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Dhumal R.,National Health Research Institute | Selkar N.A.,National Health Research Institute | Chawda M.B.,Shree Dhoothapapeshwar Ayurvedic Research Foundation SDARF | Thakur K.S.,Shree Dhoothapapeshwar Ayurvedic Research Foundation SDARF | And 3 more authors.
Asian Pacific Journal of Reproduction | Year: 2014

Objective: To evaluate the safety & efficacy of Maa-Lact granules for its galactogougue activity in Holtzman rats and its effect on suckling pups. Methods: Group I rats were treated as control, group II and III rats were treated with 500 mg/kg, 1 000 mg/kg of Maa-Lact granules for 21 days. Weekly body weights of dams and pups were collected, litter survivability for 22 days and ocular blood samples were collected on 1st day of parturition and 21st day of post parturition for the estimation of prolactin levels. On 21st day blood samples were collected from retro-orbital sinus for haemotological and biochemical estimations. On the same day of weaning rats were sacrificed and subjected to necropsy and individual organ weights were recorded. Results: No significant difference in weekly food weight consumption, body weights between control & treated groups with normal clinical signs. There is no mortaly in dams throught the study period with no significant difference in pups weights. The percentage mortality in pups was 14.43 %, 14.07 %, and 13.42% in group I, group II and group III, respectively. The histopathological finding has shown that treated groups have less convulution and adipose tissue deposition along with increase in length and branching of lactiferous duct and alveolar size. Conclusion: Based on above results, it can be concluded that Maa-Lact posseses significant galctogogue activity. © 2014 Hainan Medical College.

Jonnalagadda V.G.,Shree Dhoothapapeshwar Ayurvedic Research Foundation SDARF | Selkar N.A.,Shree Dhoothapapeshwar Ayurvedic Research Foundation SDARF | Vemula S.K.,Shree Dhoothapapeshwar Ayurvedic Research Foundation SDARF | Chawda M.B.,Shree Dhoothapapeshwar Ayurvedic Research Foundation SDARF | And 3 more authors.
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

From long back Arogyavardhani, a herbo-mineral preparation is used in the affections of liver & spleen disorders as an ayurvedic preparation. The present study was aimed to evaluate the hepatoprotective effect of Arogyavardhani in carbon tetrachloride (CCl4) induced liver damage in wistar rats. In the present study Arogyavardhani A (65 mg/kg, p.o) and Arogyavardhani B (65 mg/kg, p.o) were used to screen the hepatoprotective activity. Hepatotoxicity was induced by the CCl4 (3 ml/kg, p.o), and silymarin (50 mg/kg, p.o) was taken as a standard. Biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate trasaminase (SGPT), alkaline phosphatase (ALP), total bilirubin and direct bilirubin levels were estimated. Histapathological examination of liver samples were also done. CCl4 treated groups showed the elevated levels of biochemical parameters like SGOT, SGPT, ALP, total bilirubin, and direct bilirubin levels. In-case of Arogyavardhani treated groups significantly (p<0.01) prevented this hepatotoxicity. Histopathological examinations revealed the post-treatment of Arogyavardhani exhibited the protection of liver tissue from CCl4 induced hepatotoxicity. The observed results strongly support the hepatoprotective activity of Arogyavardhani against CCl4 induced hepatotoxicity.

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