Shree Dhanvantary Pharmacy College

Gujarat, India

Shree Dhanvantary Pharmacy College

Gujarat, India

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Patel H.M.,Rc Patel Institute Of Pharmaceutical Education And Research | Noolvi M.N.,Shree Dhanvantary Pharmacy College
European Journal of Medicinal Chemistry | Year: 2013

A novel series of 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]thiadiazoles 4 (a-d) and 7(a-i) were rationally designed through QSAR based pharmacophore approach and synthesized from 5-(1,3-benzodioxol-5-yl)-[1,3,4]thiadiazol-2-amine (1). The structures of these compounds were established by IR, 1H NMR, 13C NMR, HRMS technique. All the compounds were evaluated for their in vitro antihyperlipidemic activity using trition induced hyperlipidemic model. The newly synthesized title compound 7d, 7e and 7h showed a significant decrease in the serum, TCH, TG LDL and VLDL values along with an increase in serum HDL levels as compared to standard drug Fenofibrate. The treated groups also showed significant decrease in the atherogenic index, LDL:HDL risk ratios and the level of SGOT, SGPT and ALP activities compared to cholesterol induced hyperlipidemic control group. © 2013 Elsevier Masson SAS. All rights reserved.


Badiger A.,Shree Dhanvantary Pharmacy College
Medicinal Chemistry Research | Year: 2013

A series of 2,5,6-trisubstituted imidazo[2,1-b][1,3,4]thiadiazoles were synthesized, structures of the compounds were elucidated and evaluated for antitubercular activity against Mycobacterium tuberculosis H37Rv using microplate alamar blue assay (MABA) method, antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Vibrio cholera, and Escherichia coli by broth micro dilution assay method. Some compounds exhibited significant antibacterial and antitubercular activities. Compounds 10, 14, and 15 emerged as the most active molecules, showed significant antimicrobial activity and may serve as leads for further optimization. Graphical Abstract: Synthesis, spectral studies, and antibacterial and antitubercular activities of a novel series of imidazo[2,1-b][1,3,4]thiadiazole derivatives are described[Figure not available: see fulltext.]. © 2012 Springer Science+Business Media, LLC.


Deshmukh A.S.,Shree Dhanvantary Pharmacy College | Badiger A.M.,Shree Dhanvantary Pharmaceutical Analysis and Research Center | Muralikrishna K.S.,Shree Dhanvantary Pharmacy College
Carbohydrate Polymers | Year: 2012

Gum ghatti (Anogeissus latifolia) or Indian gum is a complex non-starch polysaccharide. It has been widely employed in food, pharmaceuticals, paper and other industries primarily due to its excellent emulsification and thickening property. Other applications of gum ghatti are inadequately investigated owing to lack of information on it. Researchers in the recent years have shown a great interest in exploring its molecular structure and functional properties. This article is aimed at discussing the structural features, functional properties and applications of gum ghatti with an emphasis on its pharmaceutical potential. © 2011 Elsevier Ltd. All rights reserved.


Noolvi M.N.,Shree Dhanvantary Pharmacy College | Kulkarni P.V.,Southwestern Medical Center
Expert Opinion on Drug Delivery | Year: 2015

Introduction: The ever-increasing developments in pharmaceutical formulations have led to the widespread use of biodegradable polymers in various forms and configurations. In particular, interpenetrating network (IPN) and semi-IPN polymer structures that are capable of releasing drugs in a controlled manner have gained much wider importance in recent years.Areas covered: Recently, IPNs and semi-IPNs have emerged as innovative materials of choice in controlled release (CR) of drugs as the release from these systems depends on pH of the media and temperature in addition to the nature of the system. These networks can be prepared as smart hydrogels following chemical or physical crosslinking methods to show remarkable drug release patterns compared to single polymer systems.Expert opinion: A large number of IPNs and semi-IPNs have been reported in the literature. The present review is focused on the preparation methods and their CR properties with reference to anticancer, anti-asthmatic, antibiotic, anti-inflammatory, anti-tuberculosis and antihypertensive drugs, as majority of these drugs have been reported to be the ideal choices for using IPNs and semi-IPNs. © 2014 Informa UK, Ltd.


Noolvi M.N.,Shree Dhanvantary Pharmacy College | Patel H.M.,Rc Patel Institute Of Pharmaceutical Education And Research
European Journal of Medicinal Chemistry | Year: 2012

In this study, some novel 2,6-disubstituted imidazo[2,1-b][1,3,4] thiadiazoles 4 (a-i), 7 (a-p) and 11 (a-i) were synthesized from 5-substituted-1,3,4-thiadiazol-2-amine. The newly synthesized compounds 4a, 4b, 4c, 4e, 4g, 7j, 7l, 11b and 11c were evaluated in the National Cancer Institute for single dose in vitro primary cytotoxicity assay. Among the tested nine compounds, compound 4b (107166/760239) and 4c (107168/760240) were passed the criteria for activity in this assay and scheduled automatically for evaluation against the full panel of 60 human tumor cell lines at a minimum of five concentrations at 10-fold dilutions. 3-(2-(4-methoxyphenyl)imidazo[2,1-b][1,3,4] thiadiazol-6-yl)aniline (4c) exhibited significant in vitro anticancer activity against Non Small Cell Lung Cancer HOP-92 cell line (GI50: 0.114 μM) and Renal Cancer CAKI-1 cell line (GI50: 0.743 μM). © 2012 Elsevier Masson SAS. All rights reserved.


