Shree Hn Shukla Institute Of Pharmaceutical Education And Research

Rājkot, India

Shree Hn Shukla Institute Of Pharmaceutical Education And Research

Rājkot, India
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Ushir Y.,Shree Hn Shukla Institute Of Pharmaceutical Education And Research
International Journal of Green Pharmacy | Year: 2010

The essential oil from the aerial part and roots of Anisomeles indica Linn. from the Toranmal forest, Maharashtra (India), was obtained by hydrodistillation after drying and grounding of the herbal material. A total of 27 components were resolved in the essential oil by GC-MS analysis, while 18 compounds were identified comparing the recorded mass spectra with the Nist 98/Nbs 75 K GC-MS library of mass spectra. The microbiological activity of the isolated essential oils was investigated as well. It was found that the essential oil shows microbiological activity on Escherichia coli, Pseudomonas aeruginosa, Bacillus pumilus and Staphylococcus aureus with a range of minimum inhibitory concentration values extended from 31.25 to 250 μg/ml. The percentage inhibition values calculated also support the minimum inhibitory concentration findings. The MBCs also performed for the same pathogens. Limonene, pinene, isobornyl acetate and eugenol can be considered as the main antimicrobial constituents in the essential oils of plants.


Singh S.K.,Shree Hn Shukla Institute Of Pharmaceutical Education And Research | Gendle R.,RITEE | Sheth N.R.,Gujarat University | Roshan P.,Shree Leuva Patel Trust Pharmacy Mahila College | Singh S.,P.A. College
Journal of Global Pharma Technology | Year: 2010

The present work reports isolation of seed mucilage of Zizyphus jujuba. Physiochemical characterization such as swelling index, hydration capacity, powder porosity, loss on drying, pH and viscosity were studied. The seed mucilage of Zizyphus jujuba has been evaluated for its granulating and binding properties in tablets, using paracetamol as a model drug. The seed mucilages of Zizyphus jujuba was used in four different concentrations 2.5, 5.0, 7.5 and 10.0%w/v. The granules were prepared by wet granulation technique. The prepared granules were evaluated for percentage of fines, average particle size and flow properties. The properties were compared with guar gum10% w/v. The tablets were prepared and evaluated for hardness, friability, content uniformity, disintegration time and in vitro dissolution profiles. They had good physicochemical properties, and the drug release was more than 80% within 2h. All the formulations (F1, F2, F3, and F4) were subjected to stability studies for three months as per ICH guidelines, only F1 and F4 showed stability with respect to release pattern and other parameters. Hence, 2.5% and 10.0% concentrations of mucilage of Zizyphus jujuba can be considered as ideal concentrations for preparation of tablets. © 2009, JGPT.


Singh S.,Shree Hn Shukla Institute Of Pharmaceutical Education And Research | Shah D.,Shree Hn Shukla Institute Of Pharmaceutical Education And Research
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: To formulate and Characterize Mouth Dissolving Tablet of Zolmitriptan to produce the intended benefits. Methods: Tablets were prepared using a direct compression method employing superdisintegrants such as Kyron T-314, Crospovidone, Croscarmellose Sodium, and Sodium Starch Glycolate. Tablets of Zolmitriptan prepared using Kyron T-314 exhibited the least friability and disintegration time 35 seconds. To decrease the disintegration time further, a sublimation technique was used along with the superdisintegrants for the preparation of Mouth Dissolving Tablet (MDTs). The addition of camphor as a subliming agent lowered the disintegration time 10 seconds further, but the percent friability was increased. A 32 full factorial design was employed to study the joint influence of the amount of superdisintegrant (Kyron T-314) and the amount of sublimating agent (Camphor) on the percent of friability and the disintegration time. Results: The results of multiple linear regression analysis revealed that an effective MDT of Zolmitriptan requires higher percentages of Kyron T-314 and camphor should be used. The approach using the optimization technique helped to produce a detailed understanding effect of formulation parameters. An optimized formulation was found to have good hardness, wetting time, disintegration time. Release kinetic model study indicated that all the formulations follow zero order kinetics. It also indicated that batch F1, F2, F5 and F8 releases the drug at constant rate as well as fast rate as per the Weibull model which was also confirmed by Hixson-Crowell model. Stability studies indicated that there are no significant changes in hardness, Percentage friability, drug content and in-vitro disintegration time and cumulative percentage drug release. Conclusions: Thus, it was concluded that by adopting a systematic formulation approach, Zolmitriptan Mouth dissolving tablet could be formulated using superdisintegrants in combination with a vacuum-drying technique for improved therapeutic efficacy. © 2012 Asian Pacific Tropical Medicine Press.


Aghera N.J.,Shree Hn Shukla Institute Of Pharmaceutical Education And Research | Shah S.D.,Shree Hn Shukla Institute Of Pharmaceutical Education And Research | Vadalia K.R.,Shree Hn Shukla Institute Of Pharmaceutical Education And Research
Asian Pacific Journal of Tropical Disease | Year: 2012

Objective: Sublingual tablets of Losartan Potassium were prepared to improve its bioavailability, to avoid pre-systemic metabolism in the gastrointestinal tract and hepatic first pass elimination. Methods: The Sublingual tablets were prepared by direct compression procedure using different concentration of Starch 1500 and microcrystalline cellulose. Compatibility studies of drug and polymer were performed by FTIR spectroscopy and DSC. Preformulation property of API was evaluated. Postcompressional parameters such disintegration time, wetting time, water absorption ratio, in vitro drug release and in vivo bioavailability study of optimized formulation were determined. Results: FTIR spectroscopy and DSC study revealed that there was no possible interaction between drug and polymers. The precompression parameters were in acceptable range of pharmacopoeial specification. The disintegration time of optimized formulation (F3) was upto 48 sec. The in vitro release of Losartan Potassium was upto 15 min. The percentage relative bioavailability of Losartan Potassium from optimized sublingual tablets was found to be 144.7 %. Conclusions: Sublingual tablets of Losartan Potassium were successfully prepared with improved bioavailability. © 2012 Asian Pacific Tropical Medicine Press.

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