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Yogesh U.,Shree H N Shukla Institute Of Pharmaceutical Education And Research | Krishnakant P.,SAL Institute of Pharmacy | Navin S.,Saurashtra University
Pharmacognosy Journal | Year: 2011

Seven fatty acids identified from the methanol extract of Anisomeles indica L., and Anisomeles malabarica L. R. Br. Ex Sims aerial parts. The extracted fatty acids were methyl-esterified and then analyzed by GC-MS. The chemical composition of the fixed oil from A. indica and A. malabarica were investigated together here for the first time. The relative contents of the fatty acids were calculated with Area normalization. Seven fatty acids amounting to 77.778% in A. indica and 68.027% in A. malabarica of the total contents detected. The major finded fatty acids in A. indica were Palmitic acid (23.334%), stearic acid (22.749%), lignoceric acid (21.54%) and, in A. malabarica, Palmitic acid (35.252%), stearic acid (21.43%). The results the content of fatty acids was abundant in Anisomeles species, and it had a great range of potential utilities and a prospect of development in foods medical and health cares. Source

Gotecha N.B.,Shree H N Shukla Institute Of Pharmaceutical Education And Research
International Journal of Pharma and Bio Sciences | Year: 2013

Three simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Aceclofenac (ACE) and Thiocolchicoside (THI) in their combined dosage form. Method A, Simultaneous equations method involves measurement of absorbance at 275 nm for ACE and 254 nm for THI, Method B, Absorption Ratio method involves measurement of absorbance at 275 nm for ACE and 264 nm for THI & Method C, Ratio first order derivative method involves measurement of amplitude at 265 nm for ACE and 240.60 nm for THI. Methanol used as a solvent. In these three UV spectrophotometric methods, first method linearity lies between 5-30 μg/mL for both ACE & THI, while for second and third method linearity lies between 10-35 μg/mL for both ACE & THI respectively with correlation coefficient > 0.998. The methods were validated according to ICH Guidelines. All validation parameters were within the acceptable range. These developed methods can be applied for routine analysis. Source

Chidrawar V.R.,Shree H N Shukla Institute Of Pharmaceutical Education And Research | Patel K.N.,SAL Institute of Pharmacy | Chitme H.R.,Oman Medical College | Shiromwar S.S.,Sudhakarrao Naik Institute of Pharmacy
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: Anti-obesity activity of alcoholic and methanolic extracts of roots of Clerodendrum phlomidis was evaluated against high fat diet (HFD) induced obesity in C57BL/6J female mice. Methods: Obesity was induced by feeding high fat diet for 13 weeks to C57BL/6J female mice and one group was kept on normal chow diet in order to evaluate the effect of Clerodendrum phlomidis on food intake, body weight changes, digestive enzyme activity, lipid metabolism, theromogenesis, adiposities diameter and histology of fat pad. Results: Among these two extracts methanolic extract of Clerodendrum phlomidis (MECP) have shown strong anti-obesity effect compare to alcoholic extract of Clerodendrum phlomidis (AECP). LD50 value was found to be more than 2000 mg/kg. Conclusions: MECP have shown more promising effects than AECP may be because of its multiple mechanisms. Anti-obesity activity produced by MECP is because of inhibition of pancreatic lipase activity which delays the intestinal absorption of dietary fat. Inhibition of pancreatic lipase activity was confirmed by in-vitro studies. MECP also contains β-sitosterol in abundant amount which was confirmed by HPTLC analysis. Moreover flavonoid content in the plant has anorexic property. By this study we concluded that MECP is beneficial for the suppression of obesity and associated complications like T2DM. © 2012 Asian Pacific Tropical Biomedical Magazine. Source

Gendle R.,Institute of Pharmacy | Kaushik B.,Institute of Pharmacy | Verma S.,Institute of Pharmacy | Patel R.,Shree H N Shukla Institute Of Pharmaceutical Education And Research | And 2 more authors.
International Journal of ChemTech Research | Year: 2010

The objective of this work was to develop sustained release tablets of highly water soluble Tramadol HCl using polymers (HPMC K100M, HPMC K15M, HPMC K 4M) as cost effective, non toxic easily available and suitable hydrophilic matrix system. Sustained release tablet of Tramadol HCl (dose 50mg) were produced by wet granulation method. After the evaluation of physical characteristics of tablets. The dissolution test was performed in 0.1 N HCl for two hr. and phosphate buffer pH 6.8 for ten hr. The release profile remains unchanged after three months storage of tablets. The best fit release kinetics was achieved with the zero order plot followed by the Higuchi and Korsmyer and Peppas equation. The data obtained proved that the formulations are useful for a sustained release of Tramadol HCl due to the percentage released after 12 hr. is nearly to 100%. Source

Singh S.K.,Shree H N Shukla Institute Of Pharmaceutical Education And Research | Sameer A.A.,Shree H N Shukla Institute Of Pharmaceutical Education And Research
Asian Pacific Journal of Tropical Biomedicine | Year: 2012

Objective: Lisinopril is the drug of choice in hypertension. Bioavailability of the drug is 25% of orally administered dose. An attempt was made to provide safe medicine meeting pharmacokinetics requirement of plasma concentration by formulating a sublingual tablet of Lisinopril. The Objective of present study is to develop the sublingual tablet of Lisinopril and improve its bioavailability, in view to maximize therapeutic effect of the drug. Method: The directly compressed tablet of Lisinopril was formulated using Mannitol, Micro Crystalline Cellulose and Kyron T-314 as super disintegrant. Formulation (F1-F7) was evaluated for disintegration time and in vitro release study. Further the optimized sublingual formulation (F6) and marketed formulation was subjected to in-vivo comparative bioavailability study using white New Zealand rabbits. Results: It was observed that concentration of Micro Crystalline Cellulose, Kyron T-314 has significant effect on the disintegration time of Lisinopril sublingual tablet formulations. The super disintegrant concentration 5% w/w (Kyron T-314) was found optimum in all tablet formulations. AUC of optimized sublingual tablet and oral tablet are 925.35μg×h/mL and 641.97 μg×h/mL with Cmax of 60.80 μg/mL and 41.21 μg/mL and Tmax of 4 h and 4 h respectively. The bioavailability of optimized sublingual tablet of Lisinopril was improved by 1.44 times as compared to conventional oral marketed tablet of Lisinopril. Conclusions: The present approach of formulating sublingual tablet of Lisinopril would definitely improve bioavailability leading to reduced conventional dose of this drug. The administration of sublingual tablet becoming easy and it will improve patient compliance to therapy for hypertension for pediatrics, geriatric and bed ridden patient. © 2012 Asian Pacific Tropical Biomedical Magazine. Source

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