Noolvi M.N.,Shree Dhanvantary Pharmacy College | Patel H.M.,Rc Patel Institute Of Pharmaceutical Education And Research
European Journal of Medicinal Chemistry | Year: 2012

Novel derivatives of 2-amino benzothiazoles 4(a-j) have been synthesized and tested for their antitumor activity using National Cancer Institute (NCI) disease oriented antitumor screen protocol against nine panel of cancer cell lines. Among the synthesized compounds, two compounds were granted NSC code and screened at National Cancer Institute (NCI)-USA for anticancer activity at a single high dose (10-5 M) and five dose in full NCI 60 cell panel. Among the selected compounds, 7-chloro-N-(2,6-dichlorophenyl)benzo[d]thiazol-2- amine (4i) with GI50 values of 7.18 × 10-8 M against Non-Small Cell HOP-92 Lung Cancer cell line proved to be the most active members in this study. Virtual screening was carried out through docking the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) to predict if these compounds have analogous binding mode to the EGFR inhibitors. © 2012 Elsevier Masson SAS. All rights reserved.


Deshmukh A.S.,Shree Dhanvantary Pharmacy College | Badiger A.M.,BDR Pharmaceuticals International Private Ltd
International Journal of Biological Macromolecules | Year: 2014

The present study details the synthesis, characterization and pharmaceutical application of hydrolysed polyacrylamide grafted maize starch (HPam-g-MS) as promising polymeric material for the development of pH responsive microbeads. Different grades of graft copolymer were synthesized by changing the net microwave irradiation time, while keeping all other factors constant. Acute oral toxicity study performed in rodents ensured the bio-safety of graft copolymer for clinical application. Various batches of aceclofenac loaded microbeads were prepared by ionic gelation method using synthesized graft copolymers and evaluated for formulation parameters. FTIR spectroscopy confirmed the chemical compatibility between drug and graft copolymer. Results of in vitro release study (USP type-II) carried out in two different pH media (pH 1.2 acid buffer and pH 7.4 phosphate buffer) showed that release rate of drug from developed microbeads was a function of both: (a) surrounding pH and (b) the matrix composition. The drug release was relatively higher at alkaline pH as compared to acidic pH and this feature is desirable from viewpoint of site specific drug delivery. A direct correlation was observed between percentage grafting and microbeads performance and it presents a scope for further research on application and optimization of HPam-g-MS based microbeads as drug delivery carriers. © 2014 Elsevier B.V.


Setty C.M.,Vishnu Institute of Pharmaceutical Education and Research | Deshmukh A.S.,Shree Dhanvantary Pharmacy College | Badiger A.M.,BDR Pharmaceuticals International Private Ltd
International Journal of Biological Macromolecules | Year: 2014

The present study investigates the pharmaceutical application of hydrolyzed polyacrylamide grafted carboxymethylxyloglucan (HPam-g-CMXG), as promising polymeric material for the development of pH responsive microbeads. The graft copolymer was synthesized by conventional free radical polymerization method and saponified to enhance its functionality and characterized. An acute oral toxicity study ensured the bio-safety of developed copolymer for clinical application. Various batches of pH responsive spherical microbeads were developed and evaluated for the effect of process parameters on their overall performance. Result of in vitro drug release study (USP Type-II, paddle method) carried out in two different pH media (pH 1.2 and pH 7.4) showed a triphasic drug release pattern in all the formulations. Both the drug release and swelling of microbeads were significantly higher in simulated intestinal (alkaline) pH compared to simulated gastric (acidic) pH and this nature is desirable for targeted drug delivery. A strong correlation was observed between the process parameters and matrix composition and it directly influenced the drug transport mechanism. In conclusion, the hydrolyzed polyacrylamide grafted carboxymethylxyloglucan holds an immense potential to be explored pharmaceutically as new matrix material for the design of targeted drug delivery system. © 2014 Elsevier B.V.


Shah V.,Shree Dhanvantary Pharmacy College | Raj H.,Shree Dhanvantary Pharmacy College
International Journal of Pharma and Bio Sciences | Year: 2012

A novel, simple, accurate, sensitive, reproducible, economical spectroscopic method was developed and validated for the determination of Azithromycin dihydrate and Cefixime trihydrate in combined dosage form. Second order derivative spectroscopy method is adopted to eliminate spectral interference. The method obeys Beer's Law in concentration ranges of 10-40 ppm for Cefixime trihydrate and 25-100 ppm of Azithromycin dihydrate. The method was validated for linearity, accuracy and precision as per ICH guidelines. The zero crossing point for Azithromycin dihydrate and Cefixime trihydrate was 328 nm and 231.6 nm, respectively in water. The LOD and LOQ value were found to be 0.13 and 0.38 ppm for Cefixime trihydrate and 0.80 and 2.44 ppm for Azithromycin dihydrate respectively. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form (ZIMNIC -AZ).


Prajapati D.,Shree Dhanvantary Pharmacy College | Raj H.,Shree Dhanvantary Pharmacy College
International Journal of Pharma and Bio Sciences | Year: 2012

RP-HPLC method was developed in mobile phase containing Acetonitrile:Monobasic potassium dihydrogen phosphate (60:40,v/v) using C 8 Luna (150 mm × 4.6 mm id, 5+μm) at wavelength 215nm. The method was linear in the concentration range of 2-6μg/ml for DICY and 50-150μg/ml for MEF. The method was validated for linearity, accuracy and precision as per ICH guidelines. The developed and validated method was successfully used for the quantitative analysis of commercially available dosage form.

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