of drug. The primary objective of bi-layer tablet is to avoid chemical incompatibilities between APIs by physical separation and to develop different drug release profiles (immediate release and modified release). In bi-layer tablet the immediate release layer act as the loading dose and modified release layer act as the maintenance dose. To produce a good quality bi-layer tablet, the machinery should be constructed as per GMP. Various machineries are available to overcome common bi-layer problems, such as layer separation, insufficient hardness, inaccurate individual weight control, cross contamination between the layers etc. In this review we focus on the different types of press, techniques, how to solve problems of bi-layer tablet, marketed products etc.


Patil S.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Salunke P.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Wagh R.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Gavit S.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | And 3 more authors.
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

The crude extract of Tridax procumbens stems in water, methanol, ethanol, ethyl acetate, chloroform, were evaluated on adult Indian earthworms Pheretima posthuma for anthelmintic activity. The stems extract of Tridax procumbens exhibited a dose dependent inhibition of spontaneous motility (paralysis) and evoked responses to pin-prick. The effects were comparable with that of albendazole. The result showed that the ethanol extract of Tridax procumbens and found to be statistically significant at the ethanolic extract possessed wormicidal activity and thus, may be useful as an anthelmintic.


Patil N.D.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Bari M.M.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Barhate S.D.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research
International Journal of Pharmaceutical Sciences Review and Research | Year: 2013

Pulsatile drug delivery which releases drug in a programmed pattern i.e. at appropriate time and/or at appropriate site of action. It refers to treatment method in which drug in vivo bioavailability is matches with rhythms of disease, in order to optimize therapeutic outcomes and minimise side effects. Currently, it is gaining increasing attention as it offers a more sophisticated approach to the traditional sustained drug delivery system i.e. a constant amount of drug released per unit time. Pulsatile drug delivery system (PDDS) delivers the drug at specific time as per the patho-physiological need of the disease, resulting in improved therapeutic efficacy and patient compliance. Diseases wherein PDDS are promising include asthma, peptic ulcer, cardiovascular diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. Various technologies such as time-controlled, pulsed, triggered and programmed drug delivery devices have been developed and extensively studied in recent years for chronopharmaceutical drug delivery. Various types of formulation such as bilayer tablet, coated tablet, pellets, tablet in capsule can be prepared to deliver drug in a pulsatile manner.


Patil S.S.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Patil S.S.,North Maharashtra University | Salunkhe P.A.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research | Salunkhe P.A.,North Maharashtra University | And 2 more authors.
International Journal of Pharmacy and Technology | Year: 2014

Objective of the present study is to formulate and validate the manufacturing process of fixed dose combination (FDC) tablets of Rifampicin and Isoniazid. The granules of Rifampicin and Isoniazid were prepared separately by wet granulation in rapid mixer granulator, then lubricated blend was compressed using tablet compression machine by setting the machine speed in the range 12-28 RPM. Coating was done in Ganscoater coating pan in two lots by polyethylene glycol (PEG). The critical parameters involved in manufacturing such as Dry mixing, Granulation, Drying, Lubrication, Compression, Coating were evaluated. Dissolution studies FDC tablets were performed along with uncoated and film coated tablets separately. The cumulative percentage drug release for coated tablet was found to be around 96%. The %RSD of content uniformity of drug in final product was found to be 0.9 and 0.8 for RIFA and INH respectively. The % weight gain after coating was found to be 97.57. From studies it was concluded that the manufacturing process of 2-FDC was validated successfully and results were obtained within specified limits.

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