Bagad Y.M.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research |
Bhurat M.R.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research |
Barhate S.D.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research
Research Journal of Pharmacy and Technology | Year: 2013
In recent years, oxidative stress and free radicals have been implicated in impaired wound healing. The wound healing parameters were evaluated by using incision, and dead space wounds in extract-treated rats and controls. free radical are generated in side every human body these free radicals are beneficial if they are generated in small amount but if they are generated in huge amount they are harmful to our body. At low concentration free radicals can stimulate the proliferation of cells as well as the formation of connective tissue and new blood vessels. Skin wounds are rich in free radicals. There was a longer-lasting free radical effect in the wounds that had been treated with acetone and aqueous extract of LBR. The wound healing activity of acetone and aqueous extracts of Bridelia airyshawii Spreng. (Euphorbiaceae) was evaluated on incision and dead space wound models on albino rats. The healing activity was more significant in acetone extract treated animals. In incision wound models the wound healing process was evidenced by increase in the tensile strength. While in dead space wound model, the weight of the granuloma and tensile strength were increased indicating the increase in collagenation. The results were also compared with control and standard drug. © RJPT.
Patil S.S.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research |
Patil S.S.,North Maharashtra University |
Salunkhe P.A.,Shree Sureshdada Jain Institute of Pharmaceutical Education and Research |
Salunkhe P.A.,North Maharashtra University |
And 2 more authors.
International Journal of Pharmacy and Technology | Year: 2014
Objective of the present study is to formulate and validate the manufacturing process of fixed dose combination (FDC) tablets of Rifampicin and Isoniazid. The granules of Rifampicin and Isoniazid were prepared separately by wet granulation in rapid mixer granulator, then lubricated blend was compressed using tablet compression machine by setting the machine speed in the range 12-28 RPM. Coating was done in Ganscoater coating pan in two lots by polyethylene glycol (PEG). The critical parameters involved in manufacturing such as Dry mixing, Granulation, Drying, Lubrication, Compression, Coating were evaluated. Dissolution studies FDC tablets were performed along with uncoated and film coated tablets separately. The cumulative percentage drug release for coated tablet was found to be around 96%. The %RSD of content uniformity of drug in final product was found to be 0.9 and 0.8 for RIFA and INH respectively. The % weight gain after coating was found to be 97.57. From studies it was concluded that the manufacturing process of 2-FDC was validated successfully and results were obtained within specified limits